ApoE gene polymorphism and vascular dementia in Chinese population: a meta-analysis
Abstract
Vascular dementia is the second common cause of dementia, only second to Alzheimer's disease in later life. The Apolipoprotein E (ApoE) gene polymorphism as a risk factor in vascular dementia has been suggested, but direct evidence from genetic association studies remains inconclusive even in Chinese population. Therefore, we performed this meta-analysis in order to evaluate the relationship between ApoE gene polymorphism and susceptibility to vascular dementia in Chinese population by pooling data from all relevant case-control studies published domestically and abroad from January 1990 to May 2011. 18 case-control studies were selected. Meta-analysis results showed that the pooled OR value of vascular dementia subjects in Chinese population with ε4 allele carriers was 2.07 [95% CI (1.69, 2.53)], and the pooled OR value of vascular dementia subjects with E4/E4 genotype was 3.34 [95% CI (1.89, 5.88)]. These results suggest that ApoE polymorphism is significantly associated with susceptibility to vascular dementia in Chinese population. The subject with at least one ε4 allele or E4/E4 genotype has higher risk suffering from vascular dementia than others.
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The ε4 allele plays a role in vascular dementia.
“ε4 also plays a role in vascular dementia [21][22][23][24][25][26]”
From APOE and vascular disease: Sequencing and genotyping in general population cohorts (2023) · cites this paper as [25]
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Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981 · see citing works
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Yin, Y.-W., Li, J.-C., Wang, J.-Z., Li, B.-H., Pi, Y., Yang, Q.-W., Fang, C.-Q., Gao, C.-Y., & Zhang, L.-L. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.031 · Cited by 84 · see citing works
APOE and vascular disease: Sequencing and genotyping in general population cohorts
Rasmussen, K. L., Luo, J., Nordestgaard, B. G., Tybjærg-Hansen, A., & Frikke-Schmidt, R. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117218 · Cited by 22 · see citing works
Wu, J., Hasselgren, C., Zettergren, A., Zetterberg, H., Blennow, K., Skoog, I., & Halleröd, B. (2020) · Aging & Mental Health · doi:10.1080/13607863.2018.1531368 · Cited by 18 · see citing works
- Authors
- Liu, X., Li, L., Liu, F., Deng, S., Zhu, R., Li, Q., & He, Z.
- Affiliations
- First Hospital of China Medical University (CN)
- Corresponding author
- He, Zhiyi
- Venue
- Journal of Neural Transmission
- Published
- 2011-10-09
- Volume
- 119
- Issue
- 3
- Pages
- 387-394
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2151217555
- Cited by
- 31
- References
- 1
- Citations by year
- 2026: 4 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 1 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 0.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- vascular dementia, apolipoprotein E, APOE polymorphism, ε4 allele, genetic susceptibility, Chinese population, case-control study, genetic association
- MeSH terms
- Alleles, Apolipoproteins E, China, Gene Frequency, Humans, Polymorphism, Genetic, Dementia, Vascular, Genetic Predisposition to Disease, Asian People
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