Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

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Metabolites: a converging node of host and microbe to explain meta-organism

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The Probiotic Lactobacillus reuteri Preferentially Synthesizes Kynurenic Acid from Kynurenine

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Dietary emulsifier polysorbate 80 exposure accelerates age-related cognitive decline

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Systematic Insights into the Relationship between the Microbiota–Gut–Brain Axis and Stroke with the Focus on Tryptophan Metabolism

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More than just a number: the gut microbiota and brain function across the extremes of life

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Microbial Metabolomes in Alzheimer’s Disease: From Pathogenesis to Therapeutic Potential

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Integrated analysis of gut metabolome, microbiome, and brain function reveal the role of gut-brain axis in longevity

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Decoding TMAO in the Gut-Organ Axis: From Biomarkers and Cell Death Mechanisms to Therapeutic Horizons

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Multiple pathways promote microtubule stabilization in senescent intestinal epithelial cells

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Exploratory Transcriptomic Profiling Reveals the Role of Gut Microbiota in Vascular Dementia

Kaur, N., LaForce, G. R., Mallela, D. P., Saha, P. P., Buffa, J. A., Li, X. S., Sangwan, N., Rothenberg, K. G., & Zhu, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098091 · Cited by 16 · see citing works

The role of brain–liver–gut Axis in neurological disorders

Li, P., Xie, L., Yang, W., Feng, S., Mao, W., Ye, L., Cheng, H., Wu, X., & Mao, X. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf011 · Cited by 16 · see citing works

The role of the intestinal microbiome in cognitive decline in patients with kidney disease

Wagner, C. A., Frey-Wagner, I. M., Ortíz, A., Unwin, R. J., Liabeuf, S., Suzumoto, Y., Iervolino, A., Stasi, A., Marzo, V. D., Gesualdo, L., et al. (2025) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae253 · Cited by 16 · see citing works

NMN reverses D-galactose-induced neurodegeneration and enhances the intestinal barrier of mice by activating the Sirt1 pathway

Lin, Y., Wang, Y., Yang, X., Ding, Z., Hu, M., Huang, X., Zhang, Q., & Yu, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1545585 · Cited by 15 · see citing works

Immune, blood-brain barrier, and metabolic biomarkers mediate gut-brain axis crosstalk in alzheimer’s disease

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Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

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Adolescent kratom exposure affects cognitive behaviours and brain metabolite profiles in Sprague-Dawley rats

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Digestive System Diseases, Genetic Risk, and Incident Dementia: A Prospective Cohort Study

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Gut Microbiome rewiring via fecal transplants: Uncovering therapeutic avenues in Alzheimer’s disease models

Upadhyay, P., Kumar, S., Tyagi, A., Tyagi, A. R., Barbhuyan, T. K., & Gupta, S. (2025) · BMC Neuroscience · doi:10.1186/s12868-025-00953-9 · Cited by 14 · see citing works

Gut Microbiota: An Ally in the Mechanisms and Interventions of Healthy Aging

Chatterjee, S. S., Hebbani, A. V., & Syed, K. (2025) · Gastrointestinal Disorders · doi:10.3390/gidisord7040068 · Cited by 15 · see citing works

An Investigation into the Relationship of Circulating Gut Microbiome Molecules and Inflammatory Markers with the Risk of Incident Dementia in Later Life

Oluwagbemigun, K., Anesi, A., Vrhovšek, U., Mattivi, F., Adami, P. V. M., Pentzek, M., Scherer, M., Riedel-Heller, S. G., Weyerer, S. B., Bickel, H., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03513-6 · Cited by 16 · see citing works

Refined diet consumption increases neuroinflammatory signalling through bile acid dysmetabolism

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Can Small Molecules Provide Clues on Disease Progression in Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer’s Disease Patients?

Andújar, B. T., Mary, A., Venegas, C., Cheng, T., Zaslavsky, L. Y., Bolton, E., Heneka, M. T., & Schymanski, E. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c10490 · Cited by 14 · see citing works

The gut microbiome and the brain

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The Link between Metabolic Syndrome and the Brain

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Gut microbiota-derived trimethylamine N-oxide involved in methamphetamine-induced depression-like behaviors of male mice

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Exploring the acute and chronic effects of a multistrain probiotic supplement on cognitive function and mood in healthy older adults: a randomized controlled trial

Eastwood, J., van Hemert, S., Stolaki, M., Williams, C. M., Walton, G., & Lamport, D. J. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.04.002 · Cited by 15 · see citing works

Microbiota-Derived Extracellular Vesicles as Potential Mediators of Gut–Brain Communication in Traumatic Brain Injury: Mechanisms, Biomarkers, and Therapeutic Implications

Tarek, B., Hasan, A., Toufig, H., Panaro, M. A., Filannino, F. M., & Porro, C. (2025) · Biomolecules · doi:10.3390/biom15101398 · Cited by 13 · see citing works

The role of gut microbiota on cognitive development in rodents: a meta-analysis

Putri, S. S. F., Irfannuddin, I., Murti, K., Kesuma, Y., Darmawan, H., & Koibuchi, N. (2023) · The Journal of Physiological Sciences · doi:10.1186/s12576-023-00869-1 · Cited by 13 · see citing works

