Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction
Open accessAbstract
For a long time, the pharmaceutical industry focused on natural biologically active molecules due to their unique properties, availability and significantly less side-effects. Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases thanks to its numerous biological activities. Many research studies have proven that mangiferin possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity. It is especially important that it has no toxicity. However, mangiferin is not being currently applied to clinical use because its oral bioavailability as well as its absorption in the body are too low. To improve the solubility, enhance the biological action and bioavailability, mangiferin integrated polymer systems have been developed. In this paper, we review molecular mechanisms of anti-cancer action as well as a number of designed polymer-mangiferin systems. Taking together, mangiferin is a very promising anti-cancer molecule with excellent properties and the absence of toxicity.
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Several frequently cited mechanisms (NF-κB or MMP-9 modulation, G2/M arrest, AMPK activation) are highly context dependent and inconsistently replicated.
“Notably, the results vary across cell lines and animal strains, and several mechanisms that are frequently cited (for example, NF-κB or MMP-9 modulation, G2/M arrest and AMPK activation) appear to be highly context dependent, with inconsistent replication under different stimuli or dosing conditions (4,13,117,124,186,187).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [4]
Sections 2.3, 2.5, and 2.8 report G2/M arrest and NF-κB or MMP-9 modulation in specified cell lines, with some dose-dependent findings. They do not establish that these mechanisms are inconsistently replicated across stimuli or dosing conditions, and the searched passages do not substantiate AMPK activation. (LLM, conf=0.82)
Experimental — accuracy not yet measuredResults vary across cell lines and animal strains.
“Notably, the results vary across cell lines and animal strains, and several mechanisms that are frequently cited (for example, NF-κB or MMP-9 modulation, G2/M arrest and AMPK activation) appear to be highly context dependent, with inconsistent replication under different stimuli or dosing conditions (4,13,117,124,186,187).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [4]
Sections 2.3, 2.8, and 2.10 describe different mangiferin responses and mechanisms in different cancer cell lines, supporting the cell-line portion of the claim. The review also reports findings from several animal models, but it does not compare results across animal strains or say that strain accounts for variation. The indexed passages have no page numbers. (LLM, conf=0.82)
Experimental — accuracy not yet measuredMGF has low water solubility (0.111 mg/ml) and poor oral bioavailability (~1.2%) due to limited lipophilicity and intestinal permeability.
“Despite its low water solubility (0.111 mg/ml) (1) and poor oral bioavailability (~1.2%) (2,3), due to its limited lipophilicity and intestinal permeability (4), MGF has been identified in 96 species, 28 genera and 19 families of angiosperms (5).”
From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [4]
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1 retracted
SHI, W., DENG, J., TONG, R., YANG, Y., HE, X., LV, J., WANG, H., DENG, S., QI, P., ZHANG, D., et al. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4947 · Cited by 50 · see citing works
RetractedNF-kB in development and progression of human cancer
Dolcet, X., Llobet‐Navàs, D., Pallarés, J., & Matías‐Guiu, X. (2005) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-005-1264-9 · Cited by 1,165 · see citing works
Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer
Roy, R., Yang, J., & Moses, M. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.5556 · Cited by 857 · see citing works
Mitochondrial reactive oxygen species drive proinflammatory cytokine production
Naik, E., & Dixit, V. M. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110367 · Cited by 783 · see citing works
Shah, K., Patel, M., Patel, R., & Parmar, P. (2010) · Pharmacognosy Reviews · doi:10.4103/0973-7847.65325 · Cited by 494 · see citing works
Muneer, P. M. A., Chandra, N., & Haorah, J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8752-3 · Cited by 463 · see citing works
Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats
Muruganandan, S., Srinivasan, K., Gupta, S., Gupta, P. K., & Lal, J. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.12.010 · Cited by 426 · see citing works
Barreto, J. C., Trevisan, M. T. S., Hull, W. E., Erben, G., de Brito, E. S., Pfundstein, B., Würtele, G., Spiegelhalder, B., & Owen, R. W. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf800738r · Cited by 418 · see citing works
Serhan, C. N., Jain, A., Marleau, S., Clish, C. B., Kantarcı, A., Behbehani, B., Colgan, S. P., Stahl, G. L., Merched, A. J., Petasis, N. A., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6856 · Cited by 405 · see citing works
Naturally occurring antinociceptive substances from plants
Calixto, J. Β., Beirith, A., Ferreira, J., Santos, A. R. S., Filho, V. C., & Yunes, R. A. (2000) · Phytotherapy Research · doi:10.1002/1099-1573(200009)14:6 · Cited by 340 · see citing works
Martı́nez-Sánchez, G., Re, L., Giuliani, A., Sellés, A. J. N., Pérez-Davison, G., & León-Fernández, O. S. (2000) · Pharmacological Research · doi:10.1006/phrs.2000.0727 · Cited by 300 · see citing works
Dar, A., Faizi, S., Naqvi, S., Roome, T., Zikr-ur-Rehman, S., Ali, M., Firdous, S., & Moin, S. T. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.596 · Cited by 289 · see citing works
Guha, S., Ghosal, S., & Chattopadhyay, U. (2009) · Chemotherapy · doi:10.1159/000239478 · Cited by 275 · see citing works
Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice
Makare, N., Bodhankar, S., & Rangari, V. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00326-9 · Cited by 258 · see citing works
Shanmugam, M. K., Kannaiyan, R., & Sethi, G. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2011.523502 · Cited by 235 · see citing works
Yoshimi, N., Matsunaga, K., Katayama, M., Yamada, Y., Kuno, T., Qiao, Z., Hara, A., Yamahara, J., & Mori, H. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00678-9 · Cited by 214 · see citing works
Das, J., Ghosh, J., Roy, A., & Sil, P. C. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.01.015 · Cited by 170 · see citing works
Analgesic and anti-inflammatory effects ofMangifera indica L. extract (Vimang)
Garrido, G., Gonz�lez, D., Delporte, C. L., Backhouse, N., Quintero, G., Sellés, A. J. N., & Morales, M. A. (2001) · Phytotherapy Research · doi:10.1002/1099-1573(200102)15:1 · Cited by 167 · see citing works
Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential
Saha, S., Sadhukhan, P., & Sil, P. C. (2016) · BioFactors · doi:10.1002/biof.1292 · Cited by 159 · see citing works
Mangiferin and Cancer: Mechanisms of Action
Gold-Smith, F., Fernandez, A., & Bishop, K. (2016) · Nutrients · doi:10.3390/nu8070396 · Cited by 158 · see citing works
Mangiferin – a Bioactive Xanthonoid, not only from Mango and not just Antioxidant
Matkowski, A., Kuś, P., Goralska, E., & Woźniak, D. (2013) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557511313030011 · Cited by 156 · see citing works
Leiro, J. M., Álvarez, E., Arranz, J. A., Siso, I. G., & Orallo, F. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00041-8 · Cited by 154 · see citing works
Leiro, J. M., Arranz, J. A., Yáñez, M., Ubeira, F. M., Sanmartín, M. L., & Orallo, F. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.03.002 · Cited by 152 · see citing works
García-Rivera, D., Delgado, R., Bougarne, N., Haegeman, G., & Vanden Berghe, W. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.02.011 · Cited by 142 · see citing works
Mangiferin: An effective therapeutic agent against several disorders (Review)
Du, S., Liu, H., Lei, T., Xie, X., Wang, H., He, X., Tong, R., & Wang, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9529 · Cited by 139 · cited 1× · see citing works
“Mangiferin also protects hepatocytes from free radical-mediated hypoxia/reoxygenation damage by forming a complex of mangiferin: Fe3+ complexes and neutralizing free radicals [40,110].”
BackgroundDou, W., Zhang, J., Ren, G., Ding, L., Sun, A., Deng, C., Wu, X., Wei, X., Mani, S., & Wang, Z. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.08.025 · Cited by 134 · see citing works
Sarkar, A., Sreenivasan, Y., Ramesh, G. T., & Manna, S. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403424200 · Cited by 124 · see citing works
Jangra, A., Lukhi, M. M., Sulakhiya, K., Baruah, C. C., & Lahkar, M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.031 · Cited by 122 · see citing works
Andreu, G. P., Delgado, R., Velho, J. A., Curti, C., & Vercesi, A. E. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.03.007 · Cited by 122 · see citing works
Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLC-MS/MS
Han, D., Chen, C., Zhang, C., Zhang, Y., & Tang, X. (2010) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.07.021 · Cited by 118 · see citing works
<i>Mangifera indica</i> L. extract (Vimang) and mangiferin modulate mouse humoral immune responses
García, D., Leiro, J., Delgado, R., Sanmartín, M. L., & Ubeira, F. M. (2003) · Phytotherapy Research · doi:10.1002/ptr.1338 · Cited by 116 · see citing works
Mangiferin – a Bioactive Xanthonoid, not only from Mango and not just Antioxidant
Matkowski, A., Kus, P., Goralska, E., & Wozniak, D. (2013) · Mini Reviews in Medicinal Chemistry · doi:10.2174/138955713804999838 · Cited by 116 · see citing works
Antiviral effect of mangiferin and isomangiferin on herpes simplex virus.
Zheng, M. S., & Lu, Z. (1990) · PubMed · Cited by 111 · see citing works
García, D., Escalante, M., Delgado, R., Ubeira, F. M., & Leiro, J. (2003) · Phytotherapy Research · doi:10.1002/ptr.1343 · Cited by 109 · see citing works
Improving permeability and oral absorption of mangiferin by phospholipid complexation
Ma, H., Chen, H., Sun, L., Tong, L., & Zhang, T. (2014) · Fitoterapia · doi:10.1016/j.fitote.2013.10.016 · Cited by 108 · see citing works
Modulation of rat macrophage function by the Mangifera indica L. extracts Vimang and mangiferin
García, D., Delgado, R., Ubeira, F. M., & Leiro, J. M. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00018-8 · Cited by 106 · see citing works
Pan, C.-W., Pan, Z.-Z., Hu, J.-J., Chen, W.-L., Zhou, G.-Y., Lin, W., Jin, L.-X., & Xu, C.-L. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.12.006 · Cited by 105 · see citing works
Li, H., Huang, J., Yang, B. L., Xiang, T., Yin, X., Peng, W., Cheng, W., Wan, J., Luo, F., Li, H., et al. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.011 · Cited by 103 · see citing works
Prabhu, S., Jainu, M., Sabitha, K. E., & Devi, C. S. S. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.02.014 · Cited by 103 · see citing works
Therapeutic and cosmetic applications of mangiferin: A patent review
Telang, M., Dhulap, S., Mandhare, A., & Hirwani, R. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.836182 · Cited by 103 · see citing works
Sebo, T. J., Cheville, J. C., Riehle, D., Lohse, C. M., Pankratz, V. S., Myers, R. P., Blute, M. L., & Zincke, H. (2001) · Cancer · doi:10.1002/1097-0142(20010601)91:11 · Cited by 100 · see citing works
Pal, P. B., Sinha, K., & Sil, P. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056894 · Cited by 98 · see citing works
Pharmacokinetic study of mangiferin in human plasma after oral administration
Hou, S., Wang, F., Li, Y., Li, Y., Wang, M., Sun, D., & Sun, C. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2011.10.079 · Cited by 98 · see citing works
García-Rivera, D., Hernández, I., León, A. Á., Hernández, B. C., Montiel, L. M., Garrido, G., Delgado, R., & Cuzzocrea, S. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.3.0014 · Cited by 96 · see citing works
Bhatia, H. S., Candelario-Jalil, E., de Oliveira, A. C. P., Olajide, O. A., Martínez-Sánchez, G., & Fiebich, B. L. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.017 · Cited by 95 · see citing works
Rodríguez, J., Pierro, D. D., Gioia, M., Monaco, S., Delgado, R., Coletta, M., & Marini, S. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.04.005 · Cited by 93 · see citing works
Wang, Z., Guo, S., Wang, J., Shen, Y., Zhang, J., & Wu, Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-12160-6 · Cited by 92 · see citing works
Kavitha, M., Nataraj, J., Essa, M. M., Memon, M. A., & Manivasagam, T. (2013) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2013.09.016 · Cited by 91 · see citing works
Rajendran, P., Ganapathy, E., Sakthisekaran, D., Nishigaki, I., Nishigaki, Y., Thangavel, J., & Vetriselvi, J. (2013) · International Journal of Biomedical Science · doi:10.59566/ijbs.2013.9068 · Cited by 87 · see citing works
Kim, H., Kim, H., Mosaddik, A., Gyawali, R., Ahn, K. S., & Cho, S. K. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.01.053 · Cited by 87 · see citing works
Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study
Jagetia, G. C., & Baliga, M. S. (2005) · Phytomedicine · doi:10.1016/j.phymed.2003.08.003 · Cited by 83 · see citing works
Dineshkumar, B., Mitra, A., & Manjunatha, M. (2010) · International Journal of Advances in Pharmaceutical Sciences · doi:10.5138/ijaps.2010.0976.1055.01009 · Cited by 83 · see citing works
Mangiferin, an Anti-HIV-1 Agent Targeting Protease and Effective against Resistant Strains
Wang, R., Gao, Y., Ma, C., Zhang, X., Huang, C., Huang, J., & Zheng, Y. (2011) · Molecules · doi:10.3390/molecules16054264 · Cited by 81 · see citing works
Carvalho, A. M., Guedes, M., de Souza, A. Q. L., Trevisan, M. T. S., de Lima, A. K. M. M. N., Santos, F. A., & Rao, V. S. N. (2007) · Planta Medica · doi:10.1055/s-2007-990231 · Cited by 80 · see citing works
(1989) · PubMed · Cited by 79 · see citing works
Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways
Jeong, J.-J., Jang, S.-E., Hyam, S. R., Han, M. J., & Kim, D.-H. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.013 · Cited by 78 · see citing works
Awny, M. M., Attia, A. S., Abd‐Ellah, M. F., & El-Abhar, H. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132497 · Cited by 76 · see citing works
Rivera, D. G., Hernández, I., Merino, N., Luque, Y., Álvarez, A., Martín, Y., Amador, A., Nuevas, L., & Delgado, R. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01328.x · Cited by 74 · see citing works
Antioxidant activity of the mangiferin inclusion complex with β-cyclodextrin
Ferreira, F. D. R., Valentim, I. B., Ramones, E. L. C., Trevisan, M. T. S., Olea-Azar, C., Perez-Cruz, F., de Abreu, F. C., & Goulart, M. O. F. (2013) · LWT - Food Science and Technology · doi:10.1016/j.lwt.2012.09.032 · Cited by 73 · see citing works
Pardo‐Andreu, G. L., Maurmann, N., Reolon, G. K., de Farias, C. B., Schwartsmann, G., Delgado, R., & Roesler, R. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.011 · Cited by 72 · see citing works
Jagetia, G. C., & Venkatesha, V. A. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20124 · Cited by 70 · see citing works
Mangiferin in cancer chemoprevention and treatment: pharmacokinetics and molecular targets
Rajendran, P., Rengarajan, T., Nandakumar, N., Divya, H., & Nishigaki, I. (2014) · Journal of Receptors and Signal Transduction · doi:10.3109/10799893.2014.931431 · Cited by 70 · see citing works
Thanitwatthanasak, S., Sagis, L. M. C., & Chitprasert, P. (2018) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2018.10.089 · Cited by 70 · see citing works
Cdc2: A monopotent or pluripotent CDK?
