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Expression of both oestrogen receptor alpha and beta in human skeletal muscle tissue
Abstract
There are two oestrogen receptors (ERs), ERalpha and ERbeta. ERbeta protein is expressed in human skeletal muscle in the nuclei of both myofibres and endothelial cells, whether ERalpha protein is present in this tissue is unknown. We studied the expression of ERalpha protein in human skeletal muscle biopsies taken from vastus lateralis from four men, four women, two children and two postmenopausal women. Immunohistochemistry was used to determine the proportions of nuclei that were positively stained for ERalpha, the proportion of ERalpha-positive nuclei located in the muscle fibres and in capillaries and to test for possible co-expression of ERalpha and ERbeta. Both ERs were expressed in all subjects. Of all nuclei, 63% stained for ERalpha with no sex difference. ERalpha was localised both in myofibres and in endothelial cells of the capillaries, 25% of the ERalpha-positive nuclei were located in the capillaries. ERalpha and ERbeta were generally expressed in the same nuclei. The present study shows for the first time the expression of ERalpha protein in human skeletal muscle independently of age and sex. These results might improve understanding of the physiological role of oestrogen in human skeletal muscle and raise new questions about activation of ERs in skeletal muscle.
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“Both ERα and ERβ are expressed in skeletal muscles of mice and humans [10,12,13,14].”
From Phytoecdysteroids and Anabolic Effect of Atriplex dimorphostegia: UPLC-PDA-MS/MS Profiling, In Silico and In Vivo Models (2023) · cites this paper as [10]
Citations
Cites
Cloning of a novel receptor expressed in rat prostate and ovary.
Kuiper, G. G. J. M., Enmark, E., Pelto‐Huikko, M., Nilsson, S., & Gustafsson, J.-Α. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5925 · Cited by 4,802
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., et al. (1995) · Science · doi:10.1126/science.270.5241.1491 · Cited by 1,964
Hall, J. M., & McDonnell, D. P. (1999) · Endocrinology · doi:10.1210/endo.140.12.7179 · Cited by 1,078
Induction of calcium-dependent nitric oxide synthases by sex hormones.
Weiner, C. P., Lizasoaín, I., Baylis, S. A., Knowles, R. G., Charles, I. G., & Moncada, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5212 · Cited by 1,066
Bunone, G., Briand, P.-A., Miksicek, R. J., & Picard, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00571.x · Cited by 985
Estrogen Receptors α and β Form Heterodimers on DNA
Cowley, S. M., Hoare, S., Mosselman, S., & Parker, M. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.19858 · Cited by 689
Pettersson, K., Grandien, K., Kuiper, G. G. J. M., & Gustafsson, J.-Α. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.10.9989 · Cited by 599
Immunolocalisation of oestrogen receptor beta in human tissues
Taylor, A. H., & Al‐Azzawi, F. (2000) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0240145 · Cited by 529
Tremblay, A., Tremblay, G. B., Labrie, F., & Giguère, V. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80479-7 · Cited by 469
Saville, B., Wormke, M., Wang, F., Nguyen, T. A., Enmark, E., Kuiper, G. G. J. M., Gustafsson, J.-Α., & Safe, S. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5379 · Cited by 401
Malm, C., Nyberg, P., Engström, M., Sjödin, B., Lenkei, R., Ekblom, B. T., & Lundberg, I. E. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00243.x · Cited by 396
Gustafsson, T. P., Puntschart, A., Kaijser, L., Jansson, E., & Sundberg, C. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.2.h679 · Cited by 364
Estrogen receptor β acts as a dominant regulator of estrogen signaling
Pettersson, K., Delaunay, F., & Gustafsson, J.-Å. (2000) · Oncogene · doi:10.1038/sj.onc.1203828 · Cited by 362
Vascular endothelial growth factor stimulates skeletal muscle regeneration in Vivo
Arsic, N., Zacchigna, S., Zentilin, L., Ramirez‐Correa, G. A., Pattarini, L., Salvi, A., Sinagra, G., & Giacca, M. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.08.007 · Cited by 360
Changes in muscle strength, relaxation rate and fatiguability during the human menstrual cycle.
