Antitumor, immunomodulatory and anti-HIV effect of mangiferin, a naturally occurring glucosylxanthone
Abstract
Mangiferin, a C-glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside) purified from plant sources was shown to have in vivo growth-inhibitory activity against ascitic fibrosarcoma in Swiss mice. Following in vivo or in vitro treatment, it also enhanced tumor cell cytotoxicity of the splenic cells and peritoneal macrophages of normal and tumor-bearing mice. In vitro treatment of the splenic cells of tumor-bearing mice with mangiferin resulted in augmented killing of tumor cells, both resistant and sensitive to natural killer cells. Mangiferin was also found to antagonize in vitro the cytopathic effect of HIV. The drug appears to act as a potent biological response modifier with antitumor and antiviral effect.
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Mangiferin has been demonstrated to possess numerous pharmacological activities, including antioxidative, antiaging, antitumor, antibacterial, antiviral, immunomodulatory, antidiabetic, hepatoprotective and analgesic effects.
“It has been demonstrated to possess numerous pharmacological activities, including antioxidative, antiaging, antitumor, antibacterial, antiviral, immunomodulatory, antidiabetic, hepatoprotective and analgesic effects (1)(2)(3).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [3]
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“[34] In vitro mangiferin was also able to inhibit HSV-1 virus replication within cells[35] and to antagonize the cytopathic effects of HIV.”
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“Mangiferin has been reported to possess an- ioxidant (Sanchez et al., 2000), antitumor (Guha et al., 996), antiviral (Zheng and Lu, 1990; Zhu et al., 1993; oosook et al., 2000) and immunomodulatory activities Guha et al., 1996; Leiro et al., 2004).”
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“Guha et al. (1996) reported that mangiferin was also able to antagonize the cytopathic effect of the human immunodeficiency virus (HIV) in vitro.”
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“Various earlier reports showed that mangiferin contains antidiabetic [29], antidiarrhea [30], anticancer [31], antiallergic [32], anti-HIV [33] antibacterial [34] and antioxidant [35] properties.”
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“Many studies indicate that mangiferin has a wide range of pharmacological properties including antidiabetic, antiHIV, anticancer, immunomodulatory and antioxidant activity (Ichiki et al., 1998; Guha et al., 1996; Yoshimi et al., 2001; Leiro et al., 2004; Sato et al., 1992).”
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<i>Mangifera indica</i> L. extract (Vimang) and mangiferin modulate mouse humoral immune responses
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“The major polyphenol component of Vimang is mangiferin, a C-glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside), which has attracted considerable interest in view of its numerous pharmacological activities, including antitumor and antiviral (Zheng and Lu, 1990; Guha et al., 1996; Yoosook et al., 2000; Yos…”
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“…(1, 3, 6,7-tetrahydroxyxanthone-C2-β-D glucoside) is a polyphenol found in many plant species (Gold-Smith et al., 2016) and has antioxidant (Dar et al., 2005), anti-tumour (Guha et al., 1996; Garcia-Rivera et al., 2011; Cheng et al., 2007), antibacterial, antiviral, Table 1 Biochemical parameters.”
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BackgroundVascular effects of the Mangifera indica L. extract (Vimang)
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“These components have been reported to have cytotoxic, antineoplasic (Muanza et al., 1995; Guha et al., 1996), antioxidant (Born et al., 1996; Leiro et al., 2003), and antiinflammatory activities (Garrido et al., 2001).”
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“Guha et al. (1996) demonstrated that this plant-derived active principle has in vitro and in vivo anti-tumor and immunomodulatory effects against ascitic fibrosarcoma in Swiss mice, and anti-HIV properties in vitro.”
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“In vivo studies showed mangiferin to be antitumor [7], antidiabetic [8], antioxidative [9], hepatoprotective [10], and immunomodulative [11], whereas its aglycone shows anti-inflammatory effects [12,13], vasorelaxatively effects [14], and antiplatelet effects [15].”
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“T Previous studies have reported that mangiferin exerts numerous beneficial biological effects, including antioxidant (2), anti-tumor (3), antibacterial, antiviral and immunomodulatory activities (4).”
