Cited by 598Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorPsychosomatic Disorders and Their Treatments

The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.

The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making

Open access

Naqvi, Nasir H., Bechara, Antoine·2010·Brain Structure and Function

DOI 10.1007/s00429-010-0268-7PMC PMC3698865

Open this paper in CoChat — free account

Abstract

We have recently shown that damage to the insula leads to a profound disruption of addiction to cigarette smoking (Naqvi et al., Science 315:531-534, 2007). Yet, there is little understanding of why the insula should play such an important role in an addictive behavior. A broad literature (much of it reviewed in this issue) has addressed the role of the insula in processes related to conscious interoception, emotional experience, and decision-making. Here, we review evidence for the role of the insula in drug addiction, and propose a novel theoretical framework for addiction in which the insula represents the interoceptive effects of drug taking, making this information available to conscious awareness, memory and executive functions. A central theme of this framework is that a primary goal for the addicted individual is to obtain the effects of the drug use ritual upon the body, and representations of this goal in interoceptive terms by the insula contribute to how addicted individuals feel, remember, and decide about taking drugs. This makes drug addiction like naturally motivated behaviors, such as eating and sex, for which an embodied ritual is the primary goal.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00429-010-0268-7

Cites

112 of 112 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738
Untitled work
(1994) · DigitalGeorgetown (Georgetown University Library) · Cited by 10,542
DESCARTES' ERROR: Emotion, Reason, and the Human Brain
Marg, E. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03988.x · Cited by 8,178
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657 · cited 4×
“without their peripheral effects, these behaviors would not be very pleasurable [this is related to Craig’s concept of ‘‘homeostatic emotion’’ ( Craig 2009 )].”
BackgroundInfluential
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
The feeling of what happens: body and emotion in the making of consciousness
(2000) · Choice Reviews Online · doi:10.5860/choice.37-6553 · Cited by 6,001
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785
Deciding advantageously before knowing the advantageous strategy
Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1997) · Science · doi:10.1126/science.275.5304.1293 · Cited by 3,547
Self-citation
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502

Show all 112 references

Sorted by citations

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
Russo, E. B. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01238.x · Cited by 1,535
Interoception and Mental Health: A Roadmap.
Khalsa, S. S., Adolphs, R., Cameron, O. G., Critchley, H. D., Davenport, P. W., Feinstein, J. S., Feusner, J. D., Garfinkel, S. N., Lane, R. D., Mehling, W. E., et al. (2018) · Biological psychiatry. Cognitive neuroscience and neuroimaging · doi:10.1016/j.bpsc.2017.12.004 · Cited by 1,453
Self-citation
The brain on drugs: from reward to addiction
Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306
Drug addiction: updating actions to habits to compulsions ten years on
Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225
Interoception, contemplative practice, and health
Farb, N., Daubenmier, J., Price, C. J., Gard, T., Kerr, C., Dunn, B. D., Klein, A. C., Paulus, M. P., & Mehling, W. E. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00763 · Cited by 650
Evidence for a large-scale brain system supporting allostasis and interoception in humans
Kleckner, I. R., Zhang, J., Touroutoglou, A., Chanes, L., Xia, C., Simmons, W. K., Quigley, K. S., Dickerson, B. C., & Feldman Barrett, L. (2017) · Nature Human Behaviour · doi:10.1038/s41562-017-0069 · Cited by 641
The insular cortex
Nieuwenhuys, R. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-53860-4.00007-6 · Cited by 580
The clinical significance of drug craving
Tiffany, S. T., & Wray, J. M. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06298.x · Cited by 556
Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking
Chen, B. T., Yau, H.-J., Hatch, C., Kusumoto-Yoshida, I., Cho, S. L., Hopf, F. W., & Bonci, A. (2013) · Nature · doi:10.1038/nature12024 · Cited by 498
Resting state functional connectivity in addiction: Lessons learned and a road ahead
Sutherland, M. T., McHugh, M. J., Pariyadath, V., & Stein, E. A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.117 · Cited by 509
Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction
Palaniyappan, L., & Liddle, P. F. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100176 · Cited by 548
Role of the anterior insula in task-level control and focal attention
Nelson, S. M., Dosenbach, N. U. F., Cohen, A. L., Wheeler, M. E., Schlaggar, B. L., & Petersen, S. E. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0260-2 · Cited by 435
A neurocognitive approach to understanding the neurobiology of addiction
Noël, X., Brevers, D., & Bechara, A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.018 · Cited by 466
Self-citation
Interoception and psychopathology: A developmental neuroscience perspective
Murphy, J., Brewer, R., Catmur, C., & Bird, G. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.12.006 · Cited by 404
Neural substrates of smoking cue reactivity: A meta-analysis of fMRI studies
Engelmann, J. M., Versace, F., Robinson, J. D., Minnix, J. A., Lam, C. Y., Cui, Y., Brown, V. L., & Cinciripini, P. M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.024 · Cited by 394
Smoking Cessation Induced by Deep Repetitive Transcranial Magnetic Stimulation of the Prefrontal and Insular Cortices: A Prospective, Randomized Controlled Trial
Dinur-Klein, L., Dannon, P., Hadar, A., Rosenberg, O., Roth, Y., Kotler, M., & Zangen, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.020 · Cited by 367
Impact of mindfulness on the neural responses to emotional pictures in experienced and beginner meditators
Taylor, V. A., Grant, J., Daneault, V., Scavone, G., Breton, E., Roffe-Vidal, S., Courtemanche, J., Lavarenne, A. S., & Beauregard, M. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.001 · Cited by 362
Brain default-mode network dysfunction in addiction
Zhang, R., & Volkow, N. D. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.06.036 · Cited by 386
The neurobiological basis of binge-eating disorder
KESSLER, R. M., Hutson, P. H., Herman, B. K., & Potenza, M. N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.013 · Cited by 386
The insula: a critical neural substrate for craving and drug seeking under conflict and risk
Naqvi, N. H., Gaznick, N., Tranel, D., & Bechara, A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12415 · Cited by 336
Self-citation
fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program
Murdaugh, D. L., Cox, J. E., Cook, E. W., & Weller, R. E. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.071 · Cited by 341
On the origin of interoception
Ceunen, E., Vlaeyen, J. W. S., & Van Diest, I. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00743 · Cited by 329
Revisiting the role of the insula in addiction
Droutman, V., Read, S. J., & Bechara, A. (2015) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.05.005 · Cited by 317
Self-citation
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake
Seif, T., Chang, S., Simms, J. A., Gibb, S. L., Dadgar, J., Chen, B. T., Harvey, B. K., Dorit Ron, A., Messing, R. O., Bonci, A., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3445 · Cited by 325
Interoception and drug addiction
Paulus, M. P., & Stewart, J. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.002 · Cited by 281
Mindful attention reduces neural and self-reported cue-induced craving in smokers
Westbrook, C., Creswell, J. D., Tabibnia, G., Julson, E., Kober, H., & Tindle, H. A. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr076 · Cited by 278
How we relate to brands: Psychological and neurophysiological insights into consumer–brand relationships
Reimann, M., Castaño, R., Zaichkowsky, J. L., & Bechara, A. (2011) · Journal of Consumer Psychology · doi:10.1016/j.jcps.2011.11.003 · Cited by 293
Self-citation
The role of interoception in addiction: A critical review
Verdejo‐García, A., Clark, L., & Dunn, B. D. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.007 · Cited by 290
Brain areas associated with numbers and calculations in children: Meta-analyses of fMRI studies
Arsalidou, M., Pawliw-Levac, M., Sadeghi, M., & Pascual‐Leone, J. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.08.002 · Cited by 285
Retraining the addicted brain: A review of hypothesized neurobiological mechanisms of mindfulness-based relapse prevention.
Witkiewitz, K., Lustyk, M. K. B., & Bowen, S. (2013) · Psychology of Addictive Behaviors · doi:10.1037/a0029258 · Cited by 207
Alexithymia is associated with a multidomain, multidimensional failure of interoception: Evidence from novel tests.
Murphy, J., Catmur, C., & Bird, G. (2017) · Journal of Experimental Psychology General · doi:10.1037/xge0000366 · Cited by 231
Pharmacological Foundations of Cannabis Chemovars
Lewis, M. A., Russo, E. B., & Smith, K. (2017) · Planta Medica · doi:10.1055/s-0043-122240 · Cited by 192
Subcortical structural connectivity of insular subregions
Ghaziri, J., Tucholka, A., Girard, G., Boucher, O., Houde, J., Descoteaux, M., Obaïd, S., Gilbert, G., Rouleau, I., & Nguyen, D. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-26995-0 · Cited by 204
Resting-State Functional Connectivity Predicts Impulsivity in Economic Decision-Making
Li, N., Ma, N., Liu, Y., He, X., Sun, D., Fu, X., Zhang, X., Han, S., & Zhang, D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1342-12.2013 · Cited by 187
Atypical interoception as a common risk factor for psychopathology: A review
Brewer, R., Murphy, J., & Bird, G. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.036 · Cited by 180
Noninvasive brain stimulation treatments for addiction and major depression
Dunlop, K., Hanlon, C. A., & Downar, J. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12985 · Cited by 171
Rodent models for compulsive alcohol intake
Hopf, F. W., & Lesscher, H. M. B. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.03.001 · Cited by 182
Decreased Functional Brain Connectivity in Adolescents with Internet Addiction
Hong, S.-B., Zalesky, A., Cocchi, L., Fornito, A., Choi, E.-J., Kim, H.-H., Suh, J.-E., Kim, C.-D., Kim, J.-W., & Yi, S.-H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057831 · Cited by 175
“emphasize pathology of fronto-striatal circuitry [8], as well as the insula [9,10].”
Background
Effects of a mindfulness‐based weight loss intervention in adults with obesity: A randomized clinical trial
Daubenmier, J., Moran, P. J., Kristeller, J., Acree, M., Bacchetti, P., Kemeny, M. E., Dallman, M., Lustig, R. H., Grunfeld, C., Nixon, D. F., et al. (2016) · Obesity · doi:10.1002/oby.21396 · Cited by 151
Methamphetamine use causes cognitive impairment and altered decision-making
Mizoguchi, H., & Yamada, K. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2018.12.019 · Cited by 154
Interoceptive awareness, positive affect, and decision making in Major Depressive Disorder
Furman, D. J., Waugh, C. E., Bhattacharjee, K., Thompson, R. J., & Gotlib, I. H. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.044 · Cited by 142
Brain networks underlying vulnerability and resilience to drug addiction
Ersche, K. D., Meng, C., Ziauddeen, H., Štochl, J., Williams, G. B., Bullmore, E. T., & Robbins, T. W. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002509117 · Cited by 143
Topography of descending projections from anterior insular and medial prefrontal regions to the lateral habenula of the epithalamus in the rat
Kim, U., & Lee, T. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08030.x · Cited by 133
A Triadic Reflective-Impulsive-Interoceptive Awareness Model of General and Impulsive Information System Use: Behavioral Tests of Neuro-Cognitive Theory
Turel, O., & Bechara, A. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00601 · Cited by 153
Self-citation
Direct and indirect effects of age on interoceptive accuracy and awareness across the adult lifespan
Murphy, J., Geary, H., Millgate, E., Catmur, C., & Bird, G. (2018) · Psychonomic Bulletin & Review · doi:10.3758/s13423-017-1339-z · Cited by 137
The Insula: A Brain Stimulation Target for the Treatment of Addiction
Ibrahim, C., Rubin-Kahana, D. S., Pushparaj, A., Musiol, M., Blumberger, D. M., Daskalakis, Z. J., Zangen, A., & Le Foll, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00720 · Cited by 133
Roles of the different sub-regions of the insular cortex in various phases of the decision-making process
Droutman, V., Bechara, A., & Read, S. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00309 · Cited by 131
Self-citation
Down-Regulation of Amygdala and Insula Functional Circuits by Varenicline and Nicotine in Abstinent Cigarette Smokers
Sutherland, M. T., Carroll, A. J., Salmeron, B. J., Ross, T. J., Hong, L. E., & Stein, E. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.035 · Cited by 134
Sensitization and Interoception as Key Neurological Concepts in Osteopathy and Other Manual Medicines
D’Alessandro, G., Cerritelli, F., & Cortelli, P. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00100 · Cited by 131
Facets of impulsivity and alcohol use: What role do emotions play?
Herman, A. M., & Duka, T. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.011 · Cited by 141
Responses to Novelty and Vulnerability to Cocaine Addiction: Contribution of a Multi-Symptomatic Animal ModelPreprint
Belin, D., & Deroche‐Gamonet, V. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011940 · Cited by 130
Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance
Hirvonen, J., Virtanen, K. A., Nummenmaa, L., Hannukainen, J. C., Honka, M., Bucci, M., Nesterov, S. V., Parkkola, R. K., Rinne, J. O., Iozzo, P., et al. (2011) · Diabetes · doi:10.2337/db10-0940 · Cited by 128
Resting-State Synchrony During Early Alcohol Abstinence Can Predict Subsequent Relapse
Camchong, J., Stenger, A., & Fein, G. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs190 · Cited by 131
Methodological recommendations for a heartbeat detection-based measure of interoceptive sensitivity
Kleckner, I. R., Wormwood, J. B., Simmons, W. K., Barrett, L. F., & Quigley, K. S. (2015) · Psychophysiology · doi:10.1111/psyp.12503 · Cited by 124
Efficacy of invasive and non-invasive brain modulation interventions for addiction
Luigjes, J., Segrave, R., de Joode, N., Figee, M., & Denys, D. (2019) · Neuropsychology Review · doi:10.1007/s11065-018-9393-5 · Cited by 125
Neurobiological Mechanisms of Nicotine Reward and Aversion
Wills, L. P., Ables, J. L., Braunscheidel, K. M., Caligiuri, S. P. B., Elayouby, K. S., Fillinger, C., Ishikawa, M., Moen, J. K., & Kenny, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000299 · Cited by 134
The insular cortex: a comparative perspective
Butti, C., & Hof, P. R. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0264-y · Cited by 125
A Tripartite Neurocognitive Model of Internet Gaming Disorder
Lei, W. I., Zhang, S., Turel, O., Bechara, A., & He, Q. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00285 · Cited by 127
Self-citation
Better living through understanding the insula: Why subregions can make all the difference
Centanni, S. W., Janes, A. C., Haggerty, D. L., Atwood, B. K., & Hopf, F. W. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108765 · Cited by 116
Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations
Sutherland, M. T., Riedel, M. C., Flannery, J. S., Yanes, J. A., Fox, P. T., Stein, E. A., & Laird, A. R. (2016) · Behavioral and Brain Functions · doi:10.1186/s12993-016-0100-5 · Cited by 114
The Developing Brain in the Digital Era: A Scoping Review of Structural and Functional Correlates of Screen Time in Adolescence
Marciano, L., Camerini, A.-L., & Morese, R. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.671817 · Cited by 139
Age-related changes in insula cortical thickness and impulsivity: Significance for emotional development and decision-making
Churchwell, J. C., & Yurgelun-Todd, D. A. (2013) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2013.07.001 · Cited by 109
Overlapping patterns of brain activation to food and cocaine cues in cocaine abusers
Tomasi, D. G., Wang, G., Wang, R., Caparelli, E. C., Logan, J., & Volkow, N. D. (2014) · Human Brain Mapping · doi:10.1002/hbm.22617 · Cited by 115
Striatal-insula circuits in cocaine addiction: implications for impulsivity and relapse risk
McHugh, M. J., Demers, C. H., Braud, J., Briggs, R. W., Adinoff, B. H., & Stein, E. A. (2013) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2013.847446 · Cited by 111
Lower regional grey matter in alcohol use disorders: evidence from a voxel-based meta-analysis
Li, L., Yu, H., Liu, Y., Meng, Y., Li, X., Zhang, C., Liang, S., Li, M., Guo, W., Wang, Q., et al. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03244-9 · Cited by 110