Sarwar, R., Niclos, B. B., & Rutherford, O. M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021381 · Cited by 359
The Ether Soluble Porphyrins Found in the Urine of Normal Man and Rabbit
Eriksen, L., Eriksen, N., & Haavaldsen, S. (1962) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365516209075148 · Cited by 358
Estrogen receptors α and β in the rodent mammary gland
Saji, S., Jensen, E. V., Nilsson, S. V., Rylander‐Rudqvist, T., Warner, M. N., & Gustafsson, J.-Α. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.337 · Cited by 357
Mueller, M. D., Vigne, J., Minchenko, О. H., Lebovic, D. I., Leitman, D. C., & Taylor, R. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200377097 · Cited by 352
Murphy, L. J., & Ghahary, A. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-3-443 · Cited by 308
Estrogens, the immune response and autoimmunity.
Cutolo, M., Sulli, A., SERIOLO, B., Accardo, S., & Masi, A. T. (1995) · PubMed · Cited by 288
In vivo imaging of transcriptionally active estrogen receptors
Ciana, P., Raviscioni, M., Mussi, P., Vegeto, E., Que, I., Parker, M. G., Löwik, C. W. G. M., & Maggi, A. C. (2002) · Nature Medicine · doi:10.1038/nm809 · Cited by 286
Hyder, S. M., Nawaz, Z., Chiappetta, C., & Stancel, G. M. (2000) · PubMed · Cited by 268
Muscle GLUT4 regulation by estrogen receptors ERβ and ERα
Barros, R. P. A., Machado, U. F., Warner, M., & Gustafsson, J.-Å. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510391103 · Cited by 263
Helguero, L. A., Faulds, M. H., Gustafsson, J.-Å., & Haldosén, L. (2005) · Oncogene · doi:10.1038/sj.onc.1208807 · Cited by 250
Expression of an Estrogen Receptor by Human Coronary Artery and Umbilical Vein Endothelial Cells
Kim‐Schulze, S., McGowan, K. A., Hubchak, S. C., Cid, M. C., Martin, M. B., Kleinman, H. K., Greene, G. L., & Schnaper, H. W. (1996) · Circulation · doi:10.1161/01.cir.94.6.1402 · Cited by 218
Localization of Nitric Oxide Synthase in Human Skeletal Muscle
Frandsen, U., López-Figueroa, M. O., & Hellsten, Y. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1472 · Cited by 212
Estrogen Receptor Alpha mRNA in Human Skeletal Muscles
LEMOINE, S., GRANIER, P., TIFFOCHE, C., RANNOU-BEKONO, F., THIEULANT, M.-L., & DELAMARCHE, P. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000053654.14410.78 · Cited by 201
The behaviour of satellite cells in response to exercise: what have we learned from human studies?
Kadi, F., Charifi, N., Denis, C., Lexell, J. E., Andersen, J. L., Schjerling, P., Olsen, S., & Kjær, M. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1406-6 · Cited by 180
Skelton, D. A., Phillips, S. K., Bruce, S., Naylor, C., & WOLEDGE, R. C. (1999) · Clinical Science · doi:10.1042/cs0960357 · Cited by 154
Gustafsson, T. P. (2001) · Frontiers in bioscience · doi:10.2741/gustafss · Cited by 148
The Ether Soluble Porphyrins Found in the Urine of Normal Man and Rabbit
Eriksen, L., Eriksen, N., & Haavaldsen, S. (1962) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516209075148 · Cited by 146
Ligand-independent Activation of Steroid Receptors: New Roles for Old Players.
