Preparation of Deep Eutectic Solvent Modified Magnetic Graphene Oxide/Metal Organic Framework Nanocomposites for the Extraction of Three Estrogens in Cosmetics
Abstract
A novel magnetic dispersive solid phase extraction (MDSPE) procedure based on the deep eutectic solvent (DES) modified magnetic graphene oxide/metal organic frameworks nanocomposites (MGO@ZIF-8@DES) was established and used for the efficient enrichment of estradiol, estrone, and diethylstilbestrol in cosmetics (toner, lotion, and cream) for the first time. Then, the three estrogens were separated and determined by UHPLC-UV analysis method. In order to study the features and morphology of the synthesized adsorbents, various techniques such as FT-IR, SEM, and VSM measurements were executed. The MGO@ZIF-8@DES nanocomposites combine the advantages of high adsorption capacity, adequate stability in aqueous solution, and convenient separation from the sample solution. To achieve high extraction recoveries, the Box-Behnken design and single factor experiment were applied in the experimental design. Under the optimum conditions, the method detection limits for three estrogens were 20-30 ng g-1. This approach showed a good correlation coefficient (r more than 0.9998) and reasonable linearity in the range 70-10000 ng g-1. The relative standard deviations for intra-day and inter-day were beneath 7.5% and 8.9%, respectively. The developed MDSPE-UHPLC-UV method was successfully used to determine three estrogens in cosmetics, and acceptable recoveries in the intervals of 83.5-95.9% were obtained. Finally, three estrogens were not detected in some cosmetic samples. In addition, the Complex GAPI tool was used to evaluate the greenness of the developed pretreatment method. The developed MDSPE-UHPLC-UV method is sensitive, accurate, rapid, and eco-friendly, which provides a promising strategy for determining hormones in different complex samples.
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DES-functionalized magnetic graphene oxide/metal-organic framework composites enhance extraction efficiency and provide more convenient magnetic separation in magnetic dispersive solid-phase extraction.
“In a recent study, Hang et al. fabricated DES-functionalized magnetic graphene oxide/metal-organic framework composites for magnetic dispersive solid-phase extraction, demonstrating enhanced extraction efficiency together with more convenient magnetic separation [115].”
From Eco-Friendly Deep Eutectic Solvent-Based Extraction Technologies: A Comprehensive Review of Principles, Applications, and Comparative Insights (2026) · cites this paper as [115]
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- Authors
- Hang, Q., Lou, Y., Yin, H., Yuan, Y., & Xiong, Z.
- Affiliations
- Shenyang Pharmaceutical University (CN)
- Corresponding author
- Xiong, Zhili
- Venue
- Microchimica Acta
- Published
- 2024-07-22
- Volume
- 191
- Issue
- 8
- Pages
- 474-474
- ISSN
- 0026-3672 (ISSN-L)
- 1436-5073
- OpenAlex
- W4400879262
- Cited by
- 12
- References
- 36
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Microchimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82174235, 81773694)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
- Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
- Keywords
- deep eutectic solvents, magnetic graphene oxide, ZIF-8, metal-organic frameworks, magnetic dispersive solid-phase extraction, estrogen, estradiol, estrone, diethylstilbestrol, cosmetics, hormone residues, green analytical chemistry
- MeSH terms
- Metal-Organic Frameworks, Deep Eutectic Solvents, Adsorption, Chromatography, High Pressure Liquid, Cosmetics, Diethylstilbestrol, Estradiol, Estrogens, Estrone, Graphite, Solid Phase Extraction, Nanocomposites, Limit of Detection
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