Short chain fatty acids in human gut and metabolic health

Blaak, E.E.; Canfora, E.E.; Theis, S.; Frost, G.; Groen, A.K.; Mithieux, G.; Nauta, A.; Scott, K.; Stahl, B.; van Harsselaar, J.; van Tol, R.; Vaughan, E.E.; Verbeke, K.

doi:10.3920/bm2020.0057

Cited by 1,103Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented Foods

Short chain fatty acids in human gut and metabolic health

Open access

Blaak, E.E., Canfora, E.E., Theis, S., Frost, G., Groen, A.K., Mithieux, G., Nauta, A., Scott, K. +5 more·2020·Beneficial Microbes

DOI 10.3920/bm2020.0057

Open this paper in CoChat — free account Open PDF

Abstract

Evidence is accumulating that short chain fatty acids (SCFA) play an important role in the maintenance of gut and metabolic health. The SCFA acetate, propionate and butyrate are produced from the microbial fermentation of indigestible carbohydrates and appear to be key mediators of the beneficial effects elicited by the gut microbiome. Microbial SCFA production is essential for gut integrity by regulating the luminal pH, mucus production, providing fuel for epithelial cells and effects on mucosal immune function. SCFA also directly modulate host metabolic health through a range of tissue-specific mechanisms related to appetite regulation, energy expenditure, glucose homeostasis and immunomodulation. Therefore, an increased microbial SCFA production can be considered as a health benefit, but data are mainly based on animal studies, whereas well-controlled human studies are limited. In this review an expert group by ILSI Europe's Prebiotics Task Force discussed the current scientific knowledge on SCFA to consider the relationship between SCFA and gut and metabolic health with a particular focus on human evidence. Overall, the available mechanistic data and limited human data on the metabolic consequences of elevated gut-derived SCFA production strongly suggest that increasing SCFA production could be a valuable strategy in the preventing gastro-intestinal dysfunction, obesity and type 2 diabetes mellitus. Nevertheless, there is an urgent need for well controlled longer term human SCFA intervention studies, including measurement of SCFA fluxes and kinetics, the heterogeneity in response based on metabolic phenotype, the type of dietary fibre and fermentation site in fibre intervention studies and the control for factors that could shape the microbiome like diet, physical activity and use of medication.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3920/bm2020.0057