Hu, X., & Moscinski, L. C. (2011) · Cell Proliferation · doi:10.1111/j.1365-2184.2011.00753.x · Cited by 69 · see citing works
Spray-drying encapsulation of mangiferin using natural polymers
de Souza, J. R. R., Feitosa, J. P. A., Ricardo, N. M. P. S., Trevisan, M. T. S., Paula, H. C. B., Ulrich, C. M., & Owen, R. W. (2013) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2013.02.017 · Cited by 68 · see citing works
Rao, B. S. S., Sreedevi, M. V., & Rao, B. N. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.12.017 · Cited by 68 · see citing works
Prabhu, S., Jainu, M., Sabitha, K. E., & Shyamala Devi, C. S. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.03.012 · Cited by 68 · see citing works
Fe(III) improves antioxidant and cytoprotecting activities of mangiferin
Pardo‐Andreu, G. L., Sánchez-Baldoquín, C., Ávila-González, R., Delgado, R., Naal, Z., & Curti, C. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.07.040 · Cited by 67 · see citing works
Pan, L.-L., Wang, A.-Y., Huang, Y.-Q., Luo, Y., & Ling, M. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.17.7065 · Cited by 66 · see citing works
Pardo‐Andreu, G. L., Delgado, R., Velho, J. A., Curti, C., & Vercesi, A. E. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.05.015 · Cited by 66 · see citing works
Zhu, X., Cheng, Y.-Q., Du, L., Li, Y., Zhang, F., Guo, H., Liu, Y.-W., & Yin, X.-X. (2015) · Phytotherapy Research · doi:10.1002/ptr.5254 · Cited by 66 · see citing works
Jung, J.-S., Jung, K., Kim, D.-H., & Kim, H.-S. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.02.013 · Cited by 65 · see citing works
Martı́nez-Sánchez, G., Candelario‐Jalil, E., Giuliani, A., León, O. S., Sam, S., Delgado, R., & Sellés, A. J. N. (2001) · Free Radical Research · doi:10.1080/10715760100301481 · Cited by 65 · see citing works
Dual mode action of mangiferin in mouse liver under high fat diet
Lim, J., Liu, Z., Apontes, P., Feng, D., Pessin, J. E., Sauve, A. A., Angeletti, R. H., & Chi, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090137 · Cited by 64 · see citing works
Bartoszewski, R., Hering, A., Marszałł, M., Stefanowicz‐Hajduk, J., Bartoszewska, S., Kapoor, N., Kochan, K., & Ochocka, J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092128 · Cited by 63 · see citing works
Rajendran, P., Ganapathy, E., & Sakthisekaran, D. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00254.x · Cited by 62 · see citing works
Louisa, M., Soediro, T. M., & Suyatna, F. D. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.4.1639 · Cited by 61 · see citing works
Mangiferin nanoemulsions in treatment of inflammatory disorders and skin regeneration
Pleguezuelos-Villa, M., Nácher, A., Hernández, M. J., Busó, M. A. O. V., Ruiz‐Saurí, A., & Dı́ez-Sales, O. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.04.056 · Cited by 61 · see citing works
Liu, R., Liu, Z., Zhang, C., & Zhang, B. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22540 · Cited by 61 · see citing works
Ren, Y., Wei, B., Song, X., An, N., Zhou, Y., Jin, X., & Zhang, Y. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2014.959121 · Cited by 60 · see citing works
Zhang, B., Zhao, J. J., Li, S., Yang, L., Zeng, L.-L., Chen, Y., & Fang, J. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.165 · Cited by 60 · see citing works
(2006) · PubMed · Cited by 60 · see citing works
Zou, T., Wu, H., Li, H., Jia, Q., & Song, G. (2013) · Journal of Separation Science · doi:10.1002/jssc.201300518 · Cited by 58 · see citing works
Shoji, K., Tsubaki, M., Yamazoe, Y., Satou, T., Itoh, T., Kidera, Y., Tanimori, Y., Yanae, M., Matsuda, H., Taga, A., et al. (2011) · Archives of Pharmacal Research · doi:10.1007/s12272-011-0316-8 · Cited by 57 · see citing works
Andréu, G. P., Delgado, R., Velho, J. A., Inada, N. M., Curti, C., & Vercesi, A. E. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2004.11.002 · Cited by 54 · see citing works
α-Glucosidase inhibitory activity of Mangifera indica bark
Prashanth, D., Amit, A., Samiulla, D. S., Asha, M. K., & Padmaja, R. J. (2001) · Fitoterapia · doi:10.1016/s0367-326x(01)00293-3 · Cited by 54 · see citing works
A Toxicological Evaluation of Mango Leaf Extract (<i>Mangifera indica</i>) Containing 60% Mangiferin
Reddeman, R. A., Glávits, R., Endres, J. R., Clewell, A. E., Hirka, G., Vértesi, A., Béres, E., & Szakonyiné, I. P. (2019) · Journal of Toxicology · doi:10.1155/2019/4763015 · Cited by 54 · see citing works
Bhatia, V. K., Ramanathan, J. D., & Seshadri, T. R. (1967) · Tetrahedron · doi:10.1016/0040-4020(67)85090-7 · Cited by 51 · see citing works
Das, S., Rao, B. N., & Rao, B. S. S. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.06.002 · Cited by 51 · see citing works
Rajendran, P., Ganapathy, E., & Sakthisekaran, D. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1053 · Cited by 51 · see citing works
XIAO, J., LIU, L., ZHONG, Z., XIAO, C., & ZHANG, J. (2015) · Oncology Reports · doi:10.3892/or.2015.3919 · Cited by 51 · see citing works
Bock, C., Waldmann, K.-H., & Ternes, W. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.08.001 · Cited by 50 · see citing works
Effect of mangiferin on benzo(a)pyrene induced lung carcinogenesis in experimental Swiss albino mice
Rajendran, P., Ekambaram, G., & Sakthisekaran, D. (2008) · Natural Product Research · doi:10.1080/14786410701824973 · Cited by 49 · see citing works
Dilshara, M. G., Kang, C.-H., Choi, Y. H., & Kim, G.-Y. (2015) · BMB Reports · doi:10.5483/bmbrep.2015.48.10.003 · Cited by 47 · see citing works
Xing, X., Li, D., Chen, D., Zhou, L., Chonan, R., Yamahara, J., Wang, J., & Li, Y. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.08.001 · Cited by 46 · see citing works
(2014) · PubMed · Cited by 46 · see citing works
van de Venter, M., du Plessis-Stoman, D., & Preez, J. D. (2011) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v8i2.63206 · Cited by 45 · see citing works
LI, M., MA, H., YANG, L., & LI, P. (2016) · Oncology Letters · doi:10.3892/ol.2015.3924 · Cited by 45 · see citing works
Garrido, G., González, D., Lemus, Y., Delporte, C. L., & Delgado, R. (2005) · Phytomedicine · doi:10.1016/j.phymed.2004.12.003 · Cited by 44 · see citing works
