The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus
Open accessAbstract
BackgroundGastrointestinal motility is impaired in patients with diabetes mellitus (DM). Interstitial cells of Cajal (ICC) in the gastrointestinal tract play a central role in gastrointestinal motility. The present study examined whether ICC density, or expression of neuronal nitric oxide synthase (nNOS)- and substance P (SP)-containing nerves in the gastric antrum, were altered in patients with type 2 DM.MethodsParaffin-embedded gastric specimens from 51 controls and 36 male DM patients with gastric cancer were used for immunohistochemistry. Serial sections were stained with Kit and mast cell tryptase-specific antibodies. Fresh-frozen gastric specimens from patients with gastric cancer were used for immunofluorescence. The specimens were stained with antibodies to Kit, nNOS, and SP, and levels of expression of these three markers were compared between controls and DM patients.ResultsICC density in the inner circular muscle layer, but not in the myenteric plexus, was lower in patients with severe DM than in controls in paraffin-embedded specimens. In addition, decreased expression of nNOS and SP accompanied by reduced ICC density was observed in frozen specimens from patients with DM.ConclusionsThese results suggest that lower gastric ICC, nNOS, and SP densities in patients with DM may be associated with the pathogenesis of diabetic gastroparesis.
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Bytzer, P., Talley, N. J., Leemon, M., Young, L. J., Jones, M. P., & Horowitz, M. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.16.1989 · Cited by 632
INTERSTITIAL CELLS OF CAJAL AS PACEMAKERS IN THE GASTROINTESTINAL TRACT
Sanders, K. M., Koh, S. D., & Ward, S. M. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040504.094718 · Cited by 619
Gender differences in irritable bowel syndrome
Chang, L., & Heitkemper, M. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.36603 · Cited by 351
Watkins, C. C., Sawa, A., Jaffrey, S., Blackshaw, S., Barrow, R. K., Snyder, S. H., & Ferris, C. D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8273 · Cited by 268
Cited by
Browning, K. N., & Travagli, R. A. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130055 · Cited by 541
Interstitial Cells: Regulators of Smooth Muscle Function
Sanders, K. M., Ward, S. M., & Koh, S. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00037.2013 · Cited by 498
Interstitial cells of Cajal in health and disease
Farrugia, G. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01109.x · Cited by 383
Gastric emptying and glycaemia in health and diabetes mellitus
Phillips, L. K., Deane, A. M., Jones, K. L., Rayner, C. K., & Horowitz, M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.202 · Cited by 273
Gastroparesis: a turning point in understanding and treatment
Grover, M., Farrugia, G., & Stanghellini, V. (2019) · Gut · doi:10.1136/gutjnl-2019-318712 · Cited by 256
Metadata
- Authors
- Iwasaki, H., Kajimura, M., Osawa, S., Kanaoka, S., Furuta, T., Ikuma, M., & Hishida, A.
- Venue
- Journal of Gastroenterology
- Published
- 2006-12-08
- Volume
- 41
- Issue
- 11
- Pages
- 1076-1087
- ISSN
- 0944-1174 (ISSN-L)
- 1435-5922
- OpenAlex
- W1991218946
- Cited by
- 190
- References
- 4
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Iwasaki, H., Kajimura, M., Osawa, S., Kanaoka, S., Furuta, T., Ikuma, M., & Hishida, A. (2006). A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus. Journal of Gastroenterology. https://doi.org/10.1007/s00535-006-1909-8
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