Vitamin D Receptor Expression in Human Muscle Tissue Decreases with Age
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UNLABELLED: Intracellular 1,25-dihydroxyvitamin D receptor (VDR) is expressed in human skeletal muscle tissue. However, it is unknown whether VDR expression in vivo is related to age or vitamin D status, or whether VDR expression differs between skeletal muscle groups. INTRODUCTION: We investigated these factors and their relation to 1,25-dihydroxyvitamin D receptor (VDR) expression in freshly removed human muscle tissue. MATERIALS AND METHODS: We investigated biopsy specimens of the gluteus medius taken at surgery from 20 female patients undergoing total hip arthroplasty (mean age, 71.6 +/- 14.5; 72% > 65 years) and biopsy specimens of the transversospinalis muscle taken at surgery from 12 female patients with spinal operations (mean age, 55.2 +/- 19.6; 28% > 65 years). The specimens were obtained by immunohistological staining of the VDR using a monoclonal rat antibody to the VDR (Clone no. 9A7). Quantitative VDR expression (number of VDR positive nuclei) was assessed by counting 500 nuclei per specimen and person. Serum concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were assessed at day of admission to surgery. RESULTS: All muscle biopsy specimens stained positive for VDR. In the univariate analyses, increased age was associated with decreased VDR expression (r = 0.5: p = 0.004), whereas there were no significant correlations between VDR expression and 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D levels. VDR expression did not differ between patients with hip and spinal surgery. In the multivariate analysis, older age was a significant predictor of decreased VDR expression after controlling biopsy location (gluteus medius or the transversospinalis muscle), and 25-hydroxyvitamin D levels (linear regression analysis: beta-estimate = -2.56; p = 0.047). CONCLUSIONS: Intranuclear immunostaining of the VDR was present in muscle biopsy specimens of all orthopedic patients. Older age was significantly associated with decreased VDR expression, independent of biopsy location and serum 25-hydroxyvitamin D levels.
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There is a significant decrease in vitamin D receptor expression with age in freshly removed muscle tissue of elderly female patients.
“The authors found a significant decrease in vitamin D receptor expression with age in freshly removed muscle tissue of the female patients.”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [67]
The age-related decline in muscle mass and function is concurrent with a decline in skeletal muscle vitamin D receptor expression.
“The age-related decline in muscle mass and function is concurrent with a decline in skeletal muscle vitamin D receptor expression [67].”
From Novel Insights on Intake of Fish and Prevention of Sarcopenia: All Reasons for an Adequate Consumption (2020) · cites this paper as [67]
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Vitamin D 3 and Calcium to Prevent Hip Fractures in Elderly Women
Chapuy, M. C., ARLOT, M. E., Duboeuf, F., Brun, J., Crouzet, B., Arnaud, S. B., Delmas, P. D., & Meunier, P. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212033272305 · Cited by 2,942 · see citing works
Dawson‐Hughes, B., Harris, S. S., Krall, E. A., & Dallal, G. E. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709043371003 · Cited by 2,276 · see citing works
Prevalence of Vitamin D Insufficiency in an Adult Normal Population
Chapuy, M. C., Preziosi, P., Maamer, M., Arnaud, S. B., Galan, P., Herçberg, S., & Meunier, P. J. (1997) · Osteoporosis International · doi:10.1007/s001980050030 · Cited by 1,438 · see citing works
Muscle strength and speed of movement in relation to age and muscle morphology
Larsson, L., Grimby, G., & Karlsson, J. (1979) · Journal of Applied Physiology · doi:10.1152/jappl.1979.46.3.451 · Cited by 1,135 · see citing works
Effects of Vitamin D and Calcium Supplementation on Falls: A Randomized Controlled Trial
Bischoff, H. A., Stähelin, H. B., Dick, W., Akos, R., Knecht, M., Salis, C., Nebiker, M., Theiler, R., Pfeifer, M. A., Begerow, B., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.2.343 · Cited by 969 · see citing works
Self-citationLeg extensor power and functional performance in very old men and women.
