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Cited by 11Genetics, Aging, and Longevity in Model OrganismsReproductive biology and impacts on aquatic speciesPhysiological and biochemical adaptations

Brain aging phenomena in migrating sockeye salmon Oncorhynchus nerka nerka

Götz, M. E., Malz, C. R., Dirr, A., Blum, D., Gsell, W., Schmidt, S., Burger, R., Pohli, S. +1 more·2005·Journal of Neural Transmission
DOI 10.1007/s00702-004-0257-1
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Abstract

Aging, a process occurring in all vertebrates, is closely related to a loss in physical and functional abilities. There is widespread interest in clarifying the relevance of environmental, metabolic, and genetic factors for vertebrate aging. In the Pacific salmon a dramatic example of aging is known. Looking for changes in the salmon brain, perhaps even in the role of initiating the aging processes, we investigated several biochemical parameters that should reflect brain functional activity and stress response such as the neurotransmitters dopamine, and serotonin, and two of their respective metabolites 3,4-dihydroxyphenylacetic acid, and 5-hydroxyindole acetic acid, as well as glutathione, glutathione disulfide, and the extent of terminal deoxynucleotidyltransferase-mediated dUTP nick end-labelling. The aging of migrating sockeye salmon (Oncorhynchus nerka nerka) is accompanied by gradual increase in dopamine and serotonin turnover and a gradual decrease of brain total protein and glutathione levels. There appears to be an increased need for detoxification of reactive biological intermediates since activities of superoxide dismutase and catalase increase with age. However, our data do not support a major increase in apoptotic cell death during late aging but rather implicate an age related downward regulation of protein and glutathione synthesis and proteolysis increasing the need for autophagocytosis or heterophagocytosis in the course of cell death.

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Crossref · 10.1007/s00702-004-0257-1

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114 of 114 references verified0 citation errors · 0 not checkable

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  • Allostatic overload can have a useful purpose for preservation of the species, such as in migrating salmon or the marsupial mouse, which die of excessive stress after mating.

    “However, allostatic overload can also have a useful purpose for the preservation of the species, such as In migrating salmon or the marsupial mouse, which die of excessive stress after mating- the stress, and allostatic load, being caused for salmon, In part, by the migration up the rapidly flowing rivers, but also because of physiological changes that represent accelerated aging.12-14”

    From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [14]

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Authors
Götz, M. E., Malz, C. R., Dirr, A., Blum, D., Gsell, W., Schmidt, S., Burger, R., Pohli, S., & Riederer, P.
Affiliations
  • University of Würzburg (DE)
  • University of Göttingen (DE)
  • Universität Ulm (DE)
ORCID
Venue
Journal of Neural Transmission
Publisher
Springer Science and Business Media LLC
Published
2005-01-31
Volume
112
Issue
9
Pages
1177-1199
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
DOI
10.1007/s00702-004-0257-1
OpenAlex
W1980424915
Cited by
11
References
114
Citations by year
2019: 1 · 2016: 1 · 2013: 1
FWCI
0.30
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
  • GRO (submittedVersion)
Funders
National Marine Fisheries Service
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
Keywords
brain aging, sockeye salmon, dopamine, serotonin, DOPAC, 5-hydroxyindoleacetic acid, glutathione, superoxide dismutase, catalase, oxidative stress, apoptosis, autophagy, neurotransmitter turnover
MeSH terms
Aging, Animals, Antioxidants, Brain, Catalase, Dopamine, Female, Glutathione, Homovanillic Acid, Hydroxyindoleacetic Acid, Nerve Degeneration, Salmon, Serotonin, Superoxide Dismutase, 3,4-Dihydroxyphenylacetic Acid, Apoptosis, Neurotransmitter Agents, Glutathione Disulfide, Animal Migration

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