Short-chain fatty acids: Important components of the gut-brain axis against AD
Open accessAbstract
Alzheimer's disease (AD) comprises a group of neurodegenerative disorders with some changes in the brain, which could lead to the deposition of certain proteins and result in the degeneration and death of brain cells. Patients with AD manifest primarily as cognitive decline, psychiatric symptoms, and behavioural disorders. Short-chain fatty acids (SCFAs) are a class of saturated fatty acids (SFAs) produced by gut microorganisms through the fermentation of dietary fibre ingested. SCFAs, as a significant mediator of signalling, can have diverse physiological and pathological roles in the brain through the gut-brain axis, and play a positive effect on AD via multiple pathways. Firstly, differences in SCFAs and microbial changes have been stated in AD cases of humans and mice in this paper. And then, mechanisms of three main SCFAs in treating with AD have been summarized, as well as differences of gut bacteria. Finally, functions of SCFAs played in regulating intestinal flora homeostasis, modulating the immune system, and the metabolic system, which were considered to be beneficial for the treatment of AD, have been elucidated, and the key roles of gut bacteria and SCFAs were pointed out. All in all, this paper provides an overview of SCFAs and gut bacteria in AD, and can help people to understand the importance of gut-brain axis in AD.
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SCFAs help preserve blood-brain barrier integrity, preventing neurotoxic substances from entering the brain.
“SCFAs help preserve blood–brain barrier (BBB) integrity, preventing neurotoxic substances from entering the brain [51].”
From The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders (2025) · cites this paper as [51]
Cites
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works
Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820 · see citing works
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204 · see citing works
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119 · see citing works
Formation of propionate and butyrate by the human colonic microbiota
Louis, P., & Flint, H. J. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13589 · Cited by 3,028 · see citing works
Colonic Health: Fermentation and Short Chain Fatty Acids
Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739 · see citing works
Fiber and prebiotics: Mechanisms and health benefits
Slavin, J. (2013) · Nutrients · doi:10.3390/nu5041417 · Cited by 2,340 · see citing works
Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204 · see citing works
The gut microbiota–brain axis in behaviour and brain disorders
Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149 · see citing works
Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130 · see citing works
The neuroactive potential of the human gut microbiota in quality of life and depression
Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963 · see citing works
Regulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939 · see citing works
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
Frost, G., Sleeth, M. L., Sahuri-Arisoylu, M., Lizarbe, B., Cerdan, S., Brody, L., Anastasovska, J., Ghourab, S., Hankir, M., Zhang, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4611 · Cited by 1,771 · see citing works
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works
The impact of diet and lifestyle on gut microbiota and human health
Conlon, M., & Bird, A. (2014) · Nutrients · doi:10.3390/nu7010017 · Cited by 1,567 · see citing works
Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7734 · Cited by 1,439 · see citing works
Blautia —a new functional genus with potential probiotic properties?
Liu, X., Mao, B., Gu, J., Wu, J., Cui, S., Wang, G., Zhao, J., Zhang, H., & Chen, W. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1875796 · Cited by 1,398 · see citing works
Gut Bacteroides species in health and disease
Zafar, H., & Saier, M. H. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1848158 · Cited by 1,258 · see citing works
Faecalibacterium prausnitzii and human intestinal health
Miquel, S., Martín, R., Rossi, O., Bermúdez‐Humarán, L. G., Chatel, J., Sokol, H., Thomas, M., Wells, J. M., & Langella, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.003 · Cited by 1,239 · see citing works
den Besten, G., Bleeker, A., Gerding, A., van Eunen, K., Havinga, R., van Dijk, T. H., Oosterveer, M. H., Jonker, J. W., Groen, A. K., Reijngoud, D.-J., et al. (2015) · Diabetes · doi:10.2337/db14-1213 · Cited by 1,125 · see citing works
Short chain fatty acids in human gut and metabolic health
Blaak, E. E., Canfora, E. E., Theis, S., Frost, G., Groen, A. K., Mithieux, G., Nauta, A., Scott, K., Stahl, B., van Harsselaar, J., et al. (2020) · Beneficial Microbes · doi:10.3920/bm2020.0057 · Cited by 1,103 · see citing works
Yang, W., Yu, T., Huang, X., Bilotta, A. J., Xu, L., Lu, Y., Sun, J., Pan, F., Zhou, J., Zhang, W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18262-6 · Cited by 1,060 · see citing works
Scheiman, J., Luber, J. M., Chavkin, T. A., MacDonald, T., Tung, A., Pham, L.-D., Wibowo, M. C., Wurth, R. C., Punthambaker, S., Tierney, B. T., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0485-4 · Cited by 892 · see citing works
Gut Microbiota is Altered in Patients with Alzheimer’s Disease
Zhuang, Z.-Q., Shen, L.-L., Li, W.-W., Fu, X., Zeng, F., Gui, L., Lü, Y., Cai, M., Zhu, C., Tan, Y.-L., et al. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180176 · Cited by 885 · see citing works
Self-citationRecent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820 · see citing works
From the gut to the peripheral tissues: the multiple effects of butyrate
Guilloteau, P., Martin, L., Eeckhaut, V., Ducatelle, R., Zabielski, R., & Immerseel, F. V. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000247 · Cited by 813 · see citing works
Wrzosek, L., Miquel, S., Noordine, M.-L., Bouet, S., Curt, M. J.-C., Robert, V., Philippe, C., Bridonneau, C., Cherbuy, C., Masselot, C. R., et al. (2013) · BMC Biology · doi:10.1186/1741-7007-11-61 · Cited by 807 · see citing works
Liu, P., Wang, Y., Yang, G., Zhang, Q., Meng, L., Xin, Y., & Jiang, X. M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105420 · Cited by 787 · see citing works
Self-citationPrevotella Diversity, Niches and Interactions with the Human Host
Tett, A., Pasolli, E., Masetti, G., Ercolini, D., & Segata, N. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00559-y · Cited by 748 · see citing works
Mukherjee, A., Lordan, C., Ross, R. P., & Cotter, P. D. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1802866 · Cited by 703 · see citing works
Nagpal, R., Neth, B. J., Wang, S., Craft, S., & Yadav, H. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.032 · Cited by 653 · see citing works
Role and Mechanism of Gut Microbiota in Human Disease
Chen, Y., Zhou, J., & Wang, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.625913 · Cited by 643 · see citing works
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works
Review article: short chain fatty acids in health and disease
Cook, & Sellin (1998) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1998.00337.x · Cited by 622 · see citing works
Yoshida, N., Emoto, T., Yamashita, T., Watanabe, H., Hayashi, T., Tabata, T., Hoshi, N., Hatano, N., Ozawa, G., Sasaki, N., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.033714 · Cited by 619 · see citing works
Kim, M.-S., Kim, Y., Choi, H., Kim, W., Park, S., Lee, D., Kim, D. K., Kim, H. J., Choi, H., Hyun, D.-W., et al. (2020) · Gut · doi:10.1136/gutjnl-2018-317431 · Cited by 614 · see citing works
Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43
Hong, Y.-H., Nishimura, Y., Hishikawa, D., Tsuzuki, H., Miyahara, H., Gotoh, C., Choi, K.-C., Feng, D. D., Chen, C., Lee, H.-G., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0545 · Cited by 613 · see citing works
Sochocka, M., Donskow-Łysoniewska, K., Diniz, B. S., Kurpas, D., Brzozowska, E., & Leszek, J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1188-4 · Cited by 584 · see citing works
The Microbiota–Gut–Brain Axis in Psychiatric Disorders
Góralczyk-Bińkowska, A., Szmajda‐Krygier, D., & Kozłowska, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911245 · Cited by 534 · see citing works
Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats
Soret, R., Chevalier, J., De Coppet, P., Poupeau, G., Derkinderen, P., Segain, J. P., & Neunlist, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.053 · Cited by 530 · see citing works
Ghaisas, S., Maher, J. M., & Kanthasamy, A. G. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.012 · Cited by 519 · see citing works
Willemsen, L. E. M., Koetsier, M. A., van Deventer, S. J. H., & van Tol, E. A. F. (2003) · Gut · doi:10.1136/gut.52.10.1442 · Cited by 518 · see citing works
Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species
Nie, K., Ma, K., Luo, W., Shen, Z., Yang, Z., Xiao, M., Tong, T., Yang, Y., & Wang, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.757718 · Cited by 514 · see citing works
Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry
Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works
Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
Gao, X. J., Lin, S., Ren, F., Li, J.-T., Chen, J.-J., Yao, C.-B., Yang, H., Jiang, S.-X., Yan, G.-Q., Wang, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms11960 · Cited by 481 · see citing works
Self-citationMild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
Li, B., He, Y., Ma, J., Huang, P., Du, J., Cao, L. H., Wang, Y., Xiao, Q., Tang, H., & Chen, S. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.07.002 · Cited by 480 · see citing works
Self-citationGe, H., Li, X., Weiszmann, J., Wang, P., Baribault, H., Chen, J., Tian, H., & Li, Y. (2008) · Endocrinology · doi:10.1210/en.2008-0059 · Cited by 477 · see citing works
Microbiota-gut-brain axis: Modulator of host metabolism and appetite
van de Wouw, M., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.240481 · Cited by 461 · see citing works
Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease
Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170020 · Cited by 449 · see citing works
Self-citationPhascolarctobacterium faecium abundant colonization in human gastrointestinal tract
Wu, F., Guo, X., Zhang, J., Zhang, M., Ou, Z., & Peng, Y. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4878 · Cited by 403 · see citing works
Zhang, S., Wang, H., & Zhu, M. J. (2018) · Talanta · doi:10.1016/j.talanta.2018.12.049 · Cited by 380 · see citing works
Biomarkers for Alzheimer’s disease—preparing for a new era of disease-modifying therapies
Zetterberg, H., & Bendlin, B. B. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0721-9 · Cited by 379 · see citing works
Ho, L., Ono, K., Tsuji, M., Mazzola, P., Singh, R., & Pasinetti, G. M. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1400909 · Cited by 376 · see citing works
Leonel, A. J., & Alvarez-Leite, J. I. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32835665fa · Cited by 362 · see citing works
Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
Colombo, A. V., Sadler, R. K., Llovera, G., Singh, V., Roth, S., Heindl, S., Sebastian Monasor, L., Verhoeven, A., Peters, F., Parhizkar, S., et al. (2021) · eLife · doi:10.7554/elife.59826 · Cited by 354 · see citing works
Recent developments in understanding the role of the gut microbiota in brain health and disease
Sherwin, E., Dinan, T. G., & Cryan, J. F. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13416 · Cited by 338 · see citing works
<i>Ruminococcus gnavus</i> : friend or foe for human health
Crost, E. H., Coletto, E., Bell, A., & Juge, N. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad014 · Cited by 335 · see citing works
Tong, L., Wang, Y., Wang, Z.-B., Liu, W., Sun, S., Li, L., Su, D., & Zhang, L. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00253 · Cited by 334 · see citing works
Self-citationZhu, F., Guo, R., Wang, W., Ju, Y., Wang, Q., Ma, Q., Sun, Q., Fan, Y., Xie, Y., Yang, Z., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0475-4 · Cited by 323 · see citing works
The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works
Kondo, T., Kishi, M., Fushimi, T., & Kaga, T. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900470c · Cited by 301 · see citing works
Hypothalamic malonyl-CoA as a mediator of feeding behavior
Hu, Z., Cha, S. H., Chohnan, S., & Lane, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834402100 · Cited by 272 · see citing works
Fu, S., Wang, J., Xue, W.-J., Liu, H., Liu, B.-R., Zeng, Y., Li, S., Huang, B., Lv, Q.-K., Wang, W., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0230-3 · Cited by 269 · see citing works
Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis
Bradburn, S., Murgatroyd, C., & Ray, N. J. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.002 · Cited by 268 · see citing works
de la Monte, S. M. (2012) · Drugs · doi:10.2165/11597760-000000000-00000 · Cited by 265 · see citing works
Huang, C., Song, P., Fan, P. F., Hou, C., Thacker, P. A., & Ma, X. (2015) · Journal of Nutrition · doi:10.3945/jn.115.217406 · Cited by 256 · see citing works
Role of resistant starch in improving gut health, adiposity, and insulin resistance
Keenan, M. J., Zhou, J., Hegsted, M., Pelkman, C., Durham, H. A., Coulon, D. B., & Martin, R. J. (2015) · Advances in Nutrition · doi:10.3945/an.114.007419 · Cited by 243 · see citing works
Hong, J., Jia, Y., Pan, S., Jia, L., Li, H., Han, Z., Cai, D., & Zhao, R. (2016) · Oncotarget · doi:10.18632/oncotarget.11267 · Cited by 236 · see citing works
Hou, Y.-F., Shan, C., Zhuang, S.-Y., Zhuang, Q.-Q., Ghosh, A., Zhu, K.-C., Kong, X.-K., Wang, S.-M., Gong, Y.-L., Yang, Y.-Y., et al. (2021) · Microbiome · doi:10.1186/s40168-020-00988-6 · Cited by 231 · see citing works
Wu, L., Han, Y., Zheng, Z., Peng, G., Liu, P., Yue, S., Zhu, S., Chen, J., Lv, H., Shao, L., et al. (2021) · Nutrients · doi:10.3390/nu13010228 · Cited by 227 · see citing works
Self-citationBui, T. P. N., Mannerås-Holm, L., Puschmann, R., Wu, H., Troise, A. D., Nijsse, B., Boeren, S. A., Bäckhed, F., Fiedler, D., & de Vos, W. M. (2021) · Nature Communications · doi:10.1038/s41467-021-25081-w · Cited by 223 · see citing works
Does butyrate protect from colorectal cancer?
Sengupta, S., Muir, J. G., & Gibson, P. R. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04213.x · Cited by 219 · see citing works
Clarke, J. R., Lyra e Silva, N. M., Figueiredo, C. P., Frozza, R. L., Ledo, J. H., Beckman, D., Katashima, C. K., Razolli, D., Carvalho, B. M., Frazão, R., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404183 · Cited by 214 · see citing works
Effect of Intestinal Microbial Ecology on the Developing Brain
Douglas‐Escobar, M., Elliott, E., & Neu, J. (2013) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.497 · Cited by 207 · see citing works
Yi, Y., Shen, L., Shi, W., Xia, F., Zhang, H., Wang, Y., Zhang, J., Wang, Y., Sun, X., Zhang, Z., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3445 · Cited by 199 · see citing works
Self-citationNutritional Factors Influencing Intestinal Health of the Neonate
Jacobi, S. K., & Odle, J. (2012) · Advances in Nutrition · doi:10.3945/an.112.002683 · Cited by 179 · see citing works
Short-chain fatty acid: An updated review on signaling, metabolism, and therapeutic effects
Rekha, K., Venkidasamy, B., Samynathan, R., Nagella, P., Ребезов, М. Б., Khayrullin, M., Ponomarev, E., Bouyahya, A., Sarkar, T., Shariati, M. A., et al. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2124231 · Cited by 166 · see citing works
Jiang, Y., Li, K., Li, X., Xu, L., & Yang, Z. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109452 · Cited by 154 · see citing works
The role of gut microbiota in the gut-brain axis: current challenges and perspectives
Chen, X., D’Souza, R., & Hong, S. (2013) · Protein & Cell · doi:10.1007/s13238-013-3017-x · Cited by 153 · see citing works
Freude, S., Schilbach, K., & Schubert, M. (2009) · Current Alzheimer Research · doi:10.2174/156720509788486527 · Cited by 147 · see citing works
Zapolska‐Downar, D., Siennicka, A., Kaczmarczyk, M., Kołodziej, B., & Naruszewicz, M. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2003.11.008 · Cited by 140 · see citing works
Increased brain uptake and oxidation of acetate in heavy drinkers
Jiang, L., Gulanski, B., Feyter, H. M. D., WEINZIMER, S. A., Pittman, B. P., Guidone, E., Koretski, J. A., Harman, S., Petrakis, I. L., Krystal, J. H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65153 · Cited by 139 · see citing works
Megasphaera elsdenii Lactate Degradation Pattern Shifts in Rumen Acidosis Models
Chen, L., Shen, Y., Wang, C., Ding, L., Zhao, F., Wang, M., Fu, J., & Wang, H. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00162 · Cited by 132 · see citing works
Physiology and Sporulation in Clostridium
Dürre, P. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbs-0010-2012 · Cited by 128 · see citing works
Li, H., Xie, J., Guo, X., Yang, G., Cai, B., Liu, J., Yue, M., Tang, Y., Wang, G., Chen, S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2127456 · Cited by 123 · see citing works
Levison, M. E. (1973) · Infection and Immunity · doi:10.1128/iai.8.1.30-35.1973 · Cited by 105 · see citing works
Fu, J., Li, J., Sun, Y., Liu, S., Song, F., & Liu, Z. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123488 · Cited by 103 · see citing works
Self-citationSynaptic plasticity in Alzheimer’s disease and healthy aging
Torres, D. M. C., & Cárdenas, F. P. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0058 · Cited by 98 · see citing works
Insulin Has Multiple Antiamyloidogenic Effects on Human Neuronal Cells
Pandini, G., Pace, V., Copani, A., Squatrito, S., Milardi, D., & Vigneri, R. (2012) · Endocrinology · doi:10.1210/en.2012-1661 · Cited by 96 · see citing works
Valerate production by Megasphaera elsdenii isolated from pig feces
Yoshikawa, S., Araoka, R., Kajihara, Y., Ito, T., Miyamoto, H., & Kodama, H. (2018) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2017.12.016 · Cited by 90 · see citing works
Saw, G., Krishna, K., Gupta, N., Soong, T. W., Mallilankaraman, K., Sajikumar, S., & Dheen, S. T. (2020) · Glia · doi:10.1002/glia.23748 · Cited by 87 · see citing works
Soliman, M. L., Combs, C. K., & Rosenberger, T. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9426-4 · Cited by 84 · see citing works
High doses of the histone deacetylase inhibitor sodium butyrate trigger a stress-like response
Gagliano, H., Delgado-Morales, R., Sanz-Garcia, A., & Armario, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.031 · Cited by 76 · see citing works
Mitra, S., Förster‐Fromme, K., Damms-Machado, A., Scheurenbrand, T., Biskup, S., Huson, D. H., & Bischoff, S. C. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-s5-s16 · Cited by 70 · see citing works
Gut Microbiota Influences Alzheimer’s Disease Pathogenesis by Regulating Acetate in Drosophila Model
Kong, Y., Jiang, B., & Luo, X. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0185 · Cited by 68 · see citing works
Liu, Y., Liu, Z., Wei, M., Hu, M., Yue, K., Bi, R., Zhai, S., Pi, Z., Song, F., & Liu, Z. (2018) · Food & Function · doi:10.1039/c8fo02067a · Cited by 64 · see citing works
Cao, T., Zhou, X., Zheng, X., Cui, Y., Tsien, J. Z., Li, C., & Wang, H. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00137 · Cited by 61 · see citing works
Dimethyl fumarate reduces the risk of mycotoxins via improving intestinal barrier and microbiota
Ma, N., Wu, Y., Xie, F., Du, K., Wang, Y., Shi, L., Ji, L., Liu, T., & Ma, X. (2017) · Oncotarget · doi:10.18632/oncotarget.17886 · Cited by 56 · see citing works
Self-citationQuantitative analysis of short-chain fatty acids in human plasma and serum by GC–MS
Yao, L., Davidson, E. A., Shaikh, M. W., Forsyth, C. B., Prenni, J. E., & Broeckling, C. D. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03785-8 · Cited by 49 · see citing works
Wang, H., Wang, C., Guo, L., Zheng, Y., Hu, W., Dong, T. T.-X., Wang, T., & Tsim, K. W. K. (2019) · Journal of Separation Science · doi:10.1002/jssc.201900249 · Cited by 43 · see citing works
Maintenance of Gastrointestinal Glucose Homeostasis by the Gut-Brain Axis
Chen, X., Eslamfam, S., Fang, L., Qiao, S., & Ma, X. (2017) · Current Protein and Peptide Science · doi:10.2174/1389203717666160627083604 · Cited by 36 · see citing works
Nagashima, H., Morio, Y., Meshitsuka, S., Yamane, K., Nanjo, Y., & Teshima, R. (2010) · European Spine Journal · doi:10.1007/s00586-010-1453-3 · Cited by 35 · see citing works
Huang, X., Li, Z., Zhu, L., Huang, H., Hou, L., & Lin, J. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000369 · Cited by 35 · see citing works
Jeong, S., Huang, L., Tsai, M.-J., Liao, Y., Lin, Y., Hu, C., & Hsu, Y. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215090 · Cited by 35 · see citing works
Intestinal Microflora Changes in Patients with Mild Alzheimer’s Disease in a Chinese Cohort
Wang, Y., Li, L., Zhao, X., Sui, S., Wang, Q., Shi, G., Xu, H.-L., Zhang, X., He, Y., & Gu, J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220076 · Cited by 31 · see citing works
Self-citationHistone Deacetylases in the Inflamed Intestinal Epithelium—Promises of New Therapeutic Strategies
Gerbeth, L., & Glauben, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.655956 · Cited by 29 · see citing works
Dual-parameter cell biosensor for real-time monitoring of effects of propionic acid on neurons
Ju, Y., Li, H., Li, J., Gu, N., & Yang, F. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115227 · Cited by 13 · see citing works
Self-citationSutterella faecalis sp. nov., isolated from human faeces
Oh, B. S., Kim, J., Yu, S. Y., Ryu, S. W., Park, S., Kang, S. W., Park, J.-E., Choi, S.-H., Han, K. I., Lee, K. C., et al. (2020) · The Journal of Microbiology · doi:10.1007/s12275-020-9396-9 · Cited by 9 · see citing works
Conjugation Protocol Optimised for Roseburia inulinivorans and Eubacterium rectale
Sheridan, P. O., Martin, J. C., & Scott, K. P. (2020) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3575 · Cited by 5 · see citing works
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The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis
Zhang, R., Ding, N., Feng, X., & Liao, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1529958 · Cited by 56 · see citing works
Gut microbial metabolism in Alzheimer's disease and related dementias
Kang, J. W., Vemuganti, V., Kuehn, J. F., Ulland, T. K., Rey, F. E., & Bendlin, B. B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00470 · Cited by 49 · see citing works
The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders
Młynarska, E., Barszcz, E., Budny, E., Gajewska, A., Kopeć, K., Wasiak, J., Rysz, J., & Franczyk, B. (2025) · Nutrients · doi:10.3390/nu17071135 · Cited by 44 · see citing works
Ravi, A., Umapathy, S., & Pan, I. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01609-2 · Cited by 33 · see citing works
Junyi, L., Yueyang, W., Liu, B., Xiaohong, D., Wenhui, C., Zhang, N., & Zhang, H. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04513-w · Cited by 31 · see citing works
Chen, Q., Shi, J., Yu, G., Xie, H., Yu, S., Xu, J., Liu, J., & Sun, J. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1478557 · Cited by 29 · see citing works
Microbial Metabolomes in Alzheimer’s Disease: From Pathogenesis to Therapeutic Potential
Borrego-Ruiz, A., & Borrego, J. J. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47090724 · Cited by 20 · see citing works
Associations of Microbiota and Nutrition with Cognitive Impairment in Diseases
Młynarska, E., Jakubowska, P., Frąk, W., Gajewska, A., Sornowska, J., Skwira, S., Wasiak, J., Rysz, J., & Franczyk, B. (2024) · Nutrients · doi:10.3390/nu16203570 · Cited by 19 · see citing works
The Metabolites Produced by Lactic Acid Bacteria and Their Role in the Microbiota–Gut–Brain Axis
Aguirre-García, Y. L., Cerda-Alvarez, N. C., Santiago-Santiago, R. M., Chantre-López, A. R., Rangel-Ortega, S. D. C., & Rodrı́guez-Herrera, R. (2025) · Fermentation · doi:10.3390/fermentation11070378 · Cited by 18 · see citing works
Role of short chain fatty acids on astrocytes and microglia in Alzheimer's disease brain
Wtpsk, S., Burton, M., Fernando, W. M. K. T., Jayasena, V., Brennan, C. S., & Fernando, W. M. A. D. B. (2024) · International Journal of Food Science & Technology · doi:10.1111/ijfs.17380 · Cited by 17 · see citing works
Association between gut microbial dysbiosis and Alzheimer’s disease: an umbrella review
Kumari, S., Desai, V., Sivakumar, S., Sikri, K., & Kumar, M. (2025) · npj Dementia · doi:10.1038/s44400-025-00048-6 · Cited by 15 · see citing works
Mir, P. A., Kumar, N. G., Bhutia, G. T., Chaudhary, P., Kaur, G., & Gupta, S. K. (2026) · GeroScience · doi:10.1007/s11357-025-02062-1 · Cited by 13 · see citing works
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Guo, H., Cheng, D., Zhang, C., & Xue, F. Z. (2025) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x25500302 · Cited by 13 · see citing works
Du, L., Wang, B., Wang, X., Wang, L., Wang, R., Zhang, Y., Hong, Z., Han, X., & Wang, Y. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03481-0 · Cited by 13 · see citing works
Self-citationRadhakrishnan, P., Viswanathan, K., Sonali, L., Suneetha, C., & Muthusamy, S. (2025) · Current Alzheimer Research · doi:10.2174/0115672050403066250904112611 · Cited by 12 · see citing works
Saadh, M. J., Ahmed, H. H., Kareem, R. A., Sanghvi, G. V., Ganesan, S., Agarwal, M., Kaur, P., Taher, W. M., Alwan, M., Jawad, M. J., et al. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.173972 · Cited by 12 · see citing works
Kim, M., Kwon, H., Sohn, S., Lee, W. J., Cho, K., & Kim, G. W. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251391820 · Cited by 12 · see citing works
Almahal, Z. H., Hasan, A., Razzak, S. A., Nzila, A. M., & Uddin, S. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00058 · Cited by 11 · see citing works
Xu, J., Song, J. M., Xu, H., Li, Z., Ding, M., Qiao, D., Zhang, B., & Li, B. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124229 · Cited by 11 · see citing works
The role of the gut microbiome in Alzheimer's disease pathophysiology
Borrego-Ruiz, A., & Borrego, J. J. (2025) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001352 · Cited by 10 · see citing works
Anticancer Potential of Prebiotics: Targeting Estrogen Receptors and PI3K/AKT/mTOR in Breast Cancer
Sabit, H., Abouelnour, S., Hassen, B. M., Magdy, S., Yasser, A., Wadan, A.-H. S., Abdel-Ghany, S. E., Radwan, F. F. Y., Alqosaibi, A. I., Hafiz, H., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13040990 · Cited by 10 · see citing works
Research Progress of Lipid Metabolism-Mediated Neuroinflammation in Alzheimer’s Disease
Shen, Y., Wang, X., Liu, X., Wang, G., Hou, X., & Zhou, X. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01648-9 · Cited by 10 · see citing works
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Li, R., Shan, S., Xu, Y., Xiong, J., & Cheng, G. (2025) · Journal of Dairy Science · doi:10.3168/jds.2024-25763 · Cited by 9 · see citing works
Short-chain fatty acids in clinical practice: where are we?
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Nita, I.-B., Văcărean-Trandafir, I.-C., Amărandi, R.-M., Ilie, O., Dobrin, R., Bejenariu, A. C., Ivanov, I.-C., & Doroftei, B. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07461-4 · Cited by 8 · see citing works
Zhu, H., He, H., Yang, M., Zhu, H., Hagiwara, A., Shu, L., Xu, J., Miao, Y., Han, X., & Wang, C. (2025) · iScience · doi:10.1016/j.isci.2025.114044 · Cited by 8 · see citing works
Pu, D., Ye, J., Wang, L., Wang, R., Li, L., Song, Y., & Han, X. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.106034 · Cited by 7 · see citing works
Micek, A., Godos, J., Giampieri, F., Battino, M., Quiles, J. L., Rio, D. D., Mena, P. R., Caruso, G., Frías-Toral, E., Azpíroz, I. D., et al. (2025) · GeroScience · doi:10.1007/s11357-025-02008-7 · Cited by 7 · see citing works
Gong, H., Zhao, H., & Mao, X. (2025) · Foods · doi:10.3390/foods14111938 · Cited by 7 · see citing works
Deshmukh, N., Kumar, P., Kumar, L. K., Balendiran, V., & Singh, P. K. (2025) · Journal of Virology · doi:10.1128/jvi.01826-25 · Cited by 6 · see citing works
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Cárdenas-Castro, A. P., Sost, M. M., Gutiérrez-Sarmiento, W., Ruíz-Valdiviezo, V. M., Mateos, R., Sáyago‐Ayerdi, S. G., & Venema, K. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140664 · Cited by 6 · see citing works
Albert, V., Subramanian, A., & Agrawal, D. K. (2025) · Indian Journal of Neurotrauma · doi:10.1055/s-0045-1807265 · Cited by 4 · see citing works
Thorat, P. A., & Dass, R. S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147102 · Cited by 4 · see citing works
Zheng, J., An, Y., Zhang, X., Cao, Z., Xu, G., Li, J., Wang, J., Chen, L., & Lu, Y. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.01.041 · Cited by 4 · see citing works
Self-citationIkewaki, N., Hegde, M. L., Rao, K. S. J., Raghavan, K., Yamamoto, N., Ichiyama, K., Senthilkumar, R., Preethy, S., & Abraham, S. J. (2025) · Future Neurology · doi:10.1080/14796708.2025.2505398 · Cited by 3 · see citing works
The brain–bone–gut axis: a microbial bridge underlying multisystem comorbidities
Xu, X., Ma, Q., You, P., & Wu, J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1755305 · Cited by 3 · see citing works
Sun, T., Sun, R., YAN, J., (149019), L. L., Que, M., (55634), X. W., Zhang, Z., Li, S., Zhou, Z., Zhao, Y., et al. (2026) · Microbiological Research · doi:10.1016/j.micres.2026.128579 · Cited by 3 · see citing works
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Amarasena, S., Hossain, K. S., Rasouli, A., Bertolo, R. F. P., Yuan, Q., & Mayengbam, S. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.08.012 · Cited by 3 · see citing works
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Wei, S., Yu, S., & Sun, M. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1580753 · Cited by 2 · see citing works
Miao, J., Huang, Y., Yi, Q., Wang, Y., Xiao, S., Liu, Y., Yang, C., Li, X., Li, T., He, K., et al. (2025) · Food & Function · doi:10.1039/d5fo01180a · Cited by 2 · see citing works
Self-citationFan, Y., Zhao, B., Jia, M., Qi, Z., Gao, Y., Wen, B., Dong, Y., Wang, W., Feng, J., Ma, X., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07619-0 · Cited by 2 · see citing works
Musich, M. L., Shenker, J. I., & Beversdorf, D. Q. (2026) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad3010004 · Cited by 2 · see citing works
Zheng, J., An, Y., Zhang, X., Cao, Z., Xu, G., Li, J., Wang, J., Chen, L., & Lu, Y. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70656 · Cited by 2 · see citing works
Self-citationLi, X., Liu, F., Zhu, Y., & Shi, H. (2026) · International Journal of General Medicine · doi:10.2147/ijgm.s593664 · Cited by 2 · see citing works
Sivamaruthi, B. S., Kesika, P., Chaiyasut, C., & Varman, D. R. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1750377 · Cited by 2 · see citing works
Darlington, D. N. (2025) · Molecules · doi:10.3390/molecules30020341 · Cited by 2 · see citing works
Adherence to Life’s Essential 8 enhances gut microbiota diversity and cognitive performance
Wadop, Y. N., Muhammad, J. A. S., Bernal, R., Satizábal, C. L., Beiser, A., Vasan, R. S., Xavier, R. J., Kautz, T. F., Seshadri, S. S., Himali, J. J., et al. (2025) · Frontiers in Microbiomes · doi:10.3389/frmbi.2025.1592023 · Cited by 1 · see citing works
Wang, H., Song, J., He, D., Yang, F., Qiao, G., Tao, J., Gao, X., & Zhu, X. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120345 · Cited by 1 · see citing works
Ren, D., Chai, X., Chenyao, X., Zhao, Y., Sun, P., Wang, M., Li, J., Wu, J., Yi, C., Chen, S., et al. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1757330 · Cited by 1 · see citing works
Self-citationYao, W., Liu, L., Wang, J., Chen, S., Zhang, C., Liao, R., Wang, Y., Ou, K., Jiang, L., Yu, Y., et al. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01738-2 · Cited by 1 · see citing works
Self-citationZang, Z., Chen, F., Tang, Q., Luo, W., Lin, Y., Li, J., & Yu, Y. (2026) · Metabolites · doi:10.3390/metabo16050314 · Cited by 1 · see citing works
Self-citationStanković, V. V., Jovic, D. P., & Rancic, N. K. (2026) · Microbiology Research · doi:10.3390/microbiolres17070124 · Cited by 1 · see citing works
Guo, J., & Gu, Y. (2025) · Nutrients · doi:10.3390/nu17121960 · Cited by 1 · see citing works
Disbiose intestinal e neurodegeneração: a relação intestino-cérebro na Doença de Alzheimer
Teles, I. T. D. P., Moraes, M. N., & de Oliveira, A. C. P. (2025) · Revista Neurociências · doi:10.34024/rnc.2025.v33.19757
Zang, Z., Chen, F., Gao, L., Tang, Q., Luo, W., Lin, Y., & Yu, Y. (2025) · Research Square · doi:10.21203/rs.3.rs-7928145/v1
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Bodur, M., Kızılyıldırım, S., Ningrum, A., Yılmaz, B., & Özoğul, F. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33296-8.00003-4
Lei, C., Liang, R., Cheng, B., Cao, X., Zhang, J., Wang, C., & Wang, Z. (2026) · Environment & Health · doi:10.1021/envhealth.5c00304
Leorda, A., Гараева, С., & Постолати, Г. (2026) · Integrare prin cercetare și inovare. Științe exacte și ale naturii · doi:10.59295/spd2025e.38
The Role of Inflammation in the Brain: A Gut-Driven Phenomenon
Mahbub, N. U., Islam, M. M., & Hong, S. T. (2026) · Springer eBooks · doi:10.1007/978-981-95-7494-0_9
Liao, S., Hu, Y., Li, X., Guo, Z., Wang, Y., Kong, C., Wang, B., & de Vos, P. (2026) · Food Research International · doi:10.1016/j.foodres.2026.119439
Self-citationIvashkin, V. T., Livzan, M. A., Abdulganieva, D., Alekseeva, O. P., Alekseenko, S. A., Бакулина, Н. В., Baranovsky, A. Y., Bordin, D. S., Volel, B. A., Zolnikova, O. Y., et al. (2026) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2026-36-2-7-24
Chandra, J., Wang, H., Hossain, T., Tillett, B. J., Berman, C., Nissen, M. D., Joseph, S. R., Simpson, F., Walpole, E. T., McCaffrey, E., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10134278/v1
Global research landscape on the brain-gut axis in early life: a bibliometric and visualized study
Jiang, F., Hu, Z., Xu, J., & Liu, Y. (2026) · Nutrición Hospitalaria · doi:10.20960/nh.06142
Che, Y., Zhang, Z., Zhai, Q., Zhao, J., Chen, W., Mao, X., & Wang, G. (2026) · Journal of Future Foods · doi:10.1016/j.jfutfo.2026.08.025
Polysaccharides targeting organelle network dysfunction in Alzheimer's disease: A review
Yu, X., Gao, P., Yao, Q., Yuan, F., & 经维新 (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.154255
Health benefits of bioactive peptides
Chukwuejim, S., Oluwajuyitan, T. D., Abioye, R. O., & Aluko, R. E. (2026) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2026.08.005
Description of Dorea chungnamensis sp. nov., an Aerotolerant Anaerobe Isolated from Pig Feces
Paek, J., Bai, L., Jang, J., Shin, Y., Kim, H., Kim, S. H., Shin, J. H., Kook, J., & Chang, Y.-H. (2026) · Current Microbiology · doi:10.1007/s00284-026-05115-6
Structured cross-omics interaction discovery with a triple-graph modelPreprint
Yu, J., Huang, L., & Chen, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.10.749540
Shao, Y., Zhang, R. F., Wang, Z., Gan, J., Jiang, X. J., & Yang, L. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06213-z
Hou, X., Li, Y., Mu, W., Wang, H., & Ji, S. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1941474
- Authors
- Huang, Y., Wang, Y. F., Miao, J., Zheng, R. F., & Li, J. Y.
- Affiliations
- Xinjiang University (CN)
- Xinjiang Institute of Materia Medica (CN)
- Corresponding author
- Miao, Jing
- Li, Jin Yao
- ORCID
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 175
- Pages
- 116601
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W4396912157
- Cited by
- 70
- References
- 110
- Citations by year
- 2026: 25 · 2025: 38 · 2024: 7
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- short-chain fatty acids, Alzheimer's disease, gut-brain axis, gut microbiota, dietary fiber fermentation, immunomodulation, metabolic regulation, neurodegeneration, cognitive decline
- MeSH terms
- Gastrointestinal Microbiome, Brain-Gut Axis, Alzheimer Disease, Animals, Brain, Fatty Acids, Volatile, Humans
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