Response to methylphenidate in children and adolescents with ADHD: does comorbid anxiety disorders matters?
Abstract
There are controversial evidence in the literature on the role of comorbid anxiety disorders (ANX) in the improvement of attention-deficit/hyperactivity disorder (ADHD) symptoms with methylphenidate (MPH) treatment. Our main objective was to assess differences in the response to MPH treatment in children and adolescents with ADHD with and without comorbid ANX. We extensively evaluated response to MPH in a naturalistic study of 280 children and adolescent with ADHD according to DSM-IV criteria. Psychiatric diagnoses (ADHD, ANX, and other comorbidities) were assessed by semi-structured interviews (K-SADS-E). Response to MPH was assessed by means of total score in the Swanson, Nolan, and Pelham Scale-version IV (SNAP-IV) after 1 month of treatment. There was no significant between-group difference in the response to treatment with MPH after 1 month either when SNAP-IV scores were assessed dimensionally or categorically (moderate response) (P > 0.05). Our findings suggest that comorbid ANX do not interfere in the response to MPH on core ADHD symptoms.
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Comorbid anxiety does not affect stimulant efficacy.
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From Advances in understanding and treating ADHD (2011) · cites this paper as [48]
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- Authors
- Garcia, S. P., Guimarães, J., Zampieri, J. F., Martinez, A. L., Polanczyk, G., & Rohde, L. A.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Duke University (US)
- Venue
- Journal of Neural Transmission
- Published
- 2009-04-16
- Volume
- 116
- Issue
- 5
- Pages
- 631-636
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2066573426
- Cited by
- 23
- References
- 32
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2017: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- methylphenidate, attention deficit hyperactivity disorder, comorbid anxiety disorders, treatment response, children and adolescents, SNAP-IV, ADHD symptom severity, comorbidities
- MeSH terms
- Adolescent, Central Nervous System Stimulants, Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Brain, Child, Child, Preschool, Drug Resistance, Female, Humans, Male, Methylphenidate, Neuropsychological Tests, Prospective Studies, Comorbidity, Causality
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