Ayurvedic medicinal plants for Alzheimer’s disease: A review
Open accessAbstract
Alzheimer's disease is an age-associated, irreversible, progressive neurodegenerative disease that is characterized by severe memory loss, unusual behavior, personality changes, and a decline in cognitive function. No cure for Alzheimer's exists, and the drugs currently available to treat the disease have limited effectiveness. It is believed that therapeutic intervention that could postpone the onset or progression of Alzheimer's disease would dramatically reduce the number of cases in the next 50 years. Ayurvedic medicinal plants have been the single most productive source of leads for the development of drugs, and over a hundred new products are already in clinical development. Indeed, several scientific studies have described the use of various Ayurvedic medicinal plants and their constituents for treatment of Alzheimer's disease. Although the exact mechanism of their action is still not clear, phytochemical studies of the different parts of the plants have shown the presence of many valuable compounds, such as lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids, that show a wide spectrum of pharmacological activities, including anti-inflammatory, anti-amyloidogenic, anti-cholinesterase, hypolipidemic, and antioxidant effects. This review gathers research on various medicinal plants that have shown promise in reversing the Alzheimer's disease pathology. The report summarizes information concerning the phytochemistry, biological, and cellular activities and clinical applications of these various plants in order to provide sufficient baseline information that could be used in drug discovery campaigns and development process, thereby providing new functional leads for Alzheimer's disease.
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Withania somnifera is one of the most conspicuous herbs prescribed for Alzheimer's disease.
“W. somnifera is one of the most conspicuous herbs prescribed for AD [80,81].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [81]
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- Authors
- Rao, R. V., Descamps, O., John, V., & Bredesen, D. E.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Rao, Rammohan V
- Venue
- Alzheimer's Research & Therapy
- Published
- 2012
- Volume
- 4
- Issue
- 3
- Pages
- 22
- ISSN
- 1758-9193 (ISSN-L)
- PMC
- PMC3506936
- OpenAlex
- W2124410890
- Cited by
- 213
- References
- 112
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 19 · 2023: 33 · 2022: 31 · 2021: 22 · 2020: 13 · 2019: 19 · 2018: 12 · 2017: 14 · 2016: 8 · 2015: 6 · 2014: 5 · 2013: 2
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Alzheimer s Research & Therapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Rosenberg Foundation
- National Institutes of Health
- National Institute on Aging (R01AG012282)
- National Institute of Neurological Disorders and Stroke (R01NS033376)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, Ayurvedic medicinal plants, phytochemicals, flavonoids, polyphenols, lignans, anti-amyloidogenic activity, anticholinesterase activity, antioxidant activity, anti-inflammatory activity, hypolipidemic activity, neurodegeneration, drug discovery
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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