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Cited by 14Pain Management and TreatmentEffects of Radiation ExposureBrain Metastases and Treatment

Modification of glucose metabolism in radiation-induced brain injury areas using cervical spinal cord stimulation

Clavo, Bernardino, Robaina, Francisco, Montz, Ricardo, Carames, Miguel A., Lloret, Marta, Ponce, Pedro, Hernandez, María A., Carreras, Jose L.·2009·Acta Neurochirurgica
DOI 10.1007/s00701-009-0400-8
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Abstract

Purpose Radiation-induced brain injury (RBI) is an insidious side-effect of radiotherapy mediated by vascular alterations, inflammation and ischaemia. In previous studies we had shown potential increases in loco-regional blood flow and glucose metabolism in brain tumours by using electrical cervical spinal cord stimulation (SCS). In this preliminary report we demonstrate the effect of cervical SCS on RBI-tissue metabolism, as assessed using [(18)F]fluorodeoxyglucose-positron emission tomography (FDG-PET).Methods SCS devices were inserted in eight patients with diagnosis of potential RBI in previously irradiated areas. While the SCS device was deactivated, each patient underwent an initial FDG-PET study to evaluate the clinical status. A second FDG-PET study was performed later the same day while the SCS device was activated in order to evaluate the effect of cervical SCS on glucose metabolism.Results Basal glucose metabolism in RBI areas was 31% lower than peri-RBI areas (p = 0.009) and 32% lower than healthy contra-lateral areas (p = 0.020). There was a significant increase in glucose uptake during SCS in both the RBI (p = 0.005) and the peri-RBI (p = 0.004) areas, with measured increases of 38 and 42%, respectively. The estimated potential maximal residual activity of the first FDG dose's contribution to the activity on the second scan was <or=14.3 +/- 4.6%.Conclusions In this study using PET, SCS increased glucose metabolism in RBI and peri-RBI areas. These results warrant further clinical investigation to elucidate more fully the clinical usefulness of SCS in these patients.

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  • FDG-PET/CT imaging after walking was previously used to study the effect of spinal cord stimulation at the cervical level.

    “This technique was previously used to study the effect of spinal cord stimulation at the cervical level52.”

    From The neurons that restore walking after paralysis (2022) · cites this paper as [52]

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Authors
Clavo, B., Robaina, F., Montz, R., Carames, M. A., Lloret, M., Ponce, P., Hernandez, M. A., & Carreras, J. L.
Affiliations
Hospital Universitario de Gran Canaria Doctor Negrín (ES)
Corresponding author
Clavo, Bernardino
ORCID
Venue
Acta Neurochirurgica
Publisher
Springer Science and Business Media LLC
Published
2009-06-05
Volume
151
Issue
11
Pages
1419-1425
ISSN
  • 0001-6268 (ISSN-L)
  • 0942-0940
DOI
10.1007/s00701-009-0400-8
OpenAlex
W2154906996
Cited by
14
References
30
Citations by year
2022: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 2
FWCI
1.91
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Acta Neurochirurgica (publishedVersion)
  • PubMed (publishedVersion)
  • Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Brain Metastases and Treatment
Keywords
radiation-induced brain injury, cervical spinal cord stimulation, glucose metabolism, FDG-PET, radiotherapy complications, brain ischaemia, glucose uptake, neuroprotection
MeSH terms
Adult, Afferent Pathways, Aged, Brain, Brain Damage, Chronic, Brain Mapping, Brain Neoplasms, Cerebrovascular Circulation, Cervical Vertebrae, Electric Stimulation, Energy Metabolism, Female, Glucose, Humans, Male, Middle Aged, Predictive Value of Tests, Radiation Injuries, Radiotherapy, Sensitivity and Specificity, Spinal Cord, Fluorodeoxyglucose F18, Positron-Emission Tomography

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