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Cited by 23Schizophrenia research and treatmentFamily Caregiving in Mental IllnessCounseling, Therapy, and Family Dynamics

Effectiveness of targeted intervention and maintenance pharmacotherapy in conjunction with family intervention in schizophrenia

Wiedemann, G., Hahlweg, K., Müller, U., Feinstein, E., Hank, G., Dose, M.·2001·European Archives of Psychiatry and Clinical Neuroscience
DOI 10.1007/s004060170056
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Abstract

A sample of 85 patients with schizophrenia, of whom 34 later dropped out, received randomised treatment. There were no significant differences between treatment-takers and drop-outs in the variables assessed. Patients received either standard-dose maintenance neuroleptic treatment or targeted maintenance pharmacotherapy and all patients received behavioural family therapy. Measures of psychopathology, social adjustment, side-effects, family burden, and expressed emotion were assessed at baseline and then periodically over an 18-month period. The study was designed to compare the two alternative pharmacological maintenance approaches, each of them supported by psychosocial intervention. Any evaluation of the impact of behavioural family treatment on relapse rates and other outcome criteria is exclusively descriptive. A significantly higher rate of relapse was observed at 18 months in patients randomised to targeted treatment compared to those randomised to standard-dose treatment (35% vs 4%). Although patients assigned to the targeted maintenance group received significantly lower mean doses of neuroleptics, there were no significant differences between the two groups with regard to side-effects, global measures of social function, and overall psychopathology. Family burden was higher in the targeted-treatment group at six months, but did not differ at the one-year and eighteen-month time points. However, both groups improved significantly from baseline to 12 or 18 months in a…

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Authors
Wiedemann, G., Hahlweg, K., Müller, U., Feinstein, E., Hank, G., & Dose, M.
Affiliations
  • University of Tübingen (DE)
  • Technische Universität Braunschweig (DE)
  • Max Planck Institute of Psychiatry (DE)
ORCID
Venue
European Archives of Psychiatry and Clinical Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2001-05-18
Volume
251
Issue
2
Pages
72-84
ISSN
  • 0003-9373 (ISSN-L)
  • 0940-1334
  • 1433-8491
DOI
10.1007/s004060170056
OpenAlex
W2011803972
Cited by
23
References
58
Citations by year
2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2016: 2 · 2015: 2 · 2013: 3 · 2012: 1
FWCI
1.51
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
  • Social Sciences › Psychology › Clinical Psychology › Counseling, Therapy, and Family Dynamics
Keywords
schizophrenia, maintenance pharmacotherapy, family intervention, relapse, family burden, expressed emotion, social adaptation, psychopathology, antipsychotic adverse effects, treatment discontinuation
MeSH terms
Adolescent, Adult, Family Therapy, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Schizophrenia, Schizophrenic Psychology, Antipsychotic Agents, Treatment Outcome, Expressed Emotion, Secondary Prevention

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