The DOI matches its Crossref record; 157 of the 161 references it cites were found in a registry or an index.
The role of microglia in amyloid clearance from the AD brain
Open accessAbstract
Alzheimer's disease (AD), the most prominent cause of senile dementia, is clinically characterized by the extracellular deposition of beta-amyloid (Abeta) and the intracellular neurofibrillary tangles. It has been well accepted that AD pathogenesis arises from perturbation in the homeostasis of Abeta in the brain. Abeta is normally produced at high levels in the brain and cleared in an equivalent rate. Thus, even a moderate decrease in the clearance leads to the accumulation of Abeta and subsequent amyloid deposition. Microglia are the tissue macrophages in the central nervous system (CNS) and have been shown to play major roles in internalization and degradation of Abeta. Abeta exists in the brain both in soluble and in fibrillar forms. Microglia interact with these two forms of Abeta in different ways. They take up soluble forms of Abeta through macropinocytosis and LDL receptor-related proteins (LRPs) mediated pathway. Fibrillar forms of Abeta interact with the cell surface innate immune receptor complex, initiating intracellular signaling cascades that stimulate phagocytosis. Inflammatory responses influence the activation status of microglia and subsequently regulate their ability to take up and degrade Abeta. ApoE and its receptors have been shown to play critical roles in these processes. In this review, we will explore the mechanisms that microglia utilize to clear Abeta and the effectors that modulate the processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Evidence for a important role of microglial phagocytosis comes from studies that show that restricting microglial A uptake leads to increased cerebral A levels (El Khoury et al., 2007;Lee and Landreth, 2010).”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Lee and Landreth, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Microglial expression of receptors that promote the clearance and phagocytosis of A, such as CD36, TLR4, and TLR6 (Lee and Landreth, 2010), are mandatory for restricting amyloid plaque formation.”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Lee and Landreth, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Thus, microglia interacts with A through a recently characterized cell-surface receptor complex comprising CD36, ␣61 integrin, and CD47 (Lee and Landreth, 2010).”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Lee and Landreth, 2010
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“For example, they facilitate the clearance of Aβ through phagocytosis42, yet they can also exacerbate neurodegeneration by driving persistent neuroinflammation43.”
From Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer’s disease models (2026) · cites this paper as [42]
The cited source says what the claim attributes to it.
In the citing paper
“Microglia, the innate immune cells of the brain, dynamically interact with these disease processes to influence AD progression.”
From PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology (2025) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“Because microglia are critical for A phagocytosis, the microglial presence at the A plaque can be interpreted as an attempt to clear this pathological deposit.”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Lee and Landreth, 2010
The cited source says what the claim attributes to it.
In the citing paper
“However, persisting neuroinflammation and sustained exposure to proinflammatory stimuli compromises microglial clearance functions as AD progresses (Lee and Landreth, 2010).”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Lee and Landreth, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
A genome-wide association study identifies novel risk loci for type 2 diabetes
Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., et al. (2007) · Nature · doi:10.1038/nature05616 · Cited by 2,993
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
Cited by
Sorted by citations
Items 401–500 of 701
NLRP3 ‐directed antisense oligonucleotides reduce microglial immunoactivities in vitro
Braatz, C., Komes, M. P., Ravichandran, K. A., de Fragas, M. G., Griep, A., Schwartz, S., McManus, R. M., & Heneka, M. T. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15778 · Cited by 20
Evaluating the Role of Microglial Cells in Clearance of Aβ from Alzheimer’s Brain
Manchikalapudi, A. L., Chilakala, R. R., Kalia, K., & Sunkaria, A. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00627 · Cited by 18
Sripetchwandee, J., Khamseekaew, J., Svasti, S., Srichairatanakool, S., Fucharoen, S., Chattipakorn, N., & Chattipakorn, S. C. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116878 · Cited by 18
Genetic analysis of TREM2 variants in Chinese Han patients with sporadic Parkinson’s disease
Tan, T., Song, Z. J., Yuan, L., Xiong, W., Deng, X., Ni, B., Chen, Y., & Deng, H. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.029 · Cited by 18
Sleep and Neuroimmunomodulation for Maintenance of Optimum Brain Function: Role of Noradrenaline
Mehta, R., Bhattacharya, R., & Mallick, B. N. (2022) · Brain Sciences · doi:10.3390/brainsci12121725 · Cited by 17
Xu, J., Song, W., Xu, Z., Danziger, M. M., Karavani, E., Zang, C., Chen, X., Li, Y., Paz, I. R., Gohel, D., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14373 · Cited by 17
Genetic analysis of MC1R variants in Chinese Han patients with sporadic Parkinson’s disease
He, S., Tan, T., Song, Z. J., Yuan, L., Deng, X., Ni, B., Chen, Y., & Deng, H. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.11.034 · Cited by 17
Experimental approaches for altering the expression of Abeta‐degrading enzymes
Loeffler, D. A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15762 · Cited by 18
Dikranian, K. T., Kim, J., Stewart, F. R., Levy, M. A., & Holtzman, D. M. (2012) · Europe PMC (PubMed Central) · Cited by 17
Fröhlich, C., Paarmann, K., Steffen, J., Stenzel, J., Krohn, M., Heinze, H., & Pahnke, J. (2013) · European Journal of Microbiology and Immunology · doi:10.1556/eujmi.3.2013.1.3 · Cited by 17
PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology
Messenger, E. J., Baar, S. A., Bedford, L. M., Tsai, A. P., Lin, P. B., Ferguson, C. A., Xu, G., Wallace, A., Landreth, G. E., Lamb, B. T., et al. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70231 · Cited by 16
Self-citationKey brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease
Saavedra, J., Nascimento, M., Liz, M. A., & Cardoso, I. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1036123 · Cited by 16
Han, S., Na, Y., Koh, I., Nho, K. T., & Lee, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189865 · Cited by 16
Recent Developments in Targeting Neuroinflammation in Disease
Hopper, A. T., Campbell, B. M., Kao, H. W., Pintchovski, S. A., & Staal, R. G. W. (2012) · Annual reports in medicinal chemistry · doi:10.1016/b978-0-12-396492-2.00004-7 · Cited by 18
Ueno, M. (2017) · Rinsho Shinkeigaku · doi:10.5692/clinicalneurol.cn-001004 · Cited by 15
Reticulocalbin-1 Facilitates Microglial Phagocytosis
Ding, Y., Caberoy, N. B., Guo, F., LeBlanc, M. E., Zhang, C., Wang, W., Wang, F., Chen, R., & Li, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126993 · Cited by 16
Tsay, H.-J., Huang, Y., Huang, F.-L., Chen, C.-P., Tsai, Y.-C., Wang, Y.-H., Wu, M.-F., Chiang, F.-Y., & Shiao, Y. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-78 · Cited by 16
Astrocytes and Microglia in Alzheimer's Disease: Friends, Foes, or Both?
Sharma, A., Parekh, B. K., Patil, V., Renuka Jyothi, S., Nayak, P. P., Janney, J. B., Singh, G., & Al-Hasnaawei, S. (2025) · Developmental Neurobiology · doi:10.1002/dneu.23015 · Cited by 17
Dollé, J.-P., Rodgers, J. M., Browne, K. D., Troxler, T., Gai, F., & Smith, D. H. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.05.023 · Cited by 15
Alzheimer’s disease: Pathophysiology and dental pulp stem cells therapeutic prospects
Xiong, W., Liu, Y., Zhou, H., Jing, S., He, Y., & Ye, Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.999024 · Cited by 15
Emerging Roles of Microglia in Blood-Brain Barrier Integrity in Aging and Neurodegeneration
Zhang, S., Meng, R., Jiang, M., Qing, H., & Ni, J. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230203103910 · Cited by 16
Yang, G., Hu, Y., Qin, X., Sun, J., Miao, Z., Wang, L., Ke, Z., & Zheng, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17848 · Cited by 16
Diet-induced glial insulin resistance impairs the clearance of neuronal debris in Drosophila brain
Alassaf, M., & Rajan, A. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002359 · Cited by 17
Cousins, O., Schubert, J. J., Chandra, A., Veronese, M., Valkimadi, P., Creese, B., Khan, Z., Arathimos, R., Hampshire, A., Rosenzweig, I., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02945-0 · Cited by 16
Mechanisms with network pharmacology approach of Ginsenosides in Alzheimer's disease
He, S., Shi, J., Chai, H., Ma, L., Pei, H., Zhang, P., Shi, D., & Li, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26642 · Cited by 17
Cyr, B. S., Ranaldi, E. D. L. R. M. C., Hadad, R., Dietrich, W. D., Keane, R. W., & Vaccari, J. P. D. R. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1369781 · Cited by 15
Pramanik, S., Harini Devi, M., Chakrabarty, S., Paylar, B., Pradhan, A., Thaker, M., Ayyadhury, S., Manavalan, A., Olsson, P., Pramanik, G., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105834 · Cited by 18
Microglial Modulation in Alzheimer’s Disease: Central Players in Neuroinflammation and Pathogenesis
Hussain, M. S., Khan, Y., Fatima, R., Maqbool, M., Ramalingam, P. S., Khan, M. G., & Bisht, A. S. (2025) · Current Alzheimer Research · doi:10.2174/0115672050364292250113063513 · Cited by 15
Chen, C., & Qian, Y. (2016) · Folia Neuropathologica · doi:10.5114/fn.2016.64817 · Cited by 15
Sun, P., Hu, Y., Xing, Q., Deng, W., Ou, Y., Pan, G., Zhong, X., & Hu, W. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00073 · Cited by 15
Oxygen Sensing and Signaling in Alzheimer’s Disease: A Breathtaking Story!
Correia, S. C., & Moreira, P. I. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01148-6 · Cited by 14
Karnik, S. J., Margetts, T. J., Wang, H. S., Movilă, A., Oblak, A. L., Fehrenbacher, J. C., Kacena, M. A., & Plotkin, L. I. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00847-x · Cited by 15
Richman, M., Perelman, A., Gertler, A. A., & Rahimipour, S. (2012) · Biomacromolecules · doi:10.1021/bm301401b · Cited by 15
The presubiculum is preserved from neurodegenerative changes in Alzheimer’s disease
Murray, C. E., Gami‐Patel, P., Gkanatsiou, E., Brinkmalm, G., Portelius, E., Wirths, O., Heywood, W., Blennow, K., Ghiso, J. A., Holton, J. L., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0563-8 · Cited by 15
Braley, T. J., Lyu, X., Dunietz, G. L., Schulz, P., Bove, R. M., Chervin, R. D., Paulson, H. L., & Shedden, K. (2024) · SLEEP Advances · doi:10.1093/sleepadvances/zpae077 · Cited by 14
Inflammatory Cytokine IL-1β Downregulates Endothelial LRP1 via MicroRNA-mediated Gene Silencing
Hsu, H.-W., Rodríguez‐Ortiz, C. J., Zumkehr, J., & Kitazawa, M. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.021 · Cited by 16
A computational model of Alzheimer's disease at the nano, micro, and macroscales
Chamberland, É., Moravveji, S., Doyon, N., & Duchesne, S. (2024) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2024.1348113 · Cited by 15
Yamaguchi, H., Nishimura, Y., Matsuse, D., Sekiya, H., Masaki, K., Tanaka, T., Saiga, T., Harada, M., Kira, Y., Dickson, D. W., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.004 · Cited by 14
Villarreal, A. E., Barron, R., Rao, K. S. J., & Britton, G. B. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140144 · Cited by 14
Reduction of microbleeds by immunosuppression in a patient with Aβ-related vascular inflammation
Traschütz, A., Tzaridis, T., Penner, A.-H., Kuchelmeister, K., Urbach, H., Hattingen, E., & Heneka, M. T. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000165 · Cited by 14
Anwar, M. M., Ali, O. S. M., Rashed, L. A., Badawi, A. M., & Eltablawy, N. A. (2021) · Gene Reports · doi:10.1016/j.genrep.2021.101323 · Cited by 13
Scarfò, G., Piccarducci, R., Daniele, S., Franzoni, F., & Martini, C. (2022) · Antioxidants · doi:10.3390/antiox11112116 · Cited by 16
Latif‐Hernandez, A., Yang, T., Butler, R. R., Losada, P. M., Minhas, P. S., White, H., Tran, K. C., Liu, H., Simmons, D. A., Langness, V. F., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13857 · Cited by 13
Var, S. R., Strell, P., Johnson, S. T., Roman, A., Vasilakos, Z., & Low, W. C. (2023) · Cell Transplantation · doi:10.1177/09636897231171001 · Cited by 15
Teng, T., Dong, L., Ridgley, D. M., Ghura, S., Tobin, M. K., Sun, G. Y., LaDu, M. J., & Lee, J. C. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1304-5 · Cited by 13
Duffy, K. B., Ray, B., Lahiri, D. K., Tilmont, E. M., Tinkler, G. P., Herbert, R. L., Greig, N. H., Ingram, D. K., Ottinger, M. A., & Mattison, J. A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180487 · Cited by 13
Fairley, L. H., Lai, K. O., Grimm, A., Eckert, A., & Barron, A. M. (2024) · Biochimie · doi:10.1016/j.biochi.2024.07.003 · Cited by 14
Microglial Lyzl4 Facilitates β‐Amyloid Clearance in Alzheimer's Disease
Pan, J., Zhong, J., Geng, J., Oberhauser, J., Shi, S., & Wan, J. (2024) · Advanced Science · doi:10.1002/advs.202412184 · Cited by 11
The Role of Probiotics in Modulating the Gut Microbiome in Alzheimer’s Disease: A Review
Dong, Y., Wu, X., Zhang, Y., Hu, A., Zhou, Q., Yue, X., Liu, Z., & Li, M. (2025) · Foods · doi:10.3390/foods14091531 · Cited by 15
Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation
van der Harg, J. M., Eggels, L., Ruigrok, S. R., Hoozemans, J. J. M., la Fleur, S. E., & Scheper, W. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00432 · Cited by 12
Kozyrev, N., Albers, S. S., Yang, J., Prado, V. F., Prado, M. A. M., Fonseca, G. J., Rylett, R. J., & Dekaban, G. A. (2020) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlaa093 · Cited by 13
Kamei, N., Hashimoto, A., Tanaka, E., Murata, K., Yamaguchi, M., Yokoyama, N., Kato, M., Oki, K., Saito, T., Saido, T. C., et al. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01117-6 · Cited by 12
Zamolodchikov, D., Duffield, M. D., Macdonald, L. E., & Alessandri‐Haber, N. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12531 · Cited by 11
Connor, S. M., Rashid, M., Ryan, K. J., Patel, K. R., Boyd, J. D., Smith, J., Elyaman, W., Bennett, D. A., & Bradshaw, E. M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.894601 · Cited by 12
Njavro, J. R., Vukicevic, M., Fiorini, E., Dinkel, L., Müller, S. A., Berghofer, A., Bordier, C., Kozlov, S. O., Halle, A., Buschmann, K., et al. (2022) · Cells · doi:10.3390/cells12010079 · Cited by 13
Baek, J. H., Kang, J. S., Song, M., Lee, D., & Kim, H. J. (2023) · Nutrients · doi:10.3390/nu15122794 · Cited by 13
Ng, T. K. S., Slowey, P. D., Beltran‐Cardona, D., Ho, R., Kua, E. H., & Mahendran, R. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.10.038 · Cited by 13
How Microglia Manages Non-cell Autonomous Vicious Cycling of Aβ Toxicity in the Pathogenesis of AD
Seol, Y., Ki, S., Ryu, H. L., Chung, S., Lee, J.-H., & Ryu, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.593724 · Cited by 12
Microglia at the Centre of Brain Research: Accomplishments and Challenges for the Future
Soares, N. L., & Vieira, H. L. A. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03456-1 · Cited by 14
Pihlaja, R., Haaparanta‐Solin, M., & Rinne, J. O. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00299 · Cited by 13
Microglial cGAS deletion protects against amyloid-β induced Alzheimer’s disease pathogenesisPreprint
He, S., Li, X., Mittra, N., Bhattacharjee, A., Wang, H., Zhao, S., Liu, F., & Han, X. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.07.552300 · Cited by 12
The Multifaceted Role of Extracellular Vesicles in Alzheimer's Disease
Conceição, A. R., Marinatto, J., Pinheiro, L. S., Rody, T., & Felice, F. G. D. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70209 · Cited by 15
Iannucci, J., Dominy, R., Bandopadhyay, S., Arthur, E. M., Noarbe, B. P., Jullienne, A., Krkasharyan, M., Tobin, R. P., Pereverzev, A., Beevers, S., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03146-z · Cited by 13
Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenerative Diseases
Singh, A. A., Khan, F., & Song, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062695 · Cited by 11
The effect of V‐ ATP ase function defects in pathogenesis of Alzheimer's disease
Zhao, Z., Yuan, Z., Zhao, D., Wang, Z., Zhu, F., & Luan, P. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12861 · Cited by 11
Lachish, M., Fainstein, N., Ganz, T., Sofer, L., & Ben‐Hur, T. (2022) · Cells · doi:10.3390/cells11050876 · Cited by 13
Liang, F., Sun, F., He, B., & Wang, J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.03.043 · Cited by 12
Connectome-based biophysics models of Alzheimer’s disease diagnosis and prognosis
Torok, J., Anand, C., Verma, P., & Raj, A. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.008 · Cited by 11
Ban, Y.-H., Park, D., Choi, E., Kim, T. M., Joo, S. S., & Kim, Y.-B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119561 · Cited by 11
Wang, C.-J., Chen, C.-C., Tsay, H.-J., Chiang, F.-Y., Wu, M.-F., & Shiao, Y. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-55 · Cited by 12
Activation and function of murine primary microglia in the absence of the prion protein
Pinheiro, L. P., Linden, R., & Mariante, R. M. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.07.002 · Cited by 11
Neuronal and glial 3D chromatin architecture illustrates cellular etiology of brain disordersPreprint
Hu, B., Won, H., Mah, W., Park, R., Kassim, B. S., Spiess, K., Kozlenkov, A., Crowley, C., Pochareddy, S., Li, Y., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.14.096917 · Cited by 11
Schober, J. M., Polina, J., Walters, F., Scott, N. R., Lodholz, E., Crider, A. M., Sandoval, K. E., & WITT, K. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254242 · Cited by 10
Hypocretin/orexin influences chronic sleep disruption injury in the hippocampus
Nick, H., Fenik, P., Zhu, Y., & Veasey, S. C. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1025402 · Cited by 10
Research on the Glial–Lymphatic System and Its Relationship With Alzheimer’s Disease
Ding, D., Wang, X., Li, Q., Li, L., & Wu, J. W. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.605586 · Cited by 11
The Role of APOE and NF-κB in Alzheimer’s Disease
Davies, D. A. (2021) · Immuno · doi:10.3390/immuno1040027 · Cited by 10
Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition
Blume, T., Deussing, M., Biechele, G., Peters, F., Zott, B., Schmidt, C., Franzmeier, N., Wind, K., Eckenweber, F., Sacher, C., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.854031 · Cited by 10
Oroszi, T., Geerts, E., Rajadhyaksha, R., Nyakas, C. J., van Heuvelen, M. J. G., & van der Zee, E. A. (2023) · Behavioral and Brain Functions · doi:10.1186/s12993-023-00208-9 · Cited by 9
Almalki, W. H., & Almujri, S. S. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155614 · Cited by 9
Kim, H., Le, B., Goshi, N., Zhu, K., Grodzki, A. C., Lein, P. J., Zhao, M., & Şeker, E. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241291142 · Cited by 11
Abbott, V., Housden, B. E., & Houldsworth, A. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf092 · Cited by 9
Proteostasis and Neuroinflammation in Alzheimer’s Disease
Potokiri, A., & Wang, H. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin39826 · Cited by 9
Huang, C.-C., Tsai, S., Liu, S., Yeh, M.-C., Hung, H., Lee, C.-W., Cheng, C., Hsu, P., & Kuo, Y.-M. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s481101 · Cited by 9
Self-citationChitotriosidase enhances TGFβ-Smad signaling and uptake of β-amyloid in N9 microglia
Wang, X., Yu, W., Fu, X. L., Ke, M., Xiao, Q., & Lü, Y. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.09.037 · Cited by 9
Argentati, C., Tortorella, I., Bazzucchi, M., Emiliani, C., Morena, F., & Martino, S. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030115 · Cited by 10
Wellman, S. M., Coyne, O., Douglas, M. M., & Kozai, T. D. Y. (2023) · Journal of Neural Engineering · doi:10.1088/1741-2552/aceca5 · Cited by 8
APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice
Zhou, Y., Zhao, W., Al‐Muhtasib, N., & Rebeck, G. W. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142184 · Cited by 9
Volk, K. M., Rodriguez, A. S., Cartailler, J., Shrestha, S., Schleh, M. W., Schroeder, K. R., Valenti, A. M., Kramer, A. T., Harrison, F. E., & Hasty, A. H. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03238-w · Cited by 9
Müller, E., Enzlein, T., Niemeyer, D., von Ammon, L., Stumpo, K. A., Biber, K., Klein, C., & Hopf, C. (2025) · Pharmaceuticals · doi:10.3390/ph18020252 · Cited by 10
Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline
Kang, S. H., Kim, S., Kim, Y. J., Yoo, H., Lee, E. H., Jang, H. J., Shin, D., Yun, J., Kim, J. P., Kim, H., et al. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-01964-2 · Cited by 8
Emerging non-proinflammatory roles of microglia in healthy and diseased brains
Sun, Y., Che, J., & Zhang, J. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110664 · Cited by 10
Gardner, R. S., Kyle, M. M., Hughes, K., & Zhao, L. (2024) · Biomolecules · doi:10.3390/biom14070827 · Cited by 7
Three‐dimensional view of microglia—amyloid plaque interactions
Gotkiewicz, M., Capra, J., Miettinen, P. O., Natunen, T., & Tanila, H. (2024) · Glia · doi:10.1002/glia.24628 · Cited by 11
Han, J. Z., Yin, Q., Yang, F., Shou, W., Zhang, C., & Guo, F. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9055 · Cited by 8
A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice
López‐Sánchez, N., Ramón‐Landreau, M., Trujillo, C., Garrido‐García, A., & Frade, J. M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02764-z · Cited by 7
Rao, A. T., Chen, N., Kim, M. J., Blumenfeld, J. R., Yip, O., Hao, Y., Liang, Z., Nelson, M. R., Koutsodendris, N., Grone, B. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.10.566510 · Cited by 8
Increased Between-Network Connectivity: A Risk Factor for Tau Elevation and Disease Progression
Hojjati, S. H., Butler, T., Luchsinger, J., Benítez, R., de Leon, M. D., Nayak, S., Razlighi, Q., & Chiang, G. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137943 · Cited by 7
Zhou, Y., Yu, G., & Li, H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0324202 · Cited by 7
Targeting the redox neuroinflammatory nexus: insights into Alzheimer’s and Parkinson’s diseases
Dharshini, L. C. P., Sakthivel, K. M., Rex, K., & Rasmi, R. R. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01831-w · Cited by 8
Alzahrani, N. A., Bahaidrah, K. A., Mansouri, R. A., Aldhahri, R. S., El-Aziz, G. S. A., & Alghamdi, B. S. A. (2024) · Biomedicines · doi:10.3390/biomedicines12051107 · Cited by 7
Metadata
- Authors
- Lee, C. Y. D., & Landreth, G. E.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Landreth, Gary E.
- ORCID
- Landreth, Gary E.
- Venue
- Journal of Neural Transmission
- Published
- 2010-06-15
- Volume
- 117
- Issue
- 8
- Pages
- 949-960
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- PMC
- PMC3653296
- OpenAlex
- W2038594716
- Cited by
- 701
- References
- 161
- Citations by year
- 2026: 26 · 2025: 49 · 2024: 74 · 2023: 54 · 2022: 66 · 2021: 50 · 2020: 51 · 2019: 43 · 2018: 56 · 2017: 31 · 2016: 29 · 2015: 43 · 2014: 35 · 2013: 36 · 2012: 31
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG020202, R01AG030482, R01AG016740)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- microglia, amyloid-beta clearance, Alzheimer's disease, amyloid deposition, macropinocytosis, LDL receptor-related protein, phagocytosis, innate immune receptors, inflammation, microglial activation, apolipoprotein E, amyloid clearance
- MeSH terms
- Alzheimer Disease, Amyloid, Apolipoproteins E, Brain, Humans, Inflammation, Microglia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
