The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
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UNLABELLED: Nonalcoholic steatohepatitis (NASH) is a well-recognized cause of cirrhosis and has been increasingly associated with the development of hepatocellular carcinoma (HCC). The aims of this study were to (1) estimate the incidence of HCC in patients with NASH-related cirrhosis, (2) compare incidence in NASH-related cirrhosis with hepatitis C virus (HCV)-related cirrhosis, and (3) identify risk factors of HCC in patients with NASH-related cirrhosis compared with HCV-related cirrhosis. Adult patients with cirrhosis secondary to chronic HCV (n = 315) or NASH (n = 195) were evaluated at our hepatobiliary clinic between 2003 and 2007. To assess for HCC development, all patients were monitored using serial abdominal computed tomography and serum alpha-fetoprotein every 6 months. Kaplan-Meier analysis was performed to estimate the cumulative incidence of HCC. Descriptive statistics were computed for all factors. Univariate and multivariate Cox regression analysis were used to assess associations between HCC and factors of interest. The median follow-up was 3.2 years (25th percentile [P25], 75th percentile [P75]: 1.7, 5.7) during which 25/195 (12.8%) of NASH-cirrhotic and 64/315 (20.3 %) of HCV-cirrhotic patients developed HCC (P = 0.03). Yearly cumulative incidence of HCC was found to be 2.6% in patients with NASH-cirrhosis, compared with 4.0% in patients with HCV cirrhosis (P = 0.09). Multivariate regression analysis revealed that older age (P = 0.006) and alcohol consumption (P = 0.002) were independent variables associated with development of HCC in patients with NASH-cirrhosis. Compared with nondrinkers, patients who reported any regular alcohol consumption were at greater risk for HCC development (hazard ratio: 3.6; P25, P75: 1.5, 8.3). CONCLUSION: Patients with NASH cirrhosis have a greatly increased risk of liver cancer. Alcohol consumption, a modifiable risk factor, appears to be the most significant factor associated with risk of HCC development in our study population.
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In a retrospective longitudinal study of 195 individuals with MASH-related cirrhosis, alcohol consumption was an independent predictor of HCC occurrence.
“In a retrospective longitudinal study of 195 individuals with MASH-related cirrhosis, alcohol consumption was an independent predictor of HCC occurrence.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [101]
Any level of alcohol consumption, including social drinking, was associated with an increased risk of HCC development versus abstinence.
“Any level of alcohol consumption, including social drinking, was associated with an increased risk of HCC development vs . abstinence.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [101]
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Cites
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696 · see citing works
Management of Hepatocellular Carcinoma *
Bruix, J., & Sherman, M. (2005) · Hepatology · doi:10.1002/hep.20933 · Cited by 5,913 · see citing works
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
El‐Serag, H. B., & Rudolph, K. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.061 · Cited by 5,401 · see citing works
Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228 · see citing works
Rising Incidence of Hepatocellular Carcinoma in the United States
El‐Serag, H. B., & Mason, A. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903113401001 · Cited by 2,865 · see citing works
Sattar, N., Gaw, A., Scherbakova, O., Ford, I., O’Reilly, D. S. J., Haffner, S. M., Isles, C., Macfarlane, P. W., Packard, C. J., Cobbe, S. M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000080897.52664.94 · Cited by 1,506 · see citing works
Bugianesi, E., Leone, N., Vanni, E., Marchesini, G., Brunello, F., CARUCCI, P., Musso, A., Paolis, P. D., Capussotti, L., Salizzoni, M., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.34168 · Cited by 1,436 · see citing works
