The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Statins: drugs for Alzheimer’s disease?
Abstract
Evidences from cell culture experiments and animal studies suggest a strong link between cholesterol and Alzheimer's disease (AD). This relationship is supported by retrospective epidemiological studies demonstrating that statin treatment reduced the prevalence of AD in patients suffering from hypercholesterolaemia. The alternative processing of the amyloid-precursor protein (APP) in the brain of AD patients leads to the production of the neurotoxic amyloid-beta protein (Abeta), a causative factor for AD pathology. In vitro, this mechanism is modulated by alterations in cellular cholesterol levels. Moreover, lowering cholesterol in animal experiments reduced the production of Abeta in most but not all studies. These findings led to prospective clinical trials of cholesterol-lowering statins in AD patients, even if many studies do not support elevated cholesterol levels in serum and brain as a risk factor for Alzheimer's disease. Most of these studies were negative. Thus, up to date there is insufficient evidence to suggest the use of statins for treatment in patients with AD.
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Patients taking statins, a cholesterol-lowering drug, are still less likely to develop AD.
“patients taking statins, a cholesterol-lowering drug, are still less likely to develop the disease (Eckert et al., 2005; Fonseca et al., 2010; Wood et al., 2014).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Eckert et al., 2005
Citations
Cites
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975
New insights into the pharmacodynamic and pharmacokinetic properties of statins
Corsini, A., Bellosta, S., Baetta, R., Fumagalli, R., Paoletti, R., & Bernini, F. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00045-5 · Cited by 796
Molecular pathways to neurodegeneration
Bossy-Wetzel, E., Schwarzenbacher, R., & Lipton, S. A. (2004) · Nature Medicine · doi:10.1038/nm1067 · Cited by 740
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Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Ayurvedic medicinal plants for Alzheimer’s disease: A review
Rao, R. V., Descamps, O., John, V., & Bredesen, D. E. (2012) · Alzheimer's Research & Therapy · doi:10.1186/alzrt125 · Cited by 213
Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease
Geifman, N., Brinton, R. D., Kennedy, R. E., Schneider, L. S., & Butte, A. J. (2017) · Alzheimer's Research & Therapy · doi:10.1186/s13195-017-0237-y · Cited by 191
Apolipoprotein E and cholesterol in aging and disease in the brain
de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164
García-González, L., Pilat, D., Baranger, K., & Rivera, S. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00244 · Cited by 88
HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival
Lacher, S. M., Bruttger, J., Kalt, B., Berthelet, J., Rajalingam, K., Wörtge, S., & Waisman, A. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.221 · Cited by 58
“On the other hand, statin application showed promising effects in the treatment of other neurodegenerative disease,(20) such as cerebrovascular disease,(21) Parkinson’s disease(22) and Alzheimer’s disease.(23) To reach an optimal neuroprotective effect of statins in patients, as well as in mice, a good diffusion of st…”
BackgroundBiological consequences of statins in Candida species and possible implications for human health
Wikhe, K., Westermeyer, C., & Macreadie, I. G. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351529 · Cited by 31
Metadata
- Authors
- Eckert, G. P., Wood, W. G., & Müller, W. E.
- Venue
- Journal of Neural Transmission
- Published
- 2005-01-31
- Volume
- 112
- Issue
- 8
- Pages
- 1057-1071
- ISSN
- 0300-9564
- 1435-1463
- Cited by
- 46
- References
- 3
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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