Cited by 71Gut microbiota and healthAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Short-chain fatty acids: Important components of the gut-brain axis against AD

Open access
Huang, Yan, Wang, Yi Feng, Miao, Jing, Zheng, Rui Fang, Li, Jin Yao·2024·Biomedicine & Pharmacotherapy

Abstract

Alzheimer's disease (AD) comprises a group of neurodegenerative disorders with some changes in the brain, which could lead to the deposition of certain proteins and result in the degeneration and death of brain cells. Patients with AD manifest primarily as cognitive decline, psychiatric symptoms, and behavioural disorders. Short-chain fatty acids (SCFAs) are a class of saturated fatty acids (SFAs) produced by gut microorganisms through the fermentation of dietary fibre ingested. SCFAs, as a significant mediator of signalling, can have diverse physiological and pathological roles in the brain through the gut-brain axis, and play a positive effect on AD via multiple pathways. Firstly, differences in SCFAs and microbial changes have been stated in AD cases of humans and mice in this paper. And then, mechanisms of three main SCFAs in treating with AD have been summarized, as well as differences of gut bacteria. Finally, functions of SCFAs played in regulating intestinal flora homeostasis, modulating the immune system, and the metabolic system, which were considered to be beneficial for the treatment of AD, have been elucidated, and the key roles of gut bacteria and SCFAs were pointed out. All in all, this paper provides an overview of SCFAs and gut bacteria in AD, and can help people to understand the importance of gut-brain axis in AD.

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Crossref · 10.1016/j.biopha.2024.116601

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Authors
Huang, Y., Wang, Y. F., Miao, J., Zheng, R. F., & Li, J. Y.
Affiliations
  • Xinjiang University (CN)
  • Xinjiang Institute of Materia Medica (CN)
Corresponding author
  • Miao, Jing
  • Li, Jin Yao
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2024-06
Volume
175
Pages
116601
ISSN
0753-3322 (ISSN-L)
OpenAlex
W4396912157
Cited by
70
References
110
Citations by year
2026: 25 · 2025: 38 · 2024: 7
FWCI
2.86
Type
journal article
Language
en
Open access
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
short-chain fatty acids, Alzheimer's disease, gut-brain axis, gut microbiota, dietary fiber fermentation, immunomodulation, metabolic regulation, neurodegeneration, cognitive decline
MeSH terms
Gastrointestinal Microbiome, Brain-Gut Axis, Alzheimer Disease, Animals, Brain, Fatty Acids, Volatile, Humans

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