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“Based on the various studies done on mangiferin, it possesses a wide range of pharmacological actions including anti-inflammatory [77], antioxidant [76], antidiabetic [78], immunomodulatory and antitumor effects [79].”
BackgroundKulkarni, V. M., & Rathod, V. K. (2014) · Biotechnology Reports · doi:10.1016/j.btre.2014.12.009 · Cited by 49 · see citing works
Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice
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“The pharmacological activities of Mangifera indica include antioxidant, antidiabetic, anti-tumor, antiviral, immunomodulatory, anti-diarrheal, anti-inflammatory, antibacterial and hepatoprotective (Bhowmik et al. 2009; Garrido et al. 2004; Guha et al. 1996; Prasad et al. 2007; Rocha Ribeiro et al. 2007; Sairam et al.…”
BackgroundWang, H.-L., Li, C.-Y., Zhang, B., Liu, Y.-D., Lu, B.-M., Shi, Z., An, N., Zhao, L.-K., Zhang, J.-J., Bao, J.-K., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15059016 · Cited by 51 · see citing works
“antioxidant [8], antitumor [9], antiviral [9] and immunomodulatory activities [10].”
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“…1 56.8% of plaque reduction was observed with decreased viral replication Zheng and Lu (1990) HIV The significant cytopathic effect in infected cells Guha et al. (1996) Poliovirus Increased virulence and replication of the virus in host cells was observed in different stages of…”
BackgroundInfluentialMangiferin: A possible strategy for periodontal disease to therapy
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“From the various studies done on mangiferin, it possesses a wide range of pharmacological actions including anti-inflammation [6], antioxidant [7], antidiabetic [8], immunomodulatory, antitumor, and anti-HIV effects [9].”
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“There are reports on antidiabetic, anti-oxidant, anti-tumor and anti-viral properties of mangiferin (Guha et al., 1996; Miura et al., 2001).”
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“…have been suggested, including antioxidant, antiviral, antitumor, anti-allergic, antidiabetic, hepato- and cardioprotective, anti-inflammatory and immunomodulatory effects (Sato et al., 1992; Guha et al., 1996; Garcia et al., 2003; Pardo-Andreu et al., 2006; Das et al., 2012; Vyas et al., 2012).”
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Mangiferin: the miraculous xanthone with diverse pharmacological properties
Dutta, T., Das, T., Gopalakrishnan, A. V., Saha, S. C., Ghorai, M., Nandy, S., Kumar, M., Radha, Ghosh, A., Mukerjee, N., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-022-02373-6 · Cited by 45 · see citing works
“Mangiferin has also been shown to be effective against HIV and Herpes simplex virus (Zheng and Lu 1990; Zhu et al. 1993; Guha et al. 1996).”
Background
- Authors
- Guha, S., Ghosal, S., & Chattopadhyay, U.
- Affiliations
- Chittaranjan National Cancer Institute (IN)
- Indian Institute of Technology BHU (IN)
- Venue
- Chemotherapy
- Publisher
- S. Karger AG
- Published
- 2009-09-11
- Volume
- 42
- Issue
- 6
- Pages
- 443-451
- ISSN
- 0009-3157 (ISSN-L)
- 1421-9794
- OpenAlex
- W2075603878
- Semantic Scholar
- 7276141b527001ab806dee3e49104cd648614652
- Cited by
- 275
- References
- 0
- Citations by year
- 2025: 3 · 2024: 8 · 2023: 14 · 2022: 7 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 19 · 2017: 16 · 2016: 14 · 2015: 15 · 2014: 24 · 2013: 13 · 2012: 15
- FWCI
- 36.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Keywords
- mangiferin, anticancer activity, immunomodulation, natural killer cells, macrophages, splenocytes, antiviral activity, biological response modifiers, xanthones
- MeSH terms
- Adjuvants, Immunologic, Animals, Antibody-Dependent Cell Cytotoxicity, Antineoplastic Agents, Fibrosarcoma, Immunologic Factors, Lymphocytes, Male, Mice, Inbred Strains, Spleen, Xanthenes, HIV Infections, Macrophages, Peritoneal, Anti-HIV Agents, Xanthones, Mice
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