(No Title) - English

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Gut microbiome‐derived metabolites in Alzheimer's disease: Regulation of immunity and potential for therapeutics

Chandra, S., & Vassar, R. J. (2024) · Immunological Reviews · doi:10.1111/imr.13412 · Cited by 14 · see citing works

Molecular mechanisms and therapeutic potential of tryptophan metabolism in gut-brain signaling transduction: a narrative review

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Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome

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Co-Housing and Fecal Microbiota Transplantation: Technical Support for TCM Herbal Treatment of Extra-Intestinal Diseases Based on Gut Microbial Ecosystem Remodeling

Sun, X., Zhou, X., He, W., Sun, W., & Xu, Z. M. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s443462 · Cited by 12 · see citing works

What We Know About the Actual Role of Traditional Probiotics in Health and Disease

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Prebiotic roles and anti-aging effects of xylo-oligosaccharide: Keystone responsive bacteria and their metabolic interactions

Feng, Y., Xiao, Y., Li, X., Guo, M., Huang, L., Lu, W., Zhao, J., & Chen, W. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116673 · Cited by 12 · see citing works

APOE4 genotype shapes the role of dietary fibers in cognitive health through gut microbiota changes

Liaquat, M., Gall, G. L., Scholey, A. B., Pontifex, M. G., Bastiaanssen, T. F. S., Müller, M. M., Minihane, A. M., & Vauzour, D. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2526133 · Cited by 12 · see citing works

6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier

Zhu, H., Yang, D., Du, P., Qian, H., & Yang, Z. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157381 · Cited by 11 · see citing works

Microbiota and their metabolites potentiate cancer immunotherapy: Therapeutic target or resource for small molecule drug discovery?

Du, P., Jing, J., & He, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1091124 · Cited by 11 · see citing works

The Intricate Interplay: Microbial Metabolites and the Gut‐Liver‐Brain Axis in Parkinson's Disease

Kishanchand, D. K., A., A. K. K., Chandrababu, K., Philips, C. A., Sivan, U., & Chakrapani, P. S. B. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70016 · Cited by 11 · see citing works

Research progress on the association between trimethylamine/trimethylamine-N-oxide and neurological disorders

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The interplay between bile acids and mucosal adaptive immunity

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Integrated Multi-Omics Analysis of Cerebrospinal Fluid in Postoperative Delirium

Tripp, B. A., Dillon, S. T., Yuan, M., Asara, J. M., Vasunilashorn, S. M., Fong, T. G., Inouye, S. K., Ngo, L. H., Marcantonio, E. R., Xie, Z., et al. (2024) · Biomolecules · doi:10.3390/biom14080924 · Cited by 10 · see citing works

Alzheimer's Disease Has Its Origins in Early Life via a Perturbed Microbiome

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Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?

Rosell-Cardona, C., Cryan, J., Clarke, G., & Kittel-Schneider, S. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00749-z · Cited by 10 · see citing works

Gut–brain communication mediates the impact of dietary lipids on cognitive capacity

Fan, C., Xu, J., Tong, H., Fang, Y., Chen, Y., Lin, Y., Chen, R., Chen, F., & Wu, G. (2024) · Food & Function · doi:10.1039/d3fo05288e · Cited by 10 · see citing works

Effects of gut microbiota-derived short-chain fatty acids on cognitive impairment: An in-silico study

Nguyen, H. D., Vu, G. H., & Kim, W. (2024) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2024.100047 · Cited by 9 · see citing works

A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice

Connell, E., Gall, G. L., McArthur, S., Láng, L., Breeze, B., Liaquat, M., Pontifex, M. G., Sami, S. A. K., Pourtau, L., Gaudout, D., et al. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2614030 · Cited by 12 · see citing works

Investigation of microbial-derived metabolites as risk factors and key mediators of the microbiota-gut-brain axis in early cognitive decline and dementia.

Connell, E. (2025) · UEA Digital Repository (University of East Anglia)

Exploration of the gut‐brain axis through metabolomics identifies serum propionic acid associated with higher cognitive decline in older persons

Neuffer, J., González‐Domínguez, R., Lefèvre‐Arbogast, S., Low, D. Y., Driollet, B., Helmer, C., Preez, A. D., de Lucia, C., Ruigrok, S. R., Altendorfer, B., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.060309

Microbiota‐microglia connections in age‐related cognition decline

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Severe Cognitive Decline in Long-term Care Is Related to Gut Microbiome Production of Metabolites Involved in Neurotransmission, Immunomodulation, and Autophagy

Shoubridge, A. P., Carpenter, L., Flynn, E. F., Papanicolas, L. E., Collins, J., Gordon, D., Lynn, D. J., Whitehead, C., Leong, L. E. X., Cations, M., et al. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf053 · Cited by 10 · see citing works

The Potential Role of Microbiota in Age-Related Cognitive Decline: A Narrative Review of the Underlying Molecular Mechanisms

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