Cited by 12Analytical chemistry methods developmentPesticide Residue Analysis and SafetyAnalytical Chemistry and Chromatography

Preparation of Deep Eutectic Solvent Modified Magnetic Graphene Oxide/Metal Organic Framework Nanocomposites for the Extraction of Three Estrogens in Cosmetics

Hang, Qian, Lou, Yanwei, Yin, Huawen, Yuan, Yue, Xiong, Zhili·2024·Microchimica Acta

Abstract

A novel magnetic dispersive solid phase extraction (MDSPE) procedure based on the deep eutectic solvent (DES) modified magnetic graphene oxide/metal organic frameworks nanocomposites (MGO@ZIF-8@DES) was established and used for the efficient enrichment of estradiol, estrone, and diethylstilbestrol in cosmetics (toner, lotion, and cream) for the first time. Then, the three estrogens were separated and determined by UHPLC-UV analysis method. In order to study the features and morphology of the synthesized adsorbents, various techniques such as FT-IR, SEM, and VSM measurements were executed. The MGO@ZIF-8@DES nanocomposites combine the advantages of high adsorption capacity, adequate stability in aqueous solution, and convenient separation from the sample solution. To achieve high extraction recoveries, the Box-Behnken design and single factor experiment were applied in the experimental design. Under the optimum conditions, the method detection limits for three estrogens were 20-30 ng g-1. This approach showed a good correlation coefficient (r more than 0.9998) and reasonable linearity in the range 70-10000 ng g-1. The relative standard deviations for intra-day and inter-day were beneath 7.5% and 8.9%, respectively. The developed MDSPE-UHPLC-UV method was successfully used to determine three estrogens in cosmetics, and acceptable recoveries in the intervals of 83.5-95.9% were obtained. Finally, three estrogens were not detected in some cosmetic samples. In addition, the Complex GAPI tool was used to evaluate the greenness of the developed pretreatment method. The developed MDSPE-UHPLC-UV method is sensitive, accurate, rapid, and eco-friendly, which provides a promising strategy for determining hormones in different complex samples.

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Crossref · 10.1007/s00604-024-06546-3

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Authors
Hang, Q., Lou, Y., Yin, H., Yuan, Y., & Xiong, Z.
Affiliations
Shenyang Pharmaceutical University (CN)
Corresponding author
Xiong, Zhili
Venue
Microchimica Acta
Published
2024-07-22
Volume
191
Issue
8
Pages
474-474
ISSN
  • 0026-3672 (ISSN-L)
  • 1436-5073
OpenAlex
W4400879262
Cited by
12
References
36
Citations by year
2026: 7 · 2025: 4 · 2024: 1
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Locations
  • Microchimica Acta (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (82174235, 81773694)
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
  • Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
Keywords
deep eutectic solvents, magnetic graphene oxide, ZIF-8, metal-organic frameworks, magnetic dispersive solid-phase extraction, estrogen, estradiol, estrone, diethylstilbestrol, cosmetics, hormone residues, green analytical chemistry
MeSH terms
Metal-Organic Frameworks, Deep Eutectic Solvents, Adsorption, Chromatography, High Pressure Liquid, Cosmetics, Diethylstilbestrol, Estradiol, Estrogens, Estrone, Graphite, Solid Phase Extraction, Nanocomposites, Limit of Detection

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