Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate
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PURPOSE: Our previous experiments show that the main constituent of green-tea catechins, (-)-epigallocatechin gallate (EGCG), completely prevents tumor promotion on mouse skin initiated with 7,12-dimethylbenz(a)anthracene followed by okadaic acid and that EGCG and green tea extract prevent cancer development in a wide range of target organs in rodents. Therefore, we focused our attention on human cancer stem cells (CSCs) as targets of cancer prevention and treatment with EGCG. METHODS: The numerous reports concerning anticancer activity of EGCG against human CSCs enriched from cancer cell lines were gathered from a search of PubMed, and we hope our review of the literatures will provide a broad selection for the effects of EGCG on various human CSCs. RESULTS: Based on our theoretical study, we discuss the findings as follows: (1) Compared with the parental cells, human CSCs express increased levels of the stemness markers Nanog, Oct4, Sox2, CD44, CD133, as well as the EMT markers, Twist, Snail, vimentin, and also aldehyde dehydrogenase. They showed decreased levels of E-cadherin and cyclin D1. (2) EGCG inhibits the transcription and translation of genes encoding stemness markers, indicating that EGCG generally inhibits the self-renewal of CSCs. (3) EGCG inhibits the expression of the epithelial-mesenchymal transition phenotypes of human CSCs. (4) The inhibition of EGCG of the stemness of CSCs was weaker compared with parental cells. (5) The weak inhibitory activity of EGCG increased synergistically in combination with anticancer drugs. CONCLUSIONS: Green tea prevents human cancer, and the combination of EGCG and anticancer drugs confers cancer treatment with tissue-agnostic efficacy.
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EGCG inhibits the initiation, promotion, and progression of different types of tumors in vitro and in vivo.
“Numerous studies, both in vitro using various cancer cell lines and in vivo in animal models, have consistently demonstrated the ability of EGCG to inhibit the initiation, promotion, and progression of different types of tumors.141–145”
From Drug repurposing for cancer therapy (2024) · cites this paper as [142]
The Introduction reports that EGCG prevented tumor promotion in an initiated mouse-skin model. The section on EMT phenotypes reports reduced melanoma metastases in mice, and other sections describe inhibitory effects in several cancer cell lines. Our copy does not show that EGCG inhibits tumor initiation, so it does not support all three stages claimed. (LLM, conf=0.84)
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- Authors
- Fujiki, H., Sueoka, E., Rawangkan, A., & Suganuma, M.
- Affiliations
- Saga University (JP)
- Saitama University (JP)
- Corresponding author
- Fujiki, Hirota
- Venue
- Journal of Cancer Research and Clinical Oncology
- Published
- 2017-09-23
- Volume
- 143
- Issue
- 12
- Pages
- 2401-2412
- ISSN
- 0084-5353 (ISSN-L)
- 0171-5216
- 1432-1335
- PMC
- PMC5693978
- OpenAlex
- W2760654622
- Cited by
- 64
- References
- 75
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 13 · 2018: 10 · 2015: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Cancer Research and Clinical Oncology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Smorking Research Foundation
- Urakami Foundation
- Princess Takamatsu Cancer Research Fund
- Takeda Science Foundation
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- epigallocatechin gallate, green tea catechins, cancer stem cells, cancer prevention, stem cell markers, epithelial-mesenchymal transition, aldehyde dehydrogenase, self-renewal, Nanog, Oct4, CD133, CD44, Twist, snails
- MeSH terms
- Animals, Catechin, Humans, Neoplasms, Biomarkers, Tumor, Neoplastic Stem Cells
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