Cited by 130Liver Diseases and ImmunityDrug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and Treatments

Bezafibrate treatment: a new medical approach for PBC patients?

Kanda, Tatsuo, Yokosuka, Osamu, Imazeki, Fumio, Saisho, Hiromitsu·2003·Journal of Gastroenterology

Abstract

Background A new medical approach to primary biliary cirrhosis (PBC) has been desired. We investigated the feasibility of using combination ursodeoxycholic acid (UDCA)-bezafibrate therapy in patients with PBC nonresponsive to UDCA monotherapy. Methods During a 6-month period, 22 PBC patients with elevated serum alkaline phosphatase (ALP) despite UDCA monotherapy received either UDCA at 600 mg/day (control group) or UDCA at 600 mg/day plus bezafibrate at 400 mg/day (bezafibrate group). Each patient underwent detailed clinical and biochemical evaluation. Results During treatment, changes in ALP level were greater in the bezafibrate group than in the control group (P< 0.01). During and at the end of treatment, serum ALP levels were significantly lower than those before treatment in patients receiving UDCA plus bezafibrate (P< 0.05). At the end of the 6 months, normalization of serum ALP was observed in 5 of 11 (45.4%) patients given bezafibrate and in 2 of 11 (18.1%) patients not given bezafibrate (P< 0.16). Bile acid proportions during the combination therapy did not change. Pruritus disappeared in 1 of 7 bezafibrate-group patients with this symptom. Conclusions UDCA at 600 mg/day plus bezafibrate at 400 mg/day may be considered as a new therapeutic option for patients with PBC.

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Crossref · 10.1007/s00535-002-1102-7

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  • Studies from the 1990s evaluated the use of bezafibrate (400 mg/day) as an adjunctive therapy to UDCA, in which normalisation of serum ALP was reported in ~45% of UDCA non-responders versus ~18% taking placebo.

    “Studies from the 1990s evaluated the use of bezafibrate (400 mg/day) as an adjunctive therapy to UDCA, in which normalisation of serum ALP was reported in ~45% of UDCA non-responders versus ~18% taking placebo.163”

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Authors
Kanda, T., Yokosuka, O., Imazeki, F., & Saisho, H.
Affiliations
Chiba University (JP)
Venue
Journal of Gastroenterology
Published
2003-06
Volume
38
Issue
6
Pages
573-578
ISSN
  • 0944-1174 (ISSN-L)
  • 1435-5922
OpenAlex
W1532206343
Cited by
129
References
41
Citations by year
2026: 4 · 2025: 7 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 8 · 2020: 3 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 12 · 2014: 11 · 2013: 6 · 2012: 5
FWCI
3.49
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
Keywords
primary biliary cirrhosis, bezafibrate, ursodeoxycholic acid, combination therapy, serum alkaline phosphatase, pruritus, bile acid composition
MeSH terms
Alkaline Phosphatase, Hypolipidemic Agents, Bezafibrate, Bile Acids and Salts, Cholagogues and Choleretics, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Liver Cirrhosis, Biliary, Male, Middle Aged, Time Factors, Ursodeoxycholic Acid

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