Improving Enrollment in Clinical Trials for Adolescents With Cancer
Abstract
Overall cancer cure rates have risen over the last 30 years. Adolescent and young adult (AYA) oncology patients aged 15 to 39 have not shared in these successes as an age group, including those who fall into the younger age group of 15 to 19 years. The reasons for this deficit in survival improvement are manifold, but research has shown that an important factor is decreased enrollment in therapeutic clinical trials in this population versus younger patients. The paucity of adolescents treated in clinical trials is itself the result of several elements of the health care landscape in the United States. On the local level, these factors include referral patterns and facilities available; on the national level, related factors include the number of clinical trials available for this age group and health care provider education in the care of these patients. We examine the data available that have contributed to this deficit in the United States and offer broad strategies to address these shortcomings with the goal of improving outcomes in this underserved population.
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Fewer than 50% of American adolescents and young adults with cancer enroll in clinical trials.
“Fewer than 50% of American AYAs with cancer enroll in clinical trials.35”
From Promoting resilience in adolescents and young adults with cancer: Results from the PRISM randomized controlled trial (2018) · cites this paper as [35]
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- Authors
- Shaw, P. H., Hayes-Lattin, B., Johnson, R., & Bleyer, A.
- Affiliations
- Children's Hospital of Pittsburgh (US)
- Oregon Health & Science University, Portland, Oregon; and
- Seattle Children's Hospital (US)
- Oregon Health & Science University (US)
- Corresponding author
- Shaw, Peter H.
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2014-06-01
- Volume
- 133
- Issue
- Supplement_3
- Pages
- S109-S113
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2151859491
- Cited by
- 35
- References
- 19
- Citations by year
- 2026: 1 · 2024: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 4
- FWCI
- 4.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Keywords
- adolescent and young adult cancer, clinical trial recruitment, barriers to clinical trial participation, referral patterns, health care provider education, underserved populations, cancer survival disparities, pediatric oncology
- MeSH terms
- Adolescent, Clinical Trials as Topic, Humans, Neoplasms, Patient Selection
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