The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model
Open accessAbstract
The metastatic invasion of cancer cells from the primary lesion into the adjacent stroma is a key step in cancer progression, and is associated with poor outcome. The principles of cancer invasion have been experimentally addressed in various in vitro models; however, key steps and mechanisms in vivo remain unclear. Here, we establish a modified skin-fold chamber model for orthotopic implantation, growth and invasion of human HT-1080 fibrosarcoma cells, dynamically reconstructed by epifluorescence and multiphoton microscopy. This strategy allows repeated imaging of tumor growth, tumor-induced angiogenesis and invasion, as either individual cells, or collective strands and cell masses that move along collagen-rich extracellular matrix and coopt host tissue including striated muscle strands and lymph vessels. This modified window model will be suited to address mechanisms of cancer invasion and metastasis, and related experimental therapy.
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Cites
Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology · doi:10.1038/ncb1658 · Cited by 1,589 · cited 2×
“Invasion promoting factors reside in the migratory capability of cancer cells, the release of invasion-enhancing factors from the adjacent tumor stroma, and the metabolic and perfusion state of the lesion (Brown et al. 2001; Condeelis and Segall 2003; Gaggioli et al. 2007; Nakamura et al. 2007).”
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Cited by
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940
Self-citationWolf, K., te Lindert, M., Krause, M., Alexander, S., te Riet, J., Willis, A. L., Hoffman, R. M., Figdor, C. G., Weiss, S. J., & Friedl, P. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201210152 · Cited by 1,375
Self-citationNuclear envelope rupture and repair during cancer cell migration
Denais, C. M., Gilbert, R. M., Isermann, P., McGregor, A. L., te Lindert, M., Weigelin, B., Davidson, P. M., Friedl, P., Wolf, K., & Lammerding, J. (2016) · Science · doi:10.1126/science.aad7297 · Cited by 1,318
Self-citationIn vitro cell migration and invasion assays
Kramer, N., Walzl, A., Unger, C., Rosner, M., Krupitza, G., Hengstschläger, M., & Dolznig, H. (2013) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.08.001 · Cited by 1,170
Collagen-based cell migration models in vitro and in vivo
Wolf, K., Alexander, S., Schacht, V., Coussens, L. M., von Andrian, U. H., van Rheenen, J., Deryugina, E., & Friedl, P. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.08.005 · Cited by 637
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Metadata
- Authors
- Alexander, S., Koehl, G. E., Hirschberg, M., Geissler, E. K., & Friedl, P.
- Venue
- Histochemistry and Cell Biology
- Published
- 2008-11-06
- Volume
- 130
- Issue
- 6
- Pages
- 1147-1154
- ISSN
- 0948-6143 (ISSN-L)
- 1432-119X
- OpenAlex
- W2062116473
- Cited by
- 260
- References
- 1
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Alexander, S., Koehl, G. E., Hirschberg, M., Geissler, E. K., & Friedl, P. (2008). Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochemistry and Cell Biology. https://doi.org/10.1007/s00418-008-0529-1
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