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Cited by 77Dementia and Cognitive Impairment ResearchTraumatic Brain Injury ResearchCognitive Functions and Memory

Traumatic brain injury and age at onset of cognitive impairment in older adults

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Li, Wei, Risacher, Shannon L., McAllister, Thomas W., Saykin, Andrew J.·2016·Journal of Neurology
DOI 10.1007/s00415-016-8093-4PMC PMC5029270
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Abstract

There is a deficiency of knowledge regarding how traumatic brain injury (TBI) is associated with age at onset (AAO) of cognitive impairment in older adults. Participants with a TBI history were identified from the Alzheimer's disease neuroimaging initiative (ADNI 1/GO/2) medical history database. Using an analysis of covariance (ANCOVA) model, the AAO was compared between those with and without TBI, and potential confounding factors were controlled. The AAO was also compared between those with mild TBI (mTBI) and moderate or severe TBI (sTBI). Lastly, the effects of mTBI were analyzed on the AAO of participants with clinical diagnoses of either mild cognitive impairment (MCI) or Alzheimer's disease (AD). The AAO for a TBI group was 68.2 ± 1.1 years [95 % confidence interval (CI) 66.2-70.3, n = 62], which was significantly earlier than the AAO for the non-TBI group of 70.9 ± 0.2 years (95 % CI 70.5-71.4, n = 1197) (p = 0.013). Participants with mTBI history showed an AAO of 68.5 ± 1.1 years (n = 56), which was significantly earlier than the AAO for the non-TBI group (p = 0.032). Participants with both MCI and mTBI showed an AAO of 66.5 ± 1.3 years (95 % CI 63.9-69.1, n = 45), compared to 70.6 ± 0.3 years for the non-TBI MCI group (95 % CI 70.1-71.1, n = 935) (p = 0.016). As a conclusion, a history of TBI may accelerate the AAO of cognitive impairment by two or more years. These results were consistent with reports of TBI as a significant risk factor for cognitive decline in older adults, and TBI is associated with an earlier AAO found in patients with MCI or AD.

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  • Numerous population-based studies demonstrate that head injury during adulthood increases the risk of AD later in life.

    “First, numerous population-based studies demonstrate that head injury during adulthood increases the risk of AD later in life (12–19)”

    From The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease (2018) · cites this paper as [18]

    The Discussion says previous studies found traumatic brain injury to be a risk factor for AD or non-AD dementia, supporting the broad association. The Introduction and References include population-based studies of dementia risk, but our copy does not establish that numerous population-based studies specifically demonstrated increased later-life AD risk following injury during adulthood. (LLM, conf=0.85)

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Authors
Li, W., Risacher, S. L., McAllister, T. W., & Saykin, A. J.
Affiliations
  • Indiana University – Purdue University Indianapolis (US)
  • Indiana University School of Medicine (US)
Corresponding author
Li, Wei
ORCID
Venue
Journal of Neurology
Publisher
Springer Science and Business Media LLC
Published
2016-03-23
Volume
263
Issue
7
Pages
1280-1285
ISSN
  • 0012-1037 (ISSN-L)
  • 0340-5354
  • 1432-1459
DOI
10.1007/s00415-016-8093-4
PMC
PMC5029270
OpenAlex
W2310324492
Cited by
77
References
36
Citations by year
2026: 3 · 2025: 5 · 2024: 9 · 2023: 4 · 2022: 14 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 10 · 2017: 9 · 2016: 4
FWCI
8.89
Type
journal article
Language
en
Update notices
correction (2016-06-09)
Open access
Licence
Locations
  • Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • IUScholarWorks (Indiana University) (submittedVersion, other-oa)
  • Purdue University Indianapolis (Indiana University) (submittedVersion, other-oa)
  • Author eBooks
Funders
National Institute on Aging (AG19771, AG049050)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
traumatic brain injury, age of onset, cognitive impairment, mild traumatic brain injury, mild cognitive impairment, Alzheimer's disease, older adults, cognitive decline, risk factors
MeSH terms
Brain Injuries, Traumatic, Aged, Aged, 80 and over, Cognition Disorders, Female, Humans, Male, Neuropsychological Tests, Trauma Severity Indices, Age of Onset

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