Nuclear envelope rupture and repair during cancer cell migration
Open accessAbstract
Repairing tears in the nuclear envelope: The nuclear envelope segregates genomic DNA from the cytoplasm and regulates protein trafficking between the cytosol and the nucleus. Maintaining nuclear envelope integrity during interphase is considered crucial. However, Raab et al. and Denais et al. show that migrating immune and cancer cells experience frequent and transitory nuclear envelope ruptures when they move through tight spaces (see the Perspective by Burke). The nuclear envelope reseals rapidly during interphase, assisted by components of the ESCRT III membrane-remodeling machinery. Science , this issue pp. 359 and 353 ; see also p. 295
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MN rupture, like nuclear rupture, is associated with extensive DNA damage.
“MN rupture, similar to nuclear rupture, is associated with extensive DNA damage (Denais et al., 2016), perhaps due to exposure of the MN to cytoplasmic factors such as the exonuclease TREX1 (Maciejowski et al., 2020) or other nucleases (Umbreit et al., 2020), so DNA damage might directly or indirectly facilitate cGAS activation.”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Denais et al., 2016
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Self-citation
- Authors
- Denais, C. M., Gilbert, R. M., Isermann, P., McGregor, A. L., te Lindert, M., Weigelin, B., Davidson, P. M., Friedl, P., Wolf, K., & Lammerding, J.
- Affiliations
- Nancy E. and Peter C. Meinig School of Biomedical Engineering and Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA.
- Cornell University (US)
- Department of Cell Biology, Radboud University Medical Center, Nijmegen, Netherlands.
- Radboud University Medical Center (NL)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Gilbert, Rachel M.
- Isermann, Philipp
- Lammerding, Jan
- ORCID
- Venue
- Science
- Published
- 2016-04-15
- Volume
- 352
- Issue
- 6283
- Pages
- 353-358
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4833568
- OpenAlex
- W2311649981
- Cited by
- 1,318
- References
- 44
- Citations by year
- 2026: 129 · 2025: 123 · 2024: 116 · 2023: 123 · 2022: 122 · 2021: 136 · 2020: 137 · 2019: 143 · 2018: 139 · 2017: 91 · 2016: 57 · 2012: 1
- FWCI
- 74.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Department of Defense Breast Cancer Research Program (BC102152, BC150580)
- National Cancer Institute
- Cornell Center on the Microenvironment and Metastasis (U54 CA143876)
- Netherlands Science Organization (NWO-VIDI 917.10.364, NWO-VICI 918.11.626)
- New York Stem Cell Foundation (NYSTEM) (CO29155)
- NIH (R01 HL082792, R01 NS059348, S10OD018516)
- NSF (CBET-1254846, DGE-1144153, ECCS-15420819, 1428922)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- nuclear envelope rupture, nuclear envelope repair, tumor cell migration, metastasis, nuclear deformation, nuclear lamins, ESCRT-III, DNA damage, cell confinement
- MeSH terms
- Cell Movement, Chromatin, Cytoplasm, DNA Damage, Humans, Neoplasms, Nuclear Envelope, Stress, Mechanical, Lamins, Cell Line, Tumor, Endosomal Sorting Complexes Required for Transport, Tumor Microenvironment
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