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Cited by 35Neurotransmitter Receptor Influence on BehaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesAttention Deficit Hyperactivity Disorder

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Sympathetic activity relates to adenosine A2A receptor gene variation in blood-injury phobia

Hohoff, C., Domschke, K., Schwarte, K., Spellmeyer, G., Vögele, C., Hetzel, G., Deckert, J., Gerlach, A. L.·2009·Journal of Neural Transmission
DOI 10.1007/s00702-008-0089-5
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Abstract

Variation in the candidate genes adenosine A(2A) receptor (A(2A)R), catechol-O-methyl-transferase (COMT), and norepinephrine transporter (NET) has been suggested to influence vulnerability to panic disorder. We therefore investigated patients with another anxiety disorder with an even higher heritability, the blood-injury phobia, for association of these variants and used sympathetic measures during venipuncture, which serve as a naturalistic trigger of anxiety and autonomic hyperarousal, as an intermediate phenotype of anxiety. Patients homozygous for the A(2A)R 1976T allele as compared to patients carrying at least one 1976C allele exhibited a significantly increased respiratory rate with a trend towards elevated measures of systolic and diastolic blood pressure and respiratory minute volume. None of the sympathetic measures were influenced by the COMT or NET polymorphisms.This study provides preliminary data suggesting an influence of the A(2A)R 1976C/T polymorphism on sympathetic psychophysiological indicators of anxiety-related arousal in blood-injury phobia and thereby further supports a role of the A(2A)R gene in the pathogenesis of anxiety disorders.

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  • Hohoff et al. found significant enhancement of respiratory and cardiac responses to venipuncture in BII-phobia patients explained by polymorphism of the adenosine A2A receptor gene.

    “In a small study, Hohoff et al. (2009) recently found significant enhancement of respiratory and cardiac responses to venipuncture in BII-phobia patients explained by polymorphism of the adenosine A2A receptor gene.”

    From The psychophysiology of blood-injection-injury phobia: Looking beyond the diphasic response paradigm (2010) · cites this paper as Hohoff et al. (2009)

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Research works printed but not linked: 20

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Metadata

Authors
Hohoff, C., Domschke, K., Schwarte, K., Spellmeyer, G., Vögele, C., Hetzel, G., Deckert, J., & Gerlach, A. L.
Affiliations
  • University of Münster (DE)
  • University of Roehampton (GB)
Corresponding author
Hohoff, C.
ORCID
Venue
Journal of Neural Transmission
Publisher
Springer Science and Business Media LLC
Published
2008-07-16
Volume
116
Issue
6
Pages
659-662
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
DOI
10.1007/s00702-008-0089-5
OpenAlex
W2034086962
Cited by
35
References
2
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 6
FWCI
1.00
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
  • Open Repository and Bibliography (University of Luxembourg) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords
adenosine A2A receptor, sympathetic nervous system, venipuncture, respiratory rate, blood pressure, catechol-O-methyltransferase, norepinephrine transporter, anxiety disorders, candidate genes, endophenotypes
MeSH terms
Adult, Female, Genotype, Humans, Male, Phobic Disorders, Polymorphism, Restriction Fragment Length, Sympathetic Nervous System, Polymerase Chain Reaction, Genetic Predisposition to Disease, Receptor, Adenosine A2A

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