Clinical research participation among adolescent and young adults at an NCI-designated Comprehensive Cancer Center and affiliated pediatric hospital
Open accessAbstract
Purpose Minimal clinical trial participation among adolescents and young adults (AYAs) with cancer limits scientific progress and ultimately their clinical care and outcomes. These analyses examine the current state of AYA clinical research participation at a Midwestern comprehensive cancer center and affiliated pediatric hospital to advise program development and increase availability of trials and AYA participation. Enrollment is examined across all diagnoses, the entire AYA age spectrum (15-39), and both cancer therapeutic and supportive care protocols.Methods his study was a retrospective review of electronic medical records via existing databases and registries for all AYAs. Data were collected for AYAs seen by an oncologist at the adult outpatient cancer center or at the pediatric hospital between the years 2010 and 2014. Descriptive statistics and logistic regression analyses were conducted to characterize this sample.Results In the pediatric setting, 42.3% of AYAs were enrolled in a study compared to 11.2% in the adult setting. Regression analyses in the pediatric setting revealed that AYAs with private insurance or Caucasian race were more likely to participate. Within the adult setting, ethnicity, race, insurance, and diagnosis were associated with study participation; 54.8% of study enrollments were for cancer therapeutic and 43.4% for supportive care studies.Conclusions These results are comparable to previously published data and support the need for new local and national AYA initiatives to increase the availability of and enrollment in therapeutic clinical trials. The same is true for supportive care studies which play a crucial role in improving quality of life.
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The enrollment rate might be explained by the large academic pediatric AYA oncology center, where research participation is frequent.
“Our enrollment may be attributable to our large, academic, pediatric-based AYA oncology center, where participation in clinical research is common.40”
From Promoting resilience in adolescents and young adults with cancer: Results from the PRISM randomized controlled trial (2018) · cites this paper as [40]
Research participation is frequent at large academic pediatric AYA oncology centers.
“where participation in clinical research is common.40”
From Promoting resilience in adolescents and young adults with cancer: Results from the PRISM randomized controlled trial (2018) · cites this paper as [40]
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Cited by
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- Authors
- Sanford, S. D., Beaumont, J. L., Snyder, M. A., Reichek, J., & Salsman, J. M.
- Affiliations
- Northwestern University (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Sanford, Stacy D.
- Venue
- Supportive Care in Cancer
- Published
- 2017-01-10
- Volume
- 25
- Issue
- 5
- Pages
- 1579-1586
- ISSN
- 0941-4355 (ISSN-L)
- 1433-7339
- PMC
- PMC5558782
- OpenAlex
- W2568897144
- Cited by
- 41
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 2 · 2022: 4 · 2021: 11 · 2020: 3 · 2019: 8 · 2018: 8
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Supportive Care in Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (K07CA158008)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health and Medical Research Impacts
- Keywords
- adolescents and young adults, cancer clinical trials, clinical trial recruitment, barriers to research participation, insurance status, racial and ethnic disparities, pediatric oncology, comprehensive cancer center, quality of life
- MeSH terms
- Adolescent, Adult, Cancer Care Facilities, Female, Hospitals, Pediatric, Humans, Male, Neoplasms, Quality of Life, Registries, Retrospective Studies, United States, Databases, Factual, Biomedical Research, National Cancer Institute (U.S.), Young Adult
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