Etiological theories of addiction: A comprehensive update on neurobiological, genetic and behavioural vulnerability
Ouzir, M., & Errami, M. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.06.005 · Cited by 122
Meta-analyses of the functional neural alterations in subjects with Internet gaming disorder: Similarities and differences across different paradigms.
Zheng, H., Hu, Y.-B., Wang, Z.-L., Wang, M., Du, X.-X., & Dong, G. (2019) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109656 · Cited by 100
Individual differences in sensitivity to reward and punishment and neural activity during reward and avoidance learning
Kim, S. H., Yoon, H., Kim, H., & Hamann, S. B. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv007 · Cited by 119
Increased functional coupling between the left fronto‐parietal network and anterior insula predicts steeper delay discounting in smokers
Clewett, D., LUO, S. H., Hsu, E., Ainslie, G. W., Mather, M., & Monterosso, J. R. (2014) · Human Brain Mapping · doi:10.1002/hbm.22436 · Cited by 106
Changes of Functional and Effective Connectivity in Smoking Replenishment on Deprived Heavy Smokers: A Resting-State fMRI Study
Ding, X., & Lee, S.-W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059331 · Cited by 103
Gray matter abnormalities in opioid-dependent patients: A neuroimaging meta-analysis
Wollman, S. C., Alhassoon, O. M., Hall, M. G., Stern, M. J., Connors, E. J., Kimmel, C. L., Allen, K. E., Stephan, R. A., & Raduà, J. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1245312 · Cited by 101
Immediate Effects of Interoceptive Awareness Training through Mindful Awareness in Body-Oriented Therapy (Mabt) for Women in Substance Use Disorder Treatment
Price, C. J., Thompson, E. A., Crowell, S. E., Pike, K., Cheng, S. C., Parent, S., & Hooven, C. (2019) · Substance Abuse · doi:10.1080/08897077.2018.1488335 · Cited by 94
Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors
Martinelli, D. C., Chew, K. S., Rohlmann, A., Lum, M. Y., Ressl, S., Hattar, S. S., Brünger, A. T., Missler, M., & Südhof, T. C. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.002 · Cited by 100
Altered functional connectivity of the insular cortex across prefrontal networks in cocaine addiction
Cisler, J. M., Elton, A., Kennedy, A. P., Young, J., Smitherman, S., Andrew James, G., & Kilts, C. D. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2013.02.007 · Cited by 99
“It has recently been proposed that interoception may play a key function in the drug use disorder process that integrates incentive salience with cognitive control and decision making processes (Naqvi and Bechara, 2009, 2010; Naqvi et al., 2007).”
Background
You are the danger: Attenuated insula response in methamphetamine users during aversive interoceptive decision-making
Stewart, J. L., May, A. C., Poppa, T., Davenport, P. W., Tapert, S. F., & Paulus, M. P. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.06.003 · Cited by 86
Functional, Structural, and Emotional Correlates of Impaired Insight in Cocaine Addiction
Moeller, S. J., Konova, A. B., Parvaz, M. A., Tomasi, D. G., Lane, R. D., Fort, C. L., & Goldstein, R. Z. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.2833 · Cited by 93
Interaction of Insular Cortex and Ventral Striatum Mediates the Effect of Incentive Memory on Choice Between Goal-Directed Actions
Parkes, S. L., Bradfield, L. A., & Balleine, B. W. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4153-14.2015 · Cited by 94
Measuring interoception: The phase adjustment task
Plans, D., Ponzo, S., Morelli, D., Cairó, M. R., Ring, C., Keating, C. T., Cunningham, A. C., Catmur, C., Murphy, J., & Bird, G. (2021) · Biological Psychology · doi:10.1016/j.biopsycho.2021.108171 · Cited by 97
Mindful awareness in body-oriented therapy as an adjunct to women’s substance use disorder treatment: a pilot feasibility study
Price, C. J., Wells, E. A., Donovan, D. M., & Rue, T. (2012) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2011.09.016 · Cited by 90
A multidimensional and multi-feature framework for cardiac interoception
Fittipaldi, S., Abrevaya, S., Fuente, A. D. L., Pascariello, G. O., Hesse, E., Birba, A., Salamone, P., Hildebrandt, M., Martí, S. A., Pautassi, R. M., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116677 · Cited by 90
Gray matter abnormalities in cocaine versus methamphetamine-dependent patients: a neuroimaging meta-analysis
Hall, M. G., Alhassoon, O. M., Stern, M. J., Wollman, S. C., Kimmel, C. L., Perez-Figueroa, A. M., & Raduà, J. (2015) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2015.1044607 · Cited by 91
Insula’s functional connectivity with ventromedial prefrontal cortex mediates the impact of trait alexithymia on state tobacco craving