Cites

250 of 250 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The genera Bacteroides, Akkermasia, Faecalibacterium, and Eubacterium can provide physiological functions not always conferred directly by bifidobacteria or lactobacilli, such as production of butyrate, propionate, and other bioactive compounds.
“Also, these genera can provide physiological functions that are not always conferred directly by bifidobacteria or lactobacilli (the production of butyrate, propionate, and other bioactive) [232].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [232]
SCFAs, specifically butyrate, have been implicated in gastrointestinal and metabolic health, exert anti-inflammatory and immunomodulatory properties, and can influence central functioning.
“SCFAs, specifically butyrate, have been implicated in gastrointestinal (main energy source of colonocytes, supporting gut barrier function) and metabolic (glucose homeostasis, lipid oxidation) health, exert anti-inflammatory and immunomodulatory properties, and can influence central functioning (as outlined in detail below) (119, 120).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [120]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Butyrate Attenuates Lipopolysaccharide-Induced Inflammation in Intestinal Cells and Crohn's Mucosa through Modulation of Antioxidant Defense Machinery
Russo, I., Luciani, A., Cicco, P. D., Troncone, E., & Ciacci, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032841 · Cited by 105 · see citing works
Retracted
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works
Self-citation
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119 · see citing works
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750 · see citing works
Review article: the role of butyrate on colonic function
HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721 · see citing works
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works
Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
Tolhurst, G., Heffron, H., Lam, Y. S., Parker, H. E., Habib, A. M., Diakogiannaki, E., Cameron, J., Grosse, J., Reimann, F., & Gribble, F. M. (2012) · Diabetes · doi:10.2337/db11-1019 · Cited by 2,404 · see citing works
Population-level analysis of gut microbiome variation
Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., Kurilshikov, A., Bonder, M. J., Valles-Colomer, M., Vandeputte, D., et al. (2016) · Science · doi:10.1126/science.aad3503 · Cited by 2,400 · see citing works
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes
Zhao, L., Zhang, F., Ding, X., Wu, G., Lam, Y. Y., Wang, X., Fu, H., Xue, X., Lu, C., Ma, J., et al. (2018) · Science · doi:10.1126/science.aao5774 · Cited by 2,304 · see citing works
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298 · see citing works
Self-citation
Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health
Ríos-Covián, D., Ruas‐Madiedo, P., Margollés, A., Gueimonde, M., Reyes‐Gavilán, C. G. D. L., & Salazar, N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00185 · Cited by 2,215 · see citing works
Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204 · see citing works
Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits
De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2014) · Cell · doi:10.1016/j.cell.2013.12.016 · Cited by 2,200 · see citing works
Self-citation
Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130 · see citing works
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Frost, G., Sleeth, M. L., Sahuri-Arisoylu, M., Lizarbe, B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4611 · Cited by 1,771 · see citing works
Self-citation
The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization
DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770 · see citing works
Regulation of inflammation by short chain fatty acids
Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724 · see citing works
Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function
Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716 · see citing works
Dominant and diet-responsive groups of bacteria within the human colonic microbiota
Walker, A. W., Ince, J., Duncan, S. H., Webster, L. M., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.118 · Cited by 1,632 · see citing works
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564 · see citing works
Inhibition of Histone Deacetylase Activity by Butyrate
Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515 · see citing works
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
Kimura, I., Ozawa, K., Inoue, D., Imamura, T., Kimura, K., Maeda, T., Terasawa, K., Kashihara, D., Hirano, K., Tani, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2852 · Cited by 1,512 · see citing works
Gut microbial metabolites in obesity, NAFLD and T2DM
Canfora, E. E., Meex, R. C. R., Venema, K., & Blaak, E. E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0156-z · Cited by 1,493 · see citing works
Self-citation
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7734 · Cited by 1,439 · see citing works
Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults
Chambers, E. S., Viardot, A., Psichas, A., Morrison, D. J., Murphy, K. G., Zac-Varghese, S. E. K., MacDougall, K., Preston, T., Tedford, C., Finlayson, G. S., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-307913 · Cited by 1,424 · see citing works
Self-citation
Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms
Lin, H. V., Frassetto, A., Kowalik Jr, E. J., Nawrocki, A. R., Lu, M. M., Kosinski, J. R., Hubert, J. A., Szeto, D., Yao, X., Forrest, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035240 · Cited by 1,378 · see citing works
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A., van der Post, S., Svensson, F., Rodríguez‐Piñeiro, A. M., Nyström, E. E. L., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12182 · Cited by 1,363 · see citing works
A new genomic blueprint of the human gut microbiota
Almeida, A., Mitchell, A. L., Boland, M., Forster, S. C., Gloor, G. B., Tarkowska, A., Lawley, T. D., & Finn, R. D. (2019) · Nature · doi:10.1038/s41586-019-0965-1 · Cited by 1,314 · see citing works
Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man.
Roediger, W. E. (1980) · Gut · doi:10.1136/gut.21.9.793 · Cited by 1,310 · see citing works
Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway
Park, J., Kim, M., Kang, S. G., Jannasch, A. H., Cooper, B., Patterson, J., & Kim, C. H. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.44 · Cited by 1,307 · see citing works
Phylogenetic distribution of three pathways for propionate production within the human gut microbiota
Reichardt, N., Duncan, S. H., Young, P., Belenguer, Á., Leitch, E. C. M., Scott, K. P., Flint, H. J., & Louis, P. (2014) · The ISME Journal · doi:10.1038/ismej.2014.14 · Cited by 1,302 · see citing works
Self-citation
Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome
Perry, R. J., Peng, L., Barry, N. A., Cline, G. W., Zhang, D., Cardone, R. L., Petersen, K. F., Kibbey, R. G., Goodman, A. L., & Shulman, G. I. (2016) · Nature · doi:10.1038/nature18309 · Cited by 1,299 · see citing works
Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice
Kim, M. H., Kang, S. G., Park, J. H., Yanagisawa, M., & Kim, C. H. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.056 · Cited by 1,127 · see citing works
Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation
den Besten, G., Bleeker, A., Gerding, A., van Eunen, K., Havinga, R., van Dijk, T. H., Oosterveer, M. H., Jonker, J. W., Groen, A. K., Reijngoud, D.-J., et al. (2015) · Diabetes · doi:10.2337/db14-1213 · Cited by 1,125 · see citing works
Self-citation
Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon
Ze, X., Duncan, S. H., Louis, P., & Flint, H. J. (2012) · The ISME Journal · doi:10.1038/ismej.2012.4 · Cited by 1,060 · see citing works
The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond
Halestrap, A. P., & Meredith, D. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1067-2 · Cited by 1,054 · see citing works
The influence of diet on the gut microbiota
Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.020 · Cited by 1,052 · see citing works
Self-citation
Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition
Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.008 · Cited by 1,039 · see citing works
Self-citation
Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces
Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J., & Lobley, G. E. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02340-06 · Cited by 941 · see citing works
The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents
Psichas, A., Sleeth, M. L., Murphy, K. G., Brooks, L., Bewick, G. A., Hanyaloglu, A. C., Ghatei, M. A., Bloom, S. R., & Frost, G. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.153 · Cited by 886 · see citing works
Self-citation
Two Routes of Metabolic Cross-Feeding between Bifidobacterium adolescentis and Butyrate-Producing Anaerobes from the Human Gut
Belenguer, A., Duncan, S. H., Calder, A. G., Holtrop, G., Louis, P., Lobley, G. E., & Flint, H. J. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.5.3593-3599.2006 · Cited by 856 · see citing works
Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein claudin-1 transcription
Wang, H.-B., Wang, P.-Y., Wang, X., Wan, Y.-L., & Liu, Y.-C. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2259-4 · Cited by 827 · see citing works
Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women
Dewulf, E. M., Cani, P. D., Claus, S. P., Fuentes, S., Puylaert, P. G., Neyrinck, A. M., Bindels, L. B., de Vos, W. M., Gibson, G. R., Thissen, J.-P., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303304 · Cited by 825 · see citing works
Effect of inulin on the human gut microbiota: stimulation of Bifidobacterium adolescentis and Faecalibacterium prausnitzii
Ramirez-Farias, C., Slezak, K., Fuller, Z., Duncan, A., Holtrop, G., & Louis, P. (2008) · British Journal of Nutrition · doi:10.1017/s0007114508019880 · Cited by 822 · see citing works
Diversity of human colonic butyrate‐producing bacteria revealed by analysis of the butyryl‐CoA:acetate CoA‐transferase gene
