Oestrogen receptor β is expressed in adult human skeletal muscle both at the mRNA and protein level

Wiik, A.; Glenmark, B.; Ekman, M.; Esbjörnsson‐Liljedahl, M.; Johansson, O.; Bodin, K.; Enmark, E.; Jansson, E.

doi:10.1046/j.0001-6772.2003.01186.x

Cited by 122Estrogen and related hormone effectsEffects and risks of endocrine disrupting chemicalsMuscle Physiology and Disorders

Oestrogen receptor β is expressed in adult human skeletal muscle both at the mRNA and protein level

Wiik, A., Glenmark, B., Ekman, M., Esbjörnsson‐Liljedahl, M., Johansson, O., Bodin, K., Enmark, E., Jansson, E.·2003·Acta Physiologica Scandinavica

DOI 10.1046/j.0001-6772.2003.01186.x

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Abstract

Aim: There are two known oestrogen receptors (ER), oestrogen receptor α (ER α) and the recently cloned oestrogen receptor β (ER β). ER α mRNA has been detected in mouse, rat, bovine and human skeletal muscle. ER β mRNA has been detected in bovine skeletal muscle. To our knowledge, no study has investigated the expression of oestrogen receptor β in human skeletal muscle. Therefore, the primary aim of the present investigation was to study ER β mRNA and protein expression in human skeletal muscle. In addition the ER α expression was also studied. Methods: Muscle biopsies were taken from vastus lateralis in six healthy adults (three women and three men). mRNA expression was detected with real‐time PCR (TaqMan) and protein localization by immunohistochemistry. Results: A clear expression of ER α and ER β mRNA was seen in skeletal muscle in all subjects. The ER α mRNA expression was 180 fold higher compared with that of ER β mRNA. Immunohistochemistry demonstrated positive staining for ER β, but not for ER α, with localization to the nuclei of skeletal muscle fibres. On average, 70% of all nuclei were ER β‐positive. Conclusion: The present study shows for the first time ER β mRNA and protein expression in human skeletal muscle tissue in both males and females.

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There is no sexually dimorphic expression in either ERα or ERβ in skeletal muscle.
“As stated previously, there is no sexually dimorphic expression in either ERα or ERβ in skeletal muscle (98).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [98]
In male and female vastus lateralis muscle, expression of ERα mRNA is 180-fold higher than ERβ, with no significant difference in expression levels between males and females.
“In male and female vastus lateralis muscle, expression of ERα mRNA is 180-fold higher than ERβ, with no significant difference in expression levels between males and females (98).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [98]
Both ERα and ERβ are expressed in skeletal muscles of mice and humans.
“Both ERα and ERβ are expressed in skeletal muscles of mice and humans [10,12,13,14].”
From Phytoecdysteroids and Anabolic Effect of Atriplex dimorphostegia: UPLC-PDA-MS/MS Profiling, In Silico and In Vivo Models (2023) · cites this paper as [13]

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Authors: Wiik, A., Glenmark, B., Ekman, M., Esbjörnsson‐Liljedahl, M., Johansson, O., Bodin, K., Enmark, E., & Jansson, E.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Glenmark, B.
Enmark, E.
ORCID: Wiik, A.
Johansson, O.
Jansson, E.
Venue: Acta Physiologica Scandinavica
Publisher: Wiley
Published: 2003-12
Volume: 179
Issue: 4
Pages: 381-387
ISSN: 0001-6772 (ISSN-L)
1365-201X
DOI: 10.1046/j.0001-6772.2003.01186.x
OpenAlex: W1995701711
Cited by: 122
References: 41
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 5
FWCI: 2.65
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8 d)
Locations: Acta Physiologica Scandinavica (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: estrogen receptor beta, estrogen receptor alpha, skeletal muscle, human muscle, mRNA expression, protein expression, vastus lateralis, nuclear localization, sex differences
MeSH terms: Adult, Female, Humans, Immunohistochemistry, Male, Receptors, Estrogen, RNA, Messenger, Gene Expression, Polymerase Chain Reaction, Muscle, Skeletal, Estrogen Receptor alpha, Estrogen Receptor beta

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Oestrogen receptor β is expressed in adult human skeletal muscle both at the mRNA and protein level

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