Cryptogenic Cirrhosis: Clinical Characterization and Risk Factors for Underlying Disease
Caldwell, S. H., Oelsner, D. H., Iezzoni, J. C., Hespenheide, E. E., Battle, E. H., & Driscoll, C. J. (1999) · Hepatology · doi:10.1002/hep.510290347 · Cited by 1,138 · see citing works
The Continuing Increase in the Incidence of Hepatocellular Carcinoma in the United States: An Update
El‐Serag, H. B., Davila, J. A., Petersen, N. J., & McGlynn, K. A. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-10-200311180-00009 · Cited by 940 · see citing works
Murray, K. F., & Carithers, R. L. (2005) · Hepatology · doi:10.1002/hep.20704 · Cited by 933 · see citing works
El‐Serag, H. B., Hampel, H., & Javadi, F. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2005.12.007 · Cited by 821 · see citing works
Davila, J. A., Morgan, R. O., Shaib, Y. H., McGlynn, K. A., & El‐Serag, H. B. (2005) · Gut · doi:10.1136/gut.2004.052167 · Cited by 703 · see citing works
Donato, F. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.4.323 · Cited by 672 · see citing works
Marrero, J., Fontana, R. J., Su, G. L., Conjeevaram, H. S., Emick, D. M., & Lok, A. S.-F. (2002) · Hepatology · doi:10.1053/jhep.2002.36939 · Cited by 659 · see citing works
A prospective study of obesity and cancer risk (Sweden)
Wolk, A., Gridley, G., Svensson, M., Nyrén, O., McLaughlin, J. K., Fraumeni, J. F., & Adami, H.-O. (2001) · Cancer Causes & Control · doi:10.1023/a:1008995217664 · Cited by 581 · see citing works
Sanyal, A. J., Banas, C. A., Sargeant, C., Luketic, V. A., Sterling, R. K., Stravitz, R. T., Shiffman, M. L., Heuman, D. M., COTTERELL, A. H., Fisher, R. A., et al. (2006) · Hepatology · doi:10.1002/hep.21103 · Cited by 521 · see citing works
Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma
Marrero, J. A., Fontana, R. J., Fu, S., Conjeevaram, H. S., Su, G. L., & Lok, A. S.-F. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.10.005 · Cited by 508 · see citing works
Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis
Ratziu, V., Bonyhay, L., Martino, V. D., Charlotte, F., Cavallaro, L. G., Sayegh-Tainturier, M.-H., Giral, P., Grimaldi, A., Opolon, P., & Poynard, T. (2002) · Hepatology · doi:10.1053/jhep.2002.33324 · Cited by 461 · see citing works
Obesity and cancer risk: a danish record-linkage study
Møller, H., Mellemgaard, A., Lindvig, K., & Olsen, J. H. (1994) · European Journal of Cancer · doi:10.1016/0959-8049(94)90254-2 · Cited by 449 · see citing works
Environmental factors and risk for hepatocellular carcinoma
Yu, M. C., & Yuan, J. (2004) · Gastroenterology · doi:10.1016/j.gastro.2004.09.018 · Cited by 425 · see citing works
Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in Southern Guangxi, China
Yeh, F.-S., Yu, M., Mo, C.-C., et al. (1990) · Health Policy · doi:10.1016/0168-8510(90)90389-u · Cited by 326 · see citing works
Hepatocellular carcinoma in patients with nonalcoholic steatohepatitis
Hashimoto, E., Yatsuji, S., Tobari, M., Taniai, M., Torii, N., Tokushige, K., & Shiratori, K. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-008-2262-x · Cited by 308 · see citing works
Yuan, J., Govindarajan, S., Arakawa, K., & Yu, M. C. (2004) · Cancer · doi:10.1002/cncr.20427 · Cited by 275 · see citing works
Obesity and diabetes as a risk factor for hepatocellular carcinoma
Regimbeau, J. M., Colombat, M., Mognol, P., Durand, F., Abdalla, E. K., Degott, C., Degos, F., Farges, O., & Belghiti, J. (2004) · Liver Transplantation · doi:10.1002/lt.20033 · Cited by 227 · see citing works
The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma
Polesel, J., Zucchetto, A., Montella, M., Maso, L. D., Crispo, A., Vecchia, C. L., Serraino, D., Franceschi, S., & Talamini, R. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn565 · Cited by 210 · see citing works
Kew, M., Yu, M.-C., Kedda, M., et al. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70233-6 · Cited by 157 · see citing works
Rising incidence of hepatocellular carcinoma in the United States
Hashem, B. J., & Andrew, C. D. (1999) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199905000-00020 · Cited by 88 · see citing works
Hepatocellular carcinoma with nonalcoholic steatohepatitis
Mori, S., Yamasaki, T., Sakaida, I., Takami, T., Sakaguchi, E., Kimura, T., Kurokawa, F., Maeyama, S., & Okita, K. (2004) · Journal of Gastroenterology · doi:10.1007/s00535-003-1308-3 · Cited by 66 · see citing works
Elgouhari, H. M., Zein, C. O., Hanouneh, I. A., et al. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0683-2 · Cited by 48 · see citing works
Self-citationHepatocellular Carcinoma Arising from Nonalcoholic Steatohepatitis: Report of Two Cases
Hai, S., Kubo, S., Shuto, T., Tanaka, H., Takemura, S., Yamamoto, T., Kanazawa, A., Ogawa, M., Hirohashi, K., & Wakasa, K. (2006) · Surgery Today · doi:10.1007/s00595-005-3167-4 · Cited by 40 · see citing works
Cigarette smoking and liver cancer among US veterans
Hsing, A. W., McLaughlin, J. K., Hrubec, Z., et al. (1990) · Cancer Causes & Control · doi:10.1007/bf00117473 · Cited by 32 · see citing works
Metwally, M. A., Zein, C. O., & Zein, N. N. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9366-z · Cited by 16 · see citing works
Self-citationHepatocellular carcinoma and NASH
Kudo, M. (2004) · Journal of Gastroenterology · doi:10.1007/s00535-004-1332-y · Cited by 12 · see citing works
Flagged first, then by citations
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Sorted by citations
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.004 · Cited by 4,836 · see citing works
MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
Eslam, M., Sanyal, A. J., George, J., Sanyal, A., Neuschwander-Tetri, B., Tiribelli, C., Kleiner, D. E., Brunt, E., Bugianesi, E., Yki-Järvinen, H., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.312 · Cited by 3,286 · see citing works
Rinella, M. E., Neuschwander-Tetri, B. A., Siddiqui, M. S., Abdelmalek, M. F., Caldwell, S., Barb, D., Kleiner, D. E., & Loomba, R. (2023) · Hepatology · doi:10.1097/hep.0000000000000323 · Cited by 2,667 · see citing works
Global burden of liver disease: 2023 update
Devarbhavi, H., Asrani, S. K., Arab, J. P., Nartey, Y. A., Pose, E., & Kamath, P. S. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.017 · Cited by 2,267 · see citing works
Non-alcoholic fatty liver disease - a global public health perspective
Younossi, Z. M. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.033 · Cited by 2,149 · see citing works
Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
Anstee, Q. M., Targher, G., & Day, C. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.41 · Cited by 1,747 · see citing works
Hernaez, R., Lazo, M., Bonekamp, S., Kamel, I., Brancati, F. L., Guallar, E., & Clark, J. M. (2011) · Hepatology · doi:10.1002/hep.24452 · Cited by 1,585 · see citing works
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392 · see citing works
Treatment of NAFLD with diet, physical activity and exercise
Romero-Gómez, M., Zelber-Sagi, S., & Trenell, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.016 · Cited by 1,347 · see citing works
Seitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabo, G., & Tsukamoto, H. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0014-7 · Cited by 1,271 · see citing works
Morbidity and mortality associated with obesity
Abdelaal, M., le Roux, C. W., & Docherty, N. G. (2017) · Annals of Translational Medicine · doi:10.21037/atm.2017.03.107 · Cited by 1,052 · see citing works
Martin, P., DiMartini, A., Feng, S., Brown, R., & Fallon, M. (2014) · Hepatology · doi:10.1002/hep.26972 · Cited by 1,045 · see citing works
Michelotti, G. A., Machado, M. V., & Diehl, A. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.183 · Cited by 974 · see citing works
Vilar-Gomez, E., Calzadilla-Bertot, L., Wai-Sun Wong, V., Castellanos, M., Aller-de la Fuente, R., Metwally, M., Eslam, M., Gonzalez-Fabian, L., Alvarez-Quiñones Sanz, M., Conde-Martin, A. F., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.04.034 · Cited by 806 · see citing works
Younossi, Z. M., Otgonsuren, M., Henry, L., Venkatesan, C., Mishra, A., Erario, M., & Hunt, S. (2015) · Hepatology · doi:10.1002/hep.28123 · Cited by 802 · see citing works
White, D. L., Kanwal, F., & El–Serag, H. B. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.10.001 · Cited by 766 · see citing works
Mittal, S., El-Serag, H. B., Sada, Y. H., Kanwal, F., Duan, Z., Temple, S., May, S. B., Kramer, J. R., Richardson, P. A., & Davila, J. A. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.07.019 · Cited by 648 · see citing works
Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team
Dyson, J., Jaques, B., Chattopadyhay, D., Lochan, R., Graham, J., Das, D., Aslam, T., Patanwala, I., Gaggar, S., Cole, M., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.08.011 · Cited by 603 · see citing works
Liu, Y.-L., Patman, G. L., Leathart, J. B. S., Piguet, A.-C., Burt, A. D., Dufour, J.-F., Day, C. P., Daly, A. K., Reeves, H. L., & Anstee, Q. M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.02.030 · Cited by 549 · see citing works
The Etiology of Hepatocellular Carcinoma and Consequences for Treatment
Sanyal, A. J., Yoon, S. K., & Lencioni, R. (2010) · The Oncologist · doi:10.1634/theoncologist.2010-s4-14 · Cited by 517 · see citing works
Fibrosis-dependent mechanisms of hepatocarcinogenesis
Zhang, D. Y., & Friedman, S. L. (2012) · Hepatology · doi:10.1002/hep.25670 · Cited by 444 · see citing works
Kwok, R., Tse, Y. ‐., Wong, G. L. ‐., Ha, Y., Lee, A. U., Ngu, M. C., Chan, H. L. ‐., & Wong, V. W. ‐. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12569 · Cited by 405 · see citing works
Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus
Targher, G., Lonardo, A., & Byrne, C. D. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.173 · Cited by 397 · see citing works
MAFLD identifies patients with significant hepatic fibrosis better than NAFLD
Yamamura, S., Eslam, M., Kawaguchi, T., Tsutsumi, T., Nakano, D., Yoshinaga, S., Takahashi, H., Anzai, K., George, J., & Torimura, T. (2020) · Liver International · doi:10.1111/liv.14675 · Cited by 401 · see citing works
Epidemiology and risk-stratification of NAFLD-associated HCC
Ioannou, G. N. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.08.012 · Cited by 361 · see citing works
Fujii, M., Shibazaki, Y., Wakamatsu, K., Honda, Y., Kawauchi, Y., Suzuki, K., Arumugam, S., Watanabe, K., Ichida, T., Asakura, H., et al. (2013) · Medical Molecular Morphology · doi:10.1007/s00795-013-0016-1 · Cited by 355 · see citing works
Liver Stiffness Measurement Using XL Probe in Patients With Nonalcoholic Fatty Liver Disease
Wong, V. W.-S., Vergniol, J., Wong, G. L.-H., Foucher, J., Chan, A. W.-H., Chermak, F., Choi, P. C.-L., Merrouche, W., Chu, S. H.-T., Pesque, S., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.331 · Cited by 345 · see citing works
Qi, J., Kim, J.-W., Zhou, Z., Lim, C.-W., & Kim, B. (2020) · The American Journal of Pathology · doi:10.1016/j.ajpath.2019.09.011 · Cited by 338 · see citing works
Medical therapies for hepatocellular carcinoma: a critical view of the evidence
Villanueva, A., Hernandez-Gea, V., & Llovet, J. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.199 · Cited by 314 · see citing works
Zelber‐Sagi, S., Salomone, F., & Mlynarsky, L. (2017) · Liver International · doi:10.1111/liv.13435 · Cited by 273 · see citing works
Loomba, R., Yang, H.-I., Su, J., Brenner, D., Barrett-Connor, E., Iloeje, U., & Chen, C.-J. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kws252 · Cited by 221 · see citing works
Orci, L. A., Sanduzzi-Zamparelli, M., Caballol, B., Sapena, V., Colucci, N., Torres, F., Bruix, J., Reig, M., & Toso, C. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.05.002 · Cited by 218 · see citing works
Yang, J. D., Ahmed, F., Mara, K. C., Addissie, B. D., Allen, A. M., Gores, G. J., & Roberts, L. R. (2020) · Hepatology · doi:10.1002/hep.30858 · Cited by 209 · see citing works
The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease
Díaz, L. A., Arab, J. P., Louvet, A., Bataller, R., & Arrese, M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00822-y · Cited by 207 · see citing works
