The impact of social networks and APOE ε4 on dementia among older adults: tests of possible interactions
Open accessAbstract
Objectives: Emerging evidence suggests that social networks may protect against the development of dementia among older adults. In this study we analysed the association between social networks, the apolipoprotein E (APOE) ε4 allele, and dementia. We also investigated whether there were gender-specific patterns in this respect.Method: The analyses used population-based longitudinal data from Gothenburg, Sweden: the H70 Birth Cohort Study and the Prospective Population Study on Women (PPSW). A total of 580 individuals born in 1930 underwent semi-structured neuropsychiatric examinations in 2000–2001. Follow-up examinations were carried out in 2005–2006 and 2009–2010. The timing of dementia onset was analysed using Cox proportional hazards regression.Results: The presence of the APOE ε4 allele affected the risk of developing dementia in both genders. Among women, distant social networks had a protective effect on dementia, while among men the significant associations between close social networks and dementia did not remain after controlling for covariates. Significant interactions between social networks and the APOE ε4 allele were not found.Conclusion: Strong social networks do not seem to moderate the increased risk of dementia implied by the APOE ε4 allele. Nevertheless, our results underline the importance of strong social networks in postponing dementia onset and indicate that their impact may differ among men and women.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Social network size is positively associated with maintenance of cognitive performance within the normal range over a longer period, thus postponing dementia onset independently of APOE status.
“Indeed, social network size was found to be positively associated with maintenance of cognitive performance within the normal range over a longer period of time, thus postponing dementia onset independently of APOE status (43).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [43]
Cites
Diagnostic and Statistical Manual of Mental Disorders
&NA; (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00022 · Cited by 12,603 · see citing works
Evaluating the use of exploratory factor analysis in psychological research.
Fabrigar, L. R., Wegener, D. T., MacCallum, R. C., & Strahan, E. J. (1999) · Psychological Methods · doi:10.1037/1082-989x.4.3.272 · Cited by 9,587 · see citing works
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, 3rd ed
Cooper, A. M., & Michels, R. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.1.128 · Cited by 7,417 · see citing works
Understanding Interaction Models: Improving Empirical Analyses
Brambor, T., Clark, W. R., & Golder, M. (2006) · Political Analysis · doi:10.1093/pan/mpi014 · Cited by 6,223 · see citing works
What is cognitive reserve? Theory and research application of the reserve concept
STERN, Y. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702813248 · Cited by 3,951 · see citing works
Cognitive reserve in ageing and Alzheimer's disease
Stern, Y. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70191-6 · Cited by 3,557 · cited 1× · see citing works
“Second, in line with the cognitive reserve hypothesis, the intellectual stimulation provided by social interaction is thought to impede degenerative brain changes by improving resilience and compensatory abilities in the neuronal networks (Kuiper et al., 2015; Stern, 2002, 2012).”
BackgroundBlennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134 · see citing works
Self-citationInternational Journal of Epidemiology
Rothman, N., Garcia-closas, M., & Hein, D. W. (1973) · Journal of Medical Genetics · doi:10.1136/jmg.10.1.100-a · Cited by 2,902 · see citing works
An active and socially integrated lifestyle in late life might protect against dementia
Fratiglioni, L., Paillard-Borg, S., & Winblad, B. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00767-7 · Cited by 2,135 · see citing works
Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
Blennow, K., Hampel, H., Weiner, M., & Zetterberg, H. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.4 · Cited by 1,863 · see citing works
Self-citationKivipelto, M., Helkala, E.-L., Laakso, M. P., Hänninen, T., Hallikainen, M., Alhainen, K., Soininen, H., Tuomilehto, J., & Nissinen, A. (2001) · BMJ · doi:10.1136/bmj.322.7300.1447 · Cited by 1,618 · see citing works
Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia: A Meta-analysis
Jansen, W. J., Ossenkoppele, R., Knol, D. L., Tijms, B. M., Scheltens, P., Verhey, F. R. J., Visser, P. J., Aalten, P., Aarsland, D., Alcolea, D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4668 · Cited by 1,610 · see citing works
Self-citation(1980) · Europe PMC (PubMed Central) · Cited by 1,390 · see citing works
Influence of social network on occurrence of dementia: a community-based longitudinal study
Fratiglioni, L., Wang, H.-X., Ericsson, K., Maytan, M., & Winblad, B. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02113-9 · Cited by 1,361 · see citing works
(2001) · The Lancet · doi:10.1016/s0140-6736(00)03589-3 · Cited by 1,338 · see citing works
Apolipoprotein E polymorphism and Alzheimer's disease
Poirier, J., Bertrand, P., Poirier, J., Kogan, S., Gauthier, S., Poirier, J., Gauthier, S., Davignon, J., Bouthillier, D., & Davignon, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)91705-q · Cited by 1,108 · see citing works
Kuiper, J. S., Zuidersma, M., Oude Voshaar, R. C., Zuidema, S. U., van den Heuvel, E. R., Stolk, R. P., & Smidt, N. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.006 · Cited by 1,090 · cited 5× · see citing works
“…the risk of dementia (Amieva et al., 2010; Anme et al., 2013; Beland, Zunzunegui, Alvarado, Otero, & del Ser, 2005; Crooks, Lubben, Petitti, Little, & Chiu, 2008; Fratiglioni, Wang, Ericsson, Maytan, & Winblad, 2000; Kuiper et al., 2015, 2016; Zunzunegui, Alvarado, del Ser, & Otero, 2003).”
BackgroundInfluentialMidlife blood pressure and dementia: the Honolulu–Asia aging study☆
Launer, L. J., Ross, G. W., Petrovitch, H., Masaki, K., Foley, D., White, L. R., & Havlik, R. J. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00096-8 · Cited by 1,008 · see citing works
Wang, H. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.12.1081 · Cited by 957 · see citing works
Influence of leisure activity on the incidence of Alzheimer's disease
Scarmeas, N., Levy, G., Tang, M.-X., Manly, J., & Stern, Y. (2001) · Neurology · doi:10.1212/wnl.57.12.2236 · Cited by 831 · see citing works
Prodromal Alzheimer's disease: successive emergence of the clinical symptoms
Amieva, H., Le Goff, M., Millet, X., Orgogozo, J. M., Pérès, K., Barberger‐Gateau, P., Jacqmin‐Gadda, H., & Dartigues, J. F. (2008) · Annals of Neurology · doi:10.1002/ana.21509 · Cited by 737 · see citing works
Zunzunegui, M.-V., Alvarado, B. E., Del Ser, T., & Otero, A. (2003) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/58.2.s93 · Cited by 719 · see citing works
The cult of statistical significance: how the standard error costs us jobs, justice, and lives
(2008) · Choice Reviews Online · doi:10.5860/choice.46-0372 · Cited by 716 · see citing works
A Population-Based Study of Dementia in 85-Year-Olds
Skoog, I. G., Nilsson, L., Palmertz, B., Andreasson, L., & Svanborg, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301213280301 · Cited by 692 · see citing works
Self-citationKivipelto, M., Helkala, E., Laakso, M. P., Hänninen, T., Hallikainen, M., Alhainen, K., Iivonen, S., Mannermaa, A., Tuomilehto, J., Nissinen, A. M., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-3-200208060-00006 · Cited by 645 · see citing works
ApoE genotype accounts for the vast majority of AD risk and AD pathology
Raber, J., Huang, Y., & Ashford, J. W. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.023 · Cited by 599 · see citing works
Brain reserve hypothesis in dementia
Fratiglioni, L., & Wang, H.-X. (2007) · Journal of Alzheimer's Disease · doi:10.3233/jad-2007-12103 · Cited by 499 · see citing works
Pathways between socioeconomic determinants of health
Lahelma, E. T., Martikainen, P., Laaksonen, M., & Aittomäki, A. (2004) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2003.011148 · Cited by 486 · see citing works
Clinico‐Neuropathological Correlation of Alzheimer's Disease in a Community‐Based Case Series
Lim, A., Tsuang, D. W., Kukull, W. A., Nochlin, D., Leverenz, J. B., McCormick, W. C., Bowen, J., Teri, L. L., Thompson, J. C., Peskind, E. R., et al. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb02571.x · Cited by 450 · see citing works
Evans, D. A., Hebert, L. E., Beckett, L. A., Scherr, P. A., Albert, M. S., Chown, M. J., Pilgrim, D. M., & Taylor, J. O. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550230066019 · Cited by 435 · see citing works
Social Network Types Among Older Adults: A Multidimensional Approach
Fiori, K. L., Smith, J., & Antonucci, T. C. (2007) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/62.6.p322 · Cited by 420 · see citing works
Social Networks Among Men and Women: The Effects of Age and Socioeconomic Status
Ajrouch, K. J., Blandon, A. Y., & Antonucci, T. C. (2005) · The Journals of Gerontology Series B · doi:10.1093/geronb/60.6.s311 · Cited by 397 · see citing works
Syndromic Validity of Apathy in Alzheimer's Disease
STARKSTEIN, S. E., Petracca, G., Chemerinski, E., & Kremer, J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.872 · Cited by 394 · see citing works
Event History and Survival Analysis
Allison, P. D. (2014) · Sage eBooks · doi:10.4135/9781452270029 · Cited by 393 · see citing works
Social Network, Cognitive Function, and Dementia Incidence Among Elderly Women
Crooks, V. C., Lubben, J., Petitti, D. B., Little, D., & Chiu, V. (2008) · American Journal of Public Health · doi:10.2105/ajph.2007.115923 · Cited by 390 · see citing works
Relation of Education and Occupation-based Socioeconomic Status to Incident Alzheimer's Disease
Karp, A. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh018 · Cited by 383 · see citing works
APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies
Tsuang, D., Leverenz, J. B., Lopez, O. L., Hamilton, R. L., Bennett, D. A., Schneider, J. A., Buchman, A. S., Larson, E. B., Crane, P. K., Kaye, J. A., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.600 · Cited by 378 · see citing works
Apolipoprotein E ɛ4 magnifies lifestyle risks for dementia: a population‐based study
Kivipelto, M., Rovio, S., Ngandu, T., Kåreholt, I., Eskelinen, M. H., Winblad, B. G., Hachinski, V., Cedazo-Mı́nguez, Á., Soininen, H. S., Tuomilehto, J., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00296.x · Cited by 348 · see citing works
Apolipoprotein E Polymorphism and Alzheimer Disease
Ganguli, M., Chandra, V., Kamboh, M. I., Johnston, J. M., Dodge, H. H., Thelma, B. K., Juyal, R. C., Pandav, R. S., Belle, S. H., & DeKosky, S. T. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.824 · Cited by 337 · see citing works
Sattler, C., Toro, P., Schönknecht, P., & Schröder, J. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.11.012 · Cited by 329 · see citing works
Giles, L. C., Glonek, G. F. V., Luszcz, M. A., & Andrews, G. R. (2005) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2004.025429 · Cited by 324 · see citing works
The Effect of Social Engagement on Incident Dementia
Saczynski, J. S., Pfeifer, L. A., Masaki, K., Korf, E. S. C., Laurin, D., White, L., & Launer, L. J. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj061 · Cited by 317 · see citing works
Kuiper, J. S., Zuidersma, M., Zuidema, S. U., Burgerhof, J. G. M., Stolk, R. P., Oude Voshaar, R. C., & Smidt, N. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw089 · Cited by 301 · see citing works
Midlife psychological stress and risk of dementia: a 35-year longitudinal population study
Johansson, L. H., Guo, X., Wærn, M., Östling, S., Gustafson, D., Bengtsson, C., & Skoog, I. G. (2010) · Brain · doi:10.1093/brain/awq116 · Cited by 291 · see citing works
Self-citationThe Use of Discrete Data in PCA: Theory, Simulations, and Applications to Socioeconomic Indices
Angeles, S. K. (2004) · Cited by 288 · see citing works
Fuhrer, R., & Stansfeld, S. A. (2002) · Social Science & Medicine · doi:10.1016/s0277-9536(01)00111-3 · Cited by 258 · see citing works
Gender Differences in Social Network Size and Satisfaction in Adults in Their 70s
McLaughlin, D., Vagenas, D., Pachana, N. A., Begum, N., & Dobson, A. J. (2010) · Journal of Health Psychology · doi:10.1177/1359105310368177 · Cited by 254 · see citing works
Trajectories of Cognitive Decline and Social Relations
Béland, F., Zunzunegui, M.-V., Alvarado, B., Otero, A., & del Ser, T. (2005) · The Journals of Gerontology: Series B · doi:10.1093/geronb/60.6.p320 · Cited by 238 · see citing works
Caetano, S. C., Silva, C. M., & Vettore, M. V. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-122 · Cited by 218 · see citing works
Amieva, H., Stoykova, R., Matharan, F., Helmer, C., Antonucci, T. C., & Dartigues, J. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181f5e121 · Cited by 217 · see citing works
Niti, M., Yap, K.-B., Kua, E. H., Tan, C., & Ng, T. P. (2007) · International Psychogeriatrics · doi:10.1017/s1041610207006655 · Cited by 198 · see citing works
The Scree Test and the Number of Factors: a Dynamic Graphics Approach
Ledesma, R. D., Valero‐Mora, P., & Macbeth, G. (2015) · The Spanish Journal of Psychology · doi:10.1017/sjp.2015.13 · Cited by 193 · see citing works
James, B. D., Boyle, P. A., Buchman, A. S., Barnes, L. L., & Bennett, D. A. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318211c219 · Cited by 177 · see citing works
Stratification and Mortality--A Comparison of Education, Class, Status, and Income
Torssander, J., & Erikson, R. S. (2009) · European Sociological Review · doi:10.1093/esr/jcp034 · Cited by 165 · see citing works
Lifestyle Factors Related to Mortality and Survival: A Mini-Review
Rizzuto, D., & Fratiglioni, L. (2014) · Gerontology · doi:10.1159/000356771 · Cited by 149 · see citing works
Research Evaluation and Prospective Diagnosis of Dementia With Lewy Bodies
López, O. L., Becker, J. T., Kaufer, D., Hamilton, R. L., Sweet, R. A., Klunk, W. E., & DeKosky, S. T. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.43 · Cited by 144 · see citing works
Beyond single indicators of social networks: A LISREL analysis of social ties among the elderly
Glass, T. A., de Leon, C. F. M., Seeman, T. E., & Berkman, L. F. (1997) · Social Science & Medicine · doi:10.1016/s0277-9536(96)00270-5 · Cited by 133 · see citing works
<i>APOE</i> ε4 allele is associated with reduced cerebrospinal fluid levels of Aβ42
Prince, J. A., Zetterberg, H., Andreasen, N., Marcusson, J., & Blennow, K. (2004) · Neurology · doi:10.1212/01.wnl.0000128088.08695.05 · Cited by 128 · see citing works
Self-citationWork‐Related Stress May Increase the Risk of Vascular Dementia
Andel, R., Crowe, M. G., Hahn, E. A., Mortimer, J. A., Pedersen, N. L., Fratiglioni, L., Johansson, B. E. A., & Gatz, M. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03777.x · Cited by 115 · see citing works
Support networks of childless older people: informal and formal support in Europe
Deindl, C., & Brandt, M. (2016) · Ageing and Society · doi:10.1017/s0144686x16000416 · Cited by 112 · see citing works
Qiu, C., Xu, W., & Fratiglioni, L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091663 · Cited by 107 · see citing works
Blennow, K., Ricksten, A., Prince, J. A., et al. (2000) · Journal of Neural Transmission · doi:10.1007/s007020070052 · Cited by 105 · see citing works
Self-citationIncidence of and Risk Factors for Dementia in the Ibadan Study of Aging
Gureje, O., Ogunniyi, A. O., Kola, L., & Abiona, T. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03374.x · Cited by 103 · see citing works
What childless older people give: is the generational link broken?
Albertini, M., & Kohli, M. (2009) · Ageing and Society · doi:10.1017/s0144686x0999033x · Cited by 102 · see citing works
Johansson, L., Guo, X., Hällström, T., Norton, M. C., Waern, M., Östling, S., Bengtsson, C., & Skoog, I. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-003142 · Cited by 101 · see citing works
Self-citationWang, H., Gustafson, D., Kivipelto, M., Pedersen, N. L., Skoog, I. G., Windblad, B., & Fratiglioni, L. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.10.003 · Cited by 99 · see citing works
Self-citationGuo, X., Wærn, M., Sjögren, K., Lissner, L., Bengtsson, C., Björkelund, C., Östling, S., Gustafson, D., & Skoog, I. G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.01.008 · Cited by 95 · see citing works
Self-citationPoey, J. L., Burr, J. A., & Roberts, J. S. (2017) · The Gerontologist · doi:10.1093/geront/gnw154 · Cited by 90 · see citing works
Salinas, J., Beiser, A., Himali, J. J., Satizabal, C. L., Aparicio, H. J., Weinstein, G., Mateen, F. J., Berkman, L. F., Rosand, J., & Seshadri, S. (2017) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.03.001 · Cited by 87 · see citing works
Skoog, I., Waern, M., Duberstein, P., Blennow, K., Zetterberg, H., Börjesson-Hanson, A., Östling, S., Guo, X., Kern, J., Gustafson, D., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.006 · Cited by 85 · see citing works
Self-citationHow can elderly apolipoprotein E ε4 carriers remain free from dementia?
Ferrari, C., Xu, W., Wang, H., Winblad, B. G., Sorbi, S., Qiu, C., & Fratiglioni, L. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.03.003 · Cited by 78 · see citing works
Is apolipoprotein E4 an important risk factor for vascular dementia?
Rohn, T. T. (2014) · PubMed Central · Cited by 68 · see citing works
Halleröd, B., & Seldén, D. (2012) · Social Indicators Research · doi:10.1007/s11205-012-0115-8 · Cited by 67 · see citing works
Self-citationThe prognosis and incidence of social phobia in an elderly population. A 5‐year follow‐up
Karlsson, B., Sigström, R., Wærn, M., Östling, S., Gustafson, D., & Skoog, I. G. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01559.x · Cited by 62 · see citing works
Self-citationMartínez, G., Vernooij, R. W. M., Padilla, P. F., Zamora, J., Bonfill, X., & Flicker, L. A. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012216.pub2 · Cited by 59 · see citing works
The Effect of APOE-ε4 on Dementia is Mediated by Alzheimer Neuropathology
Mortimer, J. A., Snowdon, D. A., & Markesbery, W. R. (2009) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318190a855 · Cited by 57 · see citing works
Hypertension and Related Factors in the Etiology of Alzheimer's Disease
Skoog, I. G., & Gustafson, D. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04796.x · Cited by 57 · see citing works
Self-citationSocial networks and their role in preventing dementia.
Pillai, J. A., & Verghese, J. (2009) · PubMed Central · Cited by 53 · see citing works
Prevalence of Social Phobia in Non-Demented Elderly From a Swedish Population Study
Karlsson, B., Klenfeldt, I. F., Sigström, R., Wærn, M., Östling, S., Gustafson, D., & Skoog, I. G. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181860051 · Cited by 46 · see citing works
Self-citationZuelsdorff, M. L., Engelman, C. D., Friedman, E. M., Koscik, R. L., Jonaitis, E. M., Rue, A. L., & Sager, M. A. (2013) · Journal of Aging and Health · doi:10.1177/0898264313498416 · Cited by 46 · see citing works
Brenowitz, W. D., Kukull, W. A., Beresford, S. A. A., Monsell, S. E., & Williams, E. C. (2014) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000020 · Cited by 33 · see citing works
ApoE gene polymorphism and vascular dementia in Chinese population: a meta-analysis
Liu, X., Li, L., Liu, F., Deng, S., Zhu, R., Li, Q., & He, Z. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0714-6 · Cited by 31 · see citing works
Halleröd, B. (2009) · Ageing and Society · doi:10.1017/s0144686x09008502 · Cited by 27 · see citing works
Self-citationHeser, K., Wagner, M., Wiese, B., Prokein, J., Ernst, A., König, H., Brettschneider, C., Riedel-Heller, S. G., Luppa, M., Weyerer, S. B., et al. (2014) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000368189 · Cited by 25 · see citing works
Halleröd, B. (2012) · Ageing and Society · doi:10.1017/s0144686x12000268 · Cited by 21 · see citing works
Self-citationGuo, S. (2010) · Cited by 18 · see citing works
New Intimate Relationships in Later Life
Bildtgård, T., & Öberg, P. (2015) · Journal of Family Issues · doi:10.1177/0192513x15579503 · Cited by 17 · see citing works
Gallacher, J., Bayer, A. J., & Ben‐Shlomo, Y. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi107 · Cited by 15 · see citing works
Hasselgren, C., Ekbrand, H., Fässberg, M. M., Zettergren, A., Zetterberg, H., Blennow, K., Skoog, I. G., & Halleröd, B. (2018) · Ageing and Society · doi:10.1017/s0144686x18000351 · Cited by 10 · see citing works
Self-citationMartínez, G., Flicker, L. A., Vernooij, R. W. M., Padilla, P. F., Zamora, J., Figuls, M. R. I., Urrútia, G., & Bonfill, X. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012216 · Cited by 6 · see citing works
Social Interaction and Dementia Prevention: Six-year follow-up study
Anme, T., Kawashima, Y., Shinohara, R., Sugisawa, Y., Watanabe, T., Tokutake, K., Mochizuki, Y., Morita, K., & Tomisaki, E. (2013) · Public Health Frontier · doi:10.5963/phf0202008 · Cited by 4 · see citing works
Effect of the Interplay Between Genetic and Behavioral Risks on Survival After Age 75
Rizzuto, D., Keller, L., Orsini, N., Graff, C., Bäckman, L., Bellocco, R., Wang, H., & Fratiglioni, L. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14391 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Manca, R., De Marco, M., & Venneri, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.585540 · Cited by 227 · see citing works
Elovainio, M., Lahti, J., Pirinen, M., Pulkki-Råback, L., Malmberg, A., Lipsanen, J., Virtanen, M., Kivimäki, M., & Hakulinen, C. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-053936 · Cited by 85 · see citing works
- Authors
- Wu, J., Hasselgren, C., Zettergren, A., Zetterberg, H., Blennow, K., Skoog, I., & Halleröd, B.
- Affiliations
- University of Gothenburg (SE)
- Sahlgrenska University Hospital (SE)
- Department of Sociology and Work Science, University of Gothenburg, Gothenburg, Sweden;
- Corresponding author
- Wu, Jing
- Venue
- Aging & Mental Health
- Publisher
- Informa UK Limited
- Published
- 2018-12-27
- Volume
- 24
- Issue
- 3
- Pages
- 395-404
- ISSN
- 1360-7863 (ISSN-L)
- 1364-6915
- OpenAlex
- W2906929042
- Cited by
- 18
- References
- 93
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Aging & Mental Health (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- the Stena Foundation
- the Swedish Research Council (2015-02830, 2013-8717)
- the Swedish Research Council for Health, Working Life and Welfare (2004-0145, 2006-0596, 2008-1111, 2010-0870, 2013-1202, 2013-2300, 2013-2496)
- the Alzheimer's Association Zenith Award (ZEN-01-3151)
- the Alzheimer's Association Stephanie B. Overstreet Scholars (IIRG-00-2159)
- Sahlgrenska University Hospital
- Alzheimerfonden
- Hjärnfonden
- Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse
- Eivind och Elsa K:son Sylvans Stiftelse
- Stiftelsen Söderström-Königska Sjukhemmet
- Stiftelsen för Gamla Tjänarinnor
- Handlanden Hjalmar Svenssons Forskningsfond
- Stiftelsen Professor Bror Gadelius’ Minnesfond
- the Swedish Brain Foundation
- the Swedish Alzheimer Foundation
- the Torsten Söderberg Foundation
- the Swedish Society of Medicine
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Health › Health disparities and outcomes
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- social networks, APOE ε4, dementia, older adults, gender differences, gene-environment interaction, dementia onset
- MeSH terms
- Aged, Aged, 80 and over, Alleles, Dementia, Female, Genotype, Humans, Male, Prospective Studies, Risk Factors, Sweden, Apolipoprotein E4, Social Networking
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
