The DOI matches its Crossref record; 77 of the 79 references it cites were found in a registry or an index.
Cognitive effects of high-frequency repetitive transcranial magnetic stimulation: a systematic review
Open accessAbstract
Transcranial magnetic stimulation (TMS) was introduced as a non-invasive tool for the investigation of the motor cortex. The repetitive application (rTMS), causing longer lasting effects, was used to study the influence on a variety of cerebral functions. High-frequency (>1 Hz) rTMS is known to depolarize neurons under the stimulating coil and to indirectly affect areas being connected and related to emotion and behavior. Researchers found selective cognitive improvement after high-frequency (HF) stimulation specifically over the left dorsolateral prefrontal cortex (DLPFC). This article provides a systematic review of HF-rTMS studies (1999-2009) stimulating over the prefrontal cortex of patients suffering from psychiatric/neurological diseases or healthy volunteers, where the effects on cognitive functions were measured. The cognitive effect was analyzed with regard to the impact of clinical status (patients/healthy volunteers) and stimulation type (verum/sham). RTMS at 10, 15 or 20 Hz, applied over the left DLPFC, within a range of 10-15 successive sessions and an individual motor threshold of 80-110%, is most likely to cause significant cognitive improvement. In comparison, patients tend to reach a greater improvement than healthy participants. Limitations concern the absence of healthy groups in clinical studies and partly the absence of sham groups. Thus, future investigations are needed to assess cognitive rTMS effects in different psychiatric disorders versus healthy subjects using an extended standardized neuropsychological test battery. Since the pathophysiological and neurobiological basis of cognitive improvement with rTMS remains unclear, additional studies including genetics, experimental neurophysiology and functional brain imaging are necessary to explore stimulation-related functional changes in the brain.
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“In addition to its role in depression, the DLPFC plays a critical role in emotion regulation, working memory, and executive functioning. These are all impaired in individuals with a history of concussion and shown to improve after rTMS targeted at the DLPFC (22, 23).”
From Adaptive trial for the treatment of depressive symptoms associated with concussion using accelerated intermittent theta burst stimulation (ADEPT): rationale, design and methods (2025) · cites this paper as [22]
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“iTBS may have induced larger performance gains in lower capacity individuals (Guse, Falkai, & Wobrock, 2010), however this effect could have been averaged out by individuals with higher capacities and a greater number of epochs.”
From Investigation of neurobiological responses to theta burst stimulation during recovery from mild traumatic brain injury (mTBI) (2023) · cites this paper as Guse, Falkai, & Wobrock, 2010
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Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
NON-INVASIVE MAGNETIC STIMULATION OF HUMAN MOTOR CORTEX
Barker, A. T., Jalinous, R., & Freeston, I. L. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92413-4 · Cited by 4,466
The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe
Fuster, J. M. (1980) · Cited by 2,367
Stuss, D. T., & Benson, D. F. (1986) · Raven Press eBooks · Cited by 2,102
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960
Posner, M. I., & Boies, S. J. (1971) · Psychological Review · doi:10.1037/h0031333 · Cited by 1,751
Carpenter, P. A., Just, M. A., & Shell, P. (1990) · Psychological Review · doi:10.1037/0033-295x.97.3.404 · Cited by 1,648
Pashler, H. (1997) · doi:10.7551/mitpress/5677.001.0001 · Cited by 1,607
Parasuraman, R., & DAVIES, D. R. (1984) · Academic Press eBooks · Cited by 1,566
Strafella, A. P., Paus, T., Barrett, J., & Dagher, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-j0003.2001 · Cited by 1,058
Research works printed but not linked: 2
- Jandl M, Bittner R, Sack A, Weber B, Günther T, Maurer K, Kaschka WP (2004) Effects of rTMS on negative symptoms and EEG-topography in schizophrenic patients. Eur Psychiatry 19(Suppl 1):164
- Zimmermann P, Fimm B (1997) Test for Attentional Performance (TAP), version 1.5. Psytest Press, Freiburg
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Items 301–339 of 339
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Jansen, J. M., van der Werf, Y. D., van den Heuvel, O. A., de Wit, S. J., van den Brink, W., & Goudriaan, A. E. (2015) · Neuropraxis · doi:10.1007/s12474-015-0080-5
Durand, F., Gaudeau, C., Moulier, V., Andrianisaina, P. S., Bertasi, E., Isaac, C., Braha-Zeitoun, S., Bouaziz, N., & Januel, D. (2014) · European Psychiatry · doi:10.1016/j.eurpsy.2014.09.329
Estimulação magnética transcraniana em indivíduos com autismo
Abujadi, C. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2014.tde-01042014-085145
Cortical Mapping with Transcranial Magnetic Stimulation
Tarapore, P. E. (2015) · Springer eBooks · doi:10.1007/978-3-319-23383-3_9
Estimulação Magnética Transcraniana – EMT
Marcolin, M. A., & Bellini, B. B. (2016) · Self - Revista do Instituto Junguiano de São Paulo · doi:10.21901/2448-3060/self-2016.vol01.0008
Hirnstimulationsverfahren zur Behandlung schizophrener Psychosen
Darmstadt-Dieburg, K., & Göttingen, G.-A.-U. (2015)
Stimulationsintensitäten in kognitiven Paradigmen
Kaminski, J. A. (2015) · Qucosa (Saxon State and University Library Dresden)
Sato, A., Liu, X., Torii, T., Iwahashi, M., & Iramina, K. (2017) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-981-10-4361-1_79
Gedächtnisstörungen und andere kognitive Störungen bei der Schizophrenie
Karch, S., Falkai, P., & Hasan, A. (2013) · Springer eBooks · doi:10.1007/978-3-642-36993-3_20
Self-citationMyczkowski, M. L. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2018.tde-02082018-100807
Executive Function and its Relevant Factors in Patients with Major Depressive Disorders
Yong-mei, H. (2021) · Psychology and Psychotherapy Research Study · doi:10.31031/pprs.2021.04.000599
Ngetich, R. K., Li, W., Jin, D., & Li, L. (2021) · International Conference on Bioinformatics and Biomedical Science (ICBBS) · doi:10.1145/3498731.3498760
Zhang, B., Zeng, S., Tang, C., Su, M., Luo, X., Liang, H., & Yang, L. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4068600
PET and SPECT Imaging of Non-pharmacological Interventions for Psychiatric Disorders
Doma, A. (2020) · Springer eBooks · doi:10.1007/978-3-030-57231-0_34
Ethical and Legal Issues in Transcranial Stimulation for Cognitive Enhancement
Jwa, A. S. (2022) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780198832256.013.36
Nahas, N. M. E., Sami, S., Aref, H., Hamid, E., Reda, R., Hazzou, A. M., & Elbokl, A. M. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4148100
Najafabadi, Y. F., Kalantari, M., Irani, A., Daryabor, A., & Baghban, A. A. (2022) · Middle East Journal of Rehabilitation and Health Studies · doi:10.5812/modernc-123407
Brain stimulation in rehabilitation
Gupta, M., Bhatia, D., & Kumar, P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99124-7.00004-3
Burhan, A. M., Goveas, D., Thiab, S., & Blair, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-53976-3_14
Estimulação magnética transcraniana em psiquiatria
Marcolin, M. A., Marra, H., Abujadi, C., Mansur, C. G., Myczkowski, M. L., Ribeiro, P. L., Alberto, R. L., & Bellini, B. B. (2012) · Debates em Psiquiatria · doi:10.25118/2763-9037.2012.v2.887
Ye, S., Wang, B., Sui, H., Xiu, M., & Wu, F. (2025) · Schizophrenia · doi:10.1038/s41537-025-00590-5 · Cited by 1
Study on Effect of Different Pulses of rTMS on Visual Working Memory in Elderly With SCD
Liu, M., Li, R., Wei, Z., Yeo, J. S. Y., Yan, J., BuMaYiLaMu, X., Zhao-Xi, T., & Li, Y. (2025) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175251322351
