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Association between male gender and cortical Lewy body pathology in large autopsy series
Open accessAbstract
Sex-linked factors may alter risk for neurodegenerative diseases. Definitive diagnoses are not established until autopsy, so neuropathological studies are critical. There have not been reported gender-related differences in neocortical Lewy bodies (LBs) using large multi-center autopsy series. We evaluated the associations between gender and pathologically characterized neurodegenerative diseases. Cases with Alzheimer's disease (AD), neocortical LBs, AD + neocortical LBs, or neither pathology were evaluated as separate groups. Results were corrected for possible confounders including age at death, smoking history, and education. The settings were the University of Kentucky Alzheimer's Disease Center and the National Alzheimer's Coordinating Center (NACC) Registry autopsy series; 3,830 subjects met inclusion criteria. Patients with neocortical ("diffuse") or intermediate ("limbic") LB pathologies tended to be male (male:female odds ratios ~2.9 with 95% CI 2.02-4.18). The preponderance of males dying with neocortical LB pathology was seen consistently across age groups and was not due to the potential confounders evaluated. By contrast, individuals dying with AD pathology were more likely to be female if dying over 80 (male:female odds ratio 0.66, 95% CI 0.50-0.88), but that tendency was not seen in individuals dying with AD pathology prior to age 80. Increased understanding of the male predominance in neocortical LB pathology may help guide clinicians, because males are more likely to be "undercalled" for neocortical LBs clinically, and females are more likely to be "overcalled" (P < 0.05 for both). Males are far more likely than females to die with neocortical LB pathology. This phenomenon may help guide medical practice including clinical trial study design.
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“Yet, to date, only a few studies have directly investigated the association between sex and AD and other common neuropathologies. Further, these included only a small sample size (less than 200 brain autopsies) [41,53], or did not examine pathologies other than AD [41,43,53].”
From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [43]
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“Likewise, two studies that reported different sex-AD pathology association in different ages did not utilize statistical interaction modeling [34,43].”
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“One clinical-pathologic study reported that the odds of AD pathology was not different between women and men if they were younger than 80 years at death, but women older than 80 years had a higher odds of AD pathology compared to men [43].”
From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [43]
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“Few if any of the previous studies which investigated the association of sex with AD pathologies have examined menopausal factors [25,41,43,53].”
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Cites
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542
Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease
(1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00057-2 · Cited by 981
McKeith, I. G. (2004) · Europe PMC (PubMed Central) · Cited by 756
Barker, W., Luis, C. A., Kashuba, A., Luis, M., Harwood, D. G., Loewenstein, D., Waters, C., Jimison, P., Shepherd, E., Sevush, S., et al. (2002) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200210000-00001 · Cited by 714
Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies
Andersen, K., Launer, L. J., Dewey, M. E., Letenneur, L., Ott, A., Copeland, J. R. M., Dartigues, J.-F., Kragh–Sorensen, P., Baldereschi, M., Brayne, C., et al. (1999) · Neurology · doi:10.1212/wnl.53.9.1992 · Cited by 650
McKeith, I. G., Mintzer, J. E., Aarsland, D., Burn, D. J., Chiu, H. F. K., Cohen‐Mansfield, J., Dickson, D. W., Dubois, B., Duda, J. E., Feldman, H., et al. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00619-7 · Cited by 640
Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., et al. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65722-7 · Cited by 533
Prospective validation of Consensus criteria for the diagnosis of dementia with Lewy bodies
McKeith, I. G., Ballard, C. G., Perry, R. H., Ince, P. G., O'Brien, J. T., Neill, D., Lowery, K., Jaros, E., Barber, R., Thompson, P., et al. (2000) · Neurology · doi:10.1212/wnl.54.5.1050 · Cited by 462
The National Alzheimer's Coordinating Center (NACC) Database: an Alzheimer disease database.
Beekly, D. L., Ramos, E. M., van Belle, G., Deitrich, W. D., Clark, A. D., Jacka, M. E., & Kukull, W. A. (2004) · PubMed · Cited by 371
A systematic review of prevalence and incidence studies of dementia with Lewy bodies
ZACCAI, J. H., McCracken, C., & Brayne, C. (2005) · Age and Ageing · doi:10.1093/ageing/afi190 · Cited by 342
α‐Synuclein pathology does not predict extrapyramidal symptoms or dementia
Parkkinen, L., Kauppinen, T., Pirttilä, T., Autere, J. M., & Alafuzoff, I. I. (2004) · Annals of Neurology · doi:10.1002/ana.20321 · Cited by 328
Cognitive decline is faster in Lewy body variant than in Alzheimer's disease
Olichney, J., Galasko, D. R., Salmon, D. P., Hofstetter, C. R., Hansen, L. A., Katzman, R., & Thal, L. J. (1998) · Neurology · doi:10.1212/wnl.51.2.351 · Cited by 306
Nelson, P. T., Jicha, G. A., Schmitt, F. A., Liu, H., Davis, D. G., Mendiondo, M. S., Abner, E. L., & Markesbery, W. R. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e31815c5efb · Cited by 292
Self-citationCognitive differences in dementia patients with autopsy-verified AD, Lewy body pathology, or both
Kraybill, M., Larson, E. B., Tsuang, D. W., Teri, L. L., McCormick, W. C., Bowen, J. D., Kukull, W. A., Leverenz, J. B., & Cherrier, M. M. (2005) · Neurology · doi:10.1212/01.wnl.0000165987.89198.65 · Cited by 286
Low sensitivity in clinical diagnoses of dementia with Lewy bodies
Nelson, P. T., Jicha, G. A., Kryscio, R. J., Abner, E. L., Schmitt, F. A., Cooper, G. E., Xu, L., Smith, C. D., & Markesbery, W. R. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5324-y · Cited by 279
Self-citationA critical evaluation of current staging of α-synuclein pathology in Lewy body disorders
Jellinger, K. A. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.07.006 · Cited by 247
Endogenous estrogen levels and Alzheimer’s disease among postmenopausal women
Manly, J. J., Merchant, C., Jacobs, D. M., Small, S. A., Bell, K. L., Ferin, M., & Mayeux, R. P. (2000) · Neurology · doi:10.1212/wnl.54.4.833 · Cited by 246
Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease
Williams, M. M., Xiong, C., Morris, J. C., & Galvin, J. E. (2006) · Neurology · doi:10.1212/01.wnl.0000247041.63081.98 · Cited by 239
Martí-Massó, J. F., & Martínez, J. R. (2000) · PubMed · Cited by 231
Gender differences in Parkinson's disease
Shulman, L. M. (2007) · Gender Medicine · doi:10.1016/s1550-8579(07)80003-9 · Cited by 183
Fujishiro, H., Ferman, T. J., Boeve, B. F., Smith, G. E., Graff‐Radford, N. R., Uitti, R. J., Wszołek, Z. K., Knopman, D. S., Petersen, R. C., Parisi, J. E., et al. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31817d7a1d · Cited by 161
Alzheimer's disease and its Lewy body variant: a clinical analysis of postmortem verified cases
Weiner, M., Risser, R. C., Cullum, C. M., Honig, L. S., White, C. L., Speciale, S. G., & Rosenberg, R. N. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.10.1269 · Cited by 110
Clinical and neuropathological correlates of Lewy body disease
Hishikawa, N., Hashizume, Y., Yoshida, M., & Sobue, G. (2003) · Acta Neuropathologica · doi:10.1007/s00401-002-0651-4 · Cited by 90
Role of Synucleins in Alzheimer’s Disease
Crews, L. A., Tsigelny, I. F., Hashimoto, M., & Masliah, E. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9073-6 · Cited by 85
Can Alzheimer’s Disease and Dementias with Lewy Bodies be Distinguished Clinically?
Weiner, M., Hynan, L. S., Parikh, B., Zaki, N., White, C. L., Bigio, E. H., Lipton, A. M., Martin‐Cook, K., Svetlik, D. A., Cullum, C. M., et al. (2003) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988703258671 · Cited by 84
McKeith, I. G., Rowan, E. N., Askew, K., Naidu, A., Allan, L. M., Barnett, N. A., Lett, D. J., Mosimann, U. P., Burn, D. J., & O'Brien, J. T. (2006) · American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000216177.08010.f4 · Cited by 81
Association Between Lifetime Cigarette Smoking and Lewy Body Accumulation
Tsuang, D. W., Larson, E. B., Li, G., Shofer, J. B., Montine, K. S., Thompson, M. L., Sonnen, J. A., Crane, P. K., Leverenz, J. B., & Montine, T. J. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00296.x · Cited by 44
Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease
Trembath, Y., Rosenberg, C., Ervin, J. F., Schmechel, D. E., Gaskell, P. C., Pericak‐Vance, M. A., Vance, J. M., & Hulette, C. M. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0670-9 · Cited by 42
Probable Alzheimer's disease: gender-related issues.
Barrett, A. M. (1999) · PubMed · Cited by 20
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Considering sex and gender in Alzheimer disease and other dementias
Podcasy, J., & Epperson, C. N. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/cepperson · Cited by 727
Neuropathology underlying clinical variability in patients with synucleinopathies
Halliday, G. M., Holton, J. L., Révész, T., & Dickson, D. W. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0852-9 · Cited by 447
Wang, W.-X., Huang, Q., Hu, Y., Stromberg, A. J., & Nelson, P. T. (2011) · Acta Neuropathologica · doi:10.1007/s00401-010-0756-0 · Cited by 339
Self-citationSex differences in Alzheimer’s disease and common neuropathologies of aging
Oveisgharan, S., Arvanitakis, Z., Yu, L., Farfel, J., Schneider, J. A., & Bennett, D. A. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1920-1 · Cited by 330
Sex and gender differences in cognitive resilience to aging and Alzheimer's disease
Arenaza‐Urquijo, E. M., Boyle, R., Casaletto, K., Anstey, K. J., Vila‐Castelar, C., Colverson, A., Palpatzis, E., Eissman, J. M., Kheng Siang Ng, T., Raghavan, S., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13844 · Cited by 223
Metadata
- Authors
- Nelson, P. T., Schmitt, F. A., Jicha, G. A., Kryscio, R. J., Abner, E. L., Smith, C. D., Van Eldik, L. J., & Markesbery, W. R.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Nelson, Peter T.
- ORCID
- Venue
- Journal of Neurology
- Published
- 2010-06-20
- Volume
- 257
- Issue
- 11
- Pages
- 1875-1881
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- PMC
- PMC3040648
- OpenAlex
- W2125396837
- Cited by
- 131
- References
- 31
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 6 · 2020: 35 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Kentucky
- National Institutes of Health
- National Institute on Aging (P30AG028383, R21AG036875, U01AG016976)
- National Institute of Neurological Disorders and Stroke (R01NS061933, K08NS050110)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- sex differences, cortical Lewy bodies, Alzheimer's disease, neurodegenerative diseases, neuropathology, autopsy findings, clinical trial design
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Autopsy, Brain, Female, Humans, Male, Risk Factors, Sex Characteristics, Lewy Body Disease
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