Louis, P., Young, P., Holtrop, G., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02066.x · Cited by 783 · see citing works
High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health
Russell, W. R., Gratz, S. W., Duncan, S. H., Holtrop, G., Ince, J., Scobbie, L., Duncan, G., Johnstone, A. M., Lobley, G. E., Wallace, R. J., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002188 · Cited by 775 · see citing works
Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
Cani, P. D., Lecourt, E., Dewulf, E. M., Sohet, F. M., Pachikian, B. D., Naslain, D., Backer, F. D., Neyrinck, A. M., & Delzenne, N. M. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28095 · Cited by 763 · see citing works
Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation
Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 748 · see citing works
Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults
Parnell, J. A., & Reimer, R. A. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27465 · Cited by 728 · see citing works
The contribution of the large intestine to energy supplies in man
N I, M. (1984) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/39.2.338 · Cited by 691 · see citing works
Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health
Chambers, E. S., Preston, T., Frost, G., & Morrison, D. J. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0248-8 · Cited by 691 · see citing works
Self-citation
Comparison of fermentation reactions in different regions of the human colon
Macfarlane, G. T., Gibson, G. R., & Cummings, J. H. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb04882.x · Cited by 676 · see citing works
Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit
Li, Z., Yi, C.-X., Katiraei, S., Kooijman, S., Zhou, E., Chung, C. K., Gao, Y., van den Heuvel, J. K., Meijer, O. C., Berbée, J. F. P., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-314050 · Cited by 674 · see citing works
Self-citation
Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways
Tan, J., McKenzie, C. I., Vuillermin, P., Goverse, G., Vinuesa, C. G., Mebius, R. E., Macia, L., & Mackay, C. R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.047 · Cited by 666 · see citing works
Resistant Starches Types 2 and 4 Have Differential Effects on the Composition of the Fecal Microbiota in Human Subjects
Martínez, I., Kim, J., Duffy, P. R., Schlegel, V. L., & Walter, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015046 · Cited by 645 · see citing works
Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating g protein-coupled receptors and gut microbiota
Lu, Y., Fan, C., Li, P., Lu, Y., Chang, X., & Qi, K. (2016) · Scientific Reports · doi:10.1038/srep37589 · Cited by 638 · see citing works
Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms
Al-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.007 · Cited by 614 · see citing works
Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43
Hong, Y.-H., Nishimura, Y., Hishikawa, D., Tsuzuki, H., Miyahara, H., Gotoh, C., Choi, K.-C., Feng, D. D., Chen, C., Lee, H.-G., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0545 · Cited by 613 · see citing works
The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: Implications for epithelial protection
Burger-van Paassen, N., Vincent, A., Puiman, P. J., van der Sluis, M., Bouma, J., Boehm, G., van Goudoever, J. B., van Seuningen, I., & Renes, I. B. (2009) · Biochemical Journal · doi:10.1042/bj20082222 · Cited by 611 · see citing works
Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids
den Besten, G., Lange, K., Havinga, R., van Dijk, T. H., Gerding, A., van Eunen, K., Müller, M. M., Groen, A. K., Hooiveld, G. J. E. J., Bakker, B. M., et al. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00265.2013 · Cited by 606 · see citing works
Self-citation
Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2
Zheng, L., Kelly, C. J., Battista, K. D., Schaefer, R., Lanis, J. M., Alexeev, E. E., Wang, R. X., Onyiah, J. C., Kominsky, D. J., & Colgan, S. P. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700105 · Cited by 549 · see citing works
Fermentation of Fructooligosaccharides and Inulin by Bifidobacteria: a Comparative Study of Pure and Fecal Cultures
Rossi, M., Corradini, C., Amaretti, A., Nicolini, M., Pompei, A., Zanoni, S., & Matteuzzi, D. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.10.6150-6158.2005 · Cited by 546 · see citing works
Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E 1 and E 2 production by intestinal myofibroblasts
Willemsen, L. E. M., Koetsier, M. A., van Deventer, S. J. H., & van Tol, E. A. F. (2003) · Gut · doi:10.1136/gut.52.10.1442 · Cited by 518 · see citing works
Restricted Distribution of the Butyrate Kinase Pathway among Butyrate-Producing Bacteria from the Human Colon
Louis, P., Duncan, S. H., McCrae, S. I., Millar, J., Jackson, M. S., & Flint, H. J. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.7.2099-2106.2004 · Cited by 517 · see citing works
Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance
McNabney, S. M., & Henagan, T. M. (2017) · Nutrients · doi:10.3390/nu9121348 · Cited by 513 · see citing works
Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion
Andrade‐Oliveira, V., Amano, M. T., Corrêa-Costa, M., Castoldi, Â., Felizardo, R. J. F., de Almeida, D. C., Bassi, Ê. J., Moraes‐Vieira, P. M., Hiyane, M. I., Rodas, A. C. D., et al. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014030288 · Cited by 504 · see citing works
The luminal short-chain fatty acid butyrate modulates NF-κB activity in a human colonic epithelial cell line
Inan, M. S., Rasoulpour, R. J., Yin, L., Hubbard, A. K., Rosenberg, D. W., & Giardina, C. A. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70142-9 · Cited by 502 · see citing works
Insulin-Sensitizing Effects of Dietary Resistant Starch and Effects on Skeletal Muscle and Adipose Tissue Metabolism
Robertson, M. D., Bickerton, A. S., Dennis, A. L., Vidal, H., & Frayn, K. N. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.3.559 · Cited by 501 · see citing works
Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43
Wu, W. H., Sun, M., Chen, F., Cao, A., Liu, H., Zhao, Y., Huang, X., Xiao, Y., Yao, S., Zhao, Q., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.114 · Cited by 500 · see citing works
Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats
Fukumoto, S., Tatewaki, M., Yamada, T., Fujimiya, M., Mantyh, C., Voss, M., Eubanks, S., Harris, M., Pappas, T. N., & Takahashi, T. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00442.2002 · Cited by 465 · see citing works
Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine
Karaki, S.-I., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J., & Kuwahara, A. (2006) · Cell and Tissue Research · doi:10.1007/s00441-005-0140-x · Cited by 465 · see citing works
Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway
Yan, H., & Ajuwon, K. M. (2017) · PLOS ONE · doi:10.1371/journal.pone.0179586 · Cited by 456 · see citing works
Systemic availability and metabolism of colonic‐derived short‐chain fatty acids in healthy subjects: a stable isotope study
Boets, E., Gomand, S. V., Deroover, L., Preston, T., Vermeulen, K., De Preter, V., Hamer, H. M., Van den Mooter, G., De Vuyst, L., Courtin, C. M., et al. (2017) · The Journal of Physiology · doi:10.1113/jp272613 · Cited by 443 · see citing works
Self-citation
Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier
Zhou, D., Pan, Q., Xin, F.-Z., Zhang, R.-N., He, C.-X., Chen, G.-Y., Liu, C., Chen, Y.-W., & Fan, J.-G. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i1.60 · Cited by 441 · see citing works
Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B 12 Production by Intestinal Symbionts
Belzer, C., Chia, L. W., Aalvink, S., Chamlagain, B., Piironen, V. I., Knol, J., & de Vos, W. M. (2017) · mBio · doi:10.1128/mbio.00770-17 · Cited by 439 · see citing works
The effect of short-chain fatty acids on human monocyte-derived dendritic cells
Nastasi, C., Candela, M., Bonefeld, C. M., Geisler, C., Hansen, M., Krejsgaard, T., Biagi, E., Andersen, M. H., Brigidi, P., Ødum, N., et al. (2015) · Scientific Reports · doi:10.1038/srep16148 · Cited by 414 · see citing works
Butyrate modulates oxidative stress in the colonic mucosa of healthy humans
Hamer, H. M., Jonkers, D. M. A. E., Bast, A., Vanhoutvin, S. A. L. W., Fischer, M. A. J. G., Kodde, A., Troost, F. J., Venema, K., & Brummer, R.-J. M. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2008.11.002 · Cited by 400 · see citing works
Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon
Barcelo, A., Claustre, J., Moro, F., Chayvialle, J.-A., Cuber, J.-C., & Plaisancié, P. (2000) · Gut · doi:10.1136/gut.46.2.218 · Cited by 375 · see citing works
Cross-Feeding between Bifidobacterium longum BB536 and Acetate-Converting, Butyrate-Producing Colon Bacteria during Growth on Oligofructose
Falony, G., Vlachou, A., Verbrugghe, K., & Vuyst, L. D. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01296-06 · Cited by 362 · see citing works
A Mixture of trans-Galactooligosaccharides Reduces Markers of Metabolic Syndrome and Modulates the Fecal Microbiota and Immune Function of Overweight Adults
Vulevic, J., Juric, A., Tzortzis, G., & Gibson, G. R. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.166132 · Cited by 349 · see citing works
Human Colonic Microbiota: Ecology, Physiology and Metabolic Potential of Intestinal Bacteria
Macfarlane, G. T., & Macfarlane, S. (1997) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1997.11720708 · Cited by 342 · see citing works
Interaction between colonic acetate and propionate in humans
Wolever, T. M. S., Spadafora, P., & Eshuis, H. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.3.681 · Cited by 333 · see citing works
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
Canfora, E. E., van der Beek, C. M., Jocken, J. W. E., Goossens, G. H., Holst, J. J., Olde Damink, S. W. M., Lenaerts, K., Dejong, C. H. C., & Blaak, E. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-02546-x · Cited by 331 · see citing works
Self-citation
Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat
Cherbut, C., Ferrier, L., Rozé, C., Anini, Y., Blottière, H. M., Lecannu, G., & Galmiche, J. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.6.g1415 · Cited by 316 · see citing works
Acetic Acid Upregulates the Expression of Genes for Fatty Acid Oxidation Enzymes in Liver to Suppress Body Fat Accumulation
Kondo, T., Kishi, M., Fushimi, T., & Kaga, T. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900470c · Cited by 301 · see citing works
Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet
Bjursell, M., Admyre, T., Göransson, M., Marley, A. E., Smith, D. M., Oscarsson, J., & Bohlooly‐Y, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00229.2010 · Cited by 301 · see citing works
Improvement of Obesity and Glucose Tolerance by Acetate in Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
YAMASHITA, H., FUJISAWA, K., ITO, E., IDEI, S., KAWAGUCHI, N., KIMOTO, M., HIEMORI, M., & TSUJI, H. (2007) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.60668 · Cited by 297 · see citing works
Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population
Liu, F., Li, P., Chen, M., Luo, Y., Prabhakar, M., Zheng, H., He, Y., Qi, Q., Long, H., Zhang, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10722-2 · Cited by 297 · see citing works
Cell Differentiation Is a Key Determinant of Cathelicidin LL-37/Human Cationic Antimicrobial Protein 18 Expression by Human Colon Epithelium
Hase, K., Eckmann, L., Leopard, J. D., Varki, N. M., & Kagnoff, M. F. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.953-963.2002 · Cited by 294 · see citing works
Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis
McLoughlin, R. F., Berthon, B. S., Jensen, M. E., Baines, K. J., & Wood, L. G. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156265 · Cited by 293 · see citing works
Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells
Iraporda, C., Errea, A. J., Romanin, D., Cayet, D., Pereyra, E. N., Pignataro, O. P., Sirard, J., Garrote, G. L., Abraham, A. G., & Rumbo, M. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.06.004 · Cited by 284 · see citing works
Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance
Da Silva, H. E., Teterina, A., Comelli, E. M., Taibi, A., Arendt, B. M., Fischer, S. E., Lou, W., & Allard, J. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-19753-9 · Cited by 283 · see citing works
Whole-Genome Transcription Profiling Reveals Genes Up-Regulated by Growth on Fucose in the Human Gut Bacterium “Roseburia inulinivorans”
Scott, K. P., Martin, J. C., Campbell, G. P., Mayer, C., & Flint, H. J. (2006) · Journal of Bacteriology · doi:10.1128/jb.00137-06 · Cited by 282 · see citing works
Self-citation
The diet‐derived short chain fatty acid propionate improves beta‐cell function in humans and stimulates insulin secretion from human islets in vitro
Pingitore, A., Chambers, E. S., Hill, T., Ruz‐Maldonado, I., Liu, B., Bewick, G. A., Morrison, D. J., Preston, T., Wallis, G. A., Tedford, C. M., et al. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12811 · Cited by 280 · see citing works
Self-citation
Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes
Cavaglieri, C. R., Nishiyama, A., Fernandes, L. C., Curi, R., Miles, E. A., & Calder, P. C. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00490-9 · Cited by 279 · see citing works
Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-α
Freeland, K. R., & Wolever, T. M. S. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509991863 · Cited by 275 · see citing works
Regulation of microglial inflammatory response by sodium butyrate and short‐chain fatty acids
Huuskonen, J., Suuronen, T., Nuutinen, T., Kyrylenko, S., & Salminen, A. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705682 · Cited by 274 · see citing works
Gut Microbiota Mediates the Protective Effects of Dietary Capsaicin against Chronic Low-Grade Inflammation and Associated Obesity Induced by High-Fat Diet
Kang, C., Wang, B., Kaliannan, K., Wang, X., Lang, H., Hui, S., Huang, L., Zhang, Y., Zhou, M., Chen, M., et al. (2017) · mBio · doi:10.1128/mbio.00470-17 · Cited by 273 · see citing works
Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation
Aguilar, E. C., Leonel, A. J., Teixeira, L. G., Silva, A. R., da Silva, J. F., Pelaez, J. M. N., Capettini, L. D. S. A., Lemos, V. S., Santos, R. A. S., & Alvarez-Leite, J. I. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.01.002 · Cited by 271 · see citing works
The nutrition‐gut microbiome‐physiology axis and allergic diseases
McKenzie, C. I., Tan, J., Macia, L., & Mackay, C. R. (2017) · Immunological Reviews · doi:10.1111/imr.12556 · Cited by 271 · see citing works
Effects of dietary propionate on carbohydrate and lipid metabolism in healthy volunteers.
Venter, C. S., Vorster, H., & Cummings, J. H. (1990) · PubMed · Cited by 269 · see citing works
Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study
Healey, G., Murphy, R., Butts, C., Brough, L., Whelan, K., & Coad, J. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114517003440 · Cited by 267 · see citing works
Acetic Acid Activates Hepatic AMPK and Reduces Hyperglycemia in Diabetic KK-A (y) Mice
Sakakibara, S., Yamauchi, T., Oshima, Y., Tsukamoto, Y., & Kadowaki, T. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.176 · Cited by 263 · see citing works
Control of the innate epithelial antimicrobial response is cell‐type specific and dependent on relevant microenvironmental stimuli
Schauber, J., Dorschner, R. A., Yamasaki, K., Brouha, B., & Gallo, R. L. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02399.x · Cited by 263 · see citing works
Colonic microflora: Nutrition and health
Cummings, J. H., & Macfarlane, G. T. (1997) · Nutrition · doi:10.1016/s0899-9007(97)00114-7 · Cited by 261 · see citing works
Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin‐degradation in humanized rats
den Abbeele, P. V., Gérard, P., Rabot, S., Bruneau, A., Aidy, S. E., Derrien, M., Kleerebezem, M., Zoetendal, E. G., Smidt, H., Verstraete, W., et al. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02533.x · Cited by 257 · see citing works
Dietary Sodium Butyrate Decreases Postweaning Diarrhea by Modulating Intestinal Permeability and Changing the Bacterial Communities in Weaned Piglets1–3
Huang, C., Song, P., Fan, P. F., Hou, C., Thacker, P. A., & Ma, X. (2015) · Journal of Nutrition · doi:10.3945/jn.115.217406 · Cited by 256 · see citing works
Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate
Sahuri-Arisoylu, M., Brody, L., Parkinson, J. R. C., Parkes, H. G., Navaratnam, N., Miller, A. D., Thomas, E. L., Frost, G. S., & Bell, J. D. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.23 · Cited by 255 · see citing works
Self-citation
On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier
Dutzan, N., Abusleme, L., Bridgeman, H., Greenwell-Wild, T., Zangerle-Murray, T., Fife, M. E., Bouladoux, N., Linley, H., Brenchley, L., Wemyss, K., et al. (2017) · Immunity · doi:10.1016/j.immuni.2016.12.010 · Cited by 252 · cited 1× · see citing works
“…studies have also reported an attenuation of body weight gain with butyrate administration (De Vadder et al. , 2014; Den Besten et al. , 2015; Dutzan et al. , 2017; Guo et al. , 2016; Henagan et al. , 2015; Hong et al. , 2016; Kang et al. , 2017; Lim et al. , 2012; Lu et al. , 2016; Zhou et…”
Intestinal microbiome landscaping: insight in community assemblage and implications for microbial modulation strategies
Shetty, S. A., Hugenholtz, F., Lahti, L., Smidt, H., & de Vos, W. M. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw045 · Cited by 248 · see citing works
Diet, Gut Microbiome, and Bone Health
Weaver, C. M. (2015) · Current Osteoporosis Reports · doi:10.1007/s11914-015-0257-0 · Cited by 246 · see citing works
Butyrate and propionate induced activated or non-activated neutrophil apoptosis via HDAC inhibitor activity but without activating GPR-41/GPR-43 pathways
Aoyama, M., Kotani, J., & Usami, M. (2009) · Nutrition · doi:10.1016/j.nut.2009.07.006 · Cited by 246 · see citing works
Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling
Kaisar, M. M. M., Pelgrom, L. R., van der Ham, A. J., Yazdanbakhsh, M., & Everts, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01429 · Cited by 245 · see citing works
Effect of rectal infusion of short chain fatty acids in human subjects.
Tm, W., Brighenti, F., Royall, D., Al, J., & Dj, J. (1989) · PubMed · Cited by 240 · see citing works
Short-Chain Fatty Acids Activate AMP-Activated Protein Kinase and Ameliorate Ethanol-Induced Intestinal Barrier Dysfunction in Caco-2 Cell Monolayers
Elamin, E. E., Masclee, A., Jan, D., Pieters, H., & Jonkers, D. M. A. E. (2013) · Journal of Nutrition · doi:10.3945/jn.113.179549 · Cited by 237 · see citing works
Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice
Hong, J., Jia, Y., Pan, S., Jia, L., Li, H., Han, Z., Cai, D., & Zhao, R. (2016) · Oncotarget · doi:10.18632/oncotarget.11267 · Cited by 236 · see citing works
Butyrate Attenuates Inflammation and Lipolysis Generated by the Interaction of Adipocytes and Macrophages
Ohira, H., Fujioka, Y., Katagiri, C., Mamoto, R., Aoyama-Ishikawa, M., Amako, K., Izumi, Y., Nishiumi, S., Yoshida, M., Usami, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.15065 · Cited by 235 · see citing works
Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects
Al-Lahham, S., Roelofsen, H., Rezaee, F., Weening, D., Hoek, A., Vonk, R. J., & Venema, K. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02590.x · Cited by 234 · see citing works
Short‐chain fatty acid topical treatment in distal ulcerative colitis
Vernia, P., Marcheggiano, A., Caprilli, R., Frieri, G., Corrao, G., Valpiani, D., Paolo, M. C. D., Paoluzi, P., & Torsoli, A. (1995) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1995.tb00386.x · Cited by 232 · see citing works
Colonic mucin synthesis is increased by sodium butyrate.
Finnie, I. A., Dwarakanath, A. D., Taylor, B. A., & Rhodes, J. M. (1995) · Gut · doi:10.1136/gut.36.1.93 · Cited by 231 · see citing works
Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men
van der Beek, C. M., Canfora, E. E., Lenaerts, K., Troost, F. J., Olde Damink, S. W. M., Holst, J. J., Masclee, A. A. M., Dejong, C. H. C., & Blaak, E. E. (2016) · Clinical Science · doi:10.1042/cs20160263 · Cited by 230 · see citing works
Self-citation
Butyrate modulates bacterial adherence on LS174T human colorectal cells by stimulating mucin secretion and MAPK signaling pathway
Jung, T., Park, J. H., Jeon, W.-M., & Han, K. (2015) · Nutrition Research and Practice · doi:10.4162/nrp.2015.9.4.343 · Cited by 229 · see citing works
Increasing Fecal Butyrate in Ulcerative Colitis Patients by Diet: Controlled Pilot Study
Hallert, C., Björck, I., NYMAN, M. E., Pousette, A., Grännö, C., & Svensson, H. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200303000-00005 · Cited by 228 · see citing works
Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals
Canfora, E. E., van der Beek, C. M., Hermes, G. D. A., Goossens, G. H., Jocken, J. W. E., Holst, J. J., van Eijk, H. M. H., Venema, K., Smidt, H., Zoetendal, E. G., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.051 · Cited by 227 · see citing works
Self-citation
Expression and membrane localization of MCT isoforms along the length of the human intestine
Gill, R. K., Saksena, S., Alrefai, W. A., Sarwar, Z. U., Goldstein, J. L., Carroll, R. E., Ramaswamy, K., & Dudeja, P. K. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00112.2005 · Cited by 223 · see citing works
Regulation of adipokine production in human adipose tissue by propionic acid
Al-Lahham, S., Roelofsen, H., Priebe, M. G., Weening, D., Dijkstra, M., Hoek, A., Rezaee, F., Venema, K., & Vonk, R. J. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02278.x · Cited by 222 · see citing works
GPR43 Potentiates β-Cell Function in Obesity
McNelis, J., Lee, Y. S., Mayoral, R., van der Kant, R., Johnson, A. M. F., Wollam, J., & Olefsky, J. M. (2015) · Diabetes · doi:10.2337/db14-1938 · Cited by 221 · see citing works
Kinetic studies on colonocyte metabolism of short chain fatty acids and glucose in ulcerative colitis.
Clausen, M. R., & Mortensen, P. B. (1995) · Gut · doi:10.1136/gut.37.5.684 · Cited by 217 · see citing works
Propionate lowers blood glucose and alters lipid metabolism in healthy subjects
Todesco, T., Rao, A., Bosello, O., & Jenkins, D. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.5.860 · Cited by 217 · see citing works
G protein-coupled receptor 43 moderates gut inflammation through cytokine regulation from mononuclear cells
Masui, R., Sasaki, M., Funaki, Y., Ogasawara, N., Mizuno, M., Iida, A., Izawa, S., Kondo, Y., Ito, Y., Tamura, Y., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000435444.14860.ea · Cited by 217 · see citing works
Increasing butyrate concentration in the distal colon by accelerating intestinal transit
Lewis, S. J., & Heaton, K. W. (1997) · Gut · doi:10.1136/gut.41.2.245 · Cited by 213 · see citing works
Influence of synbiotic containing Lactobacillus acidophilus La5, Bifidobacterium lactis Bb 12, Streptococcus thermophilus, Lactobacillus bulgaricus and oligofructose on gut barrier function and sepsis in critically ill patients: a randomised controlled trial
Jain, P. K., McNaught, C. E., Anderson, A. D. G., Macfie, J., & Mitchell, C. J. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2003.12.002 · Cited by 211 · see citing works
Deciphering bifidobacterial-mediated metabolic interactions and their impact on gut microbiota by a multi-omics approach
Turroni, F., Milani, C., Duranti, S., Mancabelli, L., Mangifesta, M., Viappiani, A., Lugli, G. A., Ferrario, C., Gioiosa, L., Ferrarini, A., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2015.236 · Cited by 207 · see citing works
Treatment of distal ulcerative colitis with short-chain fatty acid enemas a placebo-controlled trial
Scheppach, W. M., & German-Austrian Scfa Study Group (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02071409 · Cited by 204 · see citing works
Comparison of prebiotic effects of arabinoxylan oligosaccharides and inulin in a simulator of the human intestinal microbial ecosystem
Grootaert, C., den Abbeele, P. V., Marzorati, M., Broekaert, W. F., Courtin, C. M., Delcour, J. A., Verstraete, W., & de Wiele, T. V. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2009.00712.x · Cited by 201 · see citing works
Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods
Byrne, C. S., Chambers, E. S., Alhabeeb, H., Chhina, N., Morrison, D. J., Preston, T., Tedford, C., Fitzpatrick, J., Irani, C., Busza, A., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.126706 · Cited by 201 · see citing works
Diet-derived short chain fatty acids stimulate intestinal epithelial cells to induce mucosal tolerogenic dendritic cells
Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M. N., Konijn, T., Knippenberg, M., Cook, E. C. L., Hanekamp, D., Veldhoen, M., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600165 · Cited by 200 · see citing works
Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects
Bouter, K. E. C., Bakker, G. J., Levin, E., Hartstra, A. V., Kootte, R. S., Udayappan, S. D., Katiraei, S., Bahler, L., Gilijamse, P. W., Tremaroli, V., et al. (2018) · Clinical and Translational Gastroenterology · doi:10.1038/s41424-018-0025-4 · Cited by 199 · see citing works
Self-citation
The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T
Hatayama, H., Iwashita, J., Kuwajima, A., & Abé, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.025 · Cited by 196 · see citing works
Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission
Hamer, H. M., Jonkers, D. M. A. E., Vanhoutvin, S. A. L. W., Troost, F. J., Rijkers, G. T., de Bruı̈ne, A. P., Bast, A., Venema, K., & Brummer, R. J. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.04.002 · Cited by 195 · see citing works
Quantification of in Vivo Colonic Short Chain Fatty Acid Production from Inulin
Boets, E., Deroover, L., Houben, E., Vermeulen, K., Gomand, S. V., Delcour, J. A., & Verbeke, K. (2015) · Nutrients · doi:10.3390/nu7115440 · Cited by 195 · see citing works
Self-citation
Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate?
Morrison, D. J., Mackay, W. G., Edwards, C. A., Preston, T., Dodson, B., & Weaver, L. T. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061853 · Cited by 194 · see citing works
SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter
Gupta, N., Martin, P. M., Prasad, P. D., & Ganapathy, V. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.10.028 · Cited by 190 · see citing works
An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion
Priyadarshini, M., Villa, S. R., Fuller, M. H., Wicksteed, B. L., Mackay, C. R., Alquier, T., Poitout, V., Mancebo, H. S. Y., Mirmira, R. G., Gilchrist, A., et al. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1007 · Cited by 188 · see citing works
Acetic Acid Feeding Enhances Glycogen Repletion in Liver and Skeletal Muscle of Rats
Fushimi, T., Tayama, K., Fukaya, M., Tsukamoto, Y., Kitakoshi, K., Nakai, N., & Sato, Y. (2001) · Journal of Nutrition · doi:10.1093/jn/131.7.1973 · Cited by 180 · see citing works
Effects of arabinoxylan and resistant starch on intestinal microbiota and short-chain fatty acids in subjects with metabolic syndrome: a randomised crossover study
Hald, S., Schioldan, A. G., Moore, M. E., Dige, A., Lærke, H. N., Agnholt, J., Bach Knudsen, K. E., Hermansen, K., Marco, M. L., Gregersen, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159223 · Cited by 180 · see citing works
Linking phylogenetic identities of bacteria to starch fermentation in an in vitro model of the large intestine by RNA‐based stable isotope probing
Kovatcheva‐Datchary, P., Egert, M., Maathuis, A. J. H., Rajilić-Stojanović, M. D., de Graaf, A. A., Smidt, H., de Vos, W. M., & Venema, K. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01815.x · Cited by 174 · see citing works
Butyrate interferes with the differentiation and function of human monocyte-derived dendritic cells
Liu, L., Li, L., Min, J., Wang, J., Wu, H., Zeng, Y., Chen, S., & Chu, Z. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.05.011 · Cited by 172 · see citing works
Sodium butyrate epigenetically modulates high‐fat diet‐induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning
Henagan, T. M., Stefañska, B., Fang, Z., Navard, A. M., Ye, J., Lenard, N. R., & Devarshi, P. P. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13058 · Cited by 172 · see citing works
Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions
Gurav, A., Sivaprakasam, S., Bhutia, Y. D., Boettger, T., Singh, N., & Ganapathy, V. (2015) · Biochemical Journal · doi:10.1042/bj20150242 · Cited by 166 · see citing works
The relationship between the effects of short‐chain fatty acids on intestinal motility in vitro and GPR43 receptor activation
Dass, N. B., John, A. K., Bassil, A. K., Crumbley, C. W., Shehee, W. R., Maurio, F. P., Moore, G. B. T., Taylor, C. M., & Sanger, G. J. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00853.x · Cited by 166 · see citing works
Motor effects of short-chain fatty acids and lactate in the gastrointestinal tract
Cherbut, C. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2002213 · Cited by 166 · see citing works
Chronically Elevated Levels of Short-Chain Fatty Acids Induce T Cell–Mediated Ureteritis and Hydronephrosis
Park, J., Goergen, C. J., HogenEsch, H., & Kim, C. H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502046 · Cited by 166 · see citing works
Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon
Gaudier, E. A., Rival, M., Buisine, M., Robineau, I., & Hoebler, C. (2009) · Physiological Research · doi:10.33549/physiolres.931271 · Cited by 165 · see citing works
Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCβ2
Miao, W., Wu, X., Wang, K., Wang, W., Wang, Y., Li, Z., Liu, J., Li, L., & Peng, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101696 · Cited by 164 · see citing works
Kinetic modelling of lactate utilization and butyrate production by key human colonic bacterial species
Muñoz‐Tamayo, R., Laroche, B., Walter, É., Dore, J. M., Duncan, S. H., Flint, H. J., & Leclerc, M. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01085.x · Cited by 164 · see citing works
Gut-Brain Glucose Signaling in Energy Homeostasis
Soty, M., Gautier‐Stein, A., Rajas, F., & Mithieux, G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.032 · Cited by 163 · see citing works
Self-citation
Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon
Mascolo, N., Rajendran, V. M., & Binder, H. J. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90008-9 · Cited by 155 · see citing works
Effect of short‐chain fatty acids on calcium absorption by the rat colon
Lutz, T. A., & Scharrer, E. (1991) · Experimental Physiology · doi:10.1113/expphysiol.1991.sp003530 · Cited by 155 · see citing works
The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC
Schilderink, R., Verseijden, C., Seppen, J., Muncan, V., BRINK, G. R. V. D., Lambers, T. T., van Tol, E. A. F., & de Jonge, W. J. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00411.2015 · Cited by 153 · see citing works
Bifidobacterial inulin-type fructan degradation capacity determines cross-feeding interactions between bifidobacteria and Faecalibacterium prausnitzii
Moens, F., Weckx, S., & Vuyst, L. D. (2016) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2016.05.015 · Cited by 152 · see citing works
Mucin Cross-Feeding of Infant Bifidobacteria and Eubacterium hallii
Bunešová, V., Lacroix, C., & Schwab, C. (2017) · Microbial Ecology · doi:10.1007/s00248-017-1037-4 · Cited by 149 · see citing works
Effects of Acetate on Lipid Metabolism in Muscles and Adipose Tissues of Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
YAMASHITA, H., MARUTA, H., JOZUKA, M., KIMURA, R., IWABUCHI, H., YAMATO, M., SAITO, T., FUJISAWA, K., TAKAHASHI, Y., KIMOTO, M., et al. (2009) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.80634 · Cited by 146 · see citing works
Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach
Chia, L. W., Hornung, B., Aalvink, S., Schaap, P. J., de Vos, W. M., Knol, J., & Belzer, C. (2018) · Antonie van Leeuwenhoek · doi:10.1007/s10482-018-1040-x · Cited by 142 · see citing works
Oral Supplementation of Butyrate Reduces Mucositis and Intestinal Permeability Associated with 5‐Fluorouracil Administration
Ferreira, T. M. R., Leonel, A. J., de Melo, M. A. B., Santos, R. R. G., Cara, D. C., Cardoso, V. N., Correia, M. I. T. D., & Alvarez-Leite, J. I. (2012) · Lipids · doi:10.1007/s11745-012-3680-3 · Cited by 138 · see citing works
Gastrointestinal pH and Transit Time Profiling in Healthy Volunteers Using the IntelliCap System Confirms Ileo-Colonic Release of ColoPulse Tablets
Maurer, J. M., Schellekens, R. C. A., van Rieke, H. M., Wanke, C., Iordanov, V. P., Stellaard, F., Wutzke, K. D., Dijkstra, G. D. H., van der Zee, M., Woerdenbag, H. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129076 · Cited by 135 · see citing works
Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NFκB signalling
Schwab, M., Reynders, V., Loitsch, S. M., Steinhilber, D., Stein, J. M., & Schröder, O. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.04.010 · Cited by 133 · see citing works
Effects of short chain fatty acids on effector mechanisms of neutrophils
Vinolo, M. A. R., Hatanaka, E., Lambertucci, R. H., Newsholme, P., & Curi, R. (2008) · Cell Biochemistry and Function · doi:10.1002/cbf.1533 · Cited by 132 · see citing works
Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats
Raschka, L., & Daniel, H. (2005) · Bone · doi:10.1016/j.bone.2005.05.015 · Cited by 132 · see citing works
Fate of fructo-oligosaccharides in the human intestine
Alles, M. S., HAUTVAST, J. G. A. J., Nagengast, F. M., Hartemink, R., Laere, K. M. J. V., & Jansen, J. B. �. �. (1996) · British Journal Of Nutrition · doi:10.1079/bjn19960026 · Cited by 130 · see citing works
Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit
Müller, M., Hermes, G. D. A., Canfora, E. E., Smidt, H., Masclee, A., Zoetendal, E. G., & Blaak, E. E. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00283.2019 · Cited by 128 · see citing works
Self-citation
Inulin-enriched pasta improves intestinal permeability and modifies the circulating levels of zonulin and glucagon-like peptide 2 in healthy young volunteers
Russo, F., Linsalata, M., Clemente, C., Chiloiro, M., Orlando, A., Marconi, E., Chimienti, G., & Riezzo, G. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.09.010 · Cited by 126 · see citing works
Portal and peripheral blood short chain fatty acid concentrations after caecal lactulose instillation at surgery.
Peters, S. G., Pomare, E. W., & Fisher, C. A. (1992) · Gut · doi:10.1136/gut.33.9.1249 · Cited by 124 · see citing works
High-protein diets for weight management: Interactions with the intestinal microbiota and consequences for gut health. A position paper by the my new gut study group
Blachier, F., Beaumont, M., Portune, K. J., Steuer, N., Lan, A., Audebert, M., Khodorova, N., Andriamihaja, M., Airinei, G., Benamouzig, R., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.09.016 · Cited by 124 · see citing works
Host–microbiome interactions in human type 2 diabetes following prebiotic fibre (galacto-oligosaccharide) intake
Pedersen, C., Gallagher, E., Horton, F., Ellis, R. J., Ijaz, U. Z., Wu, H., Jaiyeola, E., Diribe, O., Duparc, T., Cani, P. D., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516004086 · Cited by 120 · see citing works
Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model
Jocken, J. W. E., Hernández, M. A. G., Hoebers, N., van der Beek, C. M., Essers, Y. P. G., Blaak, E. E., & Canfora, E. E. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00372 · Cited by 117 · see citing works
Self-citation
Acute oral sodium propionate supplementation raises resting energy expenditure and lipid oxidation in fasted humans
Chambers, E. S., Byrne, C., Aspey, K., Chen, Y., Khan, S., Morrison, D. J., & Frost, G. S. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13159 · Cited by 115 · see citing works
Self-citation
Dietary Fermentable Fiber Reduces Intestinal Barrier Defects and Inflammation in Colitic Mice
Hung, T. V., & Suzuki, T. (2016) · Journal of Nutrition · doi:10.3945/jn.116.232538 · Cited by 105 · see citing works
Emergence of microbial diversity due to cross-feeding interactions in a spatial model of gut microbial metabolism
Hoek, M. J. A., & Merks, R. M. H. (2017) · BMC Systems Biology · doi:10.1186/s12918-017-0430-4 · Cited by 105 · see citing works
Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice
Arnoldussen, I. A. C., Wiesmann, M., Pelgrim, C. E., Wielemaker, E. M., van Duyvenvoorde, W., Amaral-Santos, P. L., Verschuren, L., Keijser, B. J. F., Heerschap, A., Kleemann, R., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.52 · Cited by 101 · see citing works
The Gut Microbiota from Lean and Obese Subjects Contribute Differently to the Fermentation of Arabinogalactan and Inulin
Aguirre, M., de Souza, C. B., & Venema, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159236 · Cited by 100 · see citing works
Glycan cross-feeding activities between bifidobacteria under in vitro conditions
Turroni, F., Özcan, E., Milani, C., Mancabelli, L., Viappiani, A., van Sinderen, D., Sela, D. A., & Ventura, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01030 · Cited by 98 · see citing works
In vitro colonisation of the distal colon by Akkermansia muciniphila is largely mucin and pH dependent
Herreweghen, F. V., den Abbeele, P. V., Mulder, T. D., Weirdt, R. D., Geirnaert, A., Hernandez‐Sanabria, E., Vilchez‐Vargas, R., Jáuregui, R., Pieper, D. H., Belzer, C., et al. (2016) · Beneficial Microbes · doi:10.3920/bm2016.0013 · Cited by 95 · see citing works
Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes
Li, X., Chen, H., Guan, Y., Li, X., Lei, L., Liu, J., Yin, L., Liu, G., & Wang, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067880 · Cited by 92 · see citing works
Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes
Rumberger, J. M., Arch, J. R. S., & Green, A. (2014) · PeerJ · doi:10.7717/peerj.611 · Cited by 90 · see citing works
Current Data with Inulin-Type Fructans and Calcium, Targeting Bone Health in Adults
Coxam, V. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2527s · Cited by 90 · see citing works
GPR41 modulates insulin secretion and gene expression in pancreatic β‐cells and modifies metabolic homeostasis in fed and fasting states
Veprik, A., Laufer, D., Weiss, S., Rubins, N. E., & WALKER, M. D. (2016) · The FASEB Journal · doi:10.1096/fj.201500030r · Cited by 89 · see citing works
Effect of Inulin-Type Carbohydrates on Insulin Resistance in Patients with Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis
Rao, M., Gao, C., Xu, L., Jiang, L., Zhu, J., Chen, G., Law, B. Y. K., & Xu, Y. (2019) · Journal of Diabetes Research · doi:10.1155/2019/5101423 · Cited by 89 · see citing works
High fiber dietary and sodium butyrate attenuate experimental autoimmune hepatitis through regulation of immune regulatory cells and intestinal barrier
Hu, E.-D., Chen, D., Wu, J., Lu, F., Chen, L., Zheng, M., Li, H., Huang, Y., Li, J., Jin, X., et al. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.03.003 · Cited by 87 · see citing works
Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice
Lengacher, S., Nehiri, T., Steiner, N., Carneiro, L., Favrod, C., Preitner, F., Thorens, B., Stehle, J., Dix, L., Pralong, F. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082505 · Cited by 86 · see citing works
Navy and black bean supplementation primes the colonic mucosal microenvironment to improve gut health
Monk, J. M., Lepp, D., Wu, W., Pauls, K. P., Robinson, L. E., & Power, K. A. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.08.002 · Cited by 85 · see citing works
Short-chain fatty acids enhance diffusional Ca transport in the epithelium of the rat cecum and colon
Mineo, H., Hara, H., & Tomita, F. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01146-8 · Cited by 83 · see citing works
MUC2 Mucin and Butyrate Contribute to the Synthesis of the Antimicrobial Peptide Cathelicidin in Response to Entamoeba histolytica- and Dextran Sodium Sulfate-Induced Colitis
Cobo, E. R., Kissoon‐Singh, V., Moreau, F., Holani, R., & Chadee, K. (2017) · Infection and Immunity · doi:10.1128/iai.00905-16 · Cited by 81 · see citing works
The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes
Roelofsen, H., Priebe, M., & Vonk, R. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0028 · Cited by 80 · see citing works

Flagged first, then by citations

Research works printed but not linked: 19

Bellahcene, M., O'Dowd, J.F., Wargent, E.T., Zaibi, M.S., Hislop, D.C., Ngala, R.A., Smith, D.M., Cawthorne, M.A., Stocker, C.J. and Arch, J.R., 2013. Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content. British Journal of Nutrition 109: 1755-1764. https://doi.org/10.1017/ · DOI
S0007114512003923 · DOI
Bischoff, S.C., 2011. 'Gut health': a new objective in medicine? BMC Medicine 9: 24. https://doi.org/10.1186/1741-7015-9-24 https://www.wageningenacademic.com/doi/pdf/10.3920/BM2020.0057 -Tuesday, July 27, 2021 5:59:07 AM -IP Address:194.57.135.216 · DOI · Paper page
Darzi, J., Frost, G.S. and Robertson, M.D., 2012. Effects of a novel propionate-rich sourdough bread on appetite and food intake. European Journal of Clinical Nutrition 66: 789-794. https://doi. org/10.1038/ejcn.2012. · DOI
Duncan, S.H., Louis, P. and Flint, H.J., 2004. Lactate-utilizing bacteria, isolated from human feces, that produce butyrate as a major fermentation product. Applied and Environmental Microbiology 70: 5810-5817. https://doi.org/10.1128/AEM.70.10.5810-5817.2004 https://www.wageningenacademic.com/doi/pdf/10.3920/BM2020.0057 -Tuesday, July 27, 2021 5:59:07 AM -IP Address:194.57.135.216 · DOI
Guo, C., Xie, S., Chi, Z., Zhang, J., Liu, Y., Zhang, L., Zheng, M., Zhang, X., Xia, D., Ke, Y., Lu, L. and Wang, D., 2016. Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome. Immunity 45: 802-816. https://doi.org/10.1016/j. immuni.2016.09.008 https://www.wageningenacademic.com/doi/pdf/10.3920/BM2020.0057 -Tuesday, July 27, 2021 5:59:07 AM -IP Address:194.57.135.216 · DOI · Paper page
Jia, Y., Hong, J., Li, H., Hu, Y., Jia, L., Cai, D. and Zhao, R., 2016. Butyrate stimulates adipose lipolysis and mitochondrial oxidative phosphorylation through histone hyperacetylation-associated beta3- adrenergic receptor activation in high-fat diet-induced obese mice. Experimental Physiology 102: 273-281. https://doi.org/10.1113/ · DOI
EP086114 · DOI
Jiang, L., Krystal, J.H., Mason, G.F., Jiang, L., Gulanski, B.I., Feyter, H.M.D., Weinzimer, S.A., Pittman, B., Guidone, E., Koretski, J., Harman, S., Petrakis, I.L., Krystal, J.H. and Mason, G.F., 2013. Increased brain uptake and oxidation of acetate in heavy drinkers find the latest version: increased brain uptake and oxidation of acetate in heavy drinkers. Journal of Clinical Investigation 123: 1605-1614. https://doi.org/10.1172/JCI65153. · DOI
by · DOI
Kimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A. and Miyauchi, S., 2011. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41. Proceedings of the National Academy of Sciences of the USA 108: 8030-8035. https://doi.org/10.1073/pnas.1016088108/-/ DCSupplemental.www.pnas.org/cgi/doi/10.1073/pnas.1016088108 https://www.wageningenacademic.com/doi/pdf/10.3920/BM2020.0057 -Tuesday, July 27, 2021 5:59:07 AM -IP Address:194.57.135.216 · DOI
Lim, S.S., Vos, T., Flaxman, A.D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M.A., Amann, M., Anderson, H.R., Andrews, K.G., Aryee, M., Atkinson, C., Bacchus, L.J., Bahalim, A.N., Balakrishnan, K., Balmes, J., Barker-Collo, S., Baxter, A., Bell, M.L., Blore, J.D., Blyth, F., Bonner, C., Borges, G., Bourne, R., Boussinesq, M., Brauer, M., Brooks, P., Bruce, N.G., Brunekreef, B., Bryan-Hancock, C., Bucello, C., Buchbinder, R., Bull, F., Burnett, R.T., Byers, T.E., Calabria, B., Carapetis, J., Carnahan, E., Chafe, Z., Charlson, F., Chen, H., Chen, J.S., Cheng, A.T.-A., Child, J.C., Cohen, A., Colson, K.E., Cowie, B.C., Darby, S., Darling, S., Davis, A., Degenhardt, L., Dentener, F., Des Jarlais, D.C., Devries, K., Dherani, M., Ding, E.L., Dorsey, E.R., Driscoll, T., Edmond, K., Ali, S.E., Engell, R.E., Erwin, P.J., Fahimi, S., Falder, G., Farzadfar, F., Ferrari, A., Finucane, M.M., Flaxman, S., Fowkes, F.G.R., Freedman, G., Freeman, M.K., Gakidou, E., Ghosh, S., Giovannucci, E., Gmel, G., Graham, K., Grainger, R., Grant, B., Gunnell, D., Gutierrez, H.R., Hall, W., Hoek, H.W., Hogan, A., Hosgood, H.D., Hoy, D., Hu, H., Hubbell, B.J., Hutchings, S.J., Ibeanusi, S.E., Jacklyn, G.L., Jasrasaria, R., Jonas, J.B., Kan, H., Kanis, J.A., Kassebaum, N., Kawakami, N., Khang, Y.-H., Khatibzadeh, S., Khoo, J.-P., Kok, C., Laden, F., Lalloo, R., Lan, Q., Lathlean, T., Leasher, J.L., Leigh, J., Li, Y., Lin, J.K., Lipshultz, S.E., London, S., Lozano, R., Lu, Y., Mak, J., Malekzadeh, R., Mallinger, L., Marcenes, W., March, L., Marks, R., Martin, R., McGale, P., McGrath, J., Mehta, S., Memish, Z.A., Mensah, G.A., Merriman, T.R., Micha, R., Michaud, C., Mishra, V., Hanafiah, K.M., Mokdad, A.A., Morawska, L., Mozaffarian, D., Murphy, T., Naghavi, M., Neal, B., Nelson, P.K., Nolla, J.M., Norman, R., Olives, C., Omer, S.B., Orchard, J., Osborne, R., Ostro, B., Page, A., Pandey, K.D., Parry, C.D.H., Passmore, E., Patra, J., Pearce, N., Pelizzari, P.M., Petzold, M., Phillips, M.R., Pope, D., Pope, C.A., Powles, J., Rao, M., Razavi, H., Rehfuess, E.A., Rehm, J.T., Ritz, B., Rivara, F.P., Roberts, T., Robinson, C., Rodriguez-Portales, J.A., Romieu, I., Room, R., Rosenfeld, L.C., Roy, A., Rushton, L., Salomon, J.A., Sampson, U., Sanchez-Riera, L., Sanman, E., Sapkota, A., Seedat, S., Shi, P., Shield, K., Shivakoti, R., Singh, G.M., Sleet, D.A., Smith, E., Smith, K.R., Stapelberg, N.J.C., Steenland, K., Stöckl, H., Stovner, L.J., Straif, K., Straney, L., Thurston, G.D., Tran, J.H., Van Dingenen, R., van Donkelaar, A., Veerman, J.L., Vijayakumar, L., Weintraub, R., Weissman, M.M., White, R.A., Whiteford, H., Wiersma, S.T., Wilkinson, J.D., Williams, H.C., Williams, W., Wilson, N., Woolf, A.D., Yip, P., Zielinski, J.M., Lopez, A.D., Murray, C.J.L. and Ezzati, M., 2012. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet 380: 2224-2260. https://doi. org/10.1016/s0140-6736(12)61766-8 https://www.wageningenacademic.com/doi/pdf/10.3920/BM2020.0057 -Tuesday, July 27, 2021 5:59:07 AM -IP Address:194.57.135.216 · DOI · Paper page
Cummings, J.H., Rombeau, J.L. and Sakata, S. (eds.) Physiological and clinical aspects of short chain fatty acid metabolism. Cambridge University Press, Cambridge, UK, pp.
Millard, A.L., Mertes, P.M., Ittelet, D., Villard, F., Jeannesson, P. and Bernard, J., 2002. Butyrate affects differentiation, maturation and function of human monocyte-derived dendritic cells and macrophages. Clinical and Experimental Immunology 130: 245- 255. https://doi.org/10.1046/j.0009-9104.2002.01977.x https://www.wageningenacademic.com/doi/pdf/10.3920/BM2020.0057 -Tuesday, July 27, 2021 5:59:07 AM -IP Address:194.57.135.216 · DOI · Paper page
Trinidad, T.P., Wolever, T.M.S. and Thompson, L.U., 1993. Interactive effects of calcium and short chain fatty acids on absorption in the distal colon of man. Nutrition Research: 417-425. https://doi. org/10.1016/s0271 · DOI
Van der Beek, C.M., Bloemen, J.G., Van den Broek, M.A., Lenaerts, K., Venema, K., Buurman, W.A. and Dejong, C.H., 2015. Hepatic uptake of rectally administered butyrate prevents an increase in systemic butyrate concentrations in humans. Journal of Nutrition 145: 2019-2024. https://doi.org/10.3945/jn.115.211193 https://www.wageningenacademic.com/doi/pdf/10.3920/BM2020.0057 -Tuesday, July 27, 2021 5:59:07 AM -IP Address:194.57.135.216 · DOI
cs20160263 · DOI · Paper page
Westerbeek, E.A., Van den Berg, A., Lafeber, H.N., Fetter, W.P. and van Elburg, R.M., 2011. The effect of enteral supplementation of a prebiotic mixture of non-human milk galacto-, fructo-and acidic oligosaccharides on intestinal permeability in preterm infants. British Journal of Nutrition 105: 268-274. https://doi.org/10.1017/ · DOI
S0007114510003405 · DOI

Sorted by citations

Gut microbiome and health: mechanistic insights
de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut · doi:10.1136/gutjnl-2021-326789 · Cited by 2,388 · see citing works
Shaping the Future of Probiotics and Prebiotics
Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637 · see citing works
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
Rethinking healthy eating in light of the gut microbiome
Armet, A. M., Deehan, E. C., O’Sullivan, A. F., Mota, J. F., Field, C. J., Prado, C. M., Lucey, A. J., & Walter, J. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.04.016 · Cited by 252 · see citing works
Metabolic reprogramming in the tumor microenvironment of liver cancer
Lin, J., Rao, D., Zhang, M., & Gao, Q. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01527-8 · Cited by 251 · see citing works
“Butyrate is mainly produced by the gut microbiota during fermentation and is subsequently absorbed by the liver via the gut–liver axis [201].”
Background
Short-chain fatty acids: Important components of the gut-brain axis against AD
Huang, Y., Wang, Y. F., Miao, J., Zheng, R. F., & Li, J. Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116601 · Cited by 70 · see citing works
Dietary Component-Induced Inflammation and Its Amelioration by Prebiotics, Probiotics, and Synbiotics
Bilal, M., Ashraf, S., & Zhao, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.931458 · Cited by 58 · see citing works
Nutrition, gut microbiota, and alzheimer’s disease
Romanenko, M., Kholin, V., Koliada, A., & Vaiserman, A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.712673 · Cited by 56 · see citing works
The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders
Młynarska, E., Barszcz, E., Budny, E., Gajewska, A., Kopeć, K., Wasiak, J., Rysz, J., & Franczyk, B. (2025) · Nutrients · doi:10.3390/nu17071135 · Cited by 44 · see citing works
Intestinal Permeability and Its Significance in Psychiatric Disorders—A Narrative Review and Future Perspectives
Wasiak, J., & Gawlik-Kotelnicka, O. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114459 · Cited by 47 · see citing works

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ
Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019
Cloning and Characterization of Rat BAT3 cDNA
Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works
EFFECT OF THE NEMATODE PHASMARHABDITIS HERMAPHRODITA ON YOUNG STAGES OF THE PEST SLUG ARION LUSITANICUS
Grimm, B. (2002) · Journal of Molluscan Studies · doi:10.1093/mollus/68.1.25 · Cited by 41 · see citing works
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53Preprint
Sasaki, T., Gan, E. C., Wakeham, A. C., Kornbluth, S. A., Mak, T. W., & Okada, H. (2007) · Genes & Development · doi:10.1101/gad.1534107 · Cited by 127 · see citing works
Anthoxanthum Mosaic Virus
Catherall, P. L. (1970) · Plant Pathology · doi:10.1111/j.1365-3059.1970.tb00999.x · Cited by 6 · see citing works

Authors: Blaak, E. E., Canfora, E. E., Theis, S., Frost, G., Groen, A. K., Mithieux, G., Nauta, A., Scott, K., Stahl, B., van Harsselaar, J., van Tol, R., Vaughan, E. E., & Verbeke, K.
Affiliations: Maastricht University (NL)
Südzucker (Germany) (DE)
Imperial College London (GB)
University Medical Center Groningen (NL)
Inserm (FR)
FrieslandCampina (Netherlands) (NL)
University of Aberdeen (GB)
Utrecht University (NL)
Südzucker Group – Beneo, Wormser Str. 11, Mannheim, 67283, Germany.
Reckitt Benckiser/Mead Johnson Nutrition, Middenkampweg 2, 6545 CJ Nijmegen, the Netherlands.
Sensus (Royal Cosun), Borchwerf 3, 4704 RG Roosendaal, the Netherlands.
KU Leuven (BE)
ORCID: Blaak, E.E.
Canfora, E.E.
Theis, S.
Frost, G.
Groen, A.K.
Mithieux, G.
Nauta, A.
Scott, K.
Stahl, B.
Vaughan, E.E.
Verbeke, K.
Venue: Beneficial Microbes
Publisher: Walter de Gruyter GmbH
Published: 2020-09-01
Volume: 11
Issue: 5
Pages: 411-455
ISSN: 1876-2883 (ISSN-L)
1876-2891
DOI: 10.3920/bm2020.0057
OpenAlex: W3080685158
Cited by: 1,103
References: 250
Citations by year: 2026: 161 · 2025: 247 · 2024: 249 · 2023: 199 · 2022: 165 · 2021: 73 · 2020: 5 · 2017: 1
FWCI: 10.58
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
creativecommons.org/licenses/by-nc-sa/4.0 (unspecified)
Locations: Beneficial Microbes (publishedVersion, other-oa)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, cc-by-nc-sa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc-sa)
HAL (submittedVersion, other-oa)
Lirias (submittedVersion, cc-by-nc-nd)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Pure Amsterdam UMC (submittedVersion, cc-by)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc-sa)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders: National Institute for Health and Care Research (NF-SI-0508-10112, NF-SI-0513-10029)
Biotechnology and Biological Sciences Research Council (BBS/E/F/000PR10346, BB/N016947/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: short-chain fatty acids, gut microbiota, acetate, propionate, butyrate, microbial fermentation, dietary fiber, intestinal barrier, mucosal immunity, appetite regulation, energy expenditure, glucose homeostasis, obesity, type 2 diabetes, gastrointestinal dysfunction, prebiotics
MeSH terms: Gastrointestinal Microbiome, Host Microbial Interactions, Animals, Diabetes Mellitus, Type 2, Fatty Acids, Volatile, Gastrointestinal Diseases, Humans, Obesity, Gastrointestinal Tract, Carbohydrate Metabolism, Prebiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Short chain fatty acids in human gut and metabolic health

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks