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Cited by 357Vitamin D Research StudiesMuscle Physiology and DisordersExercise and Physiological Responses

Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state

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Dzik, Katarzyna Patrycja, Kaczor, Jan Jacek·2019·European Journal of Applied Physiology
DOI 10.1007/s00421-019-04104-xPMC PMC6422984
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Abstract

PURPOSE: This review provides a current perspective on the mechanism of vitamin D on skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and muscle energy metabolism. It focuses on several aspects related to cellular and molecular physiology such as VDR as the trigger point of vitamin D action, oxidative stress as a consequence of vitamin D deficiency. METHOD: The interaction between vitamin D deficiency and mitochondrial function as well as skeletal muscle atrophy signalling pathways have been studied and clarified in the last years. To the best of our knowledge, we summarize key knowledge and knowledge gaps regarding the mechanism(s) of action of vitamin D in skeletal muscle. RESULT: Vitamin D deficiency is associated with oxidative stress in skeletal muscle that influences the mitochondrial function and affects the development of skeletal muscle atrophy. Namely, vitamin D deficiency decreases oxygen consumption rate and induces disruption of mitochondrial function. These deleterious consequences on muscle may be associated through the vitamin D receptor (VDR) action. Moreover, vitamin D deficiency may contribute to the development of muscle atrophy. The possible signalling pathway triggering the expression of Atrogin-1 involves Src-ERK1/2-Akt- FOXO causing protein degradation. CONCLUSION: Based on the current knowledge we propose that vitamin D deficiency results from the loss of VDR function and it could be partly responsible for the development of neurodegenerative diseases in human beings.

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  • A high cortisol concentration in athletes is a common state and indicates stress, exercise overloading and inadequate muscle recovery.

    “A high cortisol concentration in athletes is a common state and indicates stress, exercise overloading and inadequate muscle recovery [1,41].”

    From Influence of Sunlight and Oral D3 Supplementation on Serum 25(OH)D Concentration and Exercise Performance in Elite Soccer Players (2020) · cites this paper as [1]

    The 'Vitamin D signalling with anabolic/catabolic pathways' section (page unavailable) says glucocorticoids rise under stress and describes elevated corticosterone in chronically stressed rats. It does not establish that high cortisol is common in athletes or that it indicates exercise overloading or inadequate muscle recovery. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Vitamin D plays a crucial role in both muscle strength and post-exercise recovery.

    “Experimental data has proven that vitamin D plays a crucial role in both muscle strength and post-exercise recovery [1,18].”

    From Influence of Sunlight and Oral D3 Supplementation on Serum 25(OH)D Concentration and Exercise Performance in Elite Soccer Players (2020) · cites this paper as [1]

    The review’s section on skeletal-muscle metabolism reports a role for vitamin D in muscle contraction and describes reduced tissue damage and oxidative stress after exhaustive exercise in vitamin-D-treated rats (no page given). Those findings support a role in muscle function and exercise-related damage, but they do not establish that experimental data have proven a crucial role in both muscle strength and post-exercise recovery generally. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Vitamin D induces myogenesis and muscle protein synthesis causing increases in fast-twitch muscle cells.

    “Vitamin D induces myogenesis and muscle protein synthesis causing increases in fast-twitch muscle cells [1,6,26].”

    From Influence of Sunlight and Oral D3 Supplementation on Serum 25(OH)D Concentration and Exercise Performance in Elite Soccer Players (2020) · cites this paper as [1]

    In “Vitamin D signalling with anabolic/catabolic pathways” (page unavailable), the review reports that active vitamin D enhances protein synthesis in murine myotubes when stimulated by leucine and insulin. In “VDR in musculoskeletal system” (page unavailable), it says VDR signalling is required for myoblast differentiation and that VDR is predominantly found in fast-twitch fibers. Neither passage establishes that vitamin D causes an increase in the number of fast-twitch muscle cells; the review also reports impaired differentiation with excessive vitamin D. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Dzik, K. P., & Kaczor, J. J.
Affiliations
Gdansk University of Physical Education and Sport (PL)
Corresponding author
Kaczor, Jan Jacek
ORCID
Venue
European Journal of Applied Physiology
Publisher
Springer Science and Business Media LLC
Published
2019-03-04
Volume
119
Issue
4
Pages
825-839
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
DOI
10.1007/s00421-019-04104-x
PMC
PMC6422984
OpenAlex
W2919190158
Cited by
357
References
8
Citations by year
2026: 34 · 2025: 62 · 2024: 58 · 2023: 66 · 2022: 51 · 2021: 46 · 2020: 28 · 2019: 12
FWCI
5.11
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Applied Physiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Narodowe Centrum Nauki (NCN UMO-2012/05/B/NZ7/02493)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
vitamin D, vitamin D deficiency, skeletal muscle function, oxidative stress, mitochondrial function, muscle atrophy, vitamin D receptor, muscle energy metabolism, atrogin-1, protein degradation, neurodegenerative diseases
MeSH terms
Animals, Energy Metabolism, Humans, Mitochondria, Vitamin D, Vitamin D Deficiency, Oxidative Stress, Muscle, Skeletal

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