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Cited by 65Photodynamic Therapy Research StudiesHead and Neck Cancer StudiesOral Health Pathology and Treatment

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Photodynamic therapy of premalignant lesions and local recurrence of laryngeal and hypopharyngeal cancers

Sieron, Aleksander, Namyslowski, Grzegorz, Misiolek, M., Adamek, Mariusz, Kawczyk-Krupka, Aleksandra·2001·European Archives of Oto-Rhino-Laryngology
DOI 10.1007/s004050100347
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Abstract

The main advantage of photodynamic therapy (PDT) in laryngology seems to be its non-invasiveness and the possibility of using it despite previous application of conventional methods. In the study, we gave PDT to two separate groups of patients, i.e. five patients with advanced tumour (four of them with local recurrence (squamous cell carcinoma) after surgery and radiotherapy and one with a primary hypopharyngeal tumour) and five patients with leucoplakia. In the first group delta-aminolaevulinic acid (ALA) was administered orally (dose 3 g), while in the second, an ointment containing 10% ALA was applied locally. In both groups prior to irradiation, the tissue level of protoporphyrin IX was verified using an adapted Xillix Life instrument. All treated lesions were irradiated with an argon-pumped dye laser (dose range 100-250 J/cm2, wavelength 635 nm). In the first group, partial response was obtained. In these advanced cases, diminution of cancerous ulcerations was observed. In the leucoplakia group, complete response was achieved in four out of five treated patients. On the basis of our preliminary results, PDT may be useful in eradicating premalignant lesions of the oral cavity and in the palliation of advanced lesions of the oropharynx and larynx.

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Crossref · 10.1007/s004050100347

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Metadata

Authors
Sieron, A., Namyslowski, G., Misiolek, M., Adamek, M., & Kawczyk-Krupka, A.
Affiliations
Medical University of Silesia (PL)
ORCID
Adamek, Mariusz
Venue
European Archives of Oto-Rhino-Laryngology
Publisher
Springer Science and Business Media LLC
Published
2001-09-01
Volume
258
Issue
7
Pages
349-352
ISSN
  • 0937-4477 (ISSN-L)
  • 1434-4726
DOI
10.1007/s004050100347
OpenAlex
W2053225461
Cited by
65
References
7
Citations by year
2024: 2 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 8
FWCI
2.35
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Archives of Oto-Rhino-Laryngology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
Keywords
photodynamic therapy, laryngeal cancer, hypopharyngeal cancer, local recurrence, squamous cell carcinoma, leucoplakia, precancerous lesions, 5-aminolevulinic acid, protoporphyrin IX, argon-pumped dye laser, palliative care
MeSH terms
Aminolevulinic Acid, Carcinoma, Squamous Cell, Female, Humans, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Leukoplakia, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Phototherapy, Precancerous Conditions, Neoplasms, Second Primary, Photosensitizing Agents, Laser Therapy

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CoChat. (2026). Citation check: Photodynamic therapy of premalignant lesions and local recurrence of laryngeal and hypopharyngeal cancers. https://app.cochat.ai/papers/10.1007/s004050100347
The paper
Sieron, A., Namyslowski, G., Misiolek, M., Adamek, M., & Kawczyk-Krupka, A. (2001). Photodynamic therapy of premalignant lesions and local recurrence of laryngeal and hypopharyngeal cancers. European Archives of Oto-Rhino-Laryngology. https://doi.org/10.1007/s004050100347

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.