Taylor, D. L., Caulfield, K. A., & Mischel, N. (2025) · Advances in Psychiatry and Behavioral Health · doi:10.1016/j.ypsc.2025.04.001
Bal, F. (2025) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acaf069
Enhancing visual brain-computer interface through V1-targeted RTMS by modulating visual attention
Zhang, X., Wang, S. R., Gao, Y., Wang, Y., Qiu, S., & He, H. (2025) · Imaging Neuroscience · doi:10.1162/imag.a.1013
Repetitive Transcranial Magnetic Stimulation in Dementia
Mikellides, G., Jomeh, A. A. E., Roy, E., & Kyriazis, M. (2025) · Current Aging Science · doi:10.2174/0118746098392580251003064940
Davydova, A., Sheronova, J., Kosonogov, V., Шестакова, А. Н., Klucharev, V. A., & Moiseeva, V. (2025) · Journal of Visualized Experiments · doi:10.3791/67500
Konikkou, K., Isdahl-Troye, A., Sikki, M., & Fanti, K. A. (2025) · Brain Sciences · doi:10.3390/brainsci15121328
Derakhshan, D., Lipsman, N., Feinstein, A., LEVITT, A. J., Eizenman, M., Rabin, J. S., & Giacobbe, P. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1696560 · Cited by 1
Kletzel, S., Alsakaji, R., Umbarger, A., Walker, S., Aaronson, A. L., Herrold, A., Colletta, K., Bhaumik, D., Weaver, F., & Pape, T. B. (2025) · JMIR Research Protocols · doi:10.2196/77241
Task-dependent cognitive effects of intermittent theta-burst stimulation across the adult lifespan
Miller, A., Allen, R. J., Chowdhury, R., & Burke, M. R. (2026) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2026.2628595
Hsieh, Y.-C., Huang, S., Lu, T., Chang, W. H., Bùi, V. G., Tseng, H., Lin, S.-H., & Chen, P. S. (2026) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2026.112231
Keshavarzi, A., Arandi, S. Z., Ahmadpanah, M., Haghighi, M., Jahangard, L., Soltanian, A., Hormoz, N., & Brand, S. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.05.010
Mansour, M. A., Wahid, M., Molla, M. A. S. E., Helmy, M. H., Adel, T. M., Mostafa, H. N., & Elsanafiry, M. S. (2026) · Neuroimage Reports · doi:10.1016/j.ynirp.2026.100369 · Cited by 1
Huynh, A., Noll, K. R., Ray, W. J., Lang, F. F., & Rui, M. (2026) · EClinicalMedicine · doi:10.1016/j.eclinm.2026.104001
Wesley, M. J., McGarrigle, W. J., & Fillmore, M. T. (2026) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2026.100466
Lin, Y., Chen, X., Li, D., Luo, J., He, L., Chen, Y., & Huang, C. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1826010
Comparing effects of differing frequencies of transcranial magnetic stimulation—A systematic review
Lemke, E., Abiara, D., McGrath, J., Omoniyi, E., Vetter, I., Kamath, I., Jakimier, K., Andres, G., Lueck, J. S., Shew, C., et al. (2026) · Transcranial magnetic stimulation . · doi:10.1016/j.transm.2026.100330
Metadata
- Authors
- Guse, B., Falkai, P., & Wobrock, T.
- Affiliations
- University of Göttingen (DE)
- Corresponding author
- Guse, Birgit
- Venue
- Journal of Neural Transmission
- Published
- 2009-10-27
- Volume
- 117
- Issue
- 1
- Pages
- 105-122
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- PMC
- PMC3085788
- OpenAlex
- W2084354128
- Cited by
- 340
- References
- 79
- Citations by year
- 2026: 11 · 2025: 27 · 2024: 16 · 2023: 18 · 2022: 24 · 2021: 23 · 2020: 28 · 2019: 24 · 2018: 24 · 2017: 23 · 2016: 15 · 2015: 27 · 2014: 23 · 2013: 18 · 2012: 20
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neural Transmission (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- GRO (submittedVersion, cc-by)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Sanofi
- Cilag
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- high-frequency repetitive transcranial magnetic stimulation, cognitive effects, dorsolateral prefrontal cortex, neuropsychological outcomes, sham stimulation, mental illness, neurological disorders, motor threshold, neuromodulation
- MeSH terms
- Mental Disorders, Cognition, Humans, Prefrontal Cortex, Transcranial Magnetic Stimulation
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