Mangiferin, a natural polyphenol protects the hepatic damage in mice caused by CCl4 intoxication
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Compared with silymarin, intraperitoneal pretreatment of mangiferin (30 mg/kg) has an extensive protective effect in CCl4-induced liver damage in mice via reduction of serum AST, ALT, ALP, bilirubin and TNF-β.
“Compared with silymarin, a standard hepatoprotective drug, the intraperitoneal pretreatment of mangiferin (30 mg/kg) possesses an extensive protective effect via reduction of serum aspartate and alanine aminotransferases, alkaline phosphatase, bilirubin and inflammatory mediator TNF-β (101).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [101]
Mangiferin exhibits potent hepatoprotective effects on CCl4-induced liver damage in mice.
“These results suggest that mangiferin exhibits potent hepatoprotective effects on CCl-4-induced liver damages in mice (101).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [101]
Cites
Guha, S., Ghosal, S., & Chattopadhyay, U. (2009) · Chemotherapy · doi:10.1159/000239478 · Cited by 275 · cited 2× · see citing works
“2000), antitumor (Guha et al. 1996), antiviral (Zheng and Lu 1990), anti-inflammatory, and antibacterial activity (Leiro et al.”
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Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · see citing works
“Mangiferin administration (20 mg/kg for 4 weeks) restores the function of cardiac ejection, reduces the accumulation of TNF-α and cleaved caspase-3, and upregulates Bcl-2 (80).”
InfluentialMorozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V. (2021) · Biomolecules · doi:10.3390/biom11010079 · Cited by 82 · see citing works
- Authors
- Rasool, M., Sabina, E. P., Mahinda, P. S., & Gnanaselvi, B. C.
- Affiliations
- Vellore Institute of Technology University (IN)
- Corresponding author
- Rasool, Mahaboobkhan
- ORCID
- Rasool, Mahaboobkhan
- Venue
- Comparative Clinical Pathology
- Published
- 2011-02-22
- Volume
- 21
- Issue
- 5
- Pages
- 865-872
- ISSN
- 0938-7714 (ISSN-L)
- 1618-5641
- 1618-565X
- OpenAlex
- W2070420195
- Cited by
- 10
- References
- 1
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Comparative Clinical Pathology (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- mangiferin, hepatoprotection, carbon tetrachloride, hepatotoxicity, xanthones, antioxidant enzymes, oxidative stress, malondialdehyde, silymarin, TNF-α, liver enzymes, glutathione, mango
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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