Potent chemopreventive effect of mangiferin on lung carcinogenesis in experimental Swiss albino mice
Sakthisekaran, D., Rajendran, P., Rengarajan, T., Nishigaki, I., & Ganapathy, E. (2014) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.137966 · Cited by 44 · see citing works
García-Casas, I., Montes, A., Pereyra, C. M., & de la Ossa, E. J. M. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.01.010 · Cited by 44 · see citing works
ZHAO, J., ZHANG, B., LI, S., ZENG, L., CHEN, Y., & FANG, J. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1696 · Cited by 43 · see citing works
Rodeiro, I., Hernandez, S., Morffi, J., Herrera, J., Gómez-Lechón, M. J., Delgado, R., & Espinosa-Aguirre, J. J. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.06.032 · Cited by 42 · see citing works
Takeda, T., Tsubaki, M., Sakamoto, K., Ichimura, E., Enomoto, A., Suzuki, Y., Itoh, T., Imano, M., Tanabe, G., Muraoka, O., et al. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.07.005 · Cited by 42 · see citing works
Mangiferin induces cell cycle arrest at G2/M phase through ATR-Chk1 pathway in HL-60 leukemia cells
Peng, Z. G., Yao, Y. B., Yang, J., Tang, Y. L., & Huang, X. (2015) · Genetics and Molecular Research · doi:10.4238/2015.may.12.2 · Cited by 41 · see citing works
Razura-Carmona, F. F., Pérez-Larios, A., González-Silva, N., Herrera-Martínez, M., Medina-Torres, L., Sáyago-Ayerdi, S. G., & Sánchez-Burgos, J. A. (2019) · Cancers · doi:10.3390/cancers11121965 · Cited by 40 · see citing works
Faizi, S., Zikr‐ur‐Rehman, S., Ali, M. S., & Naz, A. (2006) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.1854 · Cited by 40 · see citing works
Garrido, G., Blanco-Molina, M., Sancho, R., Macho, A., Delgado, R., & Muñóz, E. (2005) · Phytotherapy Research · doi:10.1002/ptr.1656 · Cited by 40 · see citing works
Zou, B., Wang, H., Liu, Y., Qi, P., Lei, T., Sun, M., & Wang, Y. (2017) · Oncology Reports · doi:10.3892/or.2017.5814 · Cited by 40 · see citing works
Radioprotective activity of Gentiana lutea extract and mangiferin
Menkovic, N. R., Juranić, Z. D., Stanojković, T., Raonic‐Stevanovic, T., Šavikin, K., Zdunić, G. M., & Borojević, N. (2010) · Phytotherapy Research · doi:10.1002/ptr.3225 · Cited by 37 · see citing works
[CML cell line K562 cell apoptosis induced by mangiferin].
Peng, Z., Luo, J., Xia, L.-H., Chen, Y., & Song, S.-J. (2004) · PubMed · Cited by 37 · see citing works
Peng, S., Hou, Y., Yao, J., & Fang, J. (2019) · BioFactors · doi:10.1002/biof.1488 · Cited by 37 · see citing works
Wang, H., Ye, G., Tang, Y., Zhu, H., Ma, R., Sun, Z.-L., & Huang, C. (2006) · Biomedical Chromatography · doi:10.1002/bmc.695 · Cited by 35 · see citing works
Chattopadhyay, U., Das, S., Guha, S., & Ghosal, S. (1987) · Cancer Letters · doi:10.1016/0304-3835(87)90114-5 · Cited by 35 · see citing works
Nott, P. E. (1967) · Phytochemistry · doi:10.1016/s0031-9422(00)86015-x · Cited by 34 · see citing works
Tan, H., Wang, N., Li, S., Hong, M., Guo, W., Man, K., Cheng, C., Chen, Z., & Feng, Y. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491063 · Cited by 34 · see citing works
Determination of mangiferin solubility in solvents used in the biopharmaceutical industry
Acosta, J., Sevilla, I., Salomón, S., Nuevas-Paz, L., Romero, A., & Amaro‐González, D. (2016) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres15.099_4.2.49 · Cited by 33 · see citing works
Dimitrov, M. D., Nikolova, I., Benbassat, N., Kitanov, G. M., & Danchev, N. D. (2011) · Biotechnology & Biotechnological Equipment · doi:10.5504/bbeq.2011.0099 · Cited by 33 · see citing works
Sahoo, B. K., Zaidi, S. A. H., Gupta, P., Mokhamatam, R. B., Raviprakash, N., Mahali, S. K., & Manna, S. K. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.07.046 · Cited by 32 · see citing works
Prabhu, S., Narayan, S., & Devi, C. S. S. (2009) · Phytotherapy Research · doi:10.1002/ptr.2549 · Cited by 32 · see citing works
The effects of mangiferin (Mangifera indica L) in doxorubicin-induced cardiotoxicity in rats
Arozal, W., Suyatna, F., Juniantito, V., Rosdiana, D., Amurugam, S., Aulia, R., Monayo, E., & Siswandi, R. (2014) · Drug Research · doi:10.1055/s-0034-1394457 · Cited by 32 · see citing works
Mutagenicities of xanthone derivatives in Salmonella typhimurium TA100, TA98, TA97, and TA2637
Matsushima, T., Araki, A., Yagame, O., Muramatsu, M., Koyama, K., Ohsawa, K., Natori, S., & Tomimori, H. (1985) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(85)90111-3 · Cited by 31 · see citing works
Zhang, B., Zhao, J. J., Li, S., Linglan, Z., Chen, Y., & Fang, J. (2014) · Pharmaceutical Biology · doi:10.3109/13880209.2014.927890 · Cited by 30 · see citing works
Antiviral Activity of Mangifera Extract on Influenza Virus Cultivated in Different Cell Cultures
Rawi, A. A. S. A., Dulaimi, H. S. H. A., & Rawi, M. A. A. A. (2019) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.13.1.50 · Cited by 30 · see citing works
Chitosan/mangiferin particles for Cr(VI) reduction and removal
Sampaio, C. D. G., Frota, L. S., Magalhães, H. S., Dutra, L. M. U., de Queiroz, D. C., Araújo, R. D. S., Becker, H., de Souza, J. R. R., Ricardo, N. M. P. S., & Trevisan, M. T. S. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.03.038 · Cited by 29 · see citing works
Acute and Long‐Term Toxicity of Mango Leaves Extract in Mice and Rats
Zhang, Y., Li, J., Wu, Z., Liu, E., Shi, P., Han, L., Guo, L., Gao, X., & Wang, T. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/691574 · Cited by 28 · see citing works
Tolosa, L., Rodeiro, I., Donato, M. T., Herrera, J., Delgado, R., Castell, J. V., & Gómez-Lechón, M. J. (2013) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12071 · Cited by 25 · see citing works
Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol
Wilkinson, A. S., Taing, M., Pierson, J. T., Lin, C.-N., Dietzgen, R. G., Shaw, P. N., Gidley, M. J., Monteith, G. R., & Roberts‐Thomson, S. J. (2015) · Food & Function · doi:10.1039/c5fo00133a · Cited by 23 · see citing works
[The effect of mangiferin on telomerase activity and apoptosis in leukemic K562 cells].
Peng, C., Peng, Z., Yang, J., & Song, S.-J. (2007) · PubMed · Cited by 23 · see citing works
Cardioprotective effect of mangiferin on left ventricular remodeling in rats
Zheng, D., Hou, J., Xiao, Y., Zhao, Z., & Chen, L. (2012) · Pharmacology · doi:10.1159/000339450 · Cited by 23 · see citing works
(2010) · PubMed · Cited by 22 · see citing works
Rajendran, P., Ganapathy, E., Magesh, V., & Sakthisekaran, D. (2008) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2008.05.005 · Cited by 21 · see citing works
Nott, P. E., & Roberts, J. C. Q. (1967) · Phytochemistry · doi:10.1016/s0031-9422(00)82959-3 · Cited by 21 · see citing works
Anxiolytic Activity of Canscora decussata in Albino Rats
Sethiya, N. K., Nahata, A., & Dixit, V. K. (2010) · Journal of Complementary and Integrative Medicine · doi:10.2202/1553-3840.1263 · Cited by 21 · see citing works
Co-precipitation of mangiferin with cellulose acetate phthalate by Supercritical antisolvent process
García-Casas, I., Montes, A., Pereyra, C. M., & de la Ossa, E. J. M. (2017) · Journal of CO2 Utilization · doi:10.1016/j.jcou.2017.10.003 · Cited by 21 · see citing works
Ahmad, A., Padhyé, S., & Sarkar, F. H. (2011) · Springer eBooks · doi:10.1007/978-94-007-2630-7_10 · Cited by 21 · see citing works
Phytochemical and pharmacological investigations on mangiferin.
Singh, S. K., Sharma, V., Kumar, Y., Sadasivam, S., & Sinha, S. (2009) · Herba Polonica · Cited by 20 · see citing works
Júnior, J. W. D. C., MORAES, L. R. D., dos Santos, M. H., da Silva, G. A., Brigagão, M. R. P. L., Ellena, J., & Doriguetto, A. C. (2008) · Helvetica Chimica Acta · doi:10.1002/hlca.200890005 · Cited by 19 · see citing works
Mesa, J. E. G., Rodríguez, M. D., Rodeiro, I., Morffi, J., Guerra, E., Leal, F., García, H., Goicochea, E., Guerrero, S., Garrido, G., et al. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.05.029 · Cited by 19 · see citing works
Synthesis of mangiferin derivates and study their potent PTP1B inhibitory activity
Hu, H., Wang, M. J., Zhao, Q. J., Yu, S. C., Liu, C. M., & Wu, Q. Y. (2007) · Chinese Chemical Letters · doi:10.1016/j.cclet.2007.09.011 · Cited by 16 · see citing works
Yang, G., Shang, X., Cui, G., Zhao, L., Zhao, H., & Wang, N. (2019) · Journal of Environmental Pathology, Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.2018027392 · Cited by 15 · see citing works
Hou, Y., Fan, S., Zhang, H., Gu, Y., Yu, X., & Li, B. (2010) · PubMed Central · Cited by 14 · see citing works
Activation of peritoneal macrophages by mangiferin, a naturally occurring xanthone
Guha, S., Chattopadhyay, U., & Ghosal, S. (1993) · Phytotherapy Research · doi:10.1002/ptr.2650070202 · Cited by 14 · see citing works
Antiviral potential of mangiferin against poliovirus
Rechenchoski, D. Z., Galhardi, L. C. F., Cunha, A. P., Ricardo, N. M. P. S., Nozawa, C., & Linhares, R. E. C. (2018) · International Journal of Pharmacological Research · doi:10.7439/ijpr.v8i4.4706 · Cited by 13 · see citing works
Venugopal, R., Sakthiseka, D., Rajkapoor, B., & Nishigaki, I. (2007) · Journal of Biological Sciences · doi:10.3923/jbs.2007.1227.1232 · Cited by 12 · see citing works
Mangiferin, a natural polyphenol protects the hepatic damage in mice caused by CCl4 intoxication
Rasool, M., Sabina, E. P., Mahinda, P. S., & Gnanaselvi, B. C. (2012) · Comparative Clinical Pathology · doi:10.1007/s00580-011-1190-y · Cited by 10 · see citing works
Souza, J. R. R., Trevisan, M. T. S., Feitosa, J. P. A., Ricardo, N. M. P. S., Hull, W. E., Erben, G., Würtele, G., Breuer, A., Frei, E., Ulrich, C. M., et al. (2020) · Natural Product Communications · doi:10.1177/1934578x20910286 · Cited by 9 · see citing works
Guo, L. (2002) · Zhonghua xiaohua zazhi · Cited by 8 · see citing works
Rehabilating Activity of Mangiferin in Benzo(a) Pyrene Induced Lung Carcinogenesis
Rajendran, P., Venugopal, R., Ganapathy, E., Arumugam, A., & Sakthiseka, D. (2008) · Asian Journal of Biochemistry · doi:10.3923/ajb.2008.118.125 · Cited by 8 · see citing works
Antioxidant Microemulsion-based Ethylene Vinyl Acetate Film Containing Mangiferin and Surfactants
Boonnattakorn, R., Sane, A., & Chonhenchob, V. (2016) · MATEC Web of Conferences · doi:10.1051/matecconf/20166706101 · Cited by 4 · see citing works
Maheswari, R., & Saranya, M. (2019) · Journal of Pharmaceutical and Biological Sciences · doi:10.18231/2320-1924.2018.0016 · Cited by 4 · see citing works
Secondary metabolism and therapeutic efficacy of medicinal plants
Mohiuddin, A. K. (2019) · Journal of Pharmaceutical and Biological Sciences · doi:10.18231/2320-1924.2018.0014 · Cited by 4 · see citing works
Pipattanawarothai, A., Athipornchai, A., Sripreechasak, P., & Trakulsujaritchok, T. (2019) · Burapha Science Journal (วารสารวิทยาศาสตร์บูรพา ) · Cited by 3 · see citing works
Flagged first, then by citations
6 of the 159 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [20]Lv J. Wang Z. Zhang L. Wang H.-L. Liu Y. Li C. Deng J. Yi-Wang Bao J.-K. Mangiferin induces apoptosis and cell Cycle arrest in MCF-7 cells both in vitro and in vivo J. Anim. Vet. Adv. 2013 12 352 359 10.3923/javaa.2013.352-359 · DOI
Cited by
Sorted by citations
Natural products for combating multidrug resistance in cancer
Chen, T., Xiao, Z., Liu, X., Wang, T., Wang, Y., Ye, F., Su, J., Yao, X., Xiong, L., & Yang, D. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107099 · Cited by 115 · see citing works
Mangiferin: a review of dietary sources, absorption, metabolism, bioavailability, and safety
Mei, S., Perumal, M., Battino, M., Kitts, D. D., Xiao, J., Ma, H., & Chen, X. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1983767 · Cited by 93 · see citing works
Tropical Fruits and Their Co-Products as Bioactive Compounds and Their Health Effects: A Review
Sáyago‐Ayerdi, S. G., García-Martínez, D. L., Ramírez-Castillo, A. C., Ramírez-Concepción, H. R., & Viuda‐Martos, M. (2021) · Foods · doi:10.3390/foods10081952 · Cited by 82 · see citing works
Kang, L., Zhang, H., Jia, C.-Y., Zhang, R., & Shen, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.956355 · Cited by 55 · see citing works
Natural products targeting the ATR-CHK1 signaling pathway in cancer therapy
Ahmed, S., Alam, W., Aschner, M., Alsharif, K. F., Albrakati, A., Saso, L., & Khan, H. Z. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113797 · Cited by 49 · see citing works
Živković, J., Kumar, K. A., Rushendran, R., Ilango, K., Fahmy, N. M., El‐Nashar, H. A. S., El‐Shazly, M., Ezzat, S. M., Melgar‐Lalanne, G., Romero‐Montero, A., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02682-4 · Cited by 56 · see citing works
Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives
Akter, S., Moni, A., Faisal, G. M., Uddin, M. R., Jahan, N., Hannan, M. A., Rahman, A., & Uddin, M. J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031864 · Cited by 36 · see citing works
Multiple Myeloma Inhibitory Activity of Plant Natural Products
Jöhrer, K., & Çiçek, S. S. (2021) · Cancers · doi:10.3390/cancers13112678 · Cited by 29 · see citing works
Ferroptosis: a new strategy for Chinese herbal medicine treatment of diabetic nephropathy
Wei, M., Liu, X., Tan, Z., Tian, X., Li, M., & Wei, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1188003 · Cited by 26 · see citing works
Abdul-Aziz Ahmed, K., Jabbar, A. A. J., Abdulla, M. A., Zuhair Alamri, Z., Ain Salehen, N., Abdel Aziz Ibrahim, I., Almaimani, G., Bamagous, G. A., Almaimani, R. A., Almasmoum, H. A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-023-50947-y · Cited by 26 · see citing works
Wang, H., Shao, W., Lu, X., Gao, C., Fang, L., Yang, X., & Zhu, P. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124208 · Cited by 23 · see citing works
Wu, J., Ding, H., Wang, T., Tsai, Y.-L., Ting, H., & Chang, T. (2021) · Antioxidants · doi:10.3390/antiox10111817 · Cited by 23 · see citing works
Maenpuen, S., Mee-udorn, P., Pinthong, C., Athipornchai, A., Phiwkaow, K., Watchasit, S., Pimviriyakul, P., Rungrotmongkol, T., Tinikul, R., Leartsakulpanich, U., et al. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109712 · Cited by 22 · see citing works
Zhang, J., Chen, Y., Wang, Z., Zhou, W., Ullah, H., Cao, J., Liu, Y., & Cheng, G. (2023) · Food Frontiers · doi:10.1002/fft2.306 · Cited by 22 · see citing works
Pasdaran, A., Hassani, B., Tavakoli, A., Kozuharova, E. K., & Hamedi, A. (2023) · Life · doi:10.3390/life13071589 · Cited by 21 · see citing works
Sarfraz, M., Khan, A., Batiha, G. E.-S., Akhtar, M. F., Saleem, A., Ajiboye, B. O., Kamal, M., Ali, A., Alotaibi, N. M., Aaghaz, S., et al. (2023) · Cancers · doi:10.3390/cancers15164194 · Cited by 20 · see citing works
Zheng, Y., Du, M., Shi, H., Liu, W., Zhuang, C., Chen, H., & Gao, Y. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.144952 · Cited by 21 · see citing works
Rodriguez-Gonzalez, J. C., Hernández-Balmaseda, I., Declerck, K., Pérez-Novo, C., Logie, E., Theys, C., Jakubek, P., Quiñones-Maza, O. L., Dantas-Cassali, G., Carlos dos Reis, D., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.670167 · Cited by 19 · see citing works
Mangiferin: An effective agent against human malignancies
Irshad, N., Naeem, H., Shahbaz, M., Imran, M., Mujtaba, A., Hussain, M., Abdulmonem, W. A., Alsagaby, S. A., Yehuala, T. F., Abdelgawad, M. A., et al. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4434 · Cited by 14 · see citing works
Nigussie, G., Siyadatpanah, A., Norouzi, R., Debebe, E., Alemayehu, M., & Dekebo, A. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/1901529 · Cited by 14 · see citing works
Мykhailenko, O., Іванаускас, Л., Bezruk, I. V., Petrikaitė, V., & Georgiyants, V. (2022) · Scientia Pharmaceutica · doi:10.3390/scipharm90010019 · Cited by 14 · see citing works
de Beer, D., Beelders, T., Human, C., & Joubert, E. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2096561 · Cited by 12 · see citing works
Rout, S., Tripathy, S., Ranjan, S., & Srivastav, P. P. (2025) · Sustainable Chemistry for the Environment · doi:10.1016/j.scenv.2025.100235 · Cited by 12 · see citing works
Jamal, F., Altaf, I., Ahmed, G., Asad, S., Ahmad, H., Zia, Q., Azhar, A., Farheen, S., Shafi, T., Karim, S., et al. (2023) · Vaccines · doi:10.3390/vaccines11010100 · Cited by 13 · see citing works
He, J., Wang, X., Zhao, D., Geng, B., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1028932 · Cited by 10 · see citing works
Mangiferin alleviates cisplatin-induced ototoxicity in sensorineural hearing loss
Lu, X., Yin, N., Chen, C., Zhou, Y., Ji, L., Zhang, B., & Hu, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117174 · Cited by 10 · see citing works
Ionic liquids vs. ethanol as extraction media of algicidal compounds from mango processing waste
Segatto, M. L., Schnarr, L., Olsson, O., Kümmerer, K., & Zuin, V. G. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.986987 · Cited by 10 · see citing works
Aboyewa, J. A., Sibuyi, N. R. S., Goboza, M., Murtz, L.-A., Oguntibeju, O. O., & Meyer, M. (2022) · Nanomaterials · doi:10.3390/nano12213918 · Cited by 10 · see citing works
Suryawanshi, R. M., Shimpi, R. B., Muralidharan, V., Nemade, L. S., Gurugubelli, S., Baig, S., Vikhe, S. R., Dhawale, S. A., Mortuza, M. R., Sweilam, S. H., et al. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202402738 · Cited by 9 · see citing works
