The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.
Taste representation in the human insula
Abstract
The sense of taste exists so that organisms can detect potential nutrients and toxins. Despite the fact that this ability is of critical importance to all species there appear to be significant interspecies differences in gustatory organization. For example, monkeys and humans lack a pontine taste relay, which is a critical relay underlying taste and feeding behavior in rodents. In addition, and of particular relevance to this special issue, the primary taste cortex appears to be located further caudally in the insular cortex in humans compared to in monkeys. The primary aim of this paper is to review the evidence that supports this possibility. It is also suggested that one parsimonious explanation for this apparent interspecies differences is that if, as Craig suggests, the far anterior insular cortex is newly evolved and unique to humans, then the human taste cortex may only appear to be located further caudally because it is no longer the anterior-most section of insular cortex. In addition to discussing the location of taste representation in human insular cortex, evidence is presented to support the possibility that this region is better conceptualized as an integrated oral sensory region that plays role in feeding behavior, rather than as unimodal sensory cortex.
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“In humans, taste is first projected from the tongue and oral cavity to the primary taste cortex in an area of the anterior insula and frontal operculum (see References [142,143] for reviews), along with oral texture and temperature [144,145].”
From The Role of Intrinsic and Extrinsic Sensory Factors in Sweetness Perception of Food and Beverages: A Review (2019) · cites this paper as [142]
Citations
Cites
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 2×
“However, a more parsimonious explanation is that if, as Craig (2009) suggests, the far anterior insular cortex is newly evolved and unique to humans, then the human taste cortex may only appear to be located further caudally because it is no longer in the anterior-most section of insular cortex.”
BackgroundBerti, A. (1992) · Neuropsychologia · doi:10.1016/0028-3932(92)90076-x · Cited by 4,190
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
The neural mechanisms of top-down attentional control
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The receptors and cells for mammalian taste
Chandrashekar, J. V., Hoon, M. A., Ryba, N. J. P., & Zuker, C. S. (2006) · Nature · doi:10.1038/nature05401 · Cited by 1,632
Paxinos, G., & Jürgen, K. (2004) · Cited by 1,478
T2Rs Function as Bitter Taste Receptors
Chandrashekar, J. V., Mueller, K. L., Hoon, M. A., Adler, E., Feng, L., Guo, W., Zuker, C. S., & Ryba, N. J. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80706-0 · Cited by 1,402
Handbook of Olfaction and Gustation
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Research works printed but not linked: 3
- Malik S, McGlone F, Bedrossian D, Dagher A (2008b) Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 7:400–409 · DOI · Paper page
- Small DM, Green BG (2010a) A model for a unitary flavor modality. In: Murray M, Wallace M (eds) Multisensory processes. Frontiers in Neurobiology (in press) · DOI
- Veldhuizen MG, Rudenga K, Small DM (2008) The pleasure of taste, flavor and food. In: Berridge KC, Kringelbach ML (eds) The neurobiology of pleasure. Oxford University Press, Oxford
Cited by
Sorted by citations
Kurth, F., Zilles, K., Fox, P. T., Laird, A. R., & Eickhoff, S. B. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0255-z · Cited by 1,293
Structure and Function of the Human Insula
Uddin, L. Q., Nomi, J. S., Hébert-Seropian, B., Ghaziri, J., & Boucher, O. (2017) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000377 · Cited by 1,262
Reward mechanisms in obesity: new insights and future directions
Kenny, P. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.016 · Cited by 748
Significance of the insula for the evolution of human awareness of feelings from the body
(Bud) Craig, A. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05990.x · Cited by 646
Craig, A. D. (. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0248-y · Cited by 600
Metadata
- Authors
- Small, D. M.
- Affiliations
- John B. Pierce Laboratory (US)
- Corresponding author
- Small, Dana M.
- ORCID
- Small, Dana M.
- Venue
- Brain Structure and Function
- Published
- 2010-05-29
- Volume
- 214
- Issue
- 5-6
- Pages
- 551-561
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W2024922001
- Cited by
- 300
- References
- 108
- Citations by year
- 2026: 19 · 2025: 17 · 2024: 11 · 2023: 13 · 2022: 12 · 2021: 19 · 2020: 24 · 2019: 20 · 2018: 22 · 2017: 20 · 2016: 21 · 2015: 25 · 2014: 17 · 2013: 20 · 2012: 20
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (R01 6706-04)
- National Institute on Deafness and Other Communication Disorders
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- insula, feeding behavior
- MeSH terms
- Animals, Appetite, Cerebral Cortex, Biological Evolution, Feeding Behavior, Humans, Mouth, Primates, Species Specificity, Taste, Visceral Afferents
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