Risks of light and moderate alcohol use in fatty liver disease: follow-up of population cohorts
Åberg, F., Puukka, P., Salomaa, V., Männistö, S., Lundqvist, A., Valsta, L., Perola, M., Färkkilä, M., & Jula, A. (2020) · Hepatology · doi:10.1002/hep.30864 · Cited by 176 · see citing works
Lake, A. D., Novak, P., Fisher, C. D., Jackson, J. P., Hardwick, R. N., Billheimer, D. D., Klimecki, W. T., & Cherrington, N. J. (2011) · Drug Metabolism and Disposition · doi:10.1124/dmd.111.040592 · Cited by 167 · see citing works
Mohamad, B., Shah, V., Onyshchenko, M., Elshamy, M., Aucejo, F., Lopez, R., Hanouneh, I. A., Alhaddad, R., & Alkhouri, N. (2016) · Hepatology International · doi:10.1007/s12072-015-9679-0 · Cited by 166 · see citing works
Self-citationSookoian, S., Castaño, G. O., & Pirola, C. J. (2014) · Gut · doi:10.1136/gutjnl-2013-305718 · Cited by 158 · see citing works
Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors
Dongiovanni, P. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i36.12945 · Cited by 145 · see citing works
Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease
Boyle, M., Tiniakos, D., Schattenberg, J. M., Ratziu, V., Bugianessi, E., Petta, S., Oliveira, C. P., Govaere, O., Younes, R., McPherson, S., et al. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.06.004 · Cited by 140 · see citing works
Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review
Ajmera, V. H., Terrault, N. A., & Harrison, S. A. (2017) · Hepatology · doi:10.1002/hep.29055 · Cited by 137 · see citing works
Non-alcoholic Fatty Liver Disease and Alcohol-Related Liver Disease: Two Intertwined Entities
Idalsoaga, F., Kulkarni, A. V., Mousa, O. Y., Arrese, M., & Arab, J. P. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00448 · Cited by 136 · see citing works
Pais, R., Fartoux, L., Goumard, C., Scatton, O., Wendum, D., Rosmorduc, O., & Ratziu, V. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14261 · Cited by 129 · see citing works
Lonardo, A., & Suzuki, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051278 · Cited by 129 · see citing works
Tokushige, K., Hashimoto, E., Horie, Y., Taniai, M., & Higuchi, S. (2011) · Journal of Gastroenterology · doi:10.1007/s00535-011-0431-9 · Cited by 124 · see citing works
Vuppalanchi, R., Jain, A. K., Deppe, R., Yates, K., Comerford, M., Masuoka, H. C., Neuschwander-Tetri, B. A., Loomba, R., Brunt, E. M., Kleiner, D. E., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.05.010 · Cited by 116 · see citing works
Nonalcoholic fatty liver disease – current status and future directions
Demir, M., Lang, S., & Steffen, H. (2015) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12291 · Cited by 105 · see citing works
Cimini, F. A., Barchetta, I., Carotti, S., Bertoccini, L., Baroni, M. G., Vespasiani-Gentilucci, U., Cavallo, M.-G., & Morini, S. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i19.3407 · Cited by 101 · see citing works
The impact of obesity and metabolic syndrome on alcoholic liver disease
Chiang, D. J., & McCullough, A. J. (2014) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.09.006 · Cited by 99 · see citing works
Singal, A. G., Tiro, J. A., Murphy, C. C., Marrero, J. A., McCallister, K., Fullington, H., Mejias, C., Waljee, A. K., Pechero Bishop, W., Santini, N. O., et al. (2019) · Hepatology · doi:10.1002/hep.30129 · Cited by 89 · see citing works
Gut microbiota, fatty liver disease, and hepatocellular carcinoma
Chu, H., Williams, B., & Schnabl, B. (2018) · Liver Research · doi:10.1016/j.livres.2017.11.005 · Cited by 84 · see citing works
Chen, M., Guo, W.-L., Li, Q.-Y., Xu, J.-X., Cao, Y.-J., Liu, B., Yu, X.-D., Rao, P.-F., Ni, L., & Lv, X.-C. (2020) · Food & Function · doi:10.1039/c9fo03003d · Cited by 77 · see citing works
Vilar-Gomez, E., Lou, Z., Kong, N., Vuppalanchi, R., Imperiale, T. F., & Chalasani, N. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.04.017 · Cited by 75 · see citing works
Should patients with NAFLD/NASH Be surveyed for HCC?