Melo-Betances, E., Rodríguez-Bautista, C. C., & Sellés, A. J. N. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1598719 · Cited by 8 · see citing works
Popa, A., Usatiuc, L.-O., Scurtu, I. C., Murariu, R., Cofaru, A., Pop, R., Tăbăran, F., Gherman, L.-M., Vălean, D., Bolunduț, A. C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189970 · Cited by 8 · see citing works
Askari, V. R., Saadat, S., Rahimi, V. B., Kamelnia, E., & Boskabady, M. H. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115495 · Cited by 7 · see citing works
Prabhakar, P., Pavankumar, G. S., Raghu, S. V., Rao, S., Prasad, K., George, T., & Baliga, M. S. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220601151931 · Cited by 7 · see citing works
Gan, Y., Guo, F., Roy, A., Wang, X., & Shen, Y. (2025) · Viruses · doi:10.3390/v17070873 · Cited by 6 · see citing works
Whey protein-κ-carrageenan coated Mangiferin liposomes for enhanced stability and bioavailability
Zhang, Y., Gu, Y., Yu, L.-F., & Yan, L.-X. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150763 · Cited by 6 · see citing works
Xia, J., Li, X., Yao, J., Song, D., Gu, Z., Zheng, G., & Tu, C. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111520 · Cited by 5 · see citing works
Tsyganova, A. V., Petrov, A. O., Shastin, A. V., Filatova, N. V., Mumyatova, V. A., Tarasov, A. E., Lolaeva, A. V., & Malkov, G. V. (2023) · Chemistry · doi:10.3390/chemistry6010001 · Cited by 5 · see citing works
Gu, Y., Zhang, L., & Bai, Y. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12782 · Cited by 5 · see citing works
Filonova, M. V., Krivoshchekov, S. V., Zinner, N. S., Исаков, Д. А., Reshetov, Y., Churin, A. A., & Belousov, M. V. (2024) · Russian Journal of Plant Physiology · doi:10.1134/s1021443724607298 · Cited by 4 · see citing works
Vishwakarma, K. K., Hafeez, A., Usmani, S. A., Noor, L., & Khan, I. R. (2025) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010318524240907135527 · Cited by 4 · see citing works
Mangiferin in human disease: Multifaceted mechanisms and applications (Review)
Dai, Y., Huang, Q., Tan, M., Wang, Z., Jiang, C., Liu, Z., Zhang, S., & Song, S. (2026) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2026.5736 · Cited by 3 · see citing works
“A comprehensive summary of the targets, dosages, study models, signaling pathways and mechanistic insights associated with MGF across different cancer‑related contexts is presented in Table I (4,5,7,8,13‑17,55,56,107‑114).”
InfluentialCastellote‐Caballero, Y., Beltrán-Arranz, A., Aibar‐Almazán, A., Carcelén‐Fraile, M. D. C., Rivas-Campo, Y., López-Ríos, L., Vega-Morales, T., & González-Martín, A. M. (2025) · Pharmaceuticals · doi:10.3390/ph18040571 · Cited by 3 · see citing works
Unlocking Mangiferin: A Therapeutic Candidate Revolutionizing Liver Disease Therapy
Xie, J., Su, S., Wu, J., Xing, Y., Zhang, Q., Shen, X., Zhao, L., Wang, T., Feng, N., Su, J., et al. (2025) · Nutrients · doi:10.3390/nu17213401 · Cited by 3 · see citing works
Shaikenov, R. O., Klimshina, V. I., Generalova, Y. E., Serbun, P., Косова, А. Д., Dorogov, M. V., Morozkina, S. N., & Снетков, П. П. (2024) · doi:10.3390/engproc2024081002 · Cited by 3 · see citing works
Self-citationInhibition of Peroxidation Potential and Protein Oxidative Damage by Metal Mangiferin Complexes
Sellés, A. J. N., Nuevas-Paz, L., & Martı́nez-Sánchez, G. (2022) · Applied Sciences · doi:10.3390/app12042240 · Cited by 3 · see citing works
JAIN, R., Tiwari, R., Agrawal, O. P., & Shukla, A. K. (2023) · Asian Journal of Chemistry · doi:10.14233/ajchem.2023.28268 · Cited by 3 · see citing works
Samadarsi, R., Nayak, A., & Dutta, D. (2023) · BioNanoScience · doi:10.1007/s12668-023-01275-y · Cited by 3 · see citing works
Turkar, M. K., Sahu, R., & Jain, D. (2024) · Current Organic Chemistry · doi:10.2174/0113852728327099240926074205 · Cited by 3 · see citing works
Mangiferin as a potential inhibitor of transthyretin fibrillogenesis
Грудинина, Н. А., Petukhov, M., Sokolov, A. V., Shaldzhyan, A. A., Zabrodskaya, Y. A., Gavrilova, N. V., Morozkina, S. N., & Egorov, V. V. (2025) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2025.109007 · Cited by 2 · see citing works
Self-citationIn vivo and in vitro evidence for growth hormone-like bioactivity of Rhizoma Anemarrhenae extract
Wang, Y.-C., Chen, K. T., Lin, S.-C., Hsu, Y.-A., Chang, C., Lin, E., Lin, H., Chen, C.-S., & Wan, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113489 · Cited by 2 · see citing works
Saxena, P., Sharma, D., Gautam, P., Niranjan, A., & Rastogi, S. (2024) · Natural Product Research · doi:10.1080/14786419.2024.2361476 · Cited by 4 · see citing works
Saravanan, H., Maida Engels, S. E., & Ramanathan, M. (2025) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2025.100002 · Cited by 2 · see citing works
Polymeric matrices for mangiferin delivery: Ways to enhance bioavailability and therapeutic effect
Shaikenov, R. O., Klimshina, V. I., Morozkina, S. N., & Snetkov, P. P. (2025) · The 5th International Electronic Conference on Applied Sciences · doi:10.3390/engproc2025087078 · Cited by 2 · see citing works
Self-citationShijith, K. V., Charyulu, N. R., Sarath Chandran, C., Patil, P., & Jose, J. (2025) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2025.00400 · Cited by 1 · see citing works
Jie, L., Huang, H., Sha, L., Zhang, L., Wang, Y., & Cao, Y. T. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115924 · Cited by 1 · see citing works
Lipid metabolism in cancer is regulated by the integrated natural product–miRNA–target axis
Chuang, Y.-T., Yen, C.-Y., Tsai, Y., Chang, F., Farooqı, A. A., & Chang, H.-W. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.11.024 · Cited by 1 · see citing works