Sutherland, M. T., Carroll, A. J., Salmeron, B. J., Ross, T. J., & Stein, E. A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3018-8 · Cited by 89
Brain Stimulation Methods to Treat Tobacco Addiction
Wing, V. C., Barr, M. S., Wass, C., Lipsman, N., Lozano, A. M., Daskalakis, Z. J., & George, T. P. (2012) · Brain stimulation · doi:10.1016/j.brs.2012.06.008 · Cited by 88
Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex reduces resting-state insula activity and modulates functional connectivity of the orbitofrontal cortex in cigarette smokers
Li, X., Du, L., Sahlem, G. L., Badran, B. W., Henderson, S., & George, M. S. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.02.002 · Cited by 90
A Selective Insular Perfusion Deficit Contributes to Compromised Salience Network Connectivity in Recovering Alcoholic Men
Sullivan, E. V., Müller‐Oehring, E. M., Pitel, A., Chanraud, S., Shankaranarayanan, A., Alsop, D. C., Torsten Rohlfing, B., & Pfefferbaum, A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.026 · Cited by 88
Different Decision-Making Responses Occupy Different Brain Networks for Information Processing: A Study Based on EEG and TMS
Si, Y., Wu, X., Li, F., Zhang, L., Duan, K., Li, P., Song, L., Jiang, Y., Zhang, T., Zhang, Y., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy294 · Cited by 89
Altered resting state functional connectivity of anterior insula in young smokers
Bi, Y., Yuan, K., Guan, Y., Cheng, J., Zhang, Y., Li, Y., Yu, D., Qin, W., & Tian, J. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9511-z · Cited by 90
Alexithymia mediates the relationship between interoceptive sensibility and anxiety
Palser, E. R., Palmer, C. E., Galvez-Pol, A., Hannah, R., Fotopoulou, A., & Kilner, J. M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0203212 · Cited by 86
Delay discounting mediates the association between posterior insular cortex volume and social media addiction symptoms
Turel, O., He, Q., Brevers, D., & Bechara, A. (2018) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-018-0597-1 · Cited by 84
Self-citation
Behavioral and neural mechanisms underlying habitual and compulsive drug seeking
Smith, R. J., & Laiks, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.003 · Cited by 93
Salience and default mode network dysregulation in chronic cocaine users predict treatment outcome
Geng, X., Hu, Y., Gu, H., Salmeron, B. J., Adinoff, B. H., Stein, E. A., & Yang, Y. (2017) · Brain · doi:10.1093/brain/awx036 · Cited by 85
A neurobehavioral approach to addiction: implications for the opioid epidemic and the psychology of addiction
Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B., & Stein, J. S. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619860513 · Cited by 82
Self-citation
Cigarette Exposure, Dependence, and Craving Are Related to Insula Thickness in Young Adult Smokers
Morales, A. M., Ghahremani, D. G., Kohno, M., Hellemann, G., & London, E. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.48 · Cited by 81
Modification of EEG functional connectivity and EEG power spectra in overweight and obese patients with food addiction: An eLORETA study
Imperatori, C., Fabbricatore, M., Innamorati, M., Farina, B., Quintiliani, M. I., Lamis, D. A., Mazzucchi, E., Contardi, A., Vollono, C., & Marca, G. D. (2014) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9324-x · Cited by 85
Neural Correlates of Compulsive Alcohol Seeking in Heavy Drinkers
Grodin, E. N., Sussman, L., Sundby, K. K., Brennan, G. M., Diazgranados, N., Heilig, M. A., & Momenan, R. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.06.009 · Cited by 79
The impact of accelerated right prefrontal high-frequency repetitive transcranial magnetic stimulation (rTMS) on Cue-reactivity: an fMRI study on craving in recently detoxified alcohol-dependent patients
Herremans, S. C., Van Schuerbeek, P., De Raedt, R., Matthys, F., Buyl, R., De Mey, J., & Baeken, C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136182 · Cited by 78
Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism
DeVito, E. E., Meda, S. A., Jiantonio‐Kelly, R. E., Potenza, M. N., Krystal, J. H., & Pearlson, G. D. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.92 · Cited by 80
Meta-analysis of structural and functional alterations of brain in patients with attention-deficit/hyperactivity disorder
Yu, M., Gao, X., Niu, X., Zhang, M., Yang, Z., Han, S., Cheng, J., & Zhang, Y. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1070142 · Cited by 93
Reduced grey matter in the posterior insula as a structural vulnerability or diathesis to addiction
Gardini, S., & Venneri, A. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.021 · Cited by 82
Interoceptive ability predicts aversion to losses
Sokol-Hessner, P., Hartley, C. A., Hamilton, J. R., & Phelps, E. A. (2015) · Cognition and Emotion · doi:10.1080/02699931.2014.925426 · Cited by 72

