Cited by 23Attention Deficit Hyperactivity DisorderChild and Adolescent Psychosocial and Emotional DevelopmentNeurotransmitter Receptor Influence on Behavior

Response to methylphenidate in children and adolescents with ADHD: does comorbid anxiety disorders matters?

Garcia, Sheila P., Guimarães, Julia, Zampieri, Juliana F., Martinez, Ana Luiza, Polanczyk, Guilherme, Rohde, Luis Augusto·2009·Journal of Neural Transmission

Abstract

There are controversial evidence in the literature on the role of comorbid anxiety disorders (ANX) in the improvement of attention-deficit/hyperactivity disorder (ADHD) symptoms with methylphenidate (MPH) treatment. Our main objective was to assess differences in the response to MPH treatment in children and adolescents with ADHD with and without comorbid ANX. We extensively evaluated response to MPH in a naturalistic study of 280 children and adolescent with ADHD according to DSM-IV criteria. Psychiatric diagnoses (ADHD, ANX, and other comorbidities) were assessed by semi-structured interviews (K-SADS-E). Response to MPH was assessed by means of total score in the Swanson, Nolan, and Pelham Scale-version IV (SNAP-IV) after 1 month of treatment. There was no significant between-group difference in the response to treatment with MPH after 1 month either when SNAP-IV scores were assessed dimensionally or categorically (moderate response) (P > 0.05). Our findings suggest that comorbid ANX do not interfere in the response to MPH on core ADHD symptoms.

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Crossref · 10.1007/s00702-009-0211-3

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  • Comorbid anxiety does not affect stimulant efficacy.

    “Comorbid anxiety was not found to affect stimulant efficacy in a recent study [48]”

    From Advances in understanding and treating ADHD (2011) · cites this paper as [48]

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Authors
Garcia, S. P., Guimarães, J., Zampieri, J. F., Martinez, A. L., Polanczyk, G., & Rohde, L. A.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • Duke University (US)
Venue
Journal of Neural Transmission
Published
2009-04-16
Volume
116
Issue
5
Pages
631-636
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2066573426
Cited by
23
References
32
Citations by year
2025: 1 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2017: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
1.64
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
methylphenidate, attention deficit hyperactivity disorder, comorbid anxiety disorders, treatment response, children and adolescents, SNAP-IV, ADHD symptom severity, comorbidities
MeSH terms
Adolescent, Central Nervous System Stimulants, Anxiety Disorders, Attention Deficit Disorder with Hyperactivity, Brain, Child, Child, Preschool, Drug Resistance, Female, Humans, Male, Methylphenidate, Neuropsychological Tests, Prospective Studies, Comorbidity, Causality

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