Reig, M., Gambato, M., Man, N. K., Roberts, J. P., Victor, D., Orci, L. A., & Toso, C. (2019) · Transplantation · doi:10.1097/tp.0000000000002361 · Cited by 71 · see citing works
Jarvis, H., O'Keefe, H., Craig, D., Stow, D., Hanratty, B., & Anstee, Q. M. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-049767 · Cited by 71 · see citing works
Åberg, F., Färkkilä, M., & Männistö, V. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14271 · Cited by 63 · see citing works
Jouihan, H., Will, S., Guionaud, S., Boland, M. L., Oldham, S., Ravn, P., Celeste, A., & Trevaskis, J. L. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.09.001 · Cited by 59 · see citing works
Treatment Candidacy for Pharmacologic Therapies for NASH
Rowe, I. A., Wong, V. W.-S., & Loomba, R. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.03.005 · Cited by 41 · see citing works
Lucey, M. R. (2019) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.09.013 · Cited by 39 · see citing works
Phisalprapa, P., Supakankunti, S., Charatcharoenwitthaya, P., Apisarnthanarak, P., Charoensak, A., Washirasaksiri, C., Srivanichakorn, W., & Chaiyakunapruk, N. (2017) · Medicine · doi:10.1097/md.0000000000006585 · Cited by 39 · see citing works
Behari, J., Gougol, A., Wang, R., Luu, H. N., Paragomi, P., Yu, Y.-C., Molinari, M., Chopra, K., Malik, S. M., Geller, D., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000183 · Cited by 35 · see citing works
Authors, & Collaborators: (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2388 · Cited by 30 · see citing works
Zhang, J., Fu, S., Liu, D., Wang, Y., & Tan, Y. (2023) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002517 · Cited by 27 · see citing works
Pillai, S., Duvvuru, S., Bhatnagar, P., Foster, W., Farmen, M., Shankar, S., Harris, C., Bastyr, E., Hoogwerf, B., & Haupt, A. (2018) · The Pharmacogenomics Journal · doi:10.1038/tpj.2017.45 · Cited by 19 · see citing works
MUTYH is associated with hepatocarcinogenesis in a non-alcoholic steatohepatitis mouse model
Sakamoto, H., Miyanishi, K., Tanaka, S., Ito, R., Hamaguchi, K., Sakurada, A., Sato, M., Kubo, T., Osuga, T., Murase, K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83138-8 · Cited by 8 · see citing works
- Authors
- Ascha, M. S., Hanouneh, I. A., Lopez, R., Tamimi, T. A.-R., Feldstein, A. F., & Zein, N. N.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Zein, Nizar N.
- ORCID
- Ascha, Mustafa S.
- Venue
- Hepatology
- Published
- 2010-06
- Volume
- 51
- Issue
- 6
- Pages
- 1972-1978
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2029691295
- Cited by
- 1,296
- References
- 33
- Citations by year
- 2026: 24 · 2025: 37 · 2024: 71 · 2023: 90 · 2022: 89 · 2021: 92 · 2020: 98 · 2019: 86 · 2018: 97 · 2017: 95 · 2016: 90 · 2015: 101 · 2014: 112 · 2013: 91 · 2012: 51
- FWCI
- 43.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Hepatology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Keywords
- hepatocellular carcinoma, nonalcoholic steatohepatitis, HCC incidence, HCC risk factors, alcohol consumption, age, liver cancer risk, modifiable risk factors, liver cancer prevention, hepatectomy, liver transplantation
- MeSH terms
- Alcohol Drinking, Fatty Liver, Female, Hepatitis C, Carcinoma, Hepatocellular, Humans, Liver Cirrhosis, Liver Neoplasms, Male, Middle Aged, Retrospective Studies, Risk Factors, United States, Incidence
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