Cerebral Amyloid Angiopathy

Weller, Roy O.; Massey, Adrian; Newman, Tracey A.; Hutchings, Margaret; Kuo, Yu-Min; Roher, Alex E.

doi:10.1016/s0002-9440(10)65616-7

Cited by 679Alzheimer's disease research and treatmentsIntracerebral and Subarachnoid Hemorrhage ResearchCerebrospinal fluid and hydrocephalus

Cerebral Amyloid Angiopathy

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Weller, Roy O., Massey, Adrian, Newman, Tracey A., Hutchings, Margaret, Kuo, Yu-Min, Roher, Alex E.·1998·The American Journal of Pathology

DOI 10.1016/s0002-9440(10)65616-7PMC PMC1853019

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Abstract

Cerebral amyloid angiopathy in Alzheimer's disease is characterized by deposition of amyloid beta (Abeta) in cortical and leptomeningeal vessel walls. Although it has been suggested that Abeta is derived from vascular smooth muscle, deposition of Abeta is not seen in larger cerebral vessel walls nor in extracranial vessels. In the present study, we examine evidence for the hypothesis that Abeta is deposited in periarterial interstitial fluid drainage pathways of the brain in Alzheimer's disease and that this contributes significantly to cerebral amyloid angiopathy. There is firm evidence in animals for drainage of interstitial fluid from the brain to cervical lymph nodes along periarterial spaces; similar periarterial channels exist in humans. Biochemical study of 6 brains without Alzheimer's disease revealed a pool of soluble Abeta in the cortex. Histology and immunocytochemistry of 17 brains with Alzheimer's disease showed that Abeta accumulates five times more frequently around arteries than around veins, with selective involvement of smaller arteries. Initial deposits of Abeta occur at the periphery of arteries at the site of the putative interstitial fluid drainage pathways. These observations support the hypothesis that Abeta is deposited in periarterial interstitial fluid drainage pathways of the brain and contributes significantly to cerebral amyloid angiopathy in Alzheimer's disease.

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Alzheimer's disease often involves amyloid deposition around the vasculature.
“Alzheimer's disease often involves amyloid deposition around the vasculature (Weller et al., 1998)”
From Early Alterations in Functional Connectivity and White Matter Structure in a Transgenic Mouse Model of Cerebral Amyloidosis (2014) · cites this paper as Weller et al., 1998

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Authors: Weller, R. O., Massey, A., Newman, T. A., Hutchings, M., Kuo, Y.-M., & Roher, A. E.
Affiliations: Southampton General Hospital (GB)
Corresponding author: Weller, Roy O.
ORCID: Weller, Roy O.
Newman, Tracey A.
Kuo, Yu-Min
Venue: The American Journal of Pathology
Publisher: Elsevier BV
Published: 1998-09
Volume: 153
Issue: 3
Pages: 725-733
ISSN: 0002-9440 (ISSN-L)
DOI: 10.1016/s0002-9440(10)65616-7
PMC: PMC1853019
OpenAlex: W1594119953
Cited by: 679
References: 4
Citations by year: 2026: 9 · 2025: 11 · 2024: 14 · 2023: 15 · 2022: 11 · 2021: 24 · 2020: 14 · 2019: 23 · 2018: 14 · 2017: 10 · 2016: 17 · 2015: 19 · 2014: 47 · 2013: 31 · 2012: 30
FWCI: 13.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal Of Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Funders: Neurological Foundation of New Zealand
National Institutes of Health (AG-11925)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Keywords: cerebral amyloid angiopathy, Alzheimer's disease, amyloid-beta, vascular smooth muscle, cerebral arteries
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Arteries, Cerebral Cortex, Extracellular Space, Humans, Immunohistochemistry, Lymphatic System, Meninges, Veins, Amyloid beta-Peptides, Plaque, Amyloid

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