Cerebral microbleeds in patients with Parkinson’s disease
Open accessAbstract
Cerebral microbleeds (CMBs) are known to be associated with cognitive impairments in the elderly and in patients with various diseases; however, the nature of this association has not yet been evaluated in Parkinson's disease (PD). In the present study, we analyzed the incidence of CMBs in PD according to cognitive status, and the impact of CMBs on cognitive performance was also evaluated. The CMBs in PD with dementia (n = 36), mild cognitive impairment (MCI, n = 46), or cognitively normal (n = 41) were analyzed using conventional T2*-weighted gradient-recalled echo images. Additionally, the relationship between the presence of CMBs and cognitive performance on individual tests of cognitive subdomains was analyzed using a detailed neuropsychological test. CMBs occurred more frequently in PD patients with dementia (36.1 %) compared to those with MCI (15.2 %), those who are cognitively normal (14.6 %), and normal controls (12.2 %, p = 0.025). However, the significant association of CMBs with PD dementia disappeared after adjusting white matter hyperintensities (WMHs) as a covariate. The frequencies of deep, lobar, and infratentorial CMBs did not differ among the four groups. After adjusting for age, sex, years of education, and WMHs, PD patients with CMBs had poorer performance in attention domain compared with those without CMBs (34.9 vs 42.6, p = 0.018). The present data demonstrate that even though CMBs were inseparably associated with the presence of WMHs, CMBs occur more c…
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Cerebral microbleeds are more prevalent in Parkinson's disease patients with dementia compared with those without dementia and controls, and positively correlate with white matter lesions.
“they are more prevalent in PD patients with dementia compared with those without dementia and controls, and positively correlate with white matter lesions (231, 288).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [231]
In Parkinson's disease patients, cerebral microbleeds reflecting blood-brain barrier breakdown and RBC-derived hemosiderin deposits have been detected throughout deep gray matter, cortical, and white matter regions using T2* and SWI-MRI.
“Cerebral microbleeds reflecting BBB breakdown and deposition of RBC-derived hemosiderin deposits have been detected throughout deep gray matter, cortical, and white matter regions in PD patients using T2*and SWI-MRI (231, 288).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [231]
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- Authors
- Ham, J. H., Yi, H., Sunwoo, M. K., Hong, J. Y., Sohn, Y. H., & Lee, P. H.
- Affiliations
- Yonsei University (KR)
- Bundang Jesaeng Hospital (KR)
- Corresponding author
- Lee, Phil Hyu
- Venue
- Journal of Neurology
- Published
- 2014-06-12
- Volume
- 261
- Issue
- 8
- Pages
- 1628-1635
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2038975074
- Cited by
- 65
- References
- 53
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 3 · 2015: 3
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- International Parkinson and Movement Disorder Society
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
- Keywords
- cerebral microbleeds, Parkinson's disease, Parkinson's disease dementia, mild cognitive impairment, white matter hyperintensities, cognitive impairment, attention
- MeSH terms
- Aged, Aged, 80 and over, Brain, Cerebral Hemorrhage, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Severity of Illness Index, Chi-Square Distribution
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