Translating research into practice: the Schizophrenia Patient Outcomes Research Team (PORT) treatment recommendations
Abstract
Beginning in 1992, the Agency for Health Care Policy and Research and the National Institute of Mental Health funded the Schizophrenia Patient Outcomes Research Team (PORT) to develop and disseminate recommendations for the treatment of schizophrenia based on existing scientific evidence. These Treatment Recommendations, presented here in final form for the first time, are based on exhaustive reviews of the treatment outcomes literature (previously published in Schizophrenia Bulletin, Vol. 21, No. 4, 1995) and focus on those treatments for which there is substantial evidence of efficacy. The recommendations address antipsychotic agents, adjunctive pharmacotherapies, electroconvulsive therapy, psychological interventions, family interventions, vocational rehabilitation, and assertive community treatment/intensive case management. Support for each recommendation is referenced to the previous PORT literature reviews, and the recommendations are rated according to the level of supporting evidence. The PORT Treatment Recommendations provide a basis for moving toward "evidence-based" practice for schizophrenia and identify both the strengths and limitations in our current knowledge base.
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It is likely that discontinuation studies employing linear dose reductions will be more likely to induce withdrawal reactions (including, potentially, withdrawal psychosis) because reductions in D2 antagonism become increasingly large, causing greater likelihood of dopaminergic rebound.
“It is, therefore, likely that discontinuation studies employing linear dose reductions,74,83,84,86,87 as recommended in some older guidelines,94 will be more likely to induce withdrawal reactions (including, potentially, withdrawal psychosis) because reductions in D2 antagonism become increasingly large, causing greater likelihood of dopaminergic rebound.”
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- Authors
- Lehman, A. F., Steinwachs, D. M., & The Co-Investigators of the PORT Project
- Affiliations
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Corresponding author
- Lehman, A. F.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 24
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2121113553
- Cited by
- 910
- References
- 14
- Citations by year
- 2025: 6 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 12 · 2018: 23 · 2017: 12 · 2016: 17 · 2015: 14 · 2014: 16 · 2013: 22 · 2012: 41
- FWCI
- 38.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia
- MeSH terms
- Combined Modality Therapy, Health Policy, Humans, Research Support as Topic, Schizophrenia, United States, United States Agency for Healthcare Research and Quality, Treatment Outcome, Outcome Assessment, Health Care
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