Prognostic factors and treatment options in patients with leptomeningeal metastases of different primary tumors: a retrospective analysis.
Open accessAbstract
Purpose Leptomeningeal metastases (LM) are associated with very poor prognosis and data on outcome are limited. We evaluated prognostic factors and treatment options in patients (pts) with LM of different malignancies in a single center experience.Methods Single center data on characteristics, treatment and outcome of 135 consecutive pts (73 solid tumors and 62 hematologic malignancies) with LM between 1989 and 2005 were retrospectively analyzed.Results Treatment consisted of systemic chemotherapy (SC) plus intrathecal chemotherapy (ITC) in 28%, ITC alone in 22%, radiotherapy (RT) plus ITC in 12% and other modalities (SC, RT, SC + RT) in 7%. Thirteen percent of pts received supportive care only (4% not evaluable on treatment). Median survival from diagnosis of LM was 2.5 months. Univariate analysis revealed age >50, interval between diagnosis of primary tumor and LM ≤12 months, lung cancer and malignant melanoma, and Karnofsky performance status ≤70 as significant negative predictors for overall survival. Positive predictive factors were response in cerebrospinal fluid and application of SC. In multivariate analysis, only SC was significantly associated with longer median survival (5.6 vs. 1.7 months).Conclusions In patients with LM an age >50, performance status ≤70%, interval between diagnosis of primary tumor and LM ≤12 months, primary tumor (lung cancer, malignant melanoma) and lack of cytologic response present negative prognostic factors. Systemic chemotherapy is significantly associated with longer survival time than local treatment modalities.
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Primary tumors of the meninges are quite rare, however, the leptomeninges is a relatively common site for contiguous extension of primary tumors of the central nervous system, paranasal sinuses and skull base origin or tumor metastasis which can lead to dissemination into the CNS parenchyma and poor prognosis.
“Primary tumors of the meninges are quite rare, however, the leptomeninges is a relatively common site for by contiguous extension of primary tumors of the central nervous system, paranasal sinuses and skull base origin or tumor metastasis which can lead to dissemination into the CNS parenchyma and poor prognosis”
From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Oechsle et al., 2010
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2 retracted
Chamberlain, M. C. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.01.131 · Cited by 116 · see citing works
Retracted(2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.1018 · Cited by 5 · see citing works
RetractedNonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,232 · see citing works
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158 · see citing works
Gaspar, L. E., Scott, C., Rotman, M., Asbell, S. O., Phillips, T. L., Wasserman, T. H., McKenna, W. G., & Byhardt, R. W. (1997) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(96)00619-0 · Cited by 2,548 · see citing works
Aparicio, A. M., & Chamberlain, M. C. (2002) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-002-0081-7 · Cited by 488 · see citing works
Glantz, M., LaFollette, S., Jaeckle, K. A., Shapiro, W., Swinnen, L. J., Rozental, J. R., Phuphanich, S., Rogers, L. R., Gutheil, J. C., Batchelor, T. T., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.10.3110 · Cited by 402 · see citing works
Grossman, S. A., Finkelstein, D. M., Ruckdeschel, J. C., Trump, D. L., Moynihan, T. J., & Ettinger, D. S. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.3.561 · Cited by 364 · see citing works
Glantz, M., Cole, B. F., Recht, L. D., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.4.1561 · Cited by 323 · see citing works
Boogerd, W. J., van den Bent, M. J., Koehler, P. J., Heimans, J. J., van der Sande, J. J., Aaronson, N. K., Hart, A. A. M., Benraadt, J., & Vecht, C. J. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.08.012 · Cited by 287 · see citing works
Raizer, J. J., Hwu, W., Panageas, K. S., Wilton, A. S., Baldwin, D. E., Bailey, E. M., von Althann, C., Lamb, L. A., Alvarado, G. C., Bilsky, M. H., et al. (2008) · Neuro-Oncology · doi:10.1215/15228517-2007-058 · Cited by 230 · see citing works
Adjustment of children and adolescents to parental cancer: Parents' and children's perspectives
Welch, A. S., Wadsworth, M. E., & Compas, B. E. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960401)77:7 · Cited by 217 · see citing works
Altundağ, K., Bondy, M. L., Mirza, N. Q., Kau, S., Broglio, K. R., Hortobágyi, G. N., & Rivera, E. (2007) · Cancer · doi:10.1002/cncr.23088 · Cited by 187 · see citing works
Leptomeningeal metastasis: survival and prognostic factors in 155 patients
Herrlinger, U., Förschler, H., Küker, W., et al. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.05.008 · Cited by 175 · see citing works
Bokstein, F., Lossos, A., & Siegal, T. (1998) · PubMed · Cited by 153 · see citing works
Breast cancer leptomeningeal metastasis—the role of multimodality treatment
Rudnicka, H., Niwińska, A., & Murawska, M. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-007-9340-4 · Cited by 141 · see citing works
Siegal, T., Lossos, A., & Pfeffer, M. R. (1994) · Neurology · doi:10.1212/wnl.44.8.1463 · Cited by 138 · see citing works
Systemic high-dose intravenous methotrexate for central nervous system metastases
Lassman, A. B., Abrey, L. E., Shah, G. G., Panageas, K. S., Begemann, M., Malkin, M. G., & Raizer, J. J. (2005) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9044-6 · Cited by 124 · see citing works
DeAngelis, L. M., & Boutros, D. (2005) · Cancer Investigation · doi:10.1081/cnv-50458 · Cited by 103 · see citing works
Chamberlain, M. C., & Kormanik, P. A. (1997) · Journal of Neuro-Oncology · doi:10.1023/a:1005803918194 · Cited by 100 · see citing works
Kim, D.-Y. (2003) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyg118 · Cited by 83 · see citing works
Management of leptomeningeal malignancy
Pentheroudakis, G. E., & Pavlidis, N. A. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.7.1115 · Cited by 62 · see citing works
Treatment of CNS dissemination in systemic lymphoma
Gleissner, B., & Chamberlain, M. C. (2007) · Journal of Neuro-Oncology · doi:10.1007/s11060-007-9353-z · Cited by 35 · see citing works
Treatment of central nervous system metastases: parenchymal, epidural, and leptomeningeal
Taillibert, S., & Hildebrand, J. G. (2006) · Current Opinion in Oncology · doi:10.1097/01.cco.0000245323.19411.d7 · Cited by 21 · see citing works
Hot flashes in postmenopausal women treated for breast carcinoma
Carpenter, J. S., Andrykowski, M. A., Cordova, M., Cunningham, L., Studts, J., McGrath, P., Kenady, D., Sloan, D., & Munn, R. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980501)82:9
Flagged first, then by citations
Research works printed but not linked: 4
- Chamberlain MC (2005) Meningitis neoplastica. J Clin Oncol 23:3605–3613 [DOI] [PubMed] [Google Scholar]
- De Angeles LM, Boutros D (2005) Leptomeningeal metastases. Cancer Invest 23:145–154 [PubMed] [Google Scholar]
- Fizazi K, Asselain B, Vincent-Salomon A, Jouve M, Dieras V, Palangie T, Beuzeboc P, Dorval T, Pouillart P (1996) Meningeal carcinomatosis in patients with breast carcinoma. Clinical features, prognostic factors, and results of a high-dose intrathecal methotrexate regimen. Cancer 77:1315–1323 [DOI] [PubMed] [Google Scholar]
- Kaplan EL, Meier P (1958) Non-parametric estimations from incomplete observations. J Am Stat Assoc 53:457–481 [Google Scholar]
Cited by
Sorted by citations
Le Rhun, E., Weller, M., Brandsma, D., Van den Bent, M., de Azambuja, E., Henriksson, R., Boulanger, T., Peters, S., Watts, C., Wick, W., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx221 · Cited by 637 · see citing works
Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis.
Chi, Y., Remsik, J., Kiseliovas, V., Derderian, C., Sener, U., Alghader, M., Saadeh, F., Nikishina, K., Bale, T., Iacobuzio-Donahue, C., et al. (2020) · Science · doi:10.1126/science.aaz2193 · Cited by 320 · see citing works
Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease
Derk, J., Jones, H. E., Como, C., Pawlikowski, B., & Siegenthaler, J. A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.703944 · Cited by 120 · see citing works
- Authors
- Oechsle, K., Lange-Brock, V., Kruell, A., Bokemeyer, C., & de Wit, M.
- Affiliations
- University Cancer Center Hamburg (DE)
- Corresponding author
- Oechsle, Karin
- Venue
- Journal of Cancer Research and Clinical Oncology
- Published
- 2010-03-04
- Volume
- 136
- Issue
- 11
- Pages
- 1729-1735
- ISSN
- 0084-5353 (ISSN-L)
- 0171-5216
- 1432-1335
- PMC
- PMC11828112
- OpenAlex
- W2059140616
- Cited by
- 119
- References
- 25
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 11 · 2020: 11 · 2019: 9 · 2018: 13 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 11 · 2012: 7
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Cancer Research and Clinical Oncology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Brain Metastases and Treatment
- Health Sciences › Medicine › Surgery › Management of metastatic bone disease
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- leptomeningeal metastasis, prognostic factors, systemic chemotherapy, intrathecal chemotherapy, radiotherapy, overall survival, Karnofsky performance status, lung cancer, melanoma, hematologic malignancies, treatment options
- MeSH terms
- Adolescent, Adult, Aged, Combined Modality Therapy, Female, Humans, Lung Neoplasms, Male, Melanoma, Middle Aged, Neoplasm Metastasis, Neoplasms, Prognosis, Retrospective Studies, Proportional Hazards Models, Survival Analysis, Hematologic Neoplasms, Meningeal Carcinomatosis
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