Authors: Naqvi, N. H., & Bechara, A.
Affiliations: New York State Psychiatric Institute (US)
University of Southern California (US)
Corresponding author: Naqvi, Nasir H.
ORCID: Bechara, Antoine
Venue: Brain Structure and Function
Publisher: Springer Science and Business Media LLC
Published: 2010-05-29
Volume: 214
Issue: 5-6
Pages: 435-450
ISSN: 1863-2653 (ISSN-L)
1863-2661
DOI: 10.1007/s00429-010-0268-7
PMC: PMC3698865
OpenAlex: W1976397511
Cited by: 598
References: 112
Citations by year: 2026: 23 · 2025: 28 · 2024: 29 · 2023: 32 · 2022: 30 · 2021: 41 · 2020: 98 · 2019: 46 · 2018: 44 · 2017: 38 · 2016: 38 · 2015: 36 · 2014: 28 · 2013: 46 · 2012: 22
FWCI: 3.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Brain Structure and Function (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R25MH086466)
National Institute on Drug Abuse (R01DA023051)
National Institute of General Medical Sciences (T32GM007337)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords: insula, drug addiction, interoception, decision-making, executive function, memory, embodied ritual, conscious awareness
MeSH terms: Animals, Awareness, Cerebral Cortex, Humans, Impulsive Behavior, Self Concept, Substance-Related Disorders, Pleasure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks