Apolipoprotein E and cholesterol in aging and disease in the brain

Lipid rafts and signal transduction

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Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

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Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

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Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

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Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

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Amyloid β-peptide is produced by cultured cells during normal metabolism

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Statins and the risk of dementia

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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

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CNS synaptogenesis promoted by glia-derived cholesterol

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Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

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Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

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Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

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Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

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Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management

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Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

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Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

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Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

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Cholesterol, lipid rafts, and disease

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Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

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Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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Cholesterol, lipid rafts, and disease

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Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

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Cholesterol metabolism in the brain

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Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

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Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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Alzheimer's disease: the cholesterol connection

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Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome

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Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

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Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study

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Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

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Untitled work

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Apolipoprotein E and Alzheimer disease.

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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

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Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

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Association of apolipoprotein E polymorphism with outcome after head injury

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Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

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Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E

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The Aging Brain

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Alzheimer’s disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies

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Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

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Lipid Rafts in the Maintenance of Synapses, Dendritic Spines, and Surface AMPA Receptor Stability

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Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease.

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Apolipoprotein E structure: insights into function

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Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies

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Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles

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Induction of Alzheimer-like β-Amyloid Immunoreactivity in the Brains of Rabbits with Dietary Cholesterol

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Isoform-specific binding of apolipoprotein E to beta-amyloid.

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The Oligomerization of Amyloid β-Protein Begins Intracellularly in Cells Derived from Human Brain

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Apolipoprotein E is essential for amyloid deposition in the <i>APP</i> ^V717F transgenic mouse model of Alzheimer's disease

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Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

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ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE

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New Frontiers in Alzheimer's Disease Genetics

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Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

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Alzheimer’s disease pathogenesis and therapeutic interventions

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Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human Polymorphism

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Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

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Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

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Neurodegeneration in the Central Nervous System of apoE-Deficient Mice

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

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Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain

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Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain

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Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies

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Role for glia in synaptogenesis

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Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.

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Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.

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Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

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Cholesterol in Alzheimer's disease

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Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron

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Neuronal membrane cholesterol loss enhances amyloid peptide generation

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