The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making
Open accessAbstract
We have recently shown that damage to the insula leads to a profound disruption of addiction to cigarette smoking (Naqvi et al., Science 315:531-534, 2007). Yet, there is little understanding of why the insula should play such an important role in an addictive behavior. A broad literature (much of it reviewed in this issue) has addressed the role of the insula in processes related to conscious interoception, emotional experience, and decision-making. Here, we review evidence for the role of the insula in drug addiction, and propose a novel theoretical framework for addiction in which the insula represents the interoceptive effects of drug taking, making this information available to conscious awareness, memory and executive functions. A central theme of this framework is that a primary goal for the addicted individual is to obtain the effects of the drug use ritual upon the body, and representations of this goal in interoceptive terms by the insula contribute to how addicted individuals feel, remember, and decide about taking drugs. This makes drug addiction like naturally motivated behaviors, such as eating and sex, for which an embodied ritual is the primary goal.
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“Many of the insula’s connectivity constitute areas known to be involved in addiction”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Naqvi and Bechara, 2010
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The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738
(1994) · DigitalGeorgetown (Georgetown University Library) · Cited by 10,542
DESCARTES' ERROR: Emotion, Reason, and the Human Brain
Marg, E. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03988.x · Cited by 8,178
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 4×
“without their peripheral effects, these behaviors would not be very pleasurable [this is related to Craig’s concept of ‘‘homeostatic emotion’’ ( Craig 2009 )].”
BackgroundInfluentialHow do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
The feeling of what happens: body and emotion in the making of consciousness
(2000) · Choice Reviews Online · doi:10.5860/choice.37-6553 · Cited by 6,001
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
Deciding advantageously before knowing the advantageous strategy
Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1997) · Science · doi:10.1126/science.275.5304.1293 · Cited by 3,547
Self-citationFunctional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
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Russo, E. B. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01238.x · Cited by 1,535
Interoception and Mental Health: A Roadmap.
Khalsa, S. S., Adolphs, R., Cameron, O. G., Critchley, H. D., Davenport, P. W., Feinstein, J. S., Feusner, J. D., Garfinkel, S. N., Lane, R. D., Mehling, W. E., et al. (2018) · Biological psychiatry. Cognitive neuroscience and neuroimaging · doi:10.1016/j.bpsc.2017.12.004 · Cited by 1,453
Self-citationThe brain on drugs: from reward to addiction
Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306
Drug addiction: updating actions to habits to compulsions ten years on
Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225
Interoception, contemplative practice, and health
Farb, N., Daubenmier, J., Price, C. J., Gard, T., Kerr, C., Dunn, B. D., Klein, A. C., Paulus, M. P., & Mehling, W. E. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00763 · Cited by 650
Metadata
- Authors
- Naqvi, N. H., & Bechara, A.
- Affiliations
- New York State Psychiatric Institute (US)
- University of Southern California (US)
- Corresponding author
- Naqvi, Nasir H.
- ORCID
- Bechara, Antoine
- Venue
- Brain Structure and Function
- Published
- 2010-05-29
- Volume
- 214
- Issue
- 5-6
- Pages
- 435-450
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- PMC
- PMC3698865
- OpenAlex
- W1976397511
- Cited by
- 598
- References
- 112
- Citations by year
- 2026: 23 · 2025: 28 · 2024: 29 · 2023: 32 · 2022: 30 · 2021: 41 · 2020: 98 · 2019: 46 · 2018: 44 · 2017: 38 · 2016: 38 · 2015: 36 · 2014: 28 · 2013: 46 · 2012: 22
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R25MH086466)
- National Institute on Drug Abuse (R01DA023051)
- National Institute of General Medical Sciences (T32GM007337)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- insula, drug addiction, interoception, decision-making, executive function, memory, embodied ritual, conscious awareness
- MeSH terms
- Animals, Awareness, Cerebral Cortex, Humans, Impulsive Behavior, Self Concept, Substance-Related Disorders, Pleasure
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