Cited by 82Mangiferin and Mango ExtractsNatural Compound Pharmacology StudiesNanoparticle-Based Drug Delivery

Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction

Open access
Morozkina, Svetlana N., Nhung Vu, Thi Hong, Generalova, Yuliya E., Snetkov, Petr P., Uspenskaya, Mayya V.·2021·Biomolecules

Abstract

For a long time, the pharmaceutical industry focused on natural biologically active molecules due to their unique properties, availability and significantly less side-effects. Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases thanks to its numerous biological activities. Many research studies have proven that mangiferin possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity. It is especially important that it has no toxicity. However, mangiferin is not being currently applied to clinical use because its oral bioavailability as well as its absorption in the body are too low. To improve the solubility, enhance the biological action and bioavailability, mangiferin integrated polymer systems have been developed. In this paper, we review molecular mechanisms of anti-cancer action as well as a number of designed polymer-mangiferin systems. Taking together, mangiferin is a very promising anti-cancer molecule with excellent properties and the absence of toxicity.

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Integrity signals

Registry

Crossref · 10.3390/biom11010079

Cites

153 of 153 references verified0 citation errors · 0 not checkable

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  • Several frequently cited mechanisms (NF-κB or MMP-9 modulation, G2/M arrest, AMPK activation) are highly context dependent and inconsistently replicated.

    “Notably, the results vary across cell lines and animal strains, and several mechanisms that are frequently cited (for example, NF-κB or MMP-9 modulation, G2/M arrest and AMPK activation) appear to be highly context dependent, with inconsistent replication under different stimuli or dosing conditions (4,13,117,124,186,187).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [4]

    Sections 2.3, 2.5, and 2.8 report G2/M arrest and NF-κB or MMP-9 modulation in specified cell lines, with some dose-dependent findings. They do not establish that these mechanisms are inconsistently replicated across stimuli or dosing conditions, and the searched passages do not substantiate AMPK activation. (LLM, conf=0.82)

    Experimental — accuracy not yet measured
  • Results vary across cell lines and animal strains.

    “Notably, the results vary across cell lines and animal strains, and several mechanisms that are frequently cited (for example, NF-κB or MMP-9 modulation, G2/M arrest and AMPK activation) appear to be highly context dependent, with inconsistent replication under different stimuli or dosing conditions (4,13,117,124,186,187).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [4]

    Sections 2.3, 2.8, and 2.10 describe different mangiferin responses and mechanisms in different cancer cell lines, supporting the cell-line portion of the claim. The review also reports findings from several animal models, but it does not compare results across animal strains or say that strain accounts for variation. The indexed passages have no page numbers. (LLM, conf=0.82)

    Experimental — accuracy not yet measured
  • MGF has low water solubility (0.111 mg/ml) and poor oral bioavailability (~1.2%) due to limited lipophilicity and intestinal permeability.

    “Despite its low water solubility (0.111 mg/ml) (1) and poor oral bioavailability (~1.2%) (2,3), due to its limited lipophilicity and intestinal permeability (4), MGF has been identified in 96 species, 28 genera and 19 families of angiosperms (5).”

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Cites

1 retracted

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6 of the 159 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [20]Lv J. Wang Z. Zhang L. Wang H.-L. Liu Y. Li C. Deng J. Yi-Wang Bao J.-K. Mangiferin induces apoptosis and cell Cycle arrest in MCF-7 cells both in vitro and in vivo J. Anim. Vet. Adv. 2013 12 352 359 10.3923/javaa.2013.352-359 · DOI

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Authors
Morozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V.
Affiliations
  • ITMO University (RU)
  • Institute BioEngineering, ITMO University, Kronverkskiy Prospekt, 49A, 197101 Saint-Petersburg, Russia
  • Department of Analytical Chemistry, Faculty of Industrial Technology of Dosage Forms, Saint Petersburg State Chemical Pharmaceutical University, Prof. Popova Street 14A, 197022 Saint-Petersburg, Russia
Corresponding author
Morozkina, Svetlana N.
Venue
Biomolecules
Publisher
MDPI AG
Published
2021-01-09
Volume
11
Issue
1
Pages
79
ISSN
2218-273X (ISSN-L)
OpenAlex
W3120353277
Cited by
82
References
159
Citations by year
2026: 10 · 2025: 20 · 2024: 14 · 2023: 18 · 2022: 15 · 2021: 5
FWCI
2.99
Type
journal article
Language
en
Open access
Locations
  • Biomolecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
mangiferin, anticancer activity, polymer-drug conjugates, oral bioavailability, solubility enhancement, natural products, drug delivery systems
MeSH terms
Animals, Antineoplastic Agents, Humans, Polymers, Solvents, Sonication, Nanotechnology, Xanthones

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