Li, Y., Wu, L.-S., Lyu, M.-T., Li, Y., Wang, T., Xu, F.-Q., Wu, D.-L., & Zhou, W.-X. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109592 · Cited by 1 · see citing works
Kar, S., Patra, S., Thaisaeng, W., Theppitak, C., Thasana, N., & Bag, B. G. (2026) · RSC Advances · doi:10.1039/d6ra01279e · Cited by 1 · see citing works
Mokal, R., & Jadhav, A. P. (2022) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.1032 · Cited by 1 · see citing works
Mangiferin-Loaded Nanofibers Based on Hyaluronic Acid
Klimshina, V. I., Снетков, П. П., Morozkina, S. N., & Uspenskaya, M. V. (2023) · Bulletin of the Russian Academy of Sciences Physics · doi:10.3103/s1062873823701940 · Cited by 1 · see citing works
Self-citationNikule, H. A., Nikam, T. D., Shirke, H. A., Sule, V. A., Naik, A., & Borde, M. (2023) · Notulae Scientia Biologicae · doi:10.55779/nsb15311644 · Cited by 1 · see citing works
Al‐Madhagi, H. (2025) · Journal Of Biochemical Technology · doi:10.51847/2qnw4q3ffy · Cited by 1 · see citing works
Comparison of Major Compounds of Coffee Tree Leaf Extract by Varieties Cultivated in Korea
Lee, K. I., Back, J. H., Pyo, B. S., & Cha, S. W. (2022) · Korean Journal of Medicinal Crop Science · doi:10.7783/kjmcs.2022.30.6.401 · Cited by 1 · see citing works
Hage, A. G., & Jadhav, A. P. (2022) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.1002
Lopes, L., & Sannomiya, M. (2023) · Anais Congresso Sul-Americano de Resíduos Sólidos e Sustentabilidade · doi:10.55449/conresol.6.23.i-028
Challenges associated with nanocurcumin anticancer drug delivery systems
Deb, D., Chakraborty, S., Ghosh, S., & Sil, P. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15412-6.00003-9
Mangiferin-loaded nanofibers based on hyaluronic acid
Klimshina, V. I., Снетков, П. П., Morozkina, S. N., & Uspenskaya, M. V. (2023) · Известия Российской академии наук Серия физическая · doi:10.31857/s0367676523701387
Self-citationOral toxicity of the acetone extract of Coffea arabica var. Oro Azteca leaves in CD-1 mice
Velázquez-Jiménez, I., Rocha‐Guzmán, N. E., Moreno‐Jiménez, M. R., Vázquez-Cabral, B. D., Macías-Salas, A., Salas-Pacheco, J. M., Herrera-Rocha, K. M., González‐Laredo, R. F., & Gallegos‐Infante, J. A. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.115018
Филонова, М. В., Кривощеков, С. В., Zinner, N. S., Исаков, Д. А., Reshetov, Y., Churin, A. A., & Белоусов, М. В. (2024) · Russian Journal of Plant Physiology · doi:10.31857/s0015330324060066
Снетков, П. П., Shaikenov, R. O., Klimshina, V. I., Generalova, Y. E., & Morozkina, S. N. (2025) · Drug development & registration · doi:10.33380/2305-2066-2025-14-1-1881
Self-citationAqil, A., Yasmeen, I., Parveen, I., Nadaf, A., Jiba, U., Adil, M., Hasan, N., Kesharwani, P., & Ahmad, F. J. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177354
RetractedBaruah, R. R., & Patle, D. (2025) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2025.100060
Singh, R. K., Pradhan, A. K., Roy, D., Arya, M., Chakravarti, R., Dutta, D., Kundu, A., Bhaduri, S., Singh, P., Kazi, T. A., et al. (2025) · Respiratory Medicine · doi:10.1016/j.rmed.2025.108519
Chakraborty, A., & Adhikari, T. (2025) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-025-03723-7
Zhang, Y., Zhang, R., Wang, B., Dai, X., Yan, X., Liu, X., Yang, L., Liu, B., Jin, H., Liu, L., et al. (2025) · BMC Genomics · doi:10.1186/s12864-025-12391-2
Molecular Insight of Mangiferin in Cancer Chemoprevention: A Review Article
Ateeb, M., Nazar, M. S., Zakki, S. A., Raza, A., & Hafeez, U. (2026) · Pakistan BioMedical Journal · doi:10.54393/pbmj.v9i2.1342
Dixit, T., Gawas, T., Sawardekar, M., Gaonkar, A. S., & Ravindran, S. (2026) · Discover Materials · doi:10.1007/s43939-026-00652-0
Saentaweesuk, S., Chaikham, P., & Surayot, U. (2026) · Food Chemistry Advances · doi:10.1016/j.focha.2026.101323
Belen, S. N., & Özay, Ö. (2026) · Gels · doi:10.3390/gels12070583
Ragni, G., Mushtaq, M. A., Bhat, I. A., Khanday, F. N., Kaiser, P. J., Zabeer, A., & Tasduq, S. A. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110454
Molecular Insight of Mangiferin in Cancer Chemoprevention: A Review Article
Ateeb, M., Nazar, M. S., Zakki, S. A., Raza, A., & Hafeez, U. (2026) · Pakistan BioMedical Journal · doi:10.54393/pbmj.v9i3.1342
Antiviral potential of mangiferin, a natural plant polyphenol compound
Li, Y., Yang, J., Xu, G., & Cao, Z. (2026) · Natural Product Research · doi:10.1080/14786419.2026.2748465
- Authors
- Morozkina, S. N., Nhung Vu, T. H., Generalova, Y. E., Snetkov, P. P., & Uspenskaya, M. V.
- Affiliations
- ITMO University (RU)
- Institute BioEngineering, ITMO University, Kronverkskiy Prospekt, 49A, 197101 Saint-Petersburg, Russia
- Department of Analytical Chemistry, Faculty of Industrial Technology of Dosage Forms, Saint Petersburg State Chemical Pharmaceutical University, Prof. Popova Street 14A, 197022 Saint-Petersburg, Russia
- Corresponding author
- Morozkina, Svetlana N.
- Venue
- Biomolecules
- Publisher
- MDPI AG
- Published
- 2021-01-09
- Volume
- 11
- Issue
- 1
- Pages
- 79
- ISSN
- 2218-273X (ISSN-L)
- PMC
- PMC7827323
- OpenAlex
- W3120353277
- Cited by
- 82
- References
- 159
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 14 · 2023: 18 · 2022: 15 · 2021: 5
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomolecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- mangiferin, anticancer activity, polymer-drug conjugates, oral bioavailability, solubility enhancement, natural products, drug delivery systems
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Polymers, Solvents, Sonication, Nanotechnology, Xanthones
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