FGFR1 and anosmin-1 underlying genetically distinct forms of Kallmann syndrome are co-expressed and interact in olfactory bulbs
Open accessAbstract
Kallmann syndrome is a genetically heterogeneous developmental disease characterised by a partial or complete lack of olfactory bulb development. Two genes underlying this disease have so far been identified: the KAL-1 gene, which encodes anosmin-1, an extracellular matrix protein that promotes axonal guidance and branch formation in vitro; and KAL-2, which encodes the known FGFR1. The implication of FGFR1 and anosmin-1 in the same developmental disease led us to test whether anosmin-1 and FGFR1 interact during the development of the olfactory system. In this paper, we showed that the two proteins co-localise in the olfactory bulb during development in rat. Using cross-immunoprecipitation assays of olfactory bulb extracts, we also demonstrated that anosmin-1 and FGFR1 are comprised within the same protein complex. Moreover, we show that anosmin-1 expression in CHO transfected cells increases FGFR1 accumulation, suggesting that anosmin-1 may act as a positive extracellular regulator of FGFR1 signalling. Taken together, our findings strongly suggest that anosmin-1 is an essential component of a FGFR1 pathway that plays a key role during olfactory bulb morphogenesis.
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Anosmin 1 co-localizes with FGFR-1 in the olfactory bulb during development, suggesting that anosmin 1 is a component of FGFR-1 signaling.
“Anosmin 1 co-localizes with basic fibroblast growth factor receptor 1 (FGFR-1, discussed further below), in the olfactory bulb during development, which suggests that this protein is a component of FGFR-1 signaling.”
From The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism (2009) · cites this paper as [8]
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The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism
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- Authors
- Ayari, B., & Soussi-Yanicostas, N.
- Affiliations
- Inserm (FR)
- Venue
- Development Genes and Evolution
- Published
- 2006-12-21
- Volume
- 217
- Issue
- 2
- Pages
- 169-175
- ISSN
- 0043-5546 (ISSN-L)
- 0949-944X
- 1432-041X
- OpenAlex
- W2033438101
- Cited by
- 36
- References
- 23
- Citations by year
- 2024: 5 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Development Genes and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institut de France
- Institut National de la Santé et de la Recherche Médicale (R04190SP)
- Fondation pour la Recherche Médicale (INE20050303379)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- Kallmann syndrome, FGFR1, anosmin-1, olfactory bulb development, olfactory development, protein-protein interaction, extracellular matrix, axon guidance, protein complexes
- MeSH terms
- Animals, Cricetulus, Female, Cricetinae, Humans, Immunohistochemistry, Models, Biological, Nerve Tissue Proteins, Olfactory Bulb, Pregnancy, Transfection, Gene Expression, Extracellular Matrix Proteins, CHO Cells, Rats, Wistar, Kallmann Syndrome, Rats, Receptor, Fibroblast Growth Factor, Type 1
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