Cited by 213Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Ayurvedic medicinal plants for Alzheimer’s disease: A review

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Rao, Rammohan V, Descamps, Olivier, John, Varghese, Bredesen, Dale E·2012·Alzheimer's Research & Therapy

Abstract

Alzheimer's disease is an age-associated, irreversible, progressive neurodegenerative disease that is characterized by severe memory loss, unusual behavior, personality changes, and a decline in cognitive function. No cure for Alzheimer's exists, and the drugs currently available to treat the disease have limited effectiveness. It is believed that therapeutic intervention that could postpone the onset or progression of Alzheimer's disease would dramatically reduce the number of cases in the next 50 years. Ayurvedic medicinal plants have been the single most productive source of leads for the development of drugs, and over a hundred new products are already in clinical development. Indeed, several scientific studies have described the use of various Ayurvedic medicinal plants and their constituents for treatment of Alzheimer's disease. Although the exact mechanism of their action is still not clear, phytochemical studies of the different parts of the plants have shown the presence of many valuable compounds, such as lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids, that show a wide spectrum of pharmacological activities, including anti-inflammatory, anti-amyloidogenic, anti-cholinesterase, hypolipidemic, and antioxidant effects. This review gathers research on various medicinal plants that have shown promise in reversing the Alzheimer's disease pathology. The report summarizes information concerning the phytochemistry, biological, and cellular activities and clinical applications of these various plants in order to provide sufficient baseline information that could be used in drug discovery campaigns and development process, thereby providing new functional leads for Alzheimer's disease.

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  1. Alzheimer's Association 2010 Alzheimer's disease facts and figures Alzheimers Dement 6 158 194 20298981

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Authors
Rao, R. V., Descamps, O., John, V., & Bredesen, D. E.
Affiliations
Buck Institute for Research on Aging (US)
Corresponding author
Rao, Rammohan V
Venue
Alzheimer's Research & Therapy
Published
2012
Volume
4
Issue
3
Pages
22
ISSN
1758-9193 (ISSN-L)
OpenAlex
W2124410890
Cited by
213
References
112
Citations by year
2026: 10 · 2025: 18 · 2024: 19 · 2023: 33 · 2022: 31 · 2021: 22 · 2020: 13 · 2019: 19 · 2018: 12 · 2017: 14 · 2016: 8 · 2015: 6 · 2014: 5 · 2013: 2
FWCI
10.13
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s Research & Therapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Rosenberg Foundation
  • National Institutes of Health
  • National Institute on Aging (R01AG012282)
  • National Institute of Neurological Disorders and Stroke (R01NS033376)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
Alzheimer's disease, Ayurvedic medicinal plants, phytochemicals, flavonoids, polyphenols, lignans, anti-amyloidogenic activity, anticholinesterase activity, antioxidant activity, anti-inflammatory activity, hypolipidemic activity, neurodegeneration, drug discovery

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