The DOI matches its Crossref record; 275 of the 275 references it cites were found in a registry or an index.
Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease
Open accessAbstract
A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure homeostatic control of blood glucose levels. Reduced glucose transport activity results in aberrant use of energy substrates and is associated with insulin resistance and type 2 diabetes. It is well established that GLUT2, the main regulator of hepatic hexose flux, and GLUT4, the workhorse in insulin- and contraction-stimulated glucose uptake in skeletal muscle, are critical contributors in the control of whole-body glycemia. However, the molecular mechanism how insulin controls glucose transport across membranes and its relation to impaired glycemic control in type 2 diabetes remains not sufficiently understood. An array of circulating metabolites and hormone-like molecules and potential supplementary glucose transporters play roles in fine-tuning glucose flux between the different organs in response to an altered energy demand.
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“Beyond GLUT4, skeletal muscle expresses several other glucose transporters, such as GLUT1, GLUT3, GLUT6, GLUT10, and GLUT12, albeit at lower abundance [16].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [16]
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“Beyond GLUT4, skeletal muscle expresses several other glucose transporters, such as GLUT1, GLUT3, GLUT6, GLUT10, and GLUT12, albeit at lower abundance [16].”
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Metadata
- Authors
- Chadt, A., & Al-Hasani, H.
- Affiliations
- Deutsches Diabetes-Zentrum e.V. (DE)
- ORCID
- Chadt, Alexandra
- Venue
- Pflügers Archiv - European Journal of Physiology
- Published
- 2020-06-26
- Volume
- 472
- Issue
- 9
- Pages
- 1273-1298
- ISSN
- 0031-6768 (ISSN-L)
- 1432-2013
- PMC
- PMC7462924
- OpenAlex
- W3038041948
- Cited by
- 510
- References
- 275
- Citations by year
- 2026: 62 · 2025: 89 · 2024: 128 · 2023: 99 · 2022: 84 · 2021: 45 · 2020: 3
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Pflügers Archiv - European Journal of Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Funders
- Deutsche Forschungegemeinschaft (CH1659)
- European Foundation for the Study of Diabetes (EFSD/NovoNordisk)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- glucose transporters, GLUT2, GLUT4, adipose tissue, liver, skeletal muscle, insulin resistance, type 2 diabetes, glucose uptake, hepatic glucose metabolism, skeletal muscle glucose uptake, blood glucose homeostasis, circulating metabolites, energy metabolism
- MeSH terms
- Adipose Tissue, Animals, Diabetes Mellitus, Humans, Liver, Muscle, Skeletal, Glucose Transport Proteins, Facilitative, Non-alcoholic Fatty Liver Disease
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