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Anatomical substrates for direct interactions between hippocampus, medial prefrontal cortex, and the thalamic nucleus reuniens
Open accessAbstract
The reuniens nucleus in the midline thalamus projects to the medial prefrontal cortex (mPFC) and the hippocampus, and has been suggested to modulate interactions between these regions, such as spindle-ripple correlations during sleep and theta band coherence during exploratory behavior. Feedback from the hippocampus to the nucleus reuniens has received less attention but has the potential to influence thalamocortical networks as a function of hippocampal activation. We used the retrograde tracer cholera toxin B conjugated to two fluorophores to study thalamic projections to the dorsal and ventral hippocampus and to the prelimbic and infralimbic subregions of mPFC. We also examined the feedback connections from the hippocampus to reuniens. The goal was to evaluate the anatomical basis for direct coordination between reuniens, mPFC, and hippocampus by looking for double-labeled cells in reuniens and hippocampus. In confirmation of previous reports, the nucleus reuniens was the origin of most thalamic afferents to the dorsal hippocampus, whereas both reuniens and the lateral dorsal nucleus projected to ventral hippocampus. Feedback from hippocampus to reuniens originated primarily in the dorsal and ventral subiculum. Thalamic cells with collaterals to mPFC and hippocampus were found in reuniens, across its anteroposterior axis, and represented, on average, about 8 % of the labeled cells in reuniens. Hippocampal cells with collaterals to mPFC and reuniens were less common (~1 % of the labeled subicular cells), and located in the molecular layer of the subiculum. The results indicate that a subset of reuniens cells can directly coordinate activity in mPFC and hippocampus. Cells with collaterals in the hippocampus-reuniens-mPFC network may be important for the systems consolidation of memory traces and for theta synchronization during exploratory behavior.
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“Anatomical interconnections are also found among the NR, perirhinal cortex and LEC”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Varela et al., 2014
In the citing paper
“a subpopulation of single NR and LEC neurons sends axonal collaterals to both mPFC and hippocampus, implicating that the NR and LEC can directly and simultaneously modulate the activities of mPFC and hippocampus”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Varela et al., 2014
In the citing paper
“other neural substrates that project to both mPFC and hippocampus include the amygdala, ventral tegmental area, MSDB, and hypothalamus”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Varela et al., 2014
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Research works printed but not linked: 1
- Jones EG (2007) The thalamus. Cambridge University Press, London
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Mechanisms of systems memory consolidation during sleep
Klinzing, J. G., Niethard, N., & Born, J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0467-3 · Cited by 1,176
Limbic circuitry of the midline thalamus
Vertes, R. P., Linley, S. B., & Hoover, W. B. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.014 · Cited by 400
The hippocampus and related neocortical structures in memory transformation
Sekeres, M. J., Winocur, G., & Moscovitch, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.006 · Cited by 370
Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex
Wikenheiser, A. M., & Schoenbaum, G. M. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.56 · Cited by 368
The Cognitive Thalamus as a Gateway to Mental Representations
Wolff, M., & Vann, S. D. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0479-18.2018 · Cited by 361
Metadata
- Authors
- Varela, C., Kumar, S., Yang, J. Y., & Wilson, M. A.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Varela, C.
- Venue
- Brain Structure and Function
- Published
- 2013-04-10
- Volume
- 219
- Issue
- 3
- Pages
- 911-929
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- PMC
- PMC4179252
- OpenAlex
- W1981683953
- Cited by
- 277
- References
- 69
- Citations by year
- 2026: 21 · 2025: 18 · 2024: 25 · 2023: 16 · 2022: 29 · 2021: 34 · 2020: 27 · 2019: 18 · 2018: 26 · 2017: 23 · 2016: 16 · 2015: 13 · 2014: 7 · 2013: 4
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- PMC
- Funders
- National Institute of Mental Health (R01MH061976)
- National Institute of General Medical Sciences (R01GM104948)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nucleus reuniens, medial prefrontal cortex, hippocampus, thalamocortical connections, dorsal hippocampus, ventral hippocampus, subiculum, prelimbic cortex, infralimbic cortex, retrograde tracing, cholera toxin B, thalamocortical network, memory consolidation, theta synchronization, sleep spindles
- MeSH terms
- Animals, Hippocampus, Male, Memory, Neural Pathways, Neurons, Thalamic Nuclei, Prefrontal Cortex, Rats, Long-Evans
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