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Cited by 1,960Neural and Behavioral Psychology StudiesMemory and Neural MechanismsCognitive Functions and Memory

Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory

Goldman‐Rakic, Patricia S.·1987·Comprehensive Physiology
DOI 10.1002/cphy.cp010509
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Abstract

The sections in this article are: 1 Essence of Prefrontal Function: Regulation of Behavior by Representational Knowledge 1.1 Subdivisions of Prefrontal Cortex 1.2 Global Nature of Prefrontal Syndrome in Humans 1.3 Animal Model for Prefrontal Function in Humans 1.4 Delayed-Response Tests and Varying Interpretations of Their Functional Significance 1.5 Distractability and Perseveration: Secondary Consequences of Basic Defect in Representational Memory 1.6 Representational Memory in Wisconsin Card Sort and Other Diagnostic Tests of Prefrontal Function in Humans 1.7 Localization of Delayed-Response Function: Principal Sulcus 1.8 Circuit Basis of Visuospatial Functions 2 Accessing and "On-Line" Processing of Representations in Visuospatial Domain: Parietal-Prefrontal Connections 2.1 Visuospatial Representational Memory in Humans 2.2 Spatial-Mnemonic Nature of Delayed-Response Deficit: Domain-Specific Memory Loss 2.3 Topography of Representational Memory in Prefrontal Cortex 2.4 Electrophysiological Evidence of Spatial-Mnemonic Processes in Principal Sulcus 2.5 Parietal-Prefrontal Connectivity 2.6 Columnar and Laminar Framework for Feedforward and Feedback Mechanisms 2.7 Functional Significance of Parietal-Prefrontal Collaboration 3 Long-Term Memory and "Off-Line" Processing: Prefrontal-Limbic Connections 3.1 Role of Hippocampus in Spatial Memory 3.2 Multiple Connections Between Principal Sulcus and Hippocampal Formation 3.3 Quadripartite Neural Network: Parietal-Temporal-Cingulate-Prefrontal Circuit 3.4 Limbic Contribution to Spatial Memory 4 Response Initiation and Inhibition: Projections to Striatum, Tectum, Thalamus, and Premotor Cortex 4.1 Motor-Control Functions of Prefrontal Cortex 4.2 Cortical-Striatal Pathway and Related Feedback Loops 4.3 Cortical-Tectal Pathway 4.4 Thalamic-Cortical Systems 4.5 Prefrontal-Premotor Connections: Anterior Supplementary Motor Cortex Relays 4.6 Functional Speculations 5 Modulatory Mechanisms: Brain Stem Catecholamine Projections 5.1 Activation of Cognitive Machinery 5.2 Concentration and Synthesis of Catecholamines in Primate Cortex 5.3 Brain Stem Innervation of Prefrontal Cortex 5.4 Delayed-Response Deficits and Recovery Produced by Catecholamine Loss and Replacement in Prefrontal Cortex 5.5 Circuit Basis for Neuromodulation in Principal Sulcus 6 Multiple Subsystems of Prefrontal Cortex: Unity or Diversity of Function 6.1 Unity or Diversity of Prefrontal Function 6.2 Frontal Eye Fields 6.3 Inferior Convexity 6.4 Orbital Prefrontal Cortices 6.5 Problem of Integration 7 Diseases Affecting Prefrontal Cortex 7.1 Schizophrenia: Loss of Corticocortical Processing and Regulation of Behavior by Representational Knowledge 7.2 Wernicke-Korsakoff Syndrome: Loss of Thalamocortical and Brain Stem Modulatory Mechanisms 7.3 Huntington's Chorea and Parkinson's Disease: Loss of Prefrontal-Striatal Mechanisms and Initiation or Inhibition of Motor Response 7.4 Overview of Neurobiology of Disease 8 Summary

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Crossref · 10.1002/cphy.cp010509

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  • The lateral PFC is mostly involved in language and executive processing, while the orbitofrontal and medial PFC contribute to cognitive functioning and emotional control.

    “The lPFC is mostly involved in language and executive processing, while the oFC and mPFC are known to contribute to cognitive functioning and emotional control [1–4].”

    From Development of prefrontal cortex (2022) · cites this paper as [3]

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Authors
Goldman‐Rakic, P. S.
Venue
Comprehensive Physiology
Publisher
Wiley
Published
1987-12
Pages
373-417
ISSN
2040-4603 (ISSN-L)
DOI
10.1002/cphy.cp010509
OpenAlex
W1511039218
Cited by
1,960
References
378
Citations by year
2026: 7 · 2025: 11 · 2024: 26 · 2023: 37 · 2022: 22 · 2021: 15 · 2020: 23 · 2019: 20 · 2018: 20 · 2017: 34 · 2016: 30 · 2015: 26 · 2014: 39 · 2013: 56 · 2012: 37
Type
other
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations
Comprehensive physiology (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
prefrontal cortex, primate brain, hippocampus, spatial memory, response inhibition

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