The positive effect of spermidine in older adults suffering from dementia: First results of a 3-month trial
Abstract
Summary: The worldwide prevalence of dementia is estimated at 35.6 million and will rise to 115 million by 2050. There is therefore an urgent need for well-founded dementia diagnostics and well-researched therapeutic options. Previous studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. They also confirmed that nutritional intervention with the natural polyamine spermidine can prevent memory loss in aging model organisms. This multicentric double-blind preliminary study focused on the effect of oral spermidine supplementation on older adults’ cognitive performance. Memory tests were carried out on 85 subjects aged between 60 and 96 years in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration and measurement of metabolic parameters. The results demonstrated a clear correlation between the intake of spermidine and the improvement in cognitive performance in subjects with mild and moderate dementia in the group treated with the higher spermidine dosage. The most substantial improvement in test performance was found in the group of subjects with mild dementia with an increase of 2.23 points (p = 0.026) in the mini mental state examination (MMSE) and 1.99 (p = 0.47) in phonematic fluidity. By comparison, the group which had a lower spermidine intake showed consistent or declining cognitive performance.
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Dietary supplementation with the polyamine spermidine prolongs life span and health span in several animal models, and spermidine has also been shown to enhance memory performance and counteract age-related cognitive decline.
“Similarly, dietary supplementation with the polyamine spermidine prolongs life span and health span in several animal models66, and spermidine has also been shown to enhance memory performance and counteract age-related cognitive decline79–81.”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [81]
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Single-cell multiregion dissection of Alzheimer’s disease
Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07606-7 · Cited by 343 · see citing works
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
Connell, E., Le Gall, G., Pontifex, M. G., Sami, S., Cryan, J. F., Clarke, G., Müller, M., & Vauzour, D. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00548-6 · Cited by 208 · see citing works
Caloric Restriction Mimetics in Nutrition and Clinical Trials
Hofer, S. J., Davinelli, S., Bergmann, M., Scapagnini, G., & Madeo, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.717343 · Cited by 109 · see citing works
- Authors
- Pekar, T., Bruckner, K., Pauschenwein-Frantsich, S., Gschaider, A., Oppliger, M., Willesberger, J., Ungersbäck, P., Wendzel, A., Kremer, A., Flak, W., Wantke, F., & Jarisch, R.
- ORCID
- Pekar, Thomas
- Venue
- Wiener klinische Wochenschrift
- Published
- 2020-11-19
- Volume
- 133
- Issue
- 9-10
- Pages
- 484-491
- ISSN
- 0043-5325
- 1613-7671
- PMC
- PMC8116233
- Cited by
- 54
- References
- 3
- Language
- en
- Funders
- University of Applied Sciences Wiener Neustadt
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