Cited by 124Hepatocellular Carcinoma Treatment and PrognosisLiver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease, alcoholic liver disease, and chronic liver disease of unknown etiology: report of the nationwide survey

Tokushige, Katsutoshi, Hashimoto, Etsuko, Horie, Yoshinori, Taniai, Makiko, Higuchi, Susumu·2011·Journal of Gastroenterology

Abstract

Purpose To clarify the etiology of hepatocellular carcinoma (HCC) in Japanese patients with non-viral liver disease, we performed a nationwide survey. The influence of obesity, lifestyle-related diseases, and alcohol consumption was focused on.Methods A nationwide survey of 14,530 HCC patients was conducted in 2009. Clinical features were studied for HCC patients with nonalcoholic fatty liver disease (NAFLD-HCC; n = 292), alcoholic liver disease (ALC-HCC; n = 991), and chronic liver disease of unknown etiology (unknown HCC; n = 614). The unknown HCC was divided into two subgroups, a no alcohol intake group and a modest alcohol intake group.Results ALC-HCC accounted for 7.2% of all HCC, followed by unknown HCC (5.1%) and NAFLD-HCC (2.0%). The characteristics of these three groups were clearly different (median age was 72 years for NAFLD-HCC, 68 years for ALC-HCC, and 73 years for unknown HCC, p < 0.01; female gender was 38, 4, and 37%, respectively, p < 0.01). Obesity and lifestyle-related diseases were significantly more frequent in NAFLD-HCC than in ALC-HCC and unknown HCC. The no alcohol intake subgroup of unknown HCC showed female predominance (58%) and was older, without a high prevalence of obesity and lifestyle-related diseases. In contrast, the modest alcohol intake subgroup showed the same trends regarding gender, body mass index, prevalence of lifestyle-related diseases, and liver function as the ALC-HCC group.Conclusions The clinical features of ALC-HCC, NAFLD-HCC, and unknown HCC were clearly different. Modest intake of alcohol might have a more significant role in hepatic carcinogenesis than is presently thought.

Integrity signals

Registry

Crossref · 10.1007/s00535-011-0431-9

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Tokushige, K., Hashimoto, E., Horie, Y., Taniai, M., & Higuchi, S.
Affiliations
  • Tokyo Women's Medical University (JP)
  • Sanno Hospital (JP)
  • National Hospital Organization (JP)
Corresponding author
Hashimoto, Etsuko
Venue
Journal of Gastroenterology
Published
2011-07-13
Volume
46
Issue
10
Pages
1230-1237
ISSN
  • 0944-1174 (ISSN-L)
  • 1435-5922
OpenAlex
W2092313557
Cited by
124
References
31
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 16 · 2019: 7 · 2018: 5 · 2017: 14 · 2016: 12 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 3
FWCI
5.88
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
hepatocellular carcinoma, non-alcoholic fatty liver disease, alcoholic liver disease, HCC etiology, obesity, lifestyle-related diseases, alcohol consumption, hepatocarcinogenesis, Japanese patients, clinical features
MeSH terms
Age Factors, Aged, Aged, 80 and over, Alcohol Drinking, Chronic Disease, Fatty Liver, Female, Health Surveys, Carcinoma, Hepatocellular, Humans, Japan, Life Style, Liver Diseases, Liver Diseases, Alcoholic, Liver Neoplasms, Male, Middle Aged, Obesity, Sex Factors, Prevalence, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review