Cenni, B., & Picard, D. (1999) · Trends in endocrinology and metabolism · doi:10.1016/s1043-2760(98)00121-0 · Cited by 134
Oestrogen receptor β is expressed in adult human skeletal muscle both at the mRNA and protein level
Wiik, A., Glenmark, B., Ekman, M., Esbjörnsson‐Liljedahl, M., Johansson, O., Bodin, K., Enmark, E., & Jansson, E. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.0001-6772.2003.01186.x · Cited by 122
Self-citationPorter, M. M., Stuart, S., Boij, M., & Lexell, J. E. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00744.2001 · Cited by 109
Perspective: Nonreproductive Sites of Action of Reproductive Hormones
Manolagas, S. C., & Kousteni, S. (2001) · Endocrinology · doi:10.1210/endo.142.6.8221 · Cited by 97
Ishunina, T. A., Kruijver, F. P. M., Balesar, R., & Swaab, D. F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6826 · Cited by 94
Steensberg, A., Keller, C., Hillig, T., Frøsig, C., Wojtaszewski, J. F. P., Pedersen, B. K., Pilegaard, H., & Sander, M. (2007) · The FASEB Journal · doi:10.1096/fj.06-7477com · Cited by 89
Batra, G. S., Hainey, L., Freemont, A. J., Andrew, J. G., Saunders, P. T. K., Hoyland, J. A., & Braidman, I. P. (2003) · The Journal of Pathology · doi:10.1002/path.1332 · Cited by 69
Evidence for estrogen receptor α and β expression in skeletal muscle of pigs
Kalbe, C., Mau, M., Wollenhaupt, K., & Rehfeldt, C. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0224-z · Cited by 61
Greeves, J. P., Cable, N. T., Luckas, M. J. M., Reilly, T., & Biljan, M. M. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp022016 · Cited by 57
Wiik, A., Ekman, M., Morgan, G., Johansson, O., Jansson, E., & Esbjörnsson, M. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0030-z · Cited by 52
Lawrence, T. L. J. (1980) · Medical Entomology and Zoology · Cited by 50
Gargett, C. E. (2002) · Molecular Human Reproduction · doi:10.1093/molehr/8.8.770 · Cited by 36
Gargett, C. E., Bucak, K., Zaitseva, M., Chu, S., Taylor, N., Fuller, P. J., & Rogers, P. A. W. (2002) · Human Reproduction · Cited by 33
Burleigh, I. G. (1980) · Elsevier eBooks · doi:10.1016/b978-0-408-10638-2.50011-2 · Cited by 15
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Elliott-Sale, K. J., Minahan, C. L., de Jonge, X. A. K. J., Ackerman, K. E., Sipilä, S., Constantini, N. W., Lebrun, C. M., & Hackney, A. C. (2021) · Sports Medicine · doi:10.1007/s40279-021-01435-8 · Cited by 731
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Metadata
- Authors
- Wiik, A., Ekman, M., Johansson, O., Jansson, E., & Esbjörnsson, M.
- Affiliations
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Corresponding author
- Wiik, A.
- Venue
- Histochemistry and Cell Biology
- Published
- 2008-09-30
- Volume
- 131
- Issue
- 2
- Pages
- 181-189
- ISSN
- 0948-6143 (ISSN-L)
- 1432-119X
- OpenAlex
- W2040999865
- Cited by
- 190
- References
- 44
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 18 · 2023: 18 · 2022: 14 · 2021: 15 · 2020: 14 · 2019: 5 · 2018: 12 · 2017: 6 · 2016: 11 · 2015: 8 · 2014: 9 · 2013: 7 · 2012: 10
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Histochemistry and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- estrogen receptor alpha, estrogen receptor beta, skeletal muscle, vastus lateralis, muscle capillaries, endothelial cells, sex differences, postmenopausal women, estrogen, receptor co-expression
- MeSH terms
- Adult, Age Factors, Cell Nucleus, Endothelium, Vascular, Female, Humans, Immunohistochemistry, Male, Middle Aged, Sex Factors, Postmenopause, Muscle, Skeletal, Estrogen Receptor alpha, Estrogen Receptor beta
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