Microglia and inflammatory mechanisms in the clearance of amyloid β peptide
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There is now abundant evidence that brain microglia, when activated, have the lineage, receptors, and synthetic capacity to participate in both potentially neurotoxic inflammatory responses and potentially beneficial phagocytic responses. Amyloid beta peptide (Abeta) forms highly insoluble, beta-pleated aggregates that are widely deposited in the Alzheimer's disease (AD) cortex and limbic system. Aggregated Abeta also activates the classical and alternative complement cascades. These properties make Abeta an excellent target for microglial phagocytosis, a view supported by multiple reports, through well established mechanisms of phagocyte clearance.
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In AD, microglia and astrocytes can promote clearance of Aβ; if they are not able to do that, accumulation of Aβ deposits leads to neuronal death.
“In AD, these cells can promote the clearance of Aβ, however, if they are not able to do that, there is an accumulation of Aβ deposits leading to neuronal death (Rogers et al., 2002).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Rogers et al., 2002
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- Authors
- Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R.
- Affiliations
- Banner Sun Health Research Institute (US)
- Corresponding author
- Rogers, Joseph
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2002-10-04
- Volume
- 40
- Issue
- 2
- Pages
- 260-269
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2046704592
- Cited by
- 381
- References
- 142
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 15 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 14 · 2014: 19 · 2013: 17 · 2012: 18
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association
- National Institute on Aging (AGO7367)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- microglia, amyloid-beta, Alzheimer's disease, microglial phagocytosis, neuroinflammation, complement system, microglial activation
- MeSH terms
- Alzheimer Disease, Animals, Antigen-Antibody Complex, Antigens, Chemotaxis, Encephalitis, Humans, Phagocytosis, Amyloid beta-Peptides, Microglia
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