High-resolution nuclear magnetic resonance spectroscopic study of metabolites in the cerebrospinal fluid of patients with cervical myelopathy and lumbar radiculopathy
Open accessAbstract
There have been few reports describing substances related to oxidative and intermediary metabolism in the cerebrospinal fluid (CSF) in patients with spinal degenerative disorders. This study investigated whether the concentrations of metabolites in the CSF differed between patients with spinal degenerative disorders and controls, and whether the concentrations of these metabolites correlated with the severity of symptoms. CSF samples were obtained from 30 patients with cervical myelopathy (Group M), 30 patients with lumbar radiculopathy (Group R), and 10 volunteers (control). Metabolites in these CSF samples were measured by nuclear magnetic resonance spectroscopy. There were no differences in the concentrations of lactate, alanine, acetate, glutamate, pyruvate, or citrate between Groups M and R, between Group M and the control, or between Group R and the control. In Group M, neither symptom duration nor the Japanese Orthopaedic Association score correlated with the concentration of any metabolite. In Group R, the symptom duration positively correlated with the concentration of lactate, glutamate, and citrate in CSF. The duration of nerve root block showed a negative correlation with the concentrations of acetate in CSF of the patients in Group R. In patients with lumbar radiculopathy, there is a possibility of increased aerobic metabolic activity or decreased gluconeogenic activity in patients with shorter symptom duration, and increased aerobic metabolic activity in patients with severe inflammation around a nerve root.
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Only acetate has been detected in cerebral spinal fluid at approximate concentrations of 35 μmol/L.
“As such, only acetate has been detected in cerebral spinal fluid (CSF) at approximate concentrations of 35 µmol/L (Nagashima et al., 2010)”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Nagashima et al., 2010
Table 1 reports acetate concentrations of 35.91 and 36.15 µmol/L in the two patient groups, supporting the approximate figure of 35 µmol/L. But the Results also state that lactate, alanine, glutamate, pyruvate, and citrate were detected in CSF, so acetate was not the only metabolite detected. Our copy provides no page number for these passages. (LLM, conf=0.90)
Experimental — accuracy not yet measuredAcetate is present in cerebrospinal fluid, and gut microbial-derived acetate reaches the brain and triggers PNS signaling.
“Specifically, acetate has been reported to be present in the cerebrospinal fluid, and gut microbial-derived acetate has been shown to reach the brain and trigger PNS signaling (Nagashima et al., 2010;Perry et al., 2016).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Nagashima et al., 2010
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Research works printed but not linked: 3
- Beattie DS (2006) Bioenergetics and oxidative metabolism. In: Devlin TM (ed) Textbook of biochemistry with clinical correla- tions, 6th edn. Wiley, New Jersey, pp 529-580
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- Nagashima H, Morio Y, Yamane K, Nanjo Y, Teshima R (2009) Tumor necrosis factor-a, interleukin-1b, and interleukin-6 in the cerebrospinal fluid of patients with cervical myelopathy and lumbar radiculopathy. Eur Spine J 18:1946-1950. doi: 10.1007/s00586-009-1069-7 · DOI
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The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
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- Authors
- Nagashima, H., Morio, Y., Meshitsuka, S., Yamane, K., Nanjo, Y., & Teshima, R.
- Affiliations
- Tottori University (JP)
- Misasa Onsen Hospital (JP)
- Corresponding author
- Nagashima, Hideki
- ORCID
- Nagashima, Hideki
- Venue
- European Spine Journal
- Published
- 2010-05-20
- Volume
- 19
- Issue
- 8
- Pages
- 1363-1368
- ISSN
- 0940-6719 (ISSN-L)
- 1432-0932
- PMC
- PMC2989206
- OpenAlex
- W2095400992
- Cited by
- 35
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 4 · 2018: 1 · 2016: 1 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Spine Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spine and Intervertebral Disc Pathology
- Health Sciences › Medicine › Surgery › Cervical and Thoracic Myelopathy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- cerebrospinal fluid metabolites, cervical myelopathy, lumbar radiculopathy, lactate, glutamate, citrate, acetate, pyruvate, symptom duration, nerve root inflammation, aerobic metabolism, gluconeogenesis, JOA score
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alanine, Cervical Vertebrae, Female, Humans, Lumbar Vertebrae, Male, Middle Aged, Magnetic Resonance Spectroscopy, Radiculopathy, Spinal Cord Compression, Glutamic Acid, Pyruvic Acid, Acetic Acid, Citric Acid, Lactic Acid
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