Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease

doi:10.1016/s0197-4580(97)00057-2

Cited by 981Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

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The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease·1997·Neurobiology of Aging

DOI 10.1016/s0197-4580(97)00057-2

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Abstract

This report summarizes the consensus recommendations of a panel of neuropathologists from the United States and Europe to improve the postmortem diagnostic criteria for Alzheimer’s disease. The recommendations followed from a two-day workshop sponsored by the National Institute on Aging (NIA) and the Ronald and Nancy Reagan Institute of the Alzheimer’s Association to reassess the original NIA criteria for the postmortem diagnosis of Alzheimer’s disease published in 1985 [2] . The consensus recommendations for improving the neuropathological criteria for the postmortem diagnosis of Alzheimer’s disease are reported here, and the “position papers” by members of the Working Group that accompany this report elaborate on the research findings and concepts upon which these recommendations were based. Further, commentaries by other experts in the field also are included here to provide additional perspectives on these recommendations. Finally, it is anticipated that future meetings of the Working Group will reassess these recommendations and the implementation of postmortem diagnostic criteria for Alzheimer’s disease.

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There have been several changes in neuropathological diagnostic criteria, including Khachaturian 1985, Tierney 1988, CERAD 1991, NIA-Reagan 1997.
“there have been several changes in neuropathological diagnostic criteria, including the “Khachaturian criteria” of 1985 (27), the “Tierney” criteria of 1988 (28), The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria in 1991 (29), and the National Institute on Aging (NIA)-Reagan criteria in 1997 (30).”
From Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 (2012) · cites this paper as [30]
The NIA-Reagan criteria are the most current guidelines for neuropathological diagnosis of AD.
“For the neuropathological diagnosis of AD, the NIA-Reagan criteria (30) are the most current guidelines”
From Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 (2012) · cites this paper as [30]
The neuropathological criteria for AD used by all NIA ADCs since 1997 have been the NIA-Reagan criteria.
“The neuropathological criteria for AD used by all NIA ADCs since 1997 have been the NIA-Reagan criteria (30).”
From Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 (2012) · cites this paper as [30]
The neuropathologic hallmarks of AD are neurofibrillary tangles (including pretangles) and AβPs (including diffuse and neuritic plaques).
“The neuropathologic hallmarks of AD are neurofibrillary tangles (NFTs; including pretangles) and AβPs (including diffuse and neuritic plaques, which may also be referred to as “senile plaques” [2, 18, 19]; Fig. 1 and Table 1).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [2]

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“Neither of these early criteria included a measure of neurofibrillary tau burden, and subsequently in 1997 the National Institute on Aging and Reagan Institute combined the CERAD neuritic plaque scoring and Braak staging to determine if clinical dementia had a high, intermediate or low probability of being caused by A…”
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Authors: The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease
Corresponding author: The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer’s Disease
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1997-07
Volume: 18
Issue: 4
Pages: S1-S2
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(97)00057-2
OpenAlex: W2725718031
Cited by: 981
References: 6
Citations by year: 2026: 10 · 2025: 15 · 2024: 21 · 2023: 24 · 2022: 17 · 2021: 18 · 2020: 38 · 2019: 27 · 2018: 14 · 2017: 12 · 2016: 14 · 2015: 24 · 2014: 41 · 2013: 51 · 2012: 42
FWCI: 13.07
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 196 d)
Locations: Neurobiology of Aging (publishedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, postmortem diagnosis, consensus recommendations, neuropathology, diagnostic criteria revision

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Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

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