Bassey, E. J., Fiatarone, M. A., O'neill, E. F., Kelly, M., Evans, W. J., & Lipsitz, L. A. (1992) · Clinical Science · doi:10.1042/cs0820321 · Cited by 943 · see citing works
Looker, A. C., Dawson‐Hughes, B., Calvo, M. S., Gunter, E. W., & Sahyoun, N. R. (2002) · Bone · doi:10.1016/s8756-3282(02)00692-0 · Cited by 801 · see citing works
Physiological changes in ageing muscles
Campbell, M. J., McComas, A. J., & Petito, F. (1973) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.36.2.174 · Cited by 738 · see citing works
Differences in vitamin D status between countries in young adults and the elderly
McKenna, M. J. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90682-2 · Cited by 608 · see citing works
Pfeifer, M. A., Begerow, B., Minne, H. W., Abrams, C., Nachtigall, D., & Hansen, C. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.1113 · Cited by 591 · see citing works
Hypovitaminosis D Myopathy Without Biochemical Signs of Osteomalacic Bone Involvement
Glerup, H., Mikkelsen, K., Poulsen, L., Hass, E. E., Overbeck, S., Andersen, H., Charles, P., & Eriksen, E. F. (2000) · Calcified Tissue International · doi:10.1007/s002230010085 · Cited by 514 · see citing works
In Situ Detection of 1,25-dihydroxyvitamin D Receptor In human Skeletal Muscle Tissue
Bischoff, H. A., Borchers, M., Gudat, F. G., Dürmüller, U., Theiler, R., Stähelin, H. B., & Dick, W. (2001) · The Histochemical Journal · doi:10.1023/a:1017535728844 · Cited by 514 · see citing works
Self-citationGrimby, G., & Saltin, B. (1983) · Clinical Physiology · doi:10.1111/j.1475-097x.1983.tb00704.x · Cited by 513 · see citing works
Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle.
Simpson, R. U., Thomas, G. A., & Arnold, A. J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39433-4 · Cited by 479 · see citing works
Role of Vitamin D in Skeletal Muscle Function*
Boland, R. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-4-434 · Cited by 436 · see citing works
Muscle morphology, enzymatic activity, and muscle strength in elderly men: A follow‐up study
ANIANSSON, A., Hedberg, M., Henning, G., & Grimby, G. (1986) · Muscle & Nerve · doi:10.1002/mus.880090702 · Cited by 314 · see citing works
Muscle strength in the elderly: Its relation to vitamin d metabolites
Bischoff, H. A., Stähelin, H. B., Urscheler, N., Ehrsam, R., Vonthein, R., Perrig‐Chiello, P., Tyndall, A., & Theiler, R. (1999) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(99)90307-6 · Cited by 310 · see citing works
Self-citationMyopathy in Bone Loss of Ageing: Improvement by Treatment with 1α-hydroxycholecalciferol and Calcium
Sørensen, O. H., Lund, B., Saltin, B., Lund, B., Andersen, R. B., Hjorth, L., Melsen, F., & Mosekilde, L. (1979) · Clinical Science · doi:10.1042/cs0560157 · Cited by 274 · see citing works
Falls Relate to Vitamin D and Parathyroid Hormone in an Australian Nursing Home and Hostel
Stein, M. S., Wark, J. D., Scherer, S. C., Walton, S. L., Chick, P., Carlantonio, M. D., Zajac, J. D., & Flicker, L. A. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb05199.x · Cited by 217 · see citing works
Low Serum Calcidiol Concentration in Older Adults with Reduced Muscular Function
Mowé, M., Haug, E., & Bøhmer, T. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb04581.x · Cited by 216 · see citing works
Advancing Age Results in Reduction of Intestinal and Bone 1,25-Dihydroxyvitamin D Receptor
Horst, R. L., Goff, J. P., & Reinhardt, T. A. (1990) · Endocrinology · doi:10.1210/endo-126-2-1053 · Cited by 186 · see citing works
1,25-Dihydroxyvitamin D3Receptors and Hormonal Responses in Cloned Human Skeletal Muscle Cells*
Costa, E. M., Blau, H. M., & Feldman, D. I. (1986) · Endocrinology · doi:10.1210/endo-119-5-2214 · Cited by 166 · see citing works
Effects of age and regular exercise on muscle strength and endurance
Laforest, S., St-Pierre, D. M. M., Cyr, J., & Gayton, D. (1990) · European Journal of Applied Physiology · doi:10.1007/bf00846029 · Cited by 149 · see citing works
Vitamin D3 Augments Osteoclastogenesis via Vitamin D-Responsive Element of Mouse RANKL Gene Promoter
Kitazawa, R., & Kitazawa, S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6251 · Cited by 99 · see citing works
Kinyamu, H. K., Gallagher, J. C., Prahl, J. M., DeLuca, H. F., Petranick, K. M., & Lanspa, S. J. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.6.922 · Cited by 84 · see citing works
Sandgren, M. E., & Deluca, H. F. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4312 · Cited by 64 · see citing works
Lips, P. T. A. M. (1996) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1996.176290.x · Cited by 62 · see citing works
Localisation of vitamin D receptor in normal human duodenum and in patients with coeliac disease.
Colston, K. W., Mackay, A. G., Finlayson, C., Wu, J. C., & Maxwell, J. D. (1994) · Gut · doi:10.1136/gut.35.9.1219 · Cited by 58 · see citing works
1,25-Dihydroxyvitamin D3 receptors in developing dorsal root ganglia of fetal rats
Johnson, J. A., Grande, J. P., Windebank, A. J., & Kumar, R. (1996) · Developmental Brain Research · doi:10.1016/0165-3806(95)00204-9 · Cited by 45 · see citing works
Berry, J., Farquharson, C., Whitehead, C. C., & Mawer, E. B. (1996) · Bone · doi:10.1016/8756-3282(96)00171-8 · Cited by 32 · see citing works
Immunohistochemical Analysis of 1,25-dihydroxyvitamin D3 Receptor in Cervical Carcinoma
Reichrath, J., Rafi, L., Müller, S. M., Mink, D., Reitnauer, K., Tilgen, W., Schmidt, W., & Friedrich, M. (1998) · The Histochemical Journal · doi:10.1023/a:1003283117492 · Cited by 31 · see citing works
Liang, C. T., Barnes, J., Imanaka, S., & DeLuca, H. F. (1994) · Experimental Gerontology · doi:10.1016/0531-5565(94)90049-3 · Cited by 30 · see citing works
Immunohistochemical Detection of 1,25-dihydroxyvitamin D3 Receptors (VDR) in Human Skin
Reichrath, J., Collins, E. D., Epple, S., Kerber, A. U., Norman, A. W., & Bahmer, F. A. (1996) · Pathology - Research and Practice · doi:10.1016/s0344-0338(96)80231-7 · Cited by 28 · see citing works
Stimulation of Osteopontin mRNA Expression in HL-60 Cells Is Independent of Differentiation
Atkins, K. B., Simpson, R. U., & Somerman, M. J. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0151 · Cited by 27 · see citing works
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Fracture Prevention With Vitamin D Supplementation
Bischoff-Ferrari, H. A., Willett, W. C., Wong, J. B., Giovannucci, E. L., Dietrich, T., & Dawson‐Hughes, B. (2005) · JAMA · doi:10.1001/jama.293.18.2257 · Cited by 1,514 · see citing works
Self-citationBischoff-Ferrari, H. A., Dawson‐Hughes, B., Staehelin, H. B., Orav, E. J., Stuck, A. E., Theiler, R., Wong, J. B., Egli, A., Kiel, D. P., & Henschkowski, J. (2009) · BMJ · doi:10.1136/bmj.b3692 · Cited by 1,279 · see citing works
Self-citationLips, P. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.02.016 · Cited by 1,173 · see citing works
Skeletal muscle performance and ageing
Tieland, M., Trouwborst, I., & Clark, B. C. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12238 · Cited by 904 · see citing works
The Role of Inflammation in Age-Related Sarcopenia
Dalle, S., Rossmeislova, L., & Koppo, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01045 · Cited by 668 · see citing works
Lips, P. T. A. M., Cashman, K. D., Lamberg-Allardt, C. J. E., Bischoff-Ferrari, H. A., Obermayer-Pietsch, B. M., Bianchi, M. L., Stepan, J. J., Fuleihan, G. E., & Bouillon, R. (2019) · European Journal of Endocrinology · doi:10.1530/eje-18-0736 · Cited by 671 · see citing works
Self-citationThe Vitamin D Epidemic and its Health Consequences
Holick, M. F. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2739s · Cited by 579 · see citing works
Role of vitamin D in the pathogenesis of type 2 diabetes mellitus
Palomer, X., González‐Clemente, J. M., Blanco‐Vaca, F., & Mauricio, D. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00710.x · Cited by 510 · see citing works
Bischoff-Ferrari, H. A., Dawson-Hughes, B., Orav, E. J., Staehelin, H. B., Meyer, O. W., Theiler, R., Dick, W., Willett, W. C., & Egli, A. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.7148 · Cited by 511 · see citing works
Self-citationDoes nutrition play a role in the prevention and management of sarcopenia?
Robinson, S. M., Reginster, J. Y., Rizzoli, R., Shaw, S. C., Kanis, J. A., Bautmans, I., Bischoff-Ferrari, H., Bruyère, O., Cesari, M., Dawson-Hughes, B., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.08.016 · Cited by 491 · see citing works
Self-citationRole of Vitamin D in Insulin Secretion and Insulin Sensitivity for Glucose Homeostasis
Alvarez, J. A., & Ashraf, A. P. (2009) · International Journal of Endocrinology · doi:10.1155/2010/351385 · Cited by 484 · see citing works
Muir, S. W., & Montero‐Odasso, M. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03733.x · Cited by 470 · see citing works
Clark, B., & Manini, T. (2012) · Nutrition (Burbank, Los Angeles County, Calif.) · doi:10.1016/j.nut.2011.12.002 · Cited by 415 · see citing works
The vitamin D questions: how much do you need and how should you get it?
Wolpowitz, D., & Gilchrest, B. (2006) · Journal of American Academy of Dermatology · doi:10.1016/j.jaad.2005.11.1057 · Cited by 403 · see citing works
Vitamin D Deficiency and Sarcopenia in Older Persons
Remelli, F., Vitali, A., Zurlo, A., & Volpato, S. (2019) · Nutrients · doi:10.3390/nu11122861 · Cited by 348 · see citing works
Dzik, K. P., & Kaczor, J. J. (2019) · European Journal of Applied Physiology · doi:10.1007/s00421-019-04104-x · Cited by 357 · see citing works
Rémond, D., Shahar, D., Gille, D., Pinto, P., Kachal, J., Peyron, M., dos Santos, C. D., Walther, B., Bordoni, A., Dupont, D., et al. (2015) · OncoTarget · doi:10.18632/oncotarget.4030 · Cited by 299 · see citing works
Impact of nutrition on muscle mass, strength, and performance in older adults
Mithal, A., Bonjour, J., Boonen, S., Burckhardt, P., Degens, H., Fuleihan, G. E. H., Josse, R., Lips, P., Torres, J., Rizzoli, R., et al. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2236-y · Cited by 167 · see citing works
Artaza-Artabe, I., Sáez-López, P., Sánchez-Hernández, N., Fernández-Gutiérrez, N., & Malafarina, V. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.04.009 · Cited by 261 · see citing works
Chung, J.-Y., Kang, H.-T., Lee, D.-C., Lee, H.-R., & Lee, Y.-J. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.09.007 · Cited by 283 · see citing works
Vitamin D and Human Skeletal Muscle
Hamilton, B. H. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2009.01016.x · Cited by 276 · see citing works
Optimal Vitamin D Status: A Critical Analysis on the Basis of Evidence-Based Medicine
Bouillon, R., van Schoor, N. M., Gielen, E., Boonen, S., Mathieu, C., Vanderschueren, D., & Lips, P. T. A. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1195 · Cited by 275 · see citing works
Garcia, L. A., King, K. K., Ferrini, M. G., Norris, K. C., & Artaza, J. N. (2011) · Endocrinology · doi:10.1210/en.2011-0159 · Cited by 262 · see citing works
Ceglia, L., Niramitmahapanya, S., Morais, M. D. S., Rivas, D. A., Harris, S. S., Bischoff-Ferrari, H. A., Fielding, R. A., & Dawson‐Hughes, B. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2820 · Cited by 257 · see citing works
Self-citationRizzoli, R., Stevenson, J. C., Bauer, J. M., van Loon, L. J. C., Walrand, S., Kanis, J. A., Cooper, C., Brandi, M.-L., Diez-Perez, A., & Reginster, J.-Y. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.07.005 · Cited by 291 · see citing works
Effect of Cholecalciferol Plus Calcium on Falling in Ambulatory Older Men and Women
Bischoff-Ferrari, H. A., Orav, E. J., & Dawson‐Hughes, B. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.4.424 · Cited by 246 · see citing works
Self-citationClose, G. L., Russell, J., Cobley, J. N., Owens, D. J., Wilson, G., Gregson, W., Fraser, W. D., & Morton, J. P. (2013) · Journal of Sports Sciences · doi:10.1080/02640414.2012.733822 · Cited by 246 · see citing works
Scott, D., Blizzard, L., Fell, J., Ding, C., Winzenberg, T., & Jones, G. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03858.x · Cited by 213 · see citing works
Ryan, Z. C., Craig, T. A., Folmes, C. D. L., Wang, X., Lanza, I. R., Schaible, N., Salisbury, J. L., Nair, K. S., Terzic, A., Sieck, G. C., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.684399 · Cited by 212 · see citing works
Gröber, U., Spitz, J., Reichrath, J., Kisters, K., & Holick, M. F. (2013) · Dermato-Endocrinology · doi:10.4161/derm.26738 · Cited by 198 · see citing works
Bischoff-Ferrari, H. A., Dawson‐Hughes, B., Stöcklin, E., Sidelnikov, E., Willett, W. C., Orav, E. J., Stähelin, H. B., Wolfram, S., Jetter, A., Schwager, J., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.551 · Cited by 194 · see citing works
Self-citationBoonen, S., Bischoff-Ferrari, H. A., Cooper, C. C., Lips, P. T. A. M., Ljunggren, Ö., Meunier, P. J., & Reginster, J.-Y. (2006) · Calcified Tissue International · doi:10.1007/s00223-005-0009-8 · Cited by 189 · see citing works
Self-citationVitamin D in the aging musculoskeletal system: An authentic strength preserving hormone
Montero‐Odasso, M., & Duque, G. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.01.005 · Cited by 180 · see citing works
Sarcopenia and Age-Related Endocrine Function
Sakuma, K., & Yamaguchi, A. (2012) · International Journal of Endocrinology · doi:10.1155/2012/127362 · Cited by 182 · see citing works
Moreira, L. D. F., Pedrosa, M. A. C., Teixeira, L. R., & Lazaretti‐Castro, M. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000235874 · Cited by 178 · see citing works
Kim, M. K., Baek, K. H., Song, K.-H., Il Kang, M., Park, C. Y., Lee, W. Y., & Oh, K. W. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1602 · Cited by 171 · see citing works
Rejnmark, L. (2010) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622310381934 · Cited by 170 · see citing works
Relevance of vitamin D in muscle health
Bischoff-Ferrari, H. A. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9200-6 · Cited by 168 · see citing works
Self-citationOudshoorn, C., Mattace-Raso, F. U. S., van der Velde, N., Colin, E. M., & van der Velde, N. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000134382 · Cited by 162 · see citing works
Non-musculoskeletal benefits of vitamin D
Wimalawansa, S. J. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.09.016 · Cited by 161 · see citing works
Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health
Latham, C. M., Brightwell, C. R., Keeble, A. R., Munson, B. D., Thomas, N. T., Zagzoog, A. M., Fry, C. S., & Fry, J. L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.660498 · Cited by 163 · see citing works
Kukuljan, S., Nowson, C. A., Sanders, K., & Daly, R. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00392.2009 · Cited by 154 · see citing works
Jung, H. N., Jung, C. H., & Hwang, Y. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155557 · Cited by 159 · see citing works
Mechanisms of vitamin D action in skeletal muscle
Montenegro, K. R., Cruzat, V., Carlessi, R., & Newsholme, P. (2019) · Nutrition Research Reviews · doi:10.1017/s0954422419000064 · Cited by 147 · see citing works
Girgis, C. M., Cha, K. M., Houweling, P. J., Rao, R., Mokbel, N., Lin, M. T., Clifton-Bligh, R. J., & Gunton, J. E. (2015) · Calcified Tissue International · doi:10.1007/s00223-015-0054-x · Cited by 147 · see citing works
Barnard, K., & Colon-Emeric, C. S. (2010) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2010.02.004 · Cited by 142 · see citing works
Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease
Hopkinson, N. S., Li, K., Kehoe, A., Humphries, S. E., Roughton, M., Moxham, J., Montgomery, H., & Polkey, M. I. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.385 · Cited by 143 · see citing works
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Calvani, R., Picca, A., Coelho‐Júnior, H. J., Tosato, M., Marzetti, E., & Landi, F. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155637 · Cited by 153 · see citing works
Calcium and vitamin D in the prevention and treatment of osteoporosis – a clinical update
Boonen, S., Vanderschueren, D., Haentjens, P., & Lips, P. T. A. M. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01655.x · Cited by 140 · see citing works
Rosendahl-Riise, H., Spielau, U., Ranhoff, A. H., Gudbrandsen, O. A., & Dierkes, J. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12394 · Cited by 140 · see citing works
LeBoff, M. S., Hawkes, W. G., Glowacki, J., Yu-Yahiro, J., Hurwitz, S., & Magaziner, J. (2008) · Osteoporosis International · doi:10.1007/s00198-008-0582-6 · Cited by 136 · see citing works
Girgis, C. M., Clifton-Bligh, R. J., Turner, N. A., Lau, S. L., & Gunton, J. E. (2013) · Clinical Endocrinology · doi:10.1111/cen.12368 · Cited by 135 · see citing works
Kull, M. M., Kallikorm, R., Tamm, A., & Lember, M. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-22 · Cited by 134 · see citing works
Vitamin D, Skeletal Muscle Function and Athletic Performance in Athletes—A Narrative Review
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Cruz-Jentoft, A. J., Dawson Hughes, B., Scott, D., Sanders, K. M., & Rizzoli, R. (2020) · Maturitas · doi:10.1016/j.maturitas.2019.11.007 · Cited by 144 · see citing works
Effects of Vitamin D Supplementation on Muscle Strength in Athletes: A Systematic Review
Chiang, C.-M., Ismaeel, A., Griffis, R. B., & Weems, S. (2017) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001518 · Cited by 130 · see citing works
Terushkin, V., Bender, A., Psaty, E. L., Engelsen, O., Wang, S. Q., & Halpern, A. C. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.07.028 · Cited by 129 · see citing works
Genetic Influences in Sport and Physical Performance
Puthucheary, Z., Skipworth, J. R. A., Rawal, J., Loosemore, M., van Someren, K. A., & Montgomery, H. (2011) · Sports Medicine · doi:10.2165/11593200-000000000-00000 · Cited by 129 · see citing works
Should We Be Concerned about the Vitamin D Status of Athletes?
Willis, K. S., PETERSON, N. J., & Larson‐Meyer, D. E. (2008) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.18.2.204 · Cited by 128 · see citing works
Bhat, M., Kalam, R., Qadri, S. S. Y. H., Seshacharyulu, M., & Ismail, A. (2013) · Endocrinology · doi:10.1210/en.2013-1369 · Cited by 122 · see citing works
Neelemaat, F., Lips, P., Bosmans, J. E., Thijs, A., Seidell, J. C., & van Bokhorst‐de van der Schueren, M. A. E. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03888.x · Cited by 119 · see citing works
The effects of vitamin D on skeletal muscle function and cellular signaling
Dirks‐Naylor, A. J., & Lennon, S. L. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.03.003 · Cited by 118 · see citing works
Is fall prevention by vitamin D mediated by a change in postural or dynamic balance?
Bischoff-Ferrari, H. A., Conzelmann, M., Stähelin, H. B., Dick, W., Carpenter, M. G., Adkin, A. L., Theiler, R., Pfeifer, M. A., & Allum, J. H. J. (2006) · Osteoporosis International · doi:10.1007/s00198-005-0030-9 · Cited by 117 · see citing works
Self-citationGenetics of the Musculoskeletal System: A Pleiotropic Approach
Karasik, D., & Kiel, D. P. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080218 · Cited by 117 · see citing works
Dukas, L., Schacht, E., & Stähelin, H. B. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1903-7 · Cited by 117 · see citing works
Self-citationVitamin D: What is an adequate vitamin D level and how much supplementation is necessary?
Bischoff-Ferrari, H. A. (2009) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2009.09.005 · Cited by 113 · see citing works
Self-citationLips, P. T. A. M., Binkley, N., Pfeifer, M. A., Recker, R. R., Samanta, S., Cohn, D., Chandler, J., Rosenberg, E., & Papanicolaou, D. A. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28113 · Cited by 116 · see citing works
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Bass, J. J., Nakhuda, A., Deane, C. S., Brook, M. S., Wilkinson, D. J., Phillips, B. E., Philp, A., Tarum, J., Kadi, F., Andersen, D. K., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101059 · Cited by 116 · see citing works
The Vitamin D/Vitamin D receptor (VDR) axis in muscle atrophy and sarcopenia
Bollen, S. E., Bass, J. J., Fujita, S., Wilkinson, D. J., Hewison, M., & Atherton, P. J. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110355 · Cited by 116 · see citing works
The Emerging Biomolecular Role of Vitamin D in Skeletal Muscle
Pojednic, R. M., & Ceglia, L. (2014) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000013 · Cited by 116 · see citing works
Dawson‐Hughes, B. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2017.03.018 · Cited by 116 · see citing works
Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis
Bhat, M., & Ismail, A. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.05.012 · Cited by 114 · see citing works
Grant, W. B., Karras, S. Ν., Bischoff-Ferrari, H. A., Annweiler, C., Boucher, B. J., Juzeniene, A., Garland, C. F., & Holick, M. F. (2016) · Dermato-Endocrinology · doi:10.1080/19381980.2016.1187349 · Cited by 112 · see citing works
Self-citationRelationship between serum parathyroid hormone, vitamin D sufficiency, age, and calcium intake
Adami, S., Viapiana, O., Gatti, D., Idolazzi, L., & Rossini, M. (2007) · Bone · doi:10.1016/j.bone.2007.10.003 · Cited by 111 · see citing works
Therapies for Musculoskeletal Disease: Can we Treat Two Birds with One Stone?
Girgis, C. M., Mokbel, N., & DiGirolamo, D. J. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0204-5 · Cited by 110 · see citing works
Faulkner, K. A., Cauley, J. A., Zmuda, J. M., Landsittel, D. P., Newman, A. B., Studenski, S. A., Redfern, M. S., Ensrud, K. E., Fink, H. A., Lane, N. E., et al. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0071-8 · Cited by 110 · see citing works
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Garcia, M., Seelaender, M., Sotiropoulos, A., Coletti, D., & Lancha, A. H. (2019) · Nutrition · doi:10.1016/j.nut.2018.09.031 · Cited by 105 · see citing works
A positive association of vitamin D deficiency and sarcopenia in 50 year old women, but not men
Park, S., Ham, J.-O., & Lee, B.-K. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.09.016 · Cited by 103 · see citing works
Aging of the endocrine system and its potential impact on sarcopenia
Vitale, G., Cesari, M., & Mari, D. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.07.017 · Cited by 106 · see citing works
Vitamin D and its implications for musculoskeletal health in women: An update
Pérez-López, F. R. (2007) · Maturitas · doi:10.1016/j.maturitas.2007.05.002 · Cited by 100 · see citing works
LeBoff, M. S., Murata, E. M., Cook, N. R., Cawthon, P. M., Chou, S. H.-H., Kotler, G., Bubes, V. Y., Buring, J. E., & Manson, J. E. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa311 · Cited by 98 · see citing works
The Effects of Vitamin D Deficiency in Athletes
Angeline, M. E., Gee, A. O., Shindle, M. K., Warren, R. F., & Rodeo, S. A. (2013) · The American Journal of Sports Medicine · doi:10.1177/0363546513475787 · Cited by 99 · see citing works
Seasonal variation in vitamin D status in professional soccer players of the English Premier League
Morton, J. P., Iqbal, Z., Drust, B., Burgess, D. J., Close, G. L., & Brukner, P. D. (2012) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h2012-037 · Cited by 97 · see citing works
Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysis
Marcos-Pérez, D., Sánchez-Flores, M., Proietti, S., Bonassi, S., Costa, S., Teixeira, J. P., Fernandez-Tajes, J. J., Pásaro, E., Valdiglesias, V., & Laffón, B. (2020) · Nutrients · doi:10.3390/nu12082286 · Cited by 95 · see citing works
Age-related muscle anabolic resistance: inevitable or preventable?
Aragon, A. A., Tipton, K. D., & Schoenfeld, B. J. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac062 · Cited by 93 · see citing works
Relation of Vitamin D Level to Maximal Oxygen Uptake in Adults
Ardestani, A., Parker, B. A., Mathur, S., Clarkson, P. M., Pescatello, L. S., Hoffman, H. J., Polk, D. M., & Thompson, P. D. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.12.022 · Cited by 91 · see citing works
Role of hormones in sarcopenia
Priego, T., Martı́n, A. I., González‐Hedström, D., Granado, M., & López‐Calderón, A. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.021 · Cited by 97 · see citing works
Cesari, M., Incalzi, R. A., Zamboni, V., & Pahor, M. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00668.x · Cited by 91 · see citing works
Effect of nutritional interventions and resistance exercise on aging muscle mass and strength
Candow, D. G., Forbes, S. C., Little, J. P., Cornish, S. M., Pinkoski, C., & Chilibeck, P. D. (2012) · Biogerontology · doi:10.1007/s10522-012-9385-4 · Cited by 90 · see citing works
Gunton, J. E., & Girgis, C. M. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.04.004 · Cited by 89 · see citing works
Vitamin D: Recent Advances and Implications for Athletes
Todd, J. J., Pourshahidi, L. K., McSorley, E. M., Madigan, S. M., & Magee, P. J. (2014) · Sports Medicine · doi:10.1007/s40279-014-0266-7 · Cited by 88 · see citing works
Hassan-Smith, Z. K., Jenkinson, C., Smith, D. J., Hernandez, I., Morgan, S. A., Crabtree, N. J., Gittoes, N. J., Keevil, B. G., Stewart, P. M., & Hewison, M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0170665 · Cited by 84 · see citing works
Gielen, E., Vanderschueren, D., Callewaert, F., & Boonen, S. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.08.012 · Cited by 85 · see citing works
Roux, C., Bischoff-Ferrari, H. A., Papapoulos, S. E., de Papp, A. E., West, J. A., & Bouillon, R. (2008) · Current Medical Research and Opinion · doi:10.1185/030079908x301857 · Cited by 84 · see citing works
Self-citationExtraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications
Body, J. J., Bergmann, P., Boonen, S., Devogelaer, J.-P., Gielen, E., Goemaere, S., Kaufman, J., Rozenberg, S., & Reginster, J.-Y. (2012) · Osteoporosis International · doi:10.1007/s00198-011-1891-8 · Cited by 83 · see citing works
Sunlight, tanning booths, and vitamin D
Lim, H. W., Gilchrest, B. A., Cooper, K. D., Bischoff-Ferrari, H. A., Rigel, D. S., Cyr, W. H., Miller, S. A., DeLeo, V. A., Lee, T. K., Demko, C. A., et al. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.03.015 · Cited by 83 · see citing works
Self-citationOh, C., Jho, S., No, J.-K., & Kim, H. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.07.018 · Cited by 82 · see citing works
Pojednic, R. M., Ceglia, L., Olsson, K., Gustafsson, T. P., Lichtenstein, A. H., Dawson‐Hughes, B., & Fielding, R. A. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9932-x · Cited by 82 · see citing works
Menant, J. C., Close, J., Delbaere, K., Sturnieks, D. L., Trollor, J. N., Sachdev, P. S., Brodaty, H., & Lord, S. R. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1637-7 · Cited by 82 · see citing works
Zhang, L., Quan, M., & Cao, Z. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215826 · Cited by 81 · see citing works
- Authors
- Bischoff-Ferrari, H., Borchers, M., Gudat, F., Dürmüller, U., Stähelin, H., & Dick, W.
- Affiliations
- Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA
- Ludwig-Maximilians-Universität München (DE)
- University of Basel (CH)
- Department of Geriatrics, University Basel, Basel, Switzerland
- Venue
- Journal of Bone and Mineral Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-02-01
- Volume
- 19
- Issue
- 2
- Pages
- 265-269
- ISSN
- 0884-0431 (ISSN-L)
- 1523-4681
- OpenAlex
- W2078844946
- Cited by
- 585
- References
- 34
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 16 · 2023: 22 · 2022: 32 · 2021: 35 · 2020: 38 · 2019: 30 · 2018: 34 · 2017: 30 · 2016: 28 · 2015: 31 · 2014: 32 · 2013: 31 · 2012: 38
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Bone and Mineral Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- vitamin D receptor, 1,25-dihydroxyvitamin D, skeletal muscle, aging, 25-hydroxyvitamin D, gluteus medius, muscle biopsy, vitamin D status
- MeSH terms
- Adult, Aged, Aging, Biopsy, Female, Humans, Middle Aged, Receptors, Calcitriol